The design and preliminary application of a training model for manual therapy for lymphedema (一种手法淋巴引流培训教具装置的设计与应用) by WANG Yuan (王媛), WANG Pei (王蓓), WANG Fengmei (王凤美), DING Yong (丁勇), XIA Shun (夏舜)

“…The design is very close to the clinical practice and the operation of the model is simple and convenient. …”
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Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus by Leticia Elizondo-Montemayor, Adrian M. Gonzalez-Gil, Oscar Tamez-Rivera, Carla Toledo-Salinas, Mariana Peschard-Franco, Nora A. Rodríguez-Gutiérrez, Christian Silva-Platas, Gerardo Garcia-Rivas

“…The objective of this study was to determine irisin plasma concentration and its association with metabolic and adiposity markers and with hs-CRP, a surrogate marker of inflammation used in clinical practice, in a pediatric population with T2DM. …”
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Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies by Feng Zhang, Feng Zhang, Tao Li, Junli Wan, Junli Wan, Lu Wang, Lu Wang, Wenmei Guo, Wenmei Guo, Yue Hu, Yue Hu, Hao Wang, Hao Wang, Wei Bian, Wei Bian

“…However, given that the animal research models utilized in the study may not fully reflect the intricate scenarios of multiple coexisting diseases in clinical settings, and the administration methods in animal models may differ from those in clinical practice, future studies should aim to provide higher levels of evidence to facilitate the clinical translation of these findings.Systematic Review Registration:identifier [CRD42024535673].…”
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T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration by Haixing Wang, Yashi Li, Haoxin Li, Xu Yan, Zhaowei Jiang, Lu Feng, Wenhui Hu, Yinuo Fan, Sien Lin, Gang Li

“…The translational potential of this article: Delayed unions or non-unions of bone fractures remain a challenge in clinical practice. Developing a deep understanding of the roles of immune cells, including T cells, in fracture healing will facilitate the advancement of novel therapeutics of fracture nonunion. …”
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Bifurcation analysis of multistability and hysteresis in a model of HIV infection by I. V. Mironov, M. Yu. Khristichenk, Yu. M. Nechepurenko, D. S. Grebennikov, G. A. Bocharov

“…The current approach to HIV-1 treatment is based on the use of highly active antiretroviral therapy, which has side effects and is costly. For clinical practice, it is highly important to create functional cures that can enhance immune control of viral growth and infection of target cells with a subsequent reduction in viral load and restoration of the immune status. …”
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Association between weight-adjusted-waist index and long-term prognostic outcomes in cardiovascular disease patients: results from the NHANES 1999–2018 study by Hanbin Li, Wen Zhong, Hongxin Cheng, Shiqi Wang, Ran Li, Lu Wang, Chengqi He, Quan Wei

“…Additionally, the high AUC values for WWI strengthen its potential as a meaningful prognostic marker, underscoring its utility in clinical practice for assessing long-term survival risk in patients with CVD.…”
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Impact of Methotrexate and 7‐Hydroxymethotrexate Exposure on Renal Toxicity in Pediatric Non‐Hodgkin Lymphoma by Hao Bing, Yi Ma, Jiamin Xu, Qixian Ling, Yanlong Duan, Libo Zhao

“…Altogether, this study may contribute to crucial insights for ensuring the safe administration of drugs in pediatric clinical practice.…”
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Liver Radioembolization: a New Chapter in Russian Oncology by A. D. Kaprin, S. A. Ivanov, V. V. Kucherov, A. P. Petrosyan, K. V. Mayorov, N. V. Markov, L. O. Petrov, G. A. Davydov, M. A. Sigov, N. K. Silantieva, T. P. Berezovskaya, A. Yu. Usacheva, D. B. Sanin

“…Tsyb Medical Radiological Research Centre (MRRC) — branch of the National Medical Research Radiological Centre and BEBIG LLC resulted in the production of Russian microspheres containing yttrium-90, which were subsequently introduced into routine clinical practice. The first liver embolization in Russia using microspheres containing domestic yttrium-90 (BEBIG LLC) to a patient with hepatocellular cancer was carried out by V.V. …”
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A bioabsorbable mechanoelectric fiber as electrical stimulation suture by Zhouquan Sun, Yuefan Jin, Jiabei Luo, Linpeng Li, Yue Ding, Yu Luo, Yan Qi, Yaogang Li, Qinghong Zhang, Kerui Li, Haibo Shi, Shankai Yin, Hongzhi Wang, Hui Wang, Chengyi Hou

“…This work presents an evolution of the conventional wound closure procedures, using a safe and degradable device ready to be translated into clinical practice.…”
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Efficacy of non-invasive brain stimulation interventions on cognitive impairment: an umbrella review of meta-analyses of randomized controlled trials by Minmin Wu, Wenjing Song, Xue Wang, Lili Teng, Jinting Li, Jiongliang Zhang, Xinyue Li, Donghui Yu, Huanhuan Jia, Binhan Wang, Qiang Tang, Luwen Zhu

“…By comparing our findings to recent reviews and clinical guidelines, we highlight how this study addresses current limitations in the literature, provides a more holistic perspective on NIBS interventions, and guides future research and clinical practice. Methods We searched four databases from inception to May 15, 2024, reviewing SRMAs that analyzed the effects of NIBS. …”
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Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES by Junqi Liao, Jingyi Chen, Huimin Wu, Qing Zhu, Xiaogang Tang, Li Li, Aimei Zhang, Peiyi Mo, Yan Liu, Xinyi Yang, Yang Han, Zhaoyao Chen, Wenlei Li, Yuan Zhu, Minghua Wu

“…These findings provide new ideas and possibilities for the prevention and treatment of cardiovascular and cerebrovascular diseases, offering a reference for development of clinical practice guidelines in the future.…”
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Oncological outcomes following extreme oncoplastic breast conserving surgery (eOPBCS) for locally advanced breast cancer (LABC): A systematic review and meta-analysis by Megan Chua Wern Ee, Ashley Lee Shi Hui, Wong Hung Chew, Emmeline Elaine Cua-Delos Santos, Sean Li Siwei, Sng Ming Xian, Qin Xiang Ng, Serene Goh Si Ning

“…High-quality prospective studies are essential to validate these findings and refine criteria for incorporating eOPBCS into routine clinical practice.…”
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Estimating the Cost-Effectiveness of Tumor Treating Fields (TTFields) Therapy with an Immune Checkpoint Inhibitor or Docetaxel in Metastatic Non-Small Cell Lung Cancer by Furnback W, Wu E, Koh CYC, Nino de Rivera Guzman JF, Kruhl C, Kotecha R, Wang BC

“…ICERs fall within the accepted range for US cost-effectiveness thresholds, supporting their use in clinical practice. TTFields therapy extended mean lifetime survival, offering a clinically meaningful and economically justifiable option for patients progressing after platinum-based chemotherapy.Plain language summary: Recent clinical data from the LUNAR study has shown that Tumor Treating Fields (TTFields) therapy concomitant with immune checkpoint inhibitors (ICIs) or docetaxel improves survival in patients with metastatic non-small cell lung cancer (NSCLC) on or after platinum-based therapy. …”
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Efficacy of natural killer T and gammadelta T cells in mesothelin-targeted immunotherapy of pancreatic cancer by Yuankui Zhu, Yaxi Yang, Linghe Yue, Lei Wan, Xuqian Ma, Qing Yang, Xuan Tian, Yuguan Li, Ke Wang, Shaozhong Wei, Shaozhong Wei, Shaozhong Wei, Dianbao Zuo, Mingqian Feng, Mingqian Feng

“…Despite their promise, dose-limited toxicity (DLT) remains a challenge in clinical practice. In light of these concerns, there is a growing interest in exploring alternative T cell types, natural killer T (NKT) cells and gammadelta (γδ) T cells, that possess the capacity to lyse tumors while potentially offering a safer therapeutic profile with fewer side effects. …”
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Nomogram to screen older adult patients attending the radiology department for sarcopenia by Guiying Yuan, Guoxi Ye, Jianguang Hu, Huimin Hu, Chanmei Shi, Ye Zhang, Junbing Huang, Zhiqiong Li, Xuwen Zeng, Rongshao Tan, Yuchao Xiong

“…However, it is often overlooked in clinical practice. Therefore, we aim to construct a nomogram based on simplified discriminant parameters for screening older adult patients for sarcopenia risk. …”
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Conglomerated Imiquimod and Metronidazole Incorporated Biodegradable Nanofibrous Mats for Potential Therapy of Cervical Cancer by Chen YP, Chiu CF, Wang CN, Lin CC, Shen CR, Yao YC, Kuo YH, Liu SJ

“…Yi-Pin Chen,1,2 Chiao-Fan Chiu,3,4 Chien-Neng Wang,1 Chu-Chi Lin,1 Chia-Rui Shen,5– 7 Yi-Chen Yao,8 Yi-Hua Kuo,8 Shih-Jung Liu8,9 1Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, Keelung, 20401, Taiwan; 2School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Pediatrics, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan; 4Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, 33302, Taiwan; 5Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, 33302, Taiwan; 6Department of Ophthalmology, Lin-Kou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 7R&D Center of Biochemical Engineering Technology, Department of Chemical Engineering, Ming Chi University of Technology, New Taipei, Taiwan; 8Department of Mechanical Engineering, Chang Gung University, Taoyuan, 33302, Taiwan; 9Bone and Joint Research Center, Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkou, Taoyuan, 33305, TaiwanCorrespondence: Shih-Jung Liu, Department of Mechanical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302, Taiwan, Tel +886-3-2118166, Fax +886-3-2118558, Email shihjung@mail.cgu.edu.twBackground: In clinical practice, imiquimod is used to treat Human Papillomavirus (HPV)-related lesions, such as condyloma and Cervical Intraepithelial Neoplasia (CIN). …”
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Advancing precision medicine in esophageal squamous cell carcinoma using patient-derived organoids by Suya Shen, Bing Liu, Wenyan Guan, Ziyao Liu, Yuqing Han, Yingzhe Hu, Yiqiang Chen, Siyuan Liu, Jian He, Zhiwen Li, Weifeng Tang, Pengju Zhang, Wei Ren, Yudong Qiu, Hongping Zheng, Jingjing Li

“…This study aims to evaluate the efficacy of implementing PDOs in clinical practice to benefit patients with esophageal squamous cell carcinoma (ESCC). …”
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Race as a prognostic factor of breast mucinous carcinoma by Dingyuan Wang, Yang Wang, Songlin Gao, Rongshou Zheng, Guijian Wu, Jianping Wang, Can Lu, Kena Bu, Chun Zhang, Wanqing Chen, Bailin Zhang

“…The goal was to help formulate more personalized clinical practice guidelines for the management of this rare malignancy. …”
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Real-World Persistence and Effectiveness of Upadacitinib versus Other Janus Kinase Inhibitors and Tumor Necrosis Factor Inhibitors in Australian Patients with Rheumatoid Arthritis by Peter Youssef, Sabina Ciciriello, Talib Tahir, Joanna Leadbetter, Belinda Butcher, Miriam Calao, Nicole Walsh, Catherine O’Sullivan, Tegan Smith, Geoffrey Littlejohn

“…Conclusions Overall, the breadth and depth of data from this large real-world dataset continue to support a favorable clinical profile of UPA for the treatment of RA and may inform treatment choices in everyday clinical practice.…”
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Discussion on standardization of Traditional Chinese Medicine nursing appropriate Technology based on Traditional Chinese Medicine nursing inheritance (基于中医护理传承构建标准化中医护理适宜技术)... by LIU Hongxin (刘红鑫), GUO Hailing (郭海玲), TIAN Runxi (田润溪), WANG Fang (王芳), GAO Ning (高宁), ZHENG Liping (郑莉萍), LI Yufeng (李玉凤), YU Liying (于丽英)

“…Based on the deeply understanding Professor Guo Hailing 's academic thought of " inherit traditional Chinese medicine nursing with love, evidence-based innovation and development of teaching", evidence-based nursing methods was used to standardize TCM nursing appropriate technology and promote it to clinical practice. It can help to provide basis for clinical optimization of TCM nursing appropriate technology and provide efficient nursing mode for patients. …”
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