End-to-End Stroke Imaging Analysis Using Effective Connectivity and Interpretable Artificial Intelligence by Wojciech Ciezobka, Joan Falco-Roget, Cemal Koba, Alessandro Crimi

“…This transparent analytical framework not only enhances clinical interpretability but also instills confidence in decision-making processes, crucial for translating research findings into clinical practice. Our proposed machine learning pipeline showcases the potential of reservoir computing to define causality and therefore directed graph networks, which can in turn be used in a directed graph classifier and explainable analysis of neuroimaging data. …”
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Network Pharmacology, Molecular Docking, and Molecular Dynamics Analysis of Honokiol against Triple-negative Breast Cancer by Hassan H. Alhassan

“…Context: TNBC presents a significant challenge in clinical practice due to its aggressive behavior and limited treatment options. …”
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Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis o... by Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh

“…ABSTRACT Introduction First‐line osimertinib is widely used to treat patients with epidermal growth factor receptor (EGFR)‐mutated non‐small cell lung cancers (NSCLC). In clinical practice, rechallenge therapy with another EGFR‐tyrosine kinase inhibitor (TKI) is often performed after first‐line TKI discontinuation owing to resistance or toxicity; however, the efficacy and toxicity of EGFR‐TKI rechallenge after first‐line osimertinib have not been adequately investigated. …”
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The Effects of Exercise on Inhibitory Function Interventions for Patients With Major Depressive Disorder (MDD): A Systematic Review and Meta‐Analysis by Zhihui Xu, Cong Liu, Peng Wang, Xing Wang, Yuzhang Li

“…However, the findings provide strong evidence for clinical practice and future research on the beneficial effects of exercise on inhibitory function in MDD patients. …”
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Application of artificial intelligence in the health management of chronic disease: bibliometric analysis by Mingxia Pan, Mingxia Pan, Rong Li, Junfan Wei, Huan Peng, Ziping Hu, Yuanfang Xiong, Na Li, Yuqin Guo, Weisheng Gu, Hanjiao Liu, Hanjiao Liu

“…Future research should prioritize strengthening global partnerships to facilitate cross-disciplinary and cross-regional knowledge exchange, optimizing AI technologies for more precise and effective chronic disease management, and ensuring their seamless integration into clinical practice.…”
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Effect of Combination Therapy of Canagliflozin Added to Teneligliptin Monotherapy in Japanese Subjects with Type 2 Diabetes Mellitus: A Retrospective Study by Yoshiro Fushimi, Atsushi Obata, Junpei Sanada, Yuichiro Iwamoto, Akiko Mashiko, Megumi Horiya, Akiko Mizoguchi-Tomita, Momoyo Nishioka, Yuki Kan, Tomoe Kinoshita, Seizo Okauchi, Hidenori Hirukawa, Kenji Kohara, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

“…We retrospectively analyzed 56 Japanese subjects with T2DM in the real-world clinical practice. Three months after starting the combination therapy, the change of HbA1c (ΔHbA1c) was strongly related to HbA1c levels at baseline. …”
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Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study by Stanislav Rejchrt, Milos Hroch, Rudolf Repak, Tomas Fejfar, Tomas Douda, Darina Kohoutova, Eva Peterova, Jan Bures

“…Differential diagnosis between benign and malignant biliary stenosis can be difficult in clinical practice. Histology of biopsy specimens is often indeterminate. …”
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Overall Survival of Patients with Metastatic Renal Cell Carcinoma Following the Introduction of Targeted and Immunotherapies: A Norwegian Retrospective, Real-World Registry Data St... by Puco K, Notland CS, Szulkin R, Jonasson C, Beisland C, Johannesen TB, Solli O, Oldenburg J, Heinrich D

“…The results may provide additional information on the benefits of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) in clinical practice.Patients and Methods: We performed a longitudinal, retrospective, non-interventional cohort study using data from four national registries. …”
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P Wave Duration/P Wave Voltage Ratio Plays a Promising Role in the Prediction of Atrial Fibrillation: A New Player in the Game by E. Karacop, A. Enhos, N. Bakhshaliyev, R. Ozdemir

“…Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. Identification of patients at risk for developing AF and the opportunity for early targeted intervention might have a significant impact on morbidity and mortality. …”
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Do continuous glucose monitoring (CGM) metrics predict macrovascular and microvascular complications in diabetes? The FACULTY protocol of a retrospective real-world cohort study by Eric Vicaut, Ramzi A Ajjan, J Seufert, Gérard de Pouvourville, Emmanuel Cosson, Laure Carcaillon-Bentata, Tadej Battelino, Patrick Blin, Fleur Levrat-Guillen, Michael Joubert

“…This will have an impact on routine clinical practice by setting targets for the different glycaemic markers, based on robust outcome data, thus helping to optimise glucose management in diabetes.Ethics and dissemination The study data-collection protocol is approved by the French National Commission for Informatics and Liberties, including approval from the Comité Ethique et Scientifique pour les Recherches, les Etudes et les Evaluations dans le domaine de la Santé. …”
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Development of indicators and analysis of barriers for assessment and prevention of cutaneous graft-versus-host disease after haematopoietic stem cell transplantation in children by YANG Liling, ZHAN Sha, XUE Xiaoyan, CHEN Kai, LIU Qing, WANG Li, WANG Yiyi, WU Meng, LU Qunfeng

“…Considering the results of the analysis of the implementation rate of the indicators under review and the obstacles, alternative measures were formulated.Conclusion·There is a large gap between the evidence and clinical practice for the assessment and prevention of cutaneous GVHD after paediatric haematopoietic stem cell transplantation. …”
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Hypercalcemia Following Adrenalectomy for Cushing Syndrome in a Patient with Post-Surgical Hypoparathyroidism by Pietro Locantore, Alessandro Oliva, Gianluca Cera, Rosa Maria Paragliola, Roberto Novizio, Caterina Policola, Andrea Corsello, Alfredo Pontecorvi

“…On the contrary, hypoparathyroidism is a relatively common cause of hypocalcemia, often arising as a complication of thyroid surgery. In real-world clinical practice, however, many challenges come into play, and a comprehensive approach may not be enough to establish a diagnosis. …”
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Clinical Efficacy of Muscle Energy Technology Combined with Conventional Rehabilitation Therapy on Patients with Chronic Non-Specific Neck Pain by ZHENG Kun, YANG Haolun, JIA Chengsen, ZHANG Liming

“…Before treatment and one week after treatment, visual analog scale (VAS) was used to assess the pain level; neck disability index (NDI) was used to evaluate cervical spine dysfunction; Yasuhisa Tanaka cervical spondylotic radiculopathy 20 (CSR20) was used to evaluate cervical spine function; "Clinical practice guideline for physical therapy assessment and treatment in patients with nonspecific neck pain" were used to evaluate the clinical efficacy; the adverse reaction such as aggravation of neck pain, nausea, vomiting, dizziness, increased heart rate, etc. that occurred during treatment were observed.ResultsCompared with that before treatment, VAS scores and NDI index decreased significantly of both groups after treatment (<italic>P</italic>&lt;0.05), CSR20 score increased significantly, and the differences were statistically significant (<italic>P</italic>&lt;0.05). …”
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Prediction of major adverse cardiovascular events following ST-segment elevation myocardial infarction using cardiac obesity marker—epicardial adipose tissue mass index: a prospect... by Zeyan Liu, Jinbo Wang, Yanfang Yang, Jinglin Cheng, Min Yang, Ye Zhang

“…Subgroup analyses suggested that EAMI's predictive ability was consistent across various demographic and clinical characteristics.ConclusionEAMI has high value in predicting MACE in patients 1-year after STEMI, helps identify high-risk patients with poor prognosis in early clinical practice.…”
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Acupuncture for somatosensory deficits after stroke: a systematic review and meta-analysis by Shumeng Ren, Yuhang Chen, Yu Liu, Qiuyi Lv, Jing Peng, Lei Song, Yihuai Zou, Hua Zhang, Xing Chen

“…ObjectiveThis meta-analysis aimed to evaluate the randomized controlled trials (RCTs) of acupuncture for somatosensory deficits after stroke to provide the current best evidence for clinical practice.MethodsA systematic search was performed for eligible articles on the acupuncture for somatosensory deficits after stroke based on 14 databases. …”
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Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head by Tingting Chen, Lincong Luo, Jiaying Li, Jiamin Li, Tao Lin, Mingrui Liu, Hang Sang, Xinyu Hong, Jiahao Pu, Wenhua Huang

“…In the future, the potential of 3D printing extends to combining with artificial intelligence for optimizing treatment plans, developing materials with enhanced bioactivity and compatibility, and translating these innovations from the laboratory to clinical practice. This review demonstrates how 3D printing technology uniquely addresses critical challenges in ONFH treatment, including insufficient vascularization, poor mechanical stability, and limited long-term success of conventional therapies. …”
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Comparative cardiometabolic safety and effectiveness of aripiprazole in people with severe mental illness: A target trial emulation. by Alvin Richards-Belle, Alvin Richards-Belle, Naomi Launders, Sarah Hardoon, Al Richards, Kenneth K C Man, Neil M Davies, Elvira Bramon, Joseph F Hayes, David P J Osborn

“…<h4>Methods and findings</h4>We conducted an observational emulation of a head-to-head trial of aripiprazole versus olanzapine, quetiapine, and risperidone in UK primary care using data from the Clinical Practice Research Datalink. We included adults diagnosed with severe mental illness (i.e., bipolar disorder, schizophrenia, and other non-organic psychoses) who were prescribed a new antipsychotic between 2005 and 2017, with a 2-year follow-up to 2019. …”
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Early prediction of in-hospital mortality in patients with congestive heart failure in intensive care unit: a retrospective observational cohort study by Tao Huang, Rui Yang, Jun Lyu, Didi Han, Fengshuo Xu, Shuai Zheng, Luming Zhang, Haiyan Yin

“…The novel nomogram has the potential for use in clinical practice as a tool to predict and assess mortality of patients with CHF in the ICU.…”
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Advancing Pediatric Surgery: The Use of HoloLens 2 for 3D Anatomical Reconstructions in Preoperative Planning by Marco Di Mitri, Annalisa Di Carmine, Simone D’Antonio, Benedetta Maria Capobianco, Cristian Bisanti, Edoardo Collautti, Sara Maria Cravano, Francesca Ruspi, Michele Libri, Tommaso Gargano, Mario Lima

“…This study underscores the transformative potential of mixed reality technology in pediatric surgery, advocating for further research and development to integrate these advancements into routine clinical practice.…”
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Integrated serum pharmacochemistry, pharmacokinetics, and network analysis to explore active components of BuShao Tiaozhi Capsule on hyperlipidemia by Ruiyin Tang, Guanlin Xiao, Yanchang Liu, Dezheng Jia, Zhihao Zeng, Canchao Jia, Dongmei Li, Yangxue Li, Jieyi Jiang, Sumei Li, Xiaoli Bi

“…BuShao Tiaozhi Capsule (BSTZC), a novel drug in China, has been used to treat hyperlipidemia (HLP) in clinical practice for many years. Despite our previous studies suggesting that BSTZC can treat HLP, there is a lack of a rapid and systematic method to explore its active components. …”
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