Functional status, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio as prognostic factors of one-year survival rate in elderly patients with advanced-stage non-small... by Ratna Nurhayati, Aulia Rizka, Cleopas Martin Rumende, Noorwati Sutandyo, Arif Hanafi, Edy Rizal Wahyudi, Hamzah Shatri, Anna Mira Lubis, Em Yunir, Muhammad Firdaus, Yuniar Harris Prayitno, Nadira Nibras Taqiyya

“…Factors potentially influencing outcomes included diabetes mellitus, anemia, chronic obstructive pulmonary disease, and chronic kidney disease. Statistical analyses were performed using SPSS 20.0, employing the log-rank method for bivariate analysis and Cox regression for multivariate analysis. …”
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Analysis of Role of Haematological Parameters in Diagnosis of Grampositive and Gram-negative Urinary Tract Infection: A Case-control Study by Sudha Srinivasan, Ayeesha Sithika Thajudeen, Kundhavai Chandrasekaran, Vijayashree Raghavan, D Roshini

“…Controls were also excluded if they had diabetes or chronic kidney disease. Urine cultures on blood and MacConkey agar identified pathogens such as E. coli, Pseudomonas, Klebsiella, Enterobacter, Proteus and Citrobacter. …”
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Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy by Hanyu Zhu, Moyan Liu, Hanjie Yu, Xiawei Liu, Yaogang Zhong, Jian Shu, Xinle Fu, Guangyan Cai, Xiangmei Chen, Wenjia Geng, Xiaoli Yang, Minghui Wu, Zheng Li, Dong Zhang

“…Diabetic nephropathy is a major cause of chronic kidney disease and end-stage kidney disease. However, so little is known about alterations of the glycopatterns in urine with the development of diabetic nephropathy. …”
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Protective role of vitamin D receptor against mitochondrial calcium overload from PM2.5-Induced injury in renal tubular cells by Mengqiu Lu, Zishun Zhan, Dan Li, Hengbing Chen, Aimei Li, Jing Hu, Zhijun Huang, Bin Yi

“…These results unveil a new protective role of VDR in defending against environmental pollutants and suggest that targeting the MCU could offer a potential therapeutic strategy for treating chronic kidney disease linked to pollution exposure.…”
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Development and Validation of a Nomogram for Predicting Long-Term Net Adverse Clinical Events in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention by Junyan Zhang, Zhongxiu Chen, Ran Liu, Yuxiao Li, Hongsen Zhao, Yanning Li, Minggang Zhou, Hua Wang, Chen Li, Li Rao, Yong He

“…These were then utilized to construct a prognostic prediction nomogram, including chronic kidney disease, left main stem lesion, multivessel disease, triglycerides (TG), and creatine kinase-myocardial band (CK-MB). …”
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Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study by Pedro Romero-Aroca, Marc Baget-Bernaldiz, Raul Navarro-Gil, Antonio Moreno-Ribas, Aida Valls-Mateu, Ramon Sagarra-Alamo, Joan F. Barrot-De La Puente, Xavier Mundet-Tuduri

“…We determined differences between estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio. …”
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Distinct Neutralising and Complement-Fixing Antibody Responses Can Be Induced to the Same Antigen in Haemodialysis Patients After Immunisation with Different Vaccine Platforms by Nadezhda Wall, Rachel Lamerton, Fiona Ashford, Marisol Perez-Toledo, Aleksandra Jasiulewicz, Gemma D. Banham, Maddy L. Newby, Sian E. Faustini, Alex G. Richter, Haresh Selvaskandan, Roseanne E. Billany, Sherna F. Adenwalla, Ian R. Henderson, Max Crispin, Matthew Graham-Brown, Lorraine Harper, Adam F. Cunningham

“…<b>Background/Objectives</b>: Generalised immune dysfunction in chronic kidney disease, especially in patients requiring haemodialysis (HD), significantly enhances the risk of severe infections. …”
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Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury by Kurt T. K. Giuliani, Purba Nag, Benjamin C. Adams, Xiangju Wang, Seokchan Hong, Anca Grivei, Rebecca L. Johnston, Nicola Waddell, Kenneth K. C. Ho, Yilin Tian, Muhammad Ali Khan, Chang Seong Kim, Monica S. Y. Ng, Glenda Gobe, Jacobus P. J. Ungerer, Josephine M. Forbes, Helen G. Healy, Andrew J. Kassianos

“…Abstract Hypoxia and interleukin (IL)-1β are independent mediators of tubulointerstitial fibrosis, the histological hallmark of chronic kidney disease (CKD). Here, we examine how hypoxia and IL-1β act in synergy to augment maladaptive proximal tubular epithelial cell (PTEC) repair in human CKD. …”
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Prevalence of Diabetic Retinopathy in Patients with Cerebrovascular Accident: A Cross-sectional Study by (Col.) OK Radhakrishnan, Rutu K Rao, Varsha Manade, Swaranjali Gore, Shreya Gandhi, Khushboo Goyal, Tushar Agrawal

“…Introduction: Diabetes Mellitus (DM) causes high blood sugar, leading to complications such as cerebrovascular events, chronic kidney disease, cardiovascular issues and retinopathy. …”
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Clinical portrait of a patient with acute coronary syndrome and type 2 diabetes mellitus: a novel strategy for the diagnosis, prognosis and treatment by M.I. Shved, I.O. Yastremska, L.V. Levytska, V.Yu. Kuchmiy, O.A. Prokopovych, Ya.M. Kitsak, R.M. Liakhovych

“…It was typical for these patients to have frequent comorbid conditions, namely: hypertension (94.7 %), metabolic syndrome (85.3 %), chronic kidney disease (30.7 %), chronic obstructive pulmonary disease (29.3 %), thyroid dysfunction (22.7 %), and such CAD risk factors (and their combinations in 89.3 % of cases) as atherogenic dyslipidemia (96.0 %), tobacco smoking (34.7 %), excessive alcohol use (32.0 %), family history of CAD and T2DM (29.3 and 61.3 % of patients, respectively). …”
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Evaluating the use of Uromune® autovaccine in recurrent urinary tract infections: a pilot unicenter retrospective study in Reus, Spain by Simona Iftimie, Paula Ladero-Palacio, Ana F. López-Azcona, Laia Pujol-Galarza, Antoni Pont-Salvadó, Xavier Gabaldó-Barrios, Jorge Joven, Jordi Camps, Antoni Castro, Mercè Pascual-Queralt

“…Regression analysis identified having had a urostomy, chronic kidney disease, and being immunosuppressed as predictors of recurrence. …”
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Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal... by Nanquan Rao, Xiaotong Wang, Jing Xie, Jingzhi Li, Yue Zhai, Xiaoxia Li, Tengjiaozi Fang, Yuanyuan Wang, Yuming Zhao, Lihong Ge

“…Diabetic nephropathy (DN) is a major cause of chronic kidney disease. It has been proven that mesenchymal stem cells (MSCs) have therapeutic effects on kidney disease. …”
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The effects of Tripterygium wilfordii Hook F on renal outcomes in type 2 diabetic kidney disease patients with severe proteinuria: a single-center cohort study by Yaqi Cheng, Yuhao Liu, Liling Lin, Danni Li, Liying Peng, Ke Zheng, Jianling Tao, Mingxi Li

“…TwHF significantly reduced the risk of renal outcomes (adjusted hazard ratio [HR] 0.271, 95% confidence interval [CI] 0.111–0.660, p = 0.004) in patients with chronic kidney disease (CKD) G3 (adjusted HR 0.274, 95%CI 0.081–0.932, p = 0.039). …”
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Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction by Mariko Asada, Tomoaki Morioka, Yuko Yamazaki, Yoshinori Kakutani, Reina Kawarabayashi, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masanori Emoto, Masaaki Inaba

“…We included 419 patients with type 2 diabetes, 161 of whom had chronic kidney disease (CKD). Fasting plasma CTRP9 and total adiponectin levels were measured with enzyme-linked immunosorbent assay. …”
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Enhancing diagnostic outcomes in kidney genetic disorders: the KidGen national kidney genomics study protocol by Amali Mallawaarachchi, Hugh McCarthy, Thomas A. Forbes, Kushani Jayasinghe, Chirag Patel, Stephen I. Alexander, Tiffany Boughtwood, Jeffrey Braithwaite, Aron Chakera, Sam Crafter, Ira W. Deveson, Randall Faull, Trudie Harris, Lilian Johnstone, Matthew Jose, Anna Leaver, Melissa H. Little, Daniel MacArthur, Tessa Mattiske, Christine Mincham, Kathy Nicholls, Catherine Quinlan, Michael C. J. Quinn, Gopala Rangan, Jessica Ryan, Cas Simons, Ian Smyth, Madhivanan Sundaram, Peter Trnka, Laura Wedd, Erik Biros, Zornitza Stark, Andrew Mallett

“…The study's evidence will drive changes to current diagnostic pathways, including identifying which chronic kidney disease patients are most likely to benefit from a more comprehensive genomic approach to diagnosis.…”
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A Simple Nomogram to Predict Contrast-Induced Acute Kidney Injury in Patients with Congestive Heart Failure Undergoing Coronary Angiography by Li Lei, Yibo He, Zhaodong Guo, Bowen Liu, Jin Liu, Zhiqiang Nie, Guanzhong Chen, Liwei Liu, Mengfei Lin, Wenhe Yan, Shiqun Chen, Chen Jiyan, Yong Liu

“…The simple nomogram including four predictors (age, intra-aortic balloon pump, acute myocardial infarction, and chronic kidney disease) demonstrated a similar predictive power as the Mehran score (area under the curve: 0.80 vs. 0.75, P=0.061), as well as a well-fitted calibration curve. …”
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Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association by Amy Rebecca Bentley, Ayo P. Doumatey, Guanjie Chen, Hanxia Huang, Jie Zhou, Daniel Shriner, CongQing Jiang, Zhenjian Zhang, Guozheng Liu, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Benjamin A. Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Clement Adebamowo, Albert Amoah, Joseph Acheampong, Adebowale Adeyemo, Charles N. Rotimi

“…Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear. …”
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Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach by Yujia Wang, Yan Di, Yongqi Li, Jing Lu, Bofan Ji, Yuxia Zhang, Zhiqing Chen, Sijie Chen, Bicheng Liu, Rining Tang, Yuanyuan Ji

“…Renal osteodystrophy (ROD) is a skeletal pathology associated with chronic kidney disease-mineral and bone disorder (CKD-MBD) that is characterized by aberrant bone mineralization and remodeling. …”
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Development and external validation of a nomogram for the early prediction of acute kidney injury in septic patients: a multicenter retrospective clinical study by Qin-Yue Su, Wen-Jie Chen, Yan-Jun Zheng, Wen Shi, Fang-Chen Gong, Shun-Wei Huang, Zhi-tao Yang, Hong-Ping Qu, En-Qiang Mao, Rui-Lan Wang, Du-Ming Zhu, Gang Zhao, Wei Chen, Sheng Wang, Qian Wang, Chang-Qing Zhu, Gao Yuan, Er-Zhen Chen, Ying Chen

“…The model included five independent indicators: chronic kidney disease stages 1 to 3, blood urea nitrogen, procalcitonin, D-dimer and creatine kinase isoenzyme. …”
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Atrial fibrillation outcomes in patients from Asia and non-Asia countries: insights from GARFIELD-AF by Karen Pieper, Xian-hong Fang, Kai Sun, Ajay K Kakkar, Saverio Virdone, Shinya Goto, Gloria Kayani, Zhi-Cheng Jing, John Camm, Chun-Yan Cheng, Tian-Yu Lian, Xi-Jie Zhu, Xian-Mei Li

“…Associations of moderate-to-severe chronic kidney disease and vascular disease with increased risk of all-cause mortality were stronger in Asian versus non-Asian patients (interaction p values: 0.0250 and 0.0076, respectively). …”
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