Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation by Yu Chen, Lin Mao, Qinxiang Zhou, Dingqun Bai, Yuhan Kong

“…However, to use this technology more rationally in clinical practice, a deepened understanding of the molecular mechanisms behind its therapeutic effects is needed. …”
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Meta Analysis of Efficacy and Safety of Moxibustion on Neurogenic Bladder after Spinal Cord Injury by Xueqi HAN, Huirong HUANG, Zhongbiao XIU, Jingling WU, Qinyu LIU, Shaofang MIAO, Xiaona YAN

“…It still needs to be further verified by large samples and high-quality randomized controlled trials to provide more reliable evidence-based basis for clinical practice.…”
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Open-source code for analysis of the lifetime total physical activity questionnaire (LTPAQ) by Coral Sánchez-Martín, Javier Leal-Martín, Timo Rantalainen, Irene Rodríguez-Gómez, Luis M. Alegre, Ignacio Ara

“…By facilitating the processing of physical activity data from this questionnaire, our tool is expected to encourage its application in epidemiological studies and foster new insights into the impact of lifestyle from a life course perspective, ultimately playing a crucial role in shaping public health policies and enhancing clinical practice.…”
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Survival after Locoregional Treatments for Hepatocellular Carcinoma: A Cohort Study in Real-World Patients by Simona Signoriello, Annalisa Annunziata, Nicola Lama, Giuseppe Signoriello, Paolo Chiodini, Ilario De Sio, Bruno Daniele, Giovanni G. Di Costanzo, Fulvio Calise, Graziano Olivieri, Vincenzo Castaldo, Rosario Lanzetta, Guido Piai, Giampiero Marone, Mario Visconti, Mario Fusco, Massimo Di Maio, Francesco Perrone, Ciro Gallo, Giovanni B. Gaeta

“…We investigated, in a retrospective cohort study, whether surgical resection, radiofrequency ablation (RFA), percutaneous ethanol injection (PEI), and transarterial embolization with (TACE) or without (TAE) chemotherapy resulted in different survival in clinical practice. All patients first diagnosed with HCC and treated with any locoregional therapy from 1998 to 2002 in twelve Italian hospitals were eligible. …”
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Hepatocellular carcinoma risk scores for non-viral liver disease: A systematic review and meta-analysis by Laura Burke, Alexander Hinkson, Vincent Haghnejad, Rebecca Jones, Richard Parker, Ian A. Rowe

“…This study highlights these critical issues that may hinder the implementation of risk models in clinical practice and offers key recommendations for future model development studies.…”
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Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm by Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li

“…CEUS has a high accuracy rate in diagnosing the benign or malignant nature of gallbladder space-occupying lesions, which can significantly reduce the preoperative waiting time for related examinations and provide more reliable diagnostic information for clinical practice. Results Feature selection via Lasso led to a final LR model incorporating high-density lipoprotein, smoking status, basal width, and Rad_Signature. …”
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Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial by Jinzhao Ji, Jinzhao Ji, Xiaoqing Ding, Xiaoqing Ding, Chuanli Liu, Chuanli Liu, Lingling Dai, Lingling Dai, Junting Yu, Junting Yu, Linghao Li, Linghao Li, Shaobing Wan, Shaobing Wan, Yangyang Song, Junqing Zhao, Zhetong Su, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li

“…Current treatment strategies primarily rely on antibiotics and corticosteroids; however, the emergence of antibiotic resistance and potential side effects from prolonged corticosteroid use limit the effectiveness of these therapies in clinical practice. These challenges highlight the urgent need for alternative treatments. …”
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Effect of an Internet-Based Pilates Telerehabilitation Intervention in People With Multiple Sclerosis: Protocol for a Randomized Controlled Trial by Andrea Tacchino, Michela Ponzio, Paolo Confalonieri, Letizia Leocani, Matilde Inglese, Diego Centonze, Eleonora Cocco, Paolo Gallo, Damiano Paolicelli, Marco Rovaris, Loredana Sabattini, Gioacchino Tedeschi, Luca Prosperini, Francesco Patti, Edoardo Sessa, Elisabetta Pedrazzoli, Mario Alberto Battaglia, Giampaolo Brichetto

“…With this study, we will provide evidence for the use in clinical practice of a digital tool for self-administered Pilates exercises at home as a complement to rehabilitation and for the continuity of care in MS. …”
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Research involvement among undergraduate medical students in Bangladesh: a multicenter cross-sectional study by Mohammad Jahid Hasan, Salwa Islam, Hasnat Sujon, Fahmida Islam Chowdhury, Muna Islam, Mostak Ahmed, Mahbuba Shabnam, Mahbub Mayukh Rishad, Mohammad Nurunnabi, Md Marufur Rahman, Jannatul Fardous, Mir Susmita Zaman, Mir Paramita Zaman, Mir Ahsan Ali, Md Rabiual Awal, Taha Choudhury, Ahmed Ullah Shuvo, Sabrina Sultana, Tanjina Tabassum, Monjur Rahman, Anindita Das Barshan, Tamanna Tabassum, Md. Abdur Rafi, Sharmeen Yasmeen

“…Abstract Background The involvement of undergraduate medical students in research is pivotal for the advancement of evidence-based clinical practice. This study aimed to assess the extent of research involvement and the factors influencing it among undergraduate medical students in Bangladesh. …”
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Cochlear Implant Programming: A Global Survey on the State of the Art by Bart Vaerenberg, Cas Smits, Geert De Ceulaer, Elie Zir, Sally Harman, N. Jaspers, Y. Tam, Margaret Dillon, Thomas Wesarg, D. Martin-Bonniot, L. Gärtner, Sebastian Cozma, Julie Kosaner, Sandra Prentiss, P. Sasidharan, Jeroen J. Briaire, Jane Bradley, J. Debruyne, R. Hollow, Rajesh Patadia, Lucas Mens, K. Veekmans, R. Greisiger, E. Harboun-Cohen, Stéphanie Borel, Dayse Tavora-Vieira, Patrizia Mancini, Helen Cullington, Amy Han-Chi Ng, Adam Walkowiak, William H. Shapiro, Paul J. Govaerts

“…However, no Good Clinical Practice guidelines exist. This paper reports on the results of an inventory of the current practice worldwide. …”
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Oral Cyclophosphamide for Patients With Metastatic Castration-Resistant Prostate Cancer in a Scenario of Limited Health Care Resources by Diana del Cisne Pineda, Gabriel Berlingieri Polho, Yumi Ricucci Shinkado, Gustavo Alves Contado, Nathalia de Souza Crusoe, Vivian Naomi Horita, Joao Carlos Resende, Jamile Almeida Silva, Guilherme Fialho de Freitas, David Queiroz Muniz, Caio V. Suartz, Leopoldo Alves Ribeiro-Filho, Paulo M. Hoff, José Mauricio Mota

“…However, cyclophosphamide is currently underutilized in routine clinical practice given the lack of survival benefit and the emergence of more effective treatments.METHODSWe retrospectively reviewed our institutional database to identify patients with mCRPC treated with cyclophosphamide. …”
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Germline BRCA testing in Denmark following invasive breast cancer: Progress since 2000 by Aleksandar M. Kostov, Maj-Britt Jensen, Bent Ejlertsen, Mads Thomassen, Caroline Maria Rossing, Inge S. Pedersen, Annabeth H. Petersen, Lise Lotte Christensen, Karin A.W. Wadt, Anne-Vibeke Lænkholm

“…This observational cohort study presents real-world data on BRCA testing within the context of clinical practice challenges, including incomplete family history and under-referral. …”
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Proposing a two-stage screening approach to distinguish between transient and enduring postnatal depressive symptoms: A prospective cohort study by Johanne Smith-Nielsen, Ida Egmose, Stephen Matthey, Maria Stougård, Sophie Reijman, Mette Skovgaard Væver

“…This approach significantly improves referral efficiency and minimizes over-pathologization, enhancing clinical practice in perinatal mental health.…”
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Research progress of exercise rehabilitation in patients undergoing percutaneous coronary intervention for acute myocardial infarction (急性心肌梗死患者经皮冠状动脉介入术后运动康复的研究进展)... by JIA Hongwei (贾红薇), XING Zheng (邢政), DONG Yujie (董玉洁), SHAN Li (单立), LIU Yanjie (刘艳杰), WANG Jing (王晶), YI jiaxin (益嘉欣), YANG Lin (杨林)

“…This paper summarized the status quo of exercise rehabilitation and its research status, potential problems and clinical practice in patients with acute myocardial infarction after percutaneous coronary intervention, and provided reference for the establishment of exercise rehabilitation plan after percutaneous coronary intervention. …”
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Influence of Organ‐Specific Extranodal Involvement on Survival Outcomes in Stage IV Diffuse Large B‐Cell Lymphoma by Tong‐Yoon Kim, Tae‐Jung Kim, Eun Ji Han, Gi June Min, Sung‐Soo Park, Silvia Park, Jae‐Ho Yoon, Sung‐Eun Lee, Byung‐Sik Cho, Ki‐Seong Eom, Yoo‐Jin Kim, Hee‐Je Kim, Seok Lee, Chang‐Ki Min, Jong‐Wook Lee, Youngwoo Jeon, Seok‐Goo Cho

“…Further prospective studies are needed to confirm and incorporate these findings into clinical practice.…”
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Machine learning cluster analysis identifies increased 12-month mortality risk in transcatheter aortic valve replacement recipients by Thomas Meredith, Thomas Meredith, Thomas Meredith, Farhan Mohammed, Amy Pomeroy, Sebastiano Barbieri, Sebastiano Barbieri, Erik Meijering, Louisa Jorm, David Roy, Jason Kovacic, Jason Kovacic, Jason Kovacic, Jason Kovacic, Michael Feneley, Michael Feneley, Michael Feneley, Christopher Hayward, Christopher Hayward, Christopher Hayward, David Muller, David Muller, David Muller, Mayooran Namasivayam, Mayooran Namasivayam, Mayooran Namasivayam

“…BackgroundLong-term mortality risk is seldom re-assessed in contemporary clinical practice following successful transcatheter aortic valve implantation (TAVR). …”
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Diagnosis and treatment of disorders of intracranial pressure: consensus statement of the Spanish Society of Neurology’s Headache Study Group by J. García-Ull, N. González-García, M. Torres-Ferrús, D. García-Azorín, I.F.J. Molina-Martínez, I. Beltrán-Blasco, S. Santos-Lasaosa, G. Latorre, A.B. Gago-Veiga, J.M. Láinez, J. Porta-Etessam, C. Nieves-Castellanos, A. Mínguez-Olaondo, A. López-Bravo, S. Quintas, N. Morollón, S. Díaz-Insa, R. Belvís, P. Irimia

“…Therefore, the Spanish Society of Neurology's Headache Study Group (GECSEN) deemed it necessary to prepare this consensus statement, including diagnostic and therapeutic algorithms to facilitate and improve the management of these disorders in clinical practice.This document was created by a committee of experts belonging to GECSEN, and is based on a systematic review of the literature, incorporating the experience of the participants, and establishes practical recommendations with levels of evidence and grades of recommendation. …”
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β-receptor blocker enhances anti-tumor immunity via inhibiting lactate-induced norepinephrine metabolism of macrophages during malignant pleural effusion by Ru Zhang, Weijia Wang, Aitian Li, Huishang Wang, Xiaoyan Liu, Feifei Fan, Ying Wang, Huanyu Zhang, Jingxia Chang, Yinyin Zhang, Hongmin Wang, Lijun Miao, Bo Huang, Li Yang, Li Yang, Li Yang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang

“…IntroductionMalignant pleural effusion (MPE) is associated with poor quality of life and mortality in patients with tumors. In clinical practice, we observed that patients with malignant pleural effusion (MPE) and concurrent heart disease exhibited a decrease in MPE volumes following treatment with β-receptor blockers for heart disease. …”
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Diagnóstico y tratamiento de los trastornos de la presión intracraneal: Documento de consenso del Grupo de Estudio de Cefaleas de la Sociedad Española de Neurología by J. García-Ull, N. González-García, M. Torres-Ferrús, D. García-Azorín, I.F.J. Molina-Martínez, I. Beltrán-Blasco, S. Santos-Lasaosa, G. Latorre, A.B. Gago-Veiga, J.M. Láinez, J. Porta-Etessam, C. Nieves-Castellanos, A. Mínguez-Olaondo, A. López-Bravo, S. Quintas, N. Morollón, S. Díaz-Insa, R. Belvís, P. Irimia

“…Therefore, the Spanish Society of Neurology's Headache Study Group considered it necessary to prepare this consensus document with the inclusion of diagnostic and therapeutic algorithms to facilitate and improve their management in clinical practice.This document was created by a committee of experts of the Spanish Society of Neurology's Headache Study Group based on a systematic review of the literature, incorporating the experience of the participants, and establishing practical recommendations with levels of evidence and grades of recommendation.…”
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Abnormal preoperative haematological parameters in Endometrial cancer; reflecting tumour aggressiveness or reduced response to radiotherapy? by Stephanie W. Vrede, Hannah Donkers, Casper Reijnen, Anke Smits, Nicole C.M. Visser, Peggy M. Geomini, Huy Ngo, Dennis van Hamont, Brenda M. Pijlman, Maria Caroline Vos, Marc P.L.M. Snijders, Roy Kruitwagen, Ruud L.M. Bekkers, Khadra Galaal, Johanna M.A. Pijnenborg

“…Current data demonstrate that anaemia is independent associated with decreased disease-specific survival and anaemia seems related with reduced response to radiotherapy and in specific to vaginal brachytherapy in ESGO/ESTRO/ESP intermediate risk patients.What are the implications of these findings for clinical practice and/or further research? Specific applied adjuvant treatment is needed if patients with anaemia have a reduced response to radiotherapy in EC. …”
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