Integration of unpaired single cell omics data by deep transfer graph convolutional network. by Yulong Kan, Yunjing Qi, Zhongxiao Zhang, Xikeng Liang, Weihao Wang, Shuilin Jin

“…The rapid advance of large-scale atlas-level single cell RNA sequences and single-cell chromatin accessibility data provide extraordinary avenues to broad and deep insight into complex biological mechanism. …”
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A dual role of Cohesin in DNA DSB repair by Michael Fedkenheuer, Yafang Shang, Seolkyoung Jung, Kevin Fedkenheuer, Solji Park, Davide Mazza, Robin Sebastian, Hiroyuki Nagashima, Dali Zong, Hua Tan, Sushil Kumar Jaiswal, Haiqing Fu, Anthony Cruz, Supriya V. Vartak, Jan Wisniewski, Vittorio Sartorelli, John J. O’Shea, Laura Elnitski, Andre Nussenzweig, Mirit I. Aladjem, Fei-Long Meng, Rafael Casellas

“…Cohesin, a multi-subunit protein complex, plays a crucial role in both chromosome organization and DNA repair by creating architectural loops through chromatin extrusion. However, the mechanisms by which cohesin regulates these distinct processes are not fully understood. …”
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Inhibition of miMOMP-induced SASP to combat age-related disease by Xiaoli Liao, Zhennan Guo, Zhennan Guo, Mouhai He, Yichun Zhang

“…This process is triggered by various stimuli, including oxidative stress, chromatin modifications and oncogene activation, characterized by irreversible cell-cycle arrest, resistance to apoptosis and the induction of a complex senescent associated secretory phenotype (SASP). …”
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Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Under tight spatiotemporal regulation, DSBs serve as a tool for genetic modification, widely used across cellular biology to generate diverse functionalities, ranging from the fundamental upkeep of DNA replication, transcription, and the chromatin landscape to the diversification of immunity and the germline. …”
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Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease by Sorabh Sharma, Rajeev Taliyan

“…Indeed, it is becoming increasingly evident that chromatin acetylation status can be impaired during the neurological disease conditions. …”
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Comparative Study of Spermatogenesis and Nucleolar Behavior in Testicular Lobes of Euschistus heros (Heteroptera: Pentatomidae) by Hederson Vinicius de Souza, Mary Massumi Itoyama

“…However, differences regarding the concentration of heteropyknotic chromatin and silver-positive bodies in this lobe deserve attention. …”
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Finding the Correct Partner: The Meiotic Courtship by Tomás Naranjo

“…Additional movements produced by chromatin conformational changes at early meiosis may also facilitate homologous contacts. …”
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Long Noncoding RNA Regulation of Pluripotency by Alessandro Rosa, Monica Ballarino

“…Recent evidence suggests that a complex network of transcription factors, chromatin regulators, and noncoding RNAs exist in pluripotent cells to regulate the balance between self-renewal and multilineage differentiation. …”
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The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions by Marco Muzi-Falconi, Michele Giannattasio, Marco Foiani, Paolo Plevani

“…However, pol-prim seems to play additional roles in other complex cellular processes, such as the response to DNA damage, telomere maintenance, and the epigenetic control of higher order chromatin assembly.…”
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Ultrastructural and Molecular Changes in the Developing Small Intestine of the Toad Bufo regularis by S. A. Sakr, G. M. Badawy, H. T. El-Borm

“…These included the appearance of apoptotic bodies/nuclei within the larval epithelium, the presence of macrophages, swollen mitochondria, distorted rough endoplasmic reticulum, chromatin condensation, and irregular nuclear envelop, and the presence of large vacuoles and lysosomes. …”
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Spatial integration of multi-omics single-cell data with SIMO by Penghui Yang, Kaiyu Jin, Yue Yao, Lijun Jin, Xin Shao, Chengyu Li, Xiaoyan Lu, Xiaohui Fan

“…Unlike previous tools, SIMO not only integrates spatial transcriptomics with single-cell RNA-seq but expands beyond, enabling integration across multiple single-cell modalities, such as chromatin accessibility and DNA methylation, which have not been co-profiled spatially before. …”
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A Novel Heterozygous De Novo MORC2 Missense Variant Causes an Early Onset and Severe Neurodevelopmental Disorder by Daniel Arbide, Nour Elkhateeb, Ewa Goljan, Carolina Perez Gonzalez, Anna Maw, Soo-Mi Park

“…Microrchidia CW-type zinc finger protein 2 (MORC2) is an ATPase-containing nuclear protein which regulates transcription through chromatin remodelling and epigenetic silencing. MORC2 may have a role in the development of neurones, and dominant variants in this gene have recently been linked with disorders including Charcot-Marie-Tooth type 2Z disease, spinal muscular atrophy and, more recently, a neurodevelopmental syndrome consisting of developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy (DIGFAN), presenting with hypotonia, microcephaly, brain atrophy, intellectual disability, hearing loss, faltering growth, and craniofacial dysmorphism. …”
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Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis by Desiré Casares‐Marfil, Amr H. Sawalha

“…By exploring gene expression and chromatin interaction data, we identified candidate causal genes in TAK, some of them with well‐known functional implications. …”
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Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells by Patrícia S. de Araújo-Souza, Steffi C. H. Hanschke, João P. B. Viola

“…This review will focus on the chromatin status of Ifng promoter in CD8 T cells and possible influences of epigenetic modifications in Ifng gene and conserved noncoding sequences (CNSs) in regulation of IFN-γ production by CD8 T lymphocytes.…”
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Comprehensive genome annotation of Trilocha varians, a new model species of Lepidopteran insects by Jung Lee, Toshiaki Fujimoto, Katsushi Yamaguchi, Shuji Shigenobu, Ken Sahara, Toru Shimada

“…ATAC-seq was also conducted to determine chromatin accessibility across the genome. Finally, piRNA-targeted small RNA-seq revealed T. varians genome harbours 517 piRNA clusters (piCs). …”
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Epigenetics and Breast Cancers by An T. Vo, Richard M. Millis

“…Histone demethylases such as JMJD2B and histone methyltransferases are enzymes which demethylate lysine residues on histones H3 and/or H4. This makes the chromatin accessible for transcription factors and enzymes.…”
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ROLE OF THE MODULATORY MEDIATOR SEROTONIN IN THE INDUCTION OF EPIGENETIC PROCESSES DURING LONG TERM MEMORY FORMATION IN HELIX by L. N. Grinkevich, O. V. Vorobiova

“…They include posttraslational histone modifications, which lead to chromatin remodeling and thereby influences gene expression involved in learning. …”
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The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases by Keshav Raj Sigdel, Ao Cheng, Yin Wang, Lihua Duan, YanLin Zhang

“…The lncRNAs are emerging as an important regulator of biological process, such as chromatin remodeling, gene transcription, protein transport, and trafficking through diverse mechanisms. …”
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Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells by Ying Yin, Liquan Zhou, Shuiqiao Yuan

“…Some other retrotransposons reside in the vicinity of endogenous genes and are capable of regulating nearby genes and cell fate, possibly through providing alternative promoters, regulatory modules, or orchestrating high-order chromatin assembly. In addition, retrotransposons may mediate epigenetic memory, regulate gene expression posttranscriptionally, defend virus infection, and so on. …”
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The role of epigenetics in plant pathogens interactions under the changing environments: A systematic review by Wenhao Wu, Guoqiang Fan

“…DNA methylation influences plant immunity by modulating gene expression and chromatin accessibility, while histone modifications, such as acetylation and methylation, enable plants to establish robust defenses by fine-tuning stress-responsive genes. …”
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