Emergence and clinical challenges of ST11-K64 carbapenem-resistant Klebsiella pneumoniae: molecular insights and implications for antimicrobial resistance and virulence in Southwes... by Linlin LI, Jiahui Liang, Huan Zhang, Jing Guo, Shan LI, Meng Li

“…Abstract Background In clinical practice, the emergence of ST11-K64 carbapenem-resistant Klebsiella pneumoniae (ST11-K64 CRKP) has become increasingly alarming. …”
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Closing the gap while standing still: clinimetric properties of a low-cost balance platform and a user-friendly app for posturography by Tom Vredeveld, John F. Stins, Annelies J. van Vliet, Vincent C.M. Tuinder, Stephan P.J. Ramaekers, Michel W. Coppieters, Annelies L. Pool-Goudzwaard

“…Therefore, this study aims to evaluate the concurrent validity and test–retest reliability of a WBB to measure center of pressure (COP) parameters and to provide an easy-to-use web application to improve implementation of posturography in clinical practice. Methods A cross-sectional study was carried out including 30 healthy adults who performed repeated balance tasks including single and double leg standing still with eyes open or eyes closed. …”
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AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma by Lu Li, Qing Xu, Xiuzhen Zhang, Yuan Jiang, La Zhang, Jiao Guo, Haichuan Liu, Bin Jiang, Shenglong Li, Qiling Peng, Ning Jiang, Jianwei Wang

“…Immune checkpoint inhibitors (ICIs) become integral in clinical practice, yet their application in cancer therapy is constrained by low overall response rates and the primary resistance of cancers to ICIs. …”
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Systematic Evaluation of Clinical Efficacy of Shiyiwei Shenqi (Ginseng and Astraglus, Eleven Ingredients) Preparation in Adjuvant Chemotherapy for Malignant Tumor by Bowei HUANG, Yuhui ZENG, Lisha LU, Huijuan GAN

“…In further studies, more high-quality, large-sample randomized controlled trials are still needed for further verification to provide a more reliable evidence-based basis for clinical practice.…”
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Circulating miRNA-486 as a novel diagnostic biomarker for right ventricular remodeling by Huiling Cai, Huiling Cai, Cheng Yu, Xiuchuan Li, Xuenan Wang, Xuenan Wang, Yongjian Yang, Yongjian Yang, Yongjian Yang, Cong Lan, Cong Lan

“…ObjectiveClinical practice currently faces a significant shortfall in specific biomarkers needed for diagnosing right ventricular (RV) remodeling in patients with pulmonary hypertension (PH). …”
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Improving Clinical Management of Diabetic Macular Edema: Insights from a Global Survey of Patients, Healthcare Providers, and Clinic Staff by Focke Ziemssen, Michelle Sylvanowicz, Winfried M. Amoaku, Tariq Aslam, Bora Eldem, Robert P. Finger, Richard P. Gale, Laurent Kodjikian, Jean-François Korobelnik, Xiaofeng Lin, Anat Loewenstein, Paul Mitchell, Moira Murphy, David R. Owens, Nick Parker, Ian Pearce, Francisco J. Rodríguez, Jude Stern, S. James Talks, David T. Wong, Tien Yin Wong, Jane Barratt

“…Abstract Introduction In contrast with patients receiving therapy for retinal disease during clinical trials, those treated in routine clinical practice experience various challenges (including administrative, clinic, social, and patient-related factors) that can often result in high patient and clinic burden, and contribute to suboptimal visual outcomes. …”
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Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review by Adriana Sánchez-García, René Rodríguez-Gutiérrez, Leonardo Mancillas-Adame, Victoria González-Nava, Alejandro Díaz González-Colmenero, Ricardo Cesar Solis, Neri Alejandro Álvarez-Villalobos, José Gerardo González-González

“…Due to the lack of a standardized IR definition and heterogeneity between studies, further validation and standardized cutoff values are needed to be used in clinical practice.…”
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Correlation between social support, self-efficacy and quality of life in primary trigeminal neuralgia patients (原发性三叉神经痛患者社会支持、自我效能感与生活质量的相关性研究)... by SUN Xiuxiu (孙秀秀), JIA Jianhua (贾建华), LI Yeyuan (李业园)

“…Structural equation modeling showed that social support and self-efficacy were negatively correlated with quality of life, and self-efficacy had a significant mediating effect between social support and quality of life. Conclusion In clinical practice, healthcare professionals should enhance patients' quality of life by strengthening social support and improving patients' self-efficacy. …”
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Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration by Lei Yu, Wentao Wang, Chang Lv, Qian Chen, Peng Yang, Zhenrong Qi, Haomiao Yu, Ruiqi Cao, Wenhao Li, Yi Qin, Gaoran Ge, Peilai Liu, Lixin Zhu, Houyi Sun, Dechun Geng, Liang Zhang

“…This complicates the treatment of osteoporosis and its related bone injuries in clinical practice. Despite the development of various polymer scaffolds for bone defect repair, achieving effective regeneration in osteoporotic bones—especially when combined with osteoporosis medications—remains difficult. …”
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Novel derivative of nicotinic acid ameliorates doxorubicin-induced cardiac injury via regulation of redox homeostasis by Yana V. Loboda, Mikhail V. Korokin, Alexey V. Kuznetsov, Tatiana N. Malorodova, Anton P. Danilenko, Anna A. Peresypkina, Oleg S. Gudyrev, Ol’ga A. Kop’eva, Tatyana G. Pokrovskaya, Liliya V. Korokina, Valeriya N. Khruslova, Valeriya A. Nazarenko, Tatyana V. Avtina, Alexey V. Deikin, Aleksandr A. Dolzhikov, Tatiana V. Puzanova, Lyudmila M. Danilenko

“…However, none of them fully meets the requirements of clinical practice. The aim of the study: to evaluate the cardioprotective effects of a new original heterocyclic compound, a pyridine-3-carboxylic acid derivative potassium 5-hydroxynicotinate. …”
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Comparison of PD-L1 tumor cell expression with 22C3, 28-8, and SP142 IHC assays across multiple tumor types by Jeffrey S Ross, Richard S P Huang, Jake G Maule, Lani K Clinton, Ryon P Graf, Jinpeng Xiao, Geoffrey R Oxnard

“…Here we present 22C3, 28-8, and SP142 analysis of 418 tumor specimens encountered in routine clinical practice.Methods All specimens were tested with 22C3, 28-8, and SP142 assays following the manufacturer’s established staining protocols.Results The same PD-L1 status (defined as tumor cell expression (TC) scores with all three assays ≥1% or all <1%) was observed in 60.0% (251/418) tumor specimens (45.9% (192/418) were triple negative and 14.1% (59/418) were triple positive). …”
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Factors That Affect the Sensitivity of Imaging Modalities in Primary Hyperparathyroidism by Minting Zhu, Yang He, Tingting Liu, Bei Tao, Weiwei Zhan, Yifan Zhang, Jing Xie, Xi Chen, Hongyan Zhao, Lihao Sun, Jianmin Liu

“…However, false-negative imaging results are also frequently encountered in clinical practice. Exploring the factors that affect the sensitivity of these imaging modalities is important for the surgical management of PHPT patients. …”
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Patient-centred care and quality of life and hope among Japanese patients receiving home medical care: a multicentre, cross-sectional study by Nobuhiro Ikeda, Michiko Hinata, Noriaki Kurita, Tomoka Nakamura, Takashi Fujii, Chihiro Tsuchiya, Yukio Tsugihashi, Hidekazu Iida, Shinu Hayashi, Masakazu Yasunaka, Misaki Hirose, Yutaka Shirahige, Shinsuke Muto, Tatsunobu Natsubori, Wataru Nakagawa, Akihiko Yonenaga, Lina Inagaki, Shioto Itakura, Naoya Miyashita, Takuya Furugen, Takafumi Abo, Sadayuki Okudaira, Kazuhiko Takuma, Masahiro Deguchi, Yoshitaka Harada, Seiji Matsuo, Motomichi Nakagawa, Ken Tanigawa, Yoshio Ochi, Sadanobu Ogasawara, Kazuhiko Hoshino, Momoko Aruga, Yoshinori Nakamura, Nobuhiro Sawa, Yosuke Akashi, Nobuyuki Miyagi, Toyohiro Terasaki, Kunihiro Kinoshita, Masaji Kikukawa, Hisakazu Kato, Masayuki Amano, Kentaro Asakura, Naoto Fukui

“…Patient-centredness should be strengthened in daily clinical practice.…”
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Multi-channel microelectrode arrays for detection of single-cell level neural information in the hippocampus CA1 under general anesthesia induced by low-dose isoflurane by Ruilin Hu, Penghui Fan, Yiding Wang, Jin Shan, Luyi Jing, Wei Xu, Fan Mo, Mixia Wang, Yan Luo, Ying Wang, Xinxia Cai, Jinping Luo

“…The present study provides a technical tool to study the neural mechanisms of isoflurane anesthesia and a research method for monitoring the depth of isoflurane anesthesia in clinical practice.…”
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The “prostate-pelvic syndrome” theory used in patients with type-III prostatitis and its correlation with prostate volume by Xiao-Ma Zhang, Wei-Yi Li, Zong-Yao Hao, Lei Zhou, Cheng Yang, He-Xi Du, Chao-Zhao Liang

“…However, the practical application effectiveness of PPS theory in clinical practice is still unclear. Objective The aims of this study were to verify the clinical outcome of PPS theory in diagnosing the adult patients with type-III prostatitis below 40 years old and analyze the related factors for the main symptoms of PPS in adult males below 40 years old, providing references for the prevention and treatment of PPS in young adult males. …”
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Efficacy and safety of PD-1/PD-L1 inhibitors in advanced or recurrent endometrial cancer: a meta-analysis with trial sequential analysis of randomized controlled trials by Ji Ren, Jinghe Wang, Yanan Wang, Dongying Yang, Jianming Sheng, Shili Zhu, Yunli Liu, Xiaoqi Li, Wei Liu, Binbin Zhang

“…Clinicians can tailor treatment strategies according to individual patient characteristics to optimize therapeutic outcomes, while remaining alert to the possibility of AEs in clinical practice.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024595455.…”
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Finding the right dose: a scoping review examining facilitation as an implementation strategy for evidence-based stroke care by Oyebola Fasugba, Heilok Cheng, Simeon Dale, Kelly Coughlan, Elizabeth McInnes, Dominique A. Cadilhac, Ngai W. Cheung, Kelvin Hill, Kirsty Page, Estela Sanjuan Menendez, Emily Neal, Vivien Pollnow, Julia Slark, Eileen Gilder, Anna Ranta, Christopher Levi, Jeremy M. Grimshaw, Sandy Middleton

“…Facilitation can support implementation of research into clinical practice by helping people develop the strategies to implement change. …”
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Application of PDCA cycle in continuous quality improvement of nursing inventory records in the operating room (PDCA循环法在手术室护理清点记录单持续质量改进中的应用)... by YIN Bei (尹蓓), WANG Yaling (王雅玲), QIU Murong (邱慕蓉)

“…Conclusion Application of PDCA cycle in document writing may help nurses effectively analyze and improve the detailed and important problems in clinical practice, and form a relatively complete document quality control supervision system by establishing a quality improvement team, formulating measures, and supervising with other members of the department. …”
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Norepinephrine use in cardiogenic shock patients is associated with increased 30 day mortality by Xin Lu, Xue Wang, Yanxia Gao, Joseph Harold Walline, Shiyuan Yu, Zengzheng Ge, Mubing Qin, Huadong Zhu, Yi Li

“…The survival benefit of norepinephrine therapy has not been demonstrated in clinical practice, however. This study aimed to explore the relationship between norepinephrine use and outcomes in cardiogenic shock patients in real‐world conditions. …”
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PseudoCell: Hard Negative Mining as Pseudo Labeling for Deep Learning-Based Centroblast Cell Detection by Narongrid Seesawad, Piyalitt Ittichaiwong, Thapanun Sudhawiyangkul, Phattarapong Sawangjai, Peti Thuwajit, Paisarn Boonsakan, Supasan Sripodok, Kanyakorn Veerakanjana, Komgrid Charngkaew, Ananya Pongpaibul, Napat Angkathunyakul, Narit Hnoohom, Sumeth Yuenyong, Chanitra Thuwajit, Theerawit Wilaiprasitporn

“…The discussion section provides detailed guidance for implementing <italic>PseudoCell</italic> in clinical practice.…”
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