Low transthyretin is associated with the poor prognosis of colorectal cancer by Zhe Zhang, Zhe Zhang, Zhe Zhang, Chenhao Hu, Chenhao Hu, Chenhao Hu, Feiyu Shi, Feiyu Shi, Feiyu Shi, Lei Zhang, Lei Zhang, Lei Zhang, Ya Wang, Ya Wang, Yujie Zhang, Yujie Zhang, Yujie Zhang, Xiaojiang Zhang, Xiaojiang Zhang, Xiaojiang Zhang, Junjun She, Junjun She, Junjun She

“…Compared with other models, the proportional hazards model combined with TTR demonstrates superior performance in terms of C-index, AUC, calibration chart, and DCA within the prognostic column chart.ConclusionsThe preoperative TTR was identified as a prognostic factor for predicting the long-term prognosis of CRC patients who underwent surgical treatment, supporting its role as a prognostic biomarker in clinical practice.…”
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Normative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case–Control Study by Lianne Mobbs, Vinuja Fernando, R. Dineth Fonseka, Pragadesh Natarajan, Monish Maharaj, Ralph J. Mobbs

“…The normative database provides a valuable reference future research and clinical practice. It enables a more nuanced understanding of how gait evolves with age, gender, and physical stature, thus informing the development of targeted interventions to maintain mobility and prevent falls in older adults. …”
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Modified Bloom's Taxonomy: Perspective of a Doctor of Philosophy Scholar by Wafa Omer

“…It promotes a change from learning only theory to a more comprehensive strategy that emphasises real-world application and ongoing development.6 To promote a culture of creativity and lifelong learning, educational programs would concentrate not only on the creation of knowledge but also on how that information may be applied to other professional sectors.7 Current Dilemma The most prominent challenge that is being faced in the thesis being written by PhD scholars is that the new innovative discovery never finds its way into the clinical practice or the workplace. It remains in text and the hardbound theses keep getting stacked in the storerooms of educational institutions as the scholars move on without even a pilot incorporation of their findings in the real workplace-based systems. …”
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Multi-institutional evaluation comparing guidance from International Ki67 Working Group vs National Health Commission of China on immunohistochemistry-based Ki67 assessment alongsi... by Yin Wang, Jiarui Zou, Qinghua Cao, Guihong Dai, Panhong Fan, Xue Gong, Jinyan Jiang, Yanqing Kong, Chao Liu, Chunhui Liu, Chenjia Lu, Meiren Li, Zhiqiang Lang, Yang Lin, Yan Peng, Haiyan Shi, Yuhuan Wang, Jiu Wang, Bichen Xie, Bing Yang, Guohua Yu, Cuiping Zhang, Hengming Zhang, Luting Zhou, Zilan Zhang, Zhenli Zhu, Junmei Hao

“…PurposeRecommendations from the National Health Commission of China (NHCC) and the International Ki67 Working Group (IKWG) were issued to guide immunohistochemistry (IHC)-based Ki67 scoring for breast cancer patients in daily clinical practice. They were evaluated in this multi-institutional study alongside the results from the Quantitative Dot Blot (QDB) method.MethodsThree alternative adjacent sections from 40 primary ER+ breast cancer resection blocks were randomly assigned a number from 1 to 120 for Ki67 staining and reviewed by 21 pathologists, while the other three alternative sections were sent for QDB analysis of Ki67 protein levels. …”
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Current Application and Meta-analysis of Traditional Chinese Medicine emotional nursing for colorectal cancer patients' psycho-somatic rehabilitation after radical surgery (中医情志护理在... by SUN Lingyun (孙凌云), PENG Rongyan (彭蓉晏), LIU Jiaxi (刘稼玺), YAN Yunzi (闫蕴孜), YANG Yufei (杨宇飞), ZHAO Nan (赵楠)

“…Objective To systematically evaluate the efficacy and current application of emotional nursing of Traditional Chinese Medicine(TCM) in psycho-somatic rehabilitation for early-stage colorectal cancer(CRC) patients after radical surgery, so as to provide reference for clinical practice and future research. Methods CNKI, VIP, Wanfang, Embase, Pubmed, Conchrane database were retrieved, and the randomized controlled clinical trials of TCM emotional nursing on psychosomatic rehabilitation of early-stage colorectal cancer patients after radical surgery from 2010 to 2022 was collected. …”
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Association of the blood urea nitrogen to serum albumin ratio and all-cause mortality in critical ill acute ischemic stroke patients: a retrospective cohort study of MIMIC-IV datab... by Yongwei Huang, Zongping Li, Jianjun Wang, Jianjun Wang, Decai Wang, Decai Wang, Xiaoshuang Yin

“…However, further research is needed on other racial and ethnic groups before these findings can be widely applied in clinical practice.…”
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Pragmatic algorithm for visual assessment of 4-Repeat tauopathies in [18F]PI-2620 PET Scans by Theresa Bauer, Matthias Brendel, Mirlind Zaganjori, Alexander M. Bernhardt, Alexander Jäck, Sophia Stöcklein, Maximilian Scheifele, Johannes Levin, Thilo van Eimeren, Alexander Drzezga, Osama Sabri, Henryk Barthel, Robert Perneczky, Günter Höglinger, Nicolai Franzmeier, Johannes Gnörich

“…Aim: Standardized evaluation of [18F]PI-2620 tau-PET scans in 4R-tauopathies represents an unmet need in clinical practice. This study aims to investigate the effectiveness of visual evaluation of [18F]PI-2620 images for diagnosing 4R-tauopathies and to develop a straight-forward reading algorithm to improve objectivity and data reproducibility. …”
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A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma by Jie Zha, Qinwei Chen, Wei Zhang, Hongmei Jing, Jingjing Ye, Huanhuan Liu, Haifeng Yu, Shuhua Yi, Caixia Li, Zhong Zheng, Wei Xu, Zhifeng Li, Zhijuan Lin, Lingyan Ping, Xiaohua He, Liling Zhang, Ying Xie, Feili Chen, Xiuhua Sun, Liping Su, Huilai Zhang, Haiyan Yang, Weili Zhao, Lugui Qiu, Zhiming Li, Yuqin Song, Bing Xu

“…It holds promise for informing treatment decisions and prognostic assessments in clinical practice for FL patients at high risk of POD24.…”
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Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography by Zhubin Lun, Jin Liu, Liwei Liu, Jingjing Liang, Guanzhong Chen, Shiqun Chen, Bo Wang, Qiang Li, Haozhang Huang, Zhidong Huang, Danyuan Xu, Yunzhao Hu, Ning Tan, Jiyan Chen, Yong Liu, Jianfeng Ye

“…., early CA-AKI, have better predictive value for long-term mortality. Therefore, in clinical practice, physicians should pay more attention to patients with early renal injury related to long-term prognosis and give active treatment.…”
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Evidence-based ankle pump exercise in prevention of postoperative deep-vein thrombosis in patients with lower extremity fracture (踝泵运动预防下肢骨折患者围手术期深静脉血栓的循证实践)... by BAO Xiuhong (鲍秀红), ZHANG Fang (张芳), ZHU Yi (朱屹), SHAO Ye (邵烨)

“…Methods CNKI, Wanfang, VIP, Medlive, BMJ, Cochrane library, Embase, PubMed, RNAO, ESPEN, NGC and NICE were searched for clinical practice guidelines, systematic reviews and relevant papers from August 2012 to August 2012. …”
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Surface prereacted glass-ionomer particles incorporated into resin composites promote biocompatibility for restoration of subgingival dental defects by Yueyi Yang, Jing Huang, Xuchen Hu, Meiling Jing, Yujie Zhang, Chenci Xu, Wenduo Tan, Xiaoyu Liu, Chenguang Niu, Zhengwei Huang

“…Subgingival dental defects are common in clinical practice among patients with deep dental caries and dental fractures. …”
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Case Reports: The core of practice-based evidence by Antonio Villa

“…In the era of evidence-based medicine, where meta-analysis of several randomized controlled research, is considered prominent with respect of evidence gathered from experts and clinical practice, we should not forget the essential role of practice-based evidence. …”
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Potential Antidepressant Effects of Omeprazole Introduced Through Network Analysis and Systems Biology Should Be Interpreted with Caution in the Clinical Environment by Seyed-Ali Mostafavi

“…Although I do appreciate the innovation with which the authors were able to use network analysis and systems biology to identify these potential relationships, I felt quite urged to present a more critical perspective before interpreting the findings of network analysis and systems biology into clinical practice. New investigations explore the role of long-term administration of proton pump inhibitors (PPIs), including Omeprazole, and their potential link to mood disorders, major depressive disorder, and even suicidal ideation. …”
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Development and validation of a screening tool for sepsis without laboratory results in the emergency department: a machine learning studyResearch in context by Shan Jiang, Shuai Dai, Yulin Li, Xianlong Zhou, Cheng Jiang, Cong Tian, Yana Yuan, Chengwei Li, Yan Zhao

“…However, due to its low positive predictive value (PPV), the false alarms may increase in actual clinical practice. Funding: Transformation of Scientific and Technological Achievements Fund Project of Zhongnan Hospital of Wuhan University.…”
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A meta-analysis of program for the reduction of physical restraint use in intensive care units in China (国内ICU患者缩减身体约束行动实施效果的Meta分析) by CHEN Zetao (陈泽涛), LI Xiaobing (李晓彬), SHI Yu (石宇), ZHANG Yanfei (张雁飞), YANG Wencai (杨文才), SHAN Miaohang (单妙航)

“…The collaboration of multidisciplinary teams has shown even more significant effects, which warrants further promotion and optimization in clinical practice. (目的 评价国内ICU患者缩减身体约束的实施效果。方法 计算机检索中国知网(CNKI)、万方数据库、维普数据库(VIP)、中国生物医学文献数据库(CBM)中关于缩减身体约束行动实践的随机对照试验, 检索时限为建库至2024年6月。…”
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Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury by Guanting Li, Yourong Hu, Han Zhao, Ziyu Peng, Xin Shang, Jia Zhang, Kunxin Xie, Meiwei Li, Xiaohang Zhou, Qinyao Zhou, Kai Li, Fang Zhou, Heyao Wang, Zhijian Xu, Jiali Liu, Peng Sun

“…This study demonstrates that a slow metabolism‐driven amplification of hepatic PPARγ agonism mediates BBR‐induced obesity‐specific hepatic steatosis and subsequent DILI, which also emphasizes the importance of the reduced hepatic drug metabolism capacity in patients with obesity or pre‐existing NAFLD in both clinical practice and drug discovery processes.…”
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Application of Health Education Accurately Linking System combined with case-based leaning in nursing teaching ward round in the encephalopathy clinic (健康教育精准连接系统助手联合基于案例学习模式在脑病科护理... by FU Jinna (付景娜), ZHAO Zijun (赵子珺), YANG Junxing (杨俊行), HU Zhe (胡哲), LYU Jingmin (吕静敏), SONG Ying (宋颖), SUN Yi (孙祎), GAO Jiajia (高佳佳), GENG Qingwen (耿庆文)

“…Conclusion The HEALS combined with CBL model has obvious advantages in nursing teaching ward rounds, which can better meet the needs of clinical nursing teaching, effectively cultivate clinical practice and thinking ability, and is conducive to teaching management. …”
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Evaluation of the diagnostic efficiency of fluorescence in situ hybridization for pulmonary tuberculosis: a systematic review and meta-analysis by Yu-Qi Hu, Yu-Qi Hu, Kang Liu, Kang Liu, Le-Qing Lai, Le-Qing Lai, Yi-Ru He, Yi-Ru He, Li-Ping Hong, Li-Ping Hong, Chu-Qian Jiang, Chu-Qian Jiang, Si-Min Liu, Si-Min Liu, Ming-Zhu Cao

“…ObjectiveIn clinical practice, an accurate and efficient detection approach for pulmonary tuberculosis (PTB) is highly needed. …”
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Adherence to a digital therapeutic mediates the relationship between momentary self-regulation and health risk behaviors by Enzo G. Plaitano, Enzo G. Plaitano, Daniel McNeish, Sophia M. Bartels, Sophia M. Bartels, Kathleen Bell, Jesse Dallery, Michael Grabinski, Michaela Kiernan, Hannah A. Lavoie, Hannah A. Lavoie, Shea M. Lemley, Michael R. Lowe, David P. MacKinnon, Stephen A. Metcalf, Stephen A. Metcalf, Lisa Onken, Judith J. Prochaska, Cady Lauren Sand, Cady Lauren Sand, Emily A. Scherer, Luke E. Stoeckel, Haiyi Xie, Lisa A. Marsch

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Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation: insights from a multicenter GETH-TC study to optimize outcomes and care by María Queralt Salas, María Teresa Solano, Mónica Baile González, Marina Acera Gómez, Laura Fox, María del Mar Pérez Artigas, Ana Santamaría, María del Carmen Quintela González, Andrés Sánchez Salinas, Joaquina M. Salmerón Camacho, Verónica Illana Álvaro, Zahra Abdallahi-Lefdil, Javier Cornago Navascues, Laura Pardo, Sara Fernández-Luis, Leddy Patricia Vega Suárez, Sara Villar, Patricia Beorlegui-Murillo, Albert Esquirol, Isabel Izquierdo García, Sonia Rodríguez González, Alberto Mussetti, Esperanza Lavilla, Javier Lopez-Marín, Silvia Filaferro, Ángel Cedillo, Leyre Bento, Leyre Bento, Anna Sureda, Anna Sureda

“…Multivariate analysis confirmed lower OS (HR 2.52, P=0.002) and higher NRM (HR 2.69, P=0.013) in frail patients at HCT admission compared to fit ones, with a trend towards lower OS in pre-frail patients (HR 1.54, P=0.097).ConclusionThis study highlights the feasibility of incorporating the HCT Frailty Scale into clinical practice, confirms its negative impact of frailty on transplant outcomes, and suggests that frailty is dynamic and potentially reversible through pre-transplant interventions.…”
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