Extracellular matrix re-normalization to improve cold tumor penetration by oncolytic viruses by Geofrey F. Soko, Geofrey F. Soko, Benson K. Kosgei, Stephene S. Meena, Stephene S. Meena, Ying Jing Ng, Huihui Liang, Bing Zhang, Qingjun Liu, Tielong Xu, Xinju Hou, Xinju Hou, Ray P. S. Han

“…Additionally, we investigated current clinical trials and challenges associated with translating these strategies into clinical practice to improve patient outcomes.…”
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Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice by Yihong Yang, Guanghua Xiong, Huangqi Shi, Yulin Peng, Jinghong Liu, Yaxuan Jiang, Min Lu, Hongbo Liu, Yong Liu

“…Ultimately, the use of 4-PBA to pharmacologically inhibit ER stress may substantially reduce liver damage caused by HIRI in mice.ConclusionTaken together, our results suggested that sinensetin could alleviate HIRI injury through suppressing GRP78/CHOP-mediated ER stress, which may provide a novel therapeutic strategy for treating liver ischemia-reperfusion injury in clinical practice.…”
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Baska Mask versus I-gel in Spontaneously Breathing Anaesthetised Patients: A Randomised Clinical Study by Bhagyavardhan Botta, Yogarajan Ramalingam, Grishma Robba, Tanya Elizabeth, Kala Balasubramanian, Selvamani Subramanian, Senthil Kumar Vannivedu Santhnam, Kavyasri Morampudi

“…Now-a-days, second and third generation SGADs, differing in their design, have been used in clinical practice due to their better clinical performance. …”
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Long-term outcomes of robot-assisted versus minimally invasive esophagectomy in patients with thoracic esophageal cancer: a propensity score-matched study by Toru Sakurai, Akihiro Hoshino, Kenta Miyoshi, Erika Yamada, Masaya Enomoto, Junichi Mazaki, Hiroshi Kuwabara, Kenichi Iwasaki, Yoshihiro Ota, Shingo Tachibana, Yutaka Hayashi, Tetsuo Ishizaki, Yuichi Nagakawa

“…Propensity score matching (PSM) was employed, incorporating co-variables such as confounders or risk factors derived from the literature and clinical practice. These variables included age, sex, body mass index, alcohol consumption, smoking history, American Society of Anesthesiologists stage, comorbidities, tumor location, histology, clinical TNM stage, and preoperative therapy. …”
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Artificial Intelligence in Diagnostic Breast Ultrasound: A Comparative Analysis of Decision Support Among Radiologists With Various Levels of Expertise by Filiz Çelebi, Onur Tuncer, Müge Oral, Tomris Duymaz, Tolga Orhan, Gökhan Ertaş

“…This type of guidance may reduce unnecessary biopsies by increasing the detection rate for malignant lesions and deliver significant benefits for routine clinical practice in underserved areas where experienced readers may not be available.…”
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Artificial intelligence in orthopaedic trauma by Chuwei Tian, Yucheng Gao, Chen Rui, Shengbo Qin, Liu Shi, Yunfeng Rui

“…By illuminating these dynamic research avenues, this study aimed to catalyze interdisciplinary collaboration and spur innovation at the intersection of AI and orthopedic trauma, ultimately advancing the frontiers of patient care and clinical practice.…”
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Investigating Falls Risk Awareness in Hospitals Using the Self‐Awareness of Falls Risk Measure (SAFRM): Empirical Research Quantitative by Elissa Dabkowski, Simon J. Cooper, Jhodie Duncan, Karen Missen

“…The ability to empirically measure this disparity and to determine an under‐ or overestimation of falls risk is a useful addition to clinical practice. The SAFRM facilitates a person‐centred approach to falls prevention by providing opportunities for the clinician to collaborate with the patient and tailor fall prevention strategies. …”
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The efficacy of platelet-rich plasma in ankle disease: a systematic review and meta-analysis by Qixin Ding, Xu Wang, Yurong Liu, Yuefang Li, Di Zhang, Heling Wang, Shenhong Ma, Qiaohua Han, Weisheng Zhuang

“…Platelet-rich plasma has emerged as a novel cellular therapy in clinical practice. This study evaluates the clinical efficacy of platelet-rich plasma (PRP) after intervention in ankle disorders, so as to provide strong evidence in support of clinical treatment. …”
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A generative whole-brain segmentation model for positron emission tomography images by Wenbo Li, Zhenxing Huang, Hongyan Tang, Yaping Wu, Yunlong Gao, Jing Qin, Jianmin Yuan, Yang Yang, Yan Zhang, Na Zhang, Hairong Zheng, Dong Liang, Meiyun Wang, Zhanli Hu

“…In the future, we will apply our whole-brain segmentation method to clinical practice and extend it to other multimodal tasks.…”
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Diagnostic Value of Sodium, White Blood Cell, Neutrophil Levels; White Blood Cell/Sodium and Neutrophil/Sodium Ratios in Appendicitis in Pediatric Patients by Cem Kaya, Gökhan Arkan, Fatma Nur Aracıer Uçaner, Leyla Nur Türker, Alparslan Kapısız, Ramazan Karabulut, Zafer Türkyılmaz, Kaan Sönmez

“…The WBC/sodium and neutrophil/sodium ratios could be valuable in clinical practice, especially for distinguishing between appendicitis and non-appendicitis cases. …”
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Recurrent patellar dislocation: treatments and challenges by Fei Yang, Fei Yang, Changshun Chen, Changshun Chen, Rongjin Chen, Chenhui Yang, Hefang Xiao, Zhiwei Feng, Zhiwei Feng, Bin Geng, Yayi Xia

“…Recurrent Patellar Dislocation (RPD) is a common knee sports injury, mainly affecting pediatric and adolescent populations, posing a significant challenge in orthopedic clinical practice. Although a variety of treatments have been reported, and many of them have shown good initial results, there is a lack of long-term follow-up results. …”
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Consecutive prediction of adverse maternal outcomes of preeclampsia, using the PIERS-ML and fullPIERS models: A multicountry prospective observational study. by Guiyou Yang, Tünde Montgomery-Csobán, Wessel Ganzevoort, Sanne J Gordijn, Kimberley Kavanagh, Paul Murray, Laura A Magee, Henk Groen, Peter von Dadelszen

“…We recommend using the models for consecutive prediction with greater caution and interpreting predictions with increasing uncertainty as the pregnancy progresses. For clinical practice, models should be adapted to retain accuracy when deployed serially. …”
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Prediction of long-term drug-free outcomes in ACPA-positive and ACPA-negative rheumatoid arthritis by combined clinical and ultrasound assessment of residual disease: a 5-year pros... by Carlomaurizio Montecucco, Garifallia Sakellariou, Claudia Alpini, Catherine Klersy, Serena Bugatti, Ludovico De Stefano, Emanuele Bozzalla Cassione, Antonio Manzo, Blerina Xoxi, Terenzj Luvaro, Ylenia Sammali

“…Objective To delineate, within the framework of current clinical practice and criteria, the sustainability of first-line immuno-suppressive treatment discontinuation in rheumatoid arthritis (RA) and the impact of residual disease in remission on long-term drug-free (DF) outcomes.Methods RA patients, referring to the Pavia early arthritis clinic (EAC) between 2009 and 2021 and achieving remission after Disease Activity Score-driven methotrexate (MTX) monotherapy, were recruited. …”
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Comparison of safety and effectiveness of medical adhesive and metal spring coil in preoperative localization of peripheral pulmonary nodules by Yifei Wang, Zhenhua Yue, Xiaoqian Shi, Guozhan Xia, Linlin Qin, Qi Sun, Yiling Huang, Rong Chen, Xuewei Zhao, Mingdong Wang

“…There are many methods for locating pulmonary nodules in clinical practice, but there are currently few research reports on the value of medical adhesive localization.ObjectiveTo compare the clinical value of two positioning methods, medical adhesive and metal spring coil, in the preoperative application of VATS through retrospective analysis.MethodsA total of 288 patients who underwent thoracoscopic surgery in our hospital from January 2021 to June 2024 due to the discovery of solitary pulmonary nodules during chest CT examination were included in this study. …”
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E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age by E. Meldolesi, A. Nicolì, N. Dinapoli, G. Chiloiro, A. Romano, R. Menghi, R. Persiani, F. Pacelli, C. Coco, C. Ratto, S. Manfrida, L. Boldrini, B. Corvari, M.A. Gambacorta

“…Results: All patients were classified in different risk groups, according to the ESMO 2017 rectal cancer clinical practice guidelines. 88 % of patients under 55 years old at the diagnosis belonged to the bad or advanced risk groups with an equal division. …”
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Real world pharmacovigilance assessment of drug related macular degeneration risks by Xiaodong Chen, Shinan Wu, Shaopan Wang, Chaofeng Yu, Zihan Guo, Shiya Huang, Peixin Cai, Yanliang Miao, Shiying Li, Qian Chen

“…Abstract Macular degeneration is a leading cause of irreversible vision loss, significantly impacting quality of life. To enhance clinical practice and reduce the risk of drug-related macular degeneration, we analyzed drug-related trends using real-world data. …”
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Efficacy, safety and cost-effectiveness of obinutuzumab in patients with follicular lymphoma: a rapid review by Chao Wang, Yunzhuo Dong, Peng Men, Ruixia Zhang, Ying Xiao, Yishan Bu, Yinpeng Qin, Xinran Zhang, Qianqian Dou, Yiheng Yang, Huier Gao, Yi Zhang

“…A comprehensive assessment is necessary to evaluate the efficacy, safety, and cost-effectiveness of obinutuzumab in adult patients with FL.ObjectiveTo summarize the evidence on the efficacy, safety, and cost-effectiveness of obinutuzumab in adult patients with FL, aiming to provide medical professionals with evidence for informed choices in clinical practice.MethodsThe approach to this evidence synthesis was a rapid review of systematic reviews/meta-analyses (SR/meta-analyses), health technology assessment (HTA) reports, and pharmacoeconomic studies that brings together and summarizes the efficacy, safety, and cost-effectiveness of obinutuzumab in adult patients with FL. …”
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Characteristics and real-world medication persistence of people living with HIV treated with DTG/3TC or BIC/FTC/TAF: a hospital claims database study in Japan by Rie Kanamori, Nozomi Aoki, Akio Kanazawa, Mayumi Yuda, Nao Makino, Emi Ohata, Nobuyuki Fukui, Hirotake Mori, Hirohide Yokokawa, Toshio Naito

“…There was no significant difference in medication persistence between the two cohorts (p = 0.91).ConclusionThis study showed that DTG/3TC was likely to be selected for elderly patients and those with chronic disease in real-world clinical practice, which seems in accordance with the treatment strategy recommended by guidelines. …”
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Anemia, Hyperglycemia, and Reduced Left Ventricular Ejection Fraction Improve the GRACE Score’s Predictability for In-hospital Mortality in Acute Coronary Syndrome; Single-Ce... by Turu' Allo IJ, Pramudyo M, Akbar MR

“…The modified GRACE score offers a more robust risk stratification tool for clinical practice and decision-making.Plain Language Summary: Predicting in-hospital mortality risk in acute coronary syndrome (ACS) is crucial for clinical decision-making and patient outcomes. …”
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The Association Between Mitral Regurgitation and Long-Term Outcomes in Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Retrospective Large Sample Cohor... by Yan N, Wu P, Zhu B, Ma A, Wang X, Hai X, Ma X, Jiang H, Yang S

“…After controlling confounding variables completely, we found that moderate/severe MR compared to none MR was found to be significantly associated with 3-year MACCEs [hazard ratio (HR) = 1.83; 95% confidence interval (CI) = 1.21– 2.77; p = 0.0042], all-cause mortality (HR = 3.11; 95% CI = 1.75– 5.50; p=0.001) and RHF (HR = 1.69; 95% CI = 1.09– 2.62; p= 0.019) through Cox proportional hazards regression models.Conclusion: MR significantly predicted 3-year clinical outcomes in AMI patients undergoing PCI, highlighting the need for physicians to prioritize MR assessment in clinical practice.Keywords: mitral regurgitation, acute myocardial infarction, percutaneous coronary intervention, major adverse cardiac and cerebrovascular events…”
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