Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort Study by Javier Enrique Cely, Elkin José Mendoza, Carlos Roberto Olivares, Oscar Julián Sepúlveda, Juan Sebastián Acosta, Rafael Andrés Barón, Juan José Diaztagle

“…The associated risk factors were prehospital treatment with nephrotoxic drugs (2.21 OR; 95% CI 1.12–4.36, p=0.022), chronic kidney disease (CKD) in stages 3 to 5 (3.56 OR; 95% CI 1.55–8.18, p<0.003), and venous thromboembolism (VTE) at admission (5.05 OR; 95% CI 1.59–16.0, p<0.006). …”
Get full text

Systematic review of the application of the Kidney Failure Risk Equation and Oxford classification in estimating prognosis in IgA Nephropathy by M. P. Toal, R. Fergie, M. P. Quinn, C. J. Hill, C. O’Neill, A. P. Maxwell

“…Abstract Background IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world and is an important cause of chronic kidney disease (CKD) and kidney failure. Outcomes are heterogeneous, and accurate risk stratification is important to identify the highest risk individuals for treatment and to help prevent disease progression. …”
Get full text

Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial–mesenchymal transition by Jingying Zhao, Xiuli Wang, Yubin Wu, Chengguang Zhao

“…Acute kidney injury (AKI) can progress to renal fibrosis and chronic kidney disease (CKD), which reduces quality of life and increases the economic burden on patients. …”
Get full text

Comparison of Two Creatinine-Based Equations for Predicting Decline in Renal Function in Type 2 Diabetic Patients with Nephropathy in a Korean Population by Eun Young Lee, Young-Mi Lee, Kyu Hun Choi, Hyun Chul Lee, Byung-Wan Lee, Beom Seok Kim

“…To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. …”
Get full text

Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src by Xieyi Guo, Liu Yang, Xiaoning An, Maofang Hu, Yilan Shen, Niansong Wang, Youhua Xu, Dingkun Gui

“…Abstract Background The treatment options to delay the progression of diabetic nephropathy (DN), a key contributor to chronic kidney disease (CKD), are urgently needed. Previous studies reported that traditional Chinese medicine Panax notoginseng (PNG) exerted beneficial effects on DN. …”
Get full text

Patients’ and caregivers’ perspectives on access to kidney replacement therapy in rural communities: systematic review of qualitative studies by Allison Tong, Stephen May, Jonathan Craig, Martin Howell, Talia Gutman, Rachel Chalmers, David J Tunnicliffe, Nicole Jane Scholes-Robertson, Amanda Baumgart, Victoria SInka

“…Objective Patients with chronic kidney disease (CKD) requiring kidney replacement therapy (KRT) in rural communities encounter many barriers in accessing equitable care and have worse outcomes compared with patients in urban areas. …”
Get full text

Exploring the subtle and novel renal pathological changes in diabetic nephropathy using clustering analysis with deep learning by Tomohisa Yabe, Yuko Tsuruyama, Kazutoshi Nomura, Ai Fujii, Yuto Matsuda, Keiichiro Okada, Shogo Yamakoshi, Yuya Hamabe, Shogo Omote, Akihiro Shioya, Norifumi Hayashi, Keiji Fujimoto, Yuki Todo, Tatsuro Tanaka, Sohsuke Yamada, Akira Shimizu, Katsuhito Miyazawa, Hitoshi Yokoyama, Kengo Furuichi

“…Abstract To decrease the number of chronic kidney disease (CKD), early diagnosis of diabetic kidney disease is required. …”
Get full text

Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study by Hang Zhang, Jing-jing Zuo, Si-si Dong, Yuan Lan, Chen-wei Wu, Guang-yun Mao, Chao Zheng

“…Diabetic kidney disease is a leading cause of chronic kidney disease and end-stage renal disease across the world. …”
Get full text

Nailfold capillary abnormalities as indicators of diabetic nephropathy progression: a cross-sectional study in type 2 diabetes by Po-Chi Hsu, Pei-Yung Liao, Ssu-Wei Huang, Hen-Hong Chang, John Y. Chiang, Lun-Chien Lo

“…This study investigates the correlation between DN and nailfold capillary abnormalities in type 2 DM.Methods This prospective cross-sectional study involved 453 participants with type 2 DM, divided into 3 groups based on estimated glomerular filtration rate (eGFR) or albumin-to-creatinine (A/C) ratio. Chronic kidney disease (CKD) risk categories based on the 2012 Kidney Disease Improving Global Outcomes (KDIGO) guidelines. …”
Get full text

Acute Kidney Injury, Mild Cognitive Impairment, and Dementia: A Cohort Study of Patients from SPRINT by Kristen L. Nowak, Anna Ostrow, Ester S. Oh, Zhiying You, Michel Chonchol

“…Results: Participants were 68 ± 9 years, 65% male, 28% with prevalent chronic kidney disease), with a median (interquartile range) follow-up time for the composite of 4.0 (2.1-5.4) and 4.6 (3.6-5.9) years in the AKI and non-AKI groups, respectively. …”
Get full text

Cost-effectiveness and budget impact analysis of peritoneal dialysis and haemodialysis in South Africa by Evelyn Thsehla, Micheal Kofi Boachie, Susan Goldstein

“…Abstract Background More than 800 million people are affected by chronic kidney disease (CKD) worldwide. In South Africa, the prevalence of CKD increased by 67% between 1999 and 2006. …”
Get full text

Therapeutic Approaches in Mitochondrial Dysfunction, Inflammation, and Autophagy in Uremic Cachexia: Role of Aerobic Exercise by Yumei Zhang, Yuqing Liu, Xiao Bi, Chun Hu, Feng Ding, Wei Ding

“…Chronic kidney disease (CKD) causes several systemic changes, including muscular homeostasis, and eventually results in muscle atrophy. …”
Get full text

Determinants of mortality and prolonged hospital stay among dengue patients attending tertiary care hospital: a cross-sectional retrospective analysis by Yusra Habib Khan, Tauqeer Hussain Mallhi, Amer Hayat Khan, Azmi Sarriff, Azreen Syazril Adnan

Get full text

Exploration of treatment burden through examination of workload and patient capacity during transition onto kidney replacement therapy: a systematic review of qualitative research by Catrin Jones, Ross Cairns, Heather Walker, Silje Welsh, Benjamin Edgar, Karen Stevenson, Bhautesh D. Jani, Patrick B. Mark, David Kingsmore, Katie I. Gallacher

“…Abstract Background Patients with advanced chronic kidney disease requiring initiation of kidney replacement therapy (KRT) are frequently asked to enact complex management plans. …”
Get full text

Evaluation of the Relationship between Nutritional Status of COVID-19 Patients Admitted to the ICU and Patients’ Prognosis: A Cohort Study by Parsa Mohammadi, Hesam Aldin Varpaei, Alireza Khafaee pour khamseh, Mostafa Mohammadi, Mojgan Rahimi, Amirhossein Orandi

“…There was a statistically significant association between chronic kidney disease (CKD) and mNUTRIC risk (OR = 13.5, 95% CI (1.89–16.05), P=0.002), diabetes mellitus (DM) and MNA risk (OR = 2.82, 95% CI (1.01–7.83), P=0.041), hypertension (HTN) and MNA risk (OR = 5.63, 95% CI (2.26–14.05), P<0.001), and malignancy and mNUTRIC risk (P=0.048). …”
Get full text

Diabetes is associated with a higher incidence of short-term mortality risk and readmission in patients who undergo surgical but not transcatheter aortic valve replacement by Soha Dargham, Amin Jayyousi, Jassim Al Suwaidi, Charbel Abi Khalil, Ahston D Souza, Khalifa Bsheish

“…When comparing outcomes between TAVR and sAVR in patients with diabetes, TAVR patients were older and had a higher prevalence of chronic kidney disease (CKD). Nevertheless, 30-day readmission and mortality were lower in patients who underwent TAVR (aHR=0.59 (0.53–0.67), aHR=0.29 (0.25–0.34), respectively) compared with sAVR. …”
Get full text

Targeted Polymer–Peptide Conjugates for E-Selectin Blockade in Renal Injury by Nenad Milošević, Marie Rütter, Yvonne Ventura, Valeria Feinshtein, Ayelet David

“…Background/Objectives: Leukocytes play a significant role in both acute kidney injury (AKI) and chronic kidney disease (CKD), contributing to pathogenesis and tissue damage. …”
Get full text

Clinical Characteristics of Inpatients with Diabetic Foot Ulcer Admitted with Non-Ulcer Complaints: A Retrospective Study by Li L, Li Y, Qin S, Zeng J, Ma W, Wei D

“…IWGDF/IDSA grade, cerebrovascular diseases, chronic kidney disease, infection in other parts, glycosylated hemoglobin A1c and the source of hospitalization expenses were the independent influencing factors for admission with non-ulcer complaints (all P < 0.05). …”
Get full text

PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling by Koji Hashimoto, Yuji Kamijo, Takero Nakajima, Makoto Harada, Makoto Higuchi, Takashi Ehara, Hidekazu Shigematsu, Toshifumi Aoyama

“…The vast increase of chronic kidney disease (CKD) has attracted considerable attention worldwide, and the development of a novel therapeutic option against a representative kidney disease that leads to CKD, mesangial proliferative glomerulonephritis (MsPGN) would be significant. …”
Get full text

Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus Viruria by Sara Querido, Carolina Ormonde, Teresa Adragão, Inês Costa, Maria Ana Pessanha, Perpétua Gomes, André Weigert

“…Recent data have emerged about a protective association between JCV viruria and chronic kidney disease (CKD). Material and Methods. Single-center retrospective cohort study; 230 living kidney donors (LKD) candidates and 59 potential living kidney receptors (LKR) were enrolled. …”
Get full text