The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled tria... by Zehua Zhang, Shiyun Tang, Shiyu Liu, Yulin Leng, Xiaoxu Fu, Hongyan Xie, Hong Gao, Hong Gao, Chunguang Xie, Chunguang Xie

“…A comprehensive analysis is necessary to evaluate the efficacy and safety of GBE as an adjuvant treatment for DKD.ObjectiveThis meta-analysis aimed to evaluate the efficacy and safety of GBE as a supplementary treatment to conventional renin-angiotensin-aldosterone system inhibitors for DKD patients, providing a reference for subsequent research and clinical practice.MethodsThis study has been registered in PROSPERO as CRD42023455792. …”
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Fine-tuning a local LLaMA-3 large language model for automated privacy-preserving physician letter generation in radiation oncology by Yihao Hou, Yihao Hou, Christoph Bert, Christoph Bert, Christoph Bert, Ahmed Gomaa, Ahmed Gomaa, Ahmed Gomaa, Godehard Lahmer, Godehard Lahmer, Godehard Lahmer, Daniel Höfler, Daniel Höfler, Daniel Höfler, Thomas Weissmann, Thomas Weissmann, Thomas Weissmann, Raphaela Voigt, Raphaela Voigt, Raphaela Voigt, Philipp Schubert, Philipp Schubert, Philipp Schubert, Charlotte Schmitter, Charlotte Schmitter, Charlotte Schmitter, Alina Depardon, Alina Depardon, Alina Depardon, Sabine Semrau, Sabine Semrau, Sabine Semrau, Andreas Maier, Rainer Fietkau, Rainer Fietkau, Rainer Fietkau, Yixing Huang, Yixing Huang, Florian Putz, Florian Putz, Florian Putz

“…IntroductionGenerating physician letters is a time-consuming task in daily clinical practice.MethodsThis study investigates local fine-tuning of large language models (LLMs), specifically LLaMA models, for physician letter generation in a privacy-preserving manner within the field of radiation oncology.ResultsOur findings demonstrate that base LLaMA models, without fine-tuning, are inadequate for effectively generating physician letters. …”
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Adverse events in the nervous system associated with blinatumomab: a real-world study by Wen Gao, Jingwei Yu, Yifei Sun, Zheng Song, Xia Liu, Xue Han, Lanfan Li, Lihua Qiu, Shiyong Zhou, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

“…Real-world data are needed to better understand the incidence and characteristics of NST in clinical practice. Methods Data were obtained from the FDA Adverse Event Reporting System (FAERS). …”
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Unraveling the immunological landscape and gut microbiome in sepsis: a comprehensive approach to diagnosis and prognosisResearch in context by Yali Luo, Jian Gao, Xinliang Su, Helian Li, Yingcen Li, Wenhao Qi, Xuling Han, Jingxuan Han, Yiran Zhao, Alin Zhang, Yan Zheng, Feng Qian, Hongyu He

“…Summary: Background: Comprehensive and in-depth research on the immunophenotype of septic patients remains limited, and effective biomarkers for the diagnosis and treatment of sepsis are urgently needed in clinical practice. Methods: Blood samples from 31 septic patients in the Intensive Care Unit (ICU), 25 non-septic ICU patients, and 18 healthy controls were analyzed using flow cytometry for deep immunophenotyping. …”
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Outcomes and risk factors of transported patients with extracorporeal membrane oxygenation: An ECMO center experience by Lingjuan Liu, Dingji Hu, Tong Hao, Shanshan Chen, Lei Chen, Yike Zhu, Chenhui Jin, Jing Wu, Haoya Fu, Haibo Qiu, Yi Yang, Songqiao Liu

“…Herein, we examined the safety of ECMO during the transport of critically ill patients and its impact on mortality rates, to provide more secure and effective transport strategies in clinical practice. Method: To assess the safety of ECMO patient transport, this study conducted a retrospective analysis on critically ill adults who required ECMO support and transport at the intensive care unit (ICU) center between 2017 and 2023. …”
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Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral... by Shuai Yang, En Deng, Linxin Chen, Yanbin Pi, Anhong Wang, Linghui Dai, Hongjie Huang, Xiaoning Duan, Xin Fu, Jiying Zhang, Qinwei Guo, Weili Shi

“…The translational potential of this article: As a recently developed procedure for treating osteochondral defects, AOPT has shown promising repair effect and is being increasingly adopted in clinical practice. This study presents histological evidence of the progressive transformation of the periosteum graft into cartilage-like tissue and demonstrates its ability to integrate with the surrounding tissue.…”
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Comparative Effectiveness of Rosuvastatin Versus Atorvastatin in Acute Ischemic Stroke Treatment by Joon‐Tae Kim, Ji Sung Lee, Hyunsoo Kim, Beom Joon Kim, Jihoon Kang, Keon‐Joo Lee, Jong‐Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae‐Kwan Cha, Dae‐Hyun Kim, Tai Hwan Park, Kyungbok Lee, Jun Lee, Keun‐Sik Hong, Yong‐Jin Cho, Hong‐Kyun Park, Byung‐Chul Lee, Kyung‐Ho Yu, Mi Sun Oh, Dong‐Eog Kim, Jay Chol Choi, Jee‐Hyun Kwon, Wook‐Joo Kim, Dong‐Ick Shin, Kyu Sun Yum, Sung Il Sohn, Jeong‐Ho Hong, Sang‐Hwa Lee, Man‐Seok Park, Wi‐Sun Ryu, Kwang‐Yeol Park, Juneyoung Lee, Jeffrey L. Saver, Hee‐Joon Bae

“…However, in real clinical practice, rosuvastatin is used less than one‐fifth as frequently as atorvastatin in patients with acute ischemic stroke. …”
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Nonacademic predictors of China medical licensing examination by Jie Sun, Yingying Xie, Ningnannan Zhang, Jingliang Cheng, Meiyun Wang, Bing Zhang, Wenzhen Zhu, Hui Zhang, Shijun Qiu, Xiaojun Xu, Yongqiang Yu, Tong Han, Zuojun Geng, Weihua Liao, Bo Gao, Wen Qin, Feng Liu, Meng Liang, Qiang Xu, Jilian Fu, Jiayuan Xu, Mengge Liu, Peng Zhang, Wei Li, Dapeng Shi, Caihong Wang, Xi-Nian Zuo, Quan Zhang, Feng Chen, Jiance Li, Zhihan Yan, Wen Shen, Yanwei Miao, Junfang Xian, Longjiang Zhang, Kai Xu, Zhaoxiang Ye, Jing Zhang, Guangbin Cui, Chunshui Yu, for the CHIMGEN Consortium

“…Abstract Background National Medical Licensing Examination (NMLE) is the entrance exam for medical practice in China, and its general medical knowledge test (GMKT) evaluates abilities of medical students to comprehensively apply medical knowledge to clinical practice. This study aimed to identify nonacademic predictors of GMKT performance, which would benefit medical schools in designing appropriate strategies and techniques to facilitate the transition from medical students to qualified medical practitioners. …”
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Applied pharmacogenetics to predict response to treatment of first psychotic episode: study protocol by Sergi Mas, Sergi Mas, Sergi Mas, Laura Julià, Manuel J. Cuesta, Manuel J. Cuesta, Manuel J. Cuesta, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Javier Vázquez-Bourgon, Javier Vázquez-Bourgon, Javier Vázquez-Bourgon, Carlos Spuch, Carlos Spuch, Ana Gonzalez-Pinto, Ana Gonzalez-Pinto, Angela Ibañez, Angela Ibañez, Judith Usall, Judith Usall, Cristina Romero-López-Alberca, Cristina Romero-López-Alberca, Ana Catalan, Ana Catalan, Ana Catalan, Ana Catalan, Ana Catalan, Anna Mané, Anna Mané, Anna Mané, Anna Mané, Miquel Bernardo, Miquel Bernardo, Miquel Bernardo, Miquel Bernardo

“…However, several limitations have hindered its translation into clinical practice. Here, we describe the rationale, aims and methodology of Applied Pharmacogenetics to Predict Response to Treatment of First Psychotic Episode (the FarmaPRED-PEP project), which aims to develop and validate predictive algorithms to classify FEP patients according to their response to antipsychotics, thereby allowing the most appropriate treatment strategy to be selected. …”
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Artificial intelligence-based, non-invasive assessment of the central aortic pressure in adults after operative or interventional treatment of aortic coarctation by Renate Oberhoffer, Peter Ewert, Harald Kaemmerer, Nicole Nagdyman, Oliver Dewald, Frank Klawonn, Michael Huntgeburth, Andreas Eicken, Christian Meierhofer, Sebastian Freilinger, Martin Middeke, Pinar Bambul Heck, Annika Freiberger, Frank Harig, Manuel Lösch, Fritz Mellert, Fabian von Scheidt, Elsa Ury, Nicole Wolfrum, Ann-Sophie Kaemmerer-Suleiman, Mathieu N. Suleiman

“…The study highlights the need to incorporate CABP measurements into clinical practice to avoid overdiagnosis of hypertension. …”
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Googling Patients by Emily Beer

“…But literature geared towards ethics in clinical practice ought not confuse lay and legal definitions because doing so risks legitimizing an incorrect position. …”
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First-Line Chemo-Immunotherapy in SCLC: Outcomes of a Binational Real-World Study by Laura Moliner, MD, Núria Zellweger, MSc, Sabine Schmid, MD, Martina Bertschinger, MD, Christine Waibel, MD, Ferdinando Cerciello, MD, PhD, Patrizia Froesch, MD, Michael Mark, MD, Adrienne Bettini, MD, Pirmin Häuptle, MD, Veronika Blum, MD, Lisa Holer, MSc, Stefanie Hayoz, PhD, Martin Früh, MD, Samreen Ahmed, FRCP, MD, MBBS, MSc, Shradha Bhagani, MD, Nicola Steele, MD, Hannah-Leigh Gray, BSc, Stephen D. Robinson, MD, Michael Davidson, MD (Res), Samantha Cox, MD, MSc, MBBCh, Taha Khalid, MD, Tom R. Geldart, MD, Luke Nolan, FRCS, PhD, Deborah C. Scott, MBChB (MRCP), Lindsay Hennah, MD, Tom Newsom-Davis, MD, PhD, Emma Rathbone, MD, PhD, Catherine Handforth, MD, Arshi Denton, MD, Shairoz Merchant, PhD, Fiona Blackhall, MD, PhD, Laetitia A. Mauti, MD, Raffaele Califano, MD, Sacha I. Rothschild, MD, PhD

“…In particular, the number of long-term survivors and the safety data are comparable, supporting the use of chemo-immunotherapy as first-line treatment for ES-SCLC in daily clinical practice.…”
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A systematic review and meta-analysis of influencing factors of postoperative wound healing in patients with anal fistula (肛瘘患者术后伤口愈合影响因素系统评价与Meta分析)... by CHEN Qi (陈祺), LIU Zhiping (刘志平), BAI Jianying (白建英), LIU Bo (刘博), FENG Jiangxu (冯江雪)

“…Objective To systematically evaluate the influencing factors of wound healing in patients undergoing anal fistula surgery, and to provide a theoretical basis for the formulation of reasonable treatment and nursing measures in clinical practice. Methods The computer searched CNKI, Wanfang, VIP Chinese Database, Pubmeide, Enbas, Weber Benschens and Techco Kranali Liberi English databases to collect clinical studies related to the influencing factors of anal fistula wound healing. …”
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Effect of ERAS Baduancao based on the integration of martial arts and medicine on perioperative negative emotion and sleep quality in patients undergoing surgery for gastrointestin... by CAI Hui (蔡晖), ZHOU Chen (周晨), WANG Qing (王青), QIN Mengying (秦梦颖), WANG Yan (王艳)

“…Methods Based on the integration of martial arts and medicine, combined with the theory of fitness qigong and the concept of ERAS, the ERAS Baduancaoe was developed through clinical practice. A Total of 78 patients with gastrointestinal cancer admitted from March 2020 to June 2023 were selected as the research subjects. …”
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Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence? by Christoph Riegler, Christoph Riegler, Viktoria Rücker, Regina von Rennenberg, Regina von Rennenberg, Kerstin Bollweg, Kerstin Bollweg, Bastian Cheng, Anna C. Alegiani, Fabian Flottmann, Marlena Schnieder, Marielle Ernst, Waltraud Pfeilschifter, Waltraud Pfeilschifter, Waltraud Pfeilschifter, Christoffer Kraemer, Ruben Mühl-Benninghaus, Steffen Tiedt, Steffen Tiedt, Lars Kellert, Hanna Zimmermann, Felix J. Bode, Felix J. Bode, Gabor C. Petzold, Gabor C. Petzold, Franziska Dorn, Jörg Berrouschot, Albrecht Bormann, Kathleen Bernkopf, Silke Wunderlich, Tobias Boeckh-Behrens, Martina Petersen, Lars Udo Krause, Stephan Lowens, Heinrich J. Audebert, Heinrich J. Audebert, Eberhard Siebert, Peter U. Heuschmann, Peter U. Heuschmann, Peter U. Heuschmann, Christian H. Nolte, Christian H. Nolte, Christian H. Nolte, Christian H. Nolte

“…Our study aimed to evaluate the temporal changes in patients’ characteristics, treatment, and outcomes in clinical practice.MethodsWe used data from the German Stroke Registry, a large national multicentre prospective registry, which includes all patients receiving EVT for ischaemic stroke at its participating centers. …”
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60-month follow-up of Long Limb vs. Standard Limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT by Saleem Ansari, Anna Kamocka, Tina Mazaheri, Ibiyemi Ilesanmi, Lara Jimenez-Pacheco, Kleopatra Alexiadou, Joanna Tan, Harvinder Chahal, Krishna Moorthy, Sanjay Purkayastha, Anne Margot Umpleby, Stephen Robert Bloom, Francesco Rubino, Alexander Dimitri Miras, Ahmed Rashid Ahmed, Tricia Tan

“…Limitations Although the surgical procedures were designed according to United Kingdom clinical practice at the time of study inception, there is substantial variation in practice internationally. …”
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Comparison of objectively measured and estimated cardiorespiratory fitness to predict all-cause and cardiovascular disease mortality in adults: A systematic review and meta-analysi... by Ben Singh, Cristina Cadenas-Sanchez, Bruno G.G. da Costa, José Castro-Piñero, Jean-Philippe Chaput, Magdalena Cuenca-García, Carol Maher, Nuria Marín-Jiménez, Ryan McGrath, Pablo Molina-García, Jonathan Myers, Bethany Gower, Francisco B. Ortega, Justin J. Lang, Grant R. Tomkinson

“…Our findings underscore the health-related benefits of higher CRF and advocate for its integration into clinical practice to enhance risk stratification.…”
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The role of platelet-rich plasma in biomedicine: A comprehensive overview by Zhixin Zhang, Peng Liu, Xinmiao Xue, Zhiyu Zhang, Li Wang, Yvke Jiang, Chi Zhang, Hanwen Zhou, Shuhan Lv, Weidong Shen, Shiming Yang, Fangyuan Wang

“…Summary: Biomedicine has seen significant advancements in the 21st century, with platelet-rich plasma (PRP) playing a crucial role in clinical practice. This blood derivative, enriched with platelet components, has shown great potential for promoting tissue repair and regeneration. …”
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Cardiovascular risk assessment: Missing albuminuria contributing to gender inequality by Patricia de Sequera, Javier Arias, Borja Quiroga, María Benavent, Fabio Procaccini, Iago Romero, Guillermo López, Javier Diez, Alberto Ortiz

“…The European Society Cardiology (ESC) guidelines, he European Renal Association (ERA) Council and the Spanish Society of Nephrology (S.E.N.) in collaboration with 15 Scientific Societies recommend assessing albuminuria in all these populations.We have evaluated current clinical practice regarding the assessment of CVD risk factors (blood pressure, albuminuria, serum cholesterol, glycemia and creatinine) in different adult health user populations, analyzing the results separately for men and women, given recent evidence on gender differences in the recognition, monitoring, and management of CKD. …”
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The TB27 Transcriptomic Model for Predicting Mycobacterium tuberculosis Culture Conversion by Maja Reimann, Korkut Avsar, Andrew DiNardo, Torsten Goldmann, Gunar Günther, Michael Hoelscher, Elmira Ibraim, Barbara Kalsdorf, Stefan Kaufmann, Niklas Köhler, Anna Mandalakas, Florian Maurer, Marius Müller, Dörte Nitschkowski, Ioana Olaru, Cristina Popa, Andrea Rachow, Thierry Rolling, Helmut Salzer, Patricia Sanchez-Carballo, Maren Schuhmann, Dagmar Schaub, Victor Spinu, Elena Terhalle, Markus Unnewehr, Nika Zielinski, Jan Heyckendorf, Christoph Lange

“…TB27 is a potential useful biomarker for anti-tuberculosis drug development and for prediction of treatment responses in clinical practice.  …”
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