Divalent Metal- and High Mobility Group N Protein-Dependent Nucleosome Stability and Conformation by Michelle S. Ong, Dileep Vasudevan, Curt A. Davey

“…High mobility group N proteins (HMGNs) bind specifically to the nucleosome core and act as chromatin unfolding and activating factors. Using an all-Xenopus system, we found that HMGN1 and HMGN2 binding to nucleosomes results in distinct ion-dependent conformation and stability. …”
Get full text

A Systemic Network Triggered by Human Cytomegalovirus Entry by Anyou Wang, Li Ren, Hong Li

“…The up-regulated network contains various functional modules, such as cell surface receptors, skeletal development, endocytosis, ion transport, and chromatin remodeling. Interestingly, macromolecule metabolism and chromatin remodeling module predominates this over-expressed system, suggesting that the fundamental nuclear process modulation is one of the most important events in HCMV entry. …”
Get full text

A biallelically active embryonic enhancer dictates GNAS imprinting through allele-specific conformations by Yorihiro Iwasaki, Monica Reyes, Harald Jüppner, Murat Bastepe

“…Here, we show that the STX16-ICR forms different chromatin conformations with each GNAS parental allele and enhances two GNAS promoters in human embryonic stem cells. …”
Get full text

Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders by I. De Toma, L. Manubens Gil, S. Ossowski, M. Dierssen

“…Epigenetic treatments act in a context specific manner, targeting different regions based on cell and state specific chromatin accessibility, facilitating the establishment of the lost balance. …”
Get full text

CHD7 Regulates Osteogenic Differentiation of Human Dental Follicle Cells via PTH1R Signaling by Caojie Liu, Qiwen Li, Qingyue Xiao, Ping Gong, Ning Kang

“…Chromodomain helicase DNA-binding protein 7 (CHD7) is an ATP-dependent chromatin remodeling enzyme, functioning as chromatin reader to conduct epigenetic modification. …”
Get full text

PIWI proteins and piRNAs: key regulators of stem cell biology by Fernando Claro-Linares, Patricia Rojas-Ríos

“…Precisely, in GSCs, PIWI proteins and piRNAs regulate gene expression by modulating chromatin states and directly influencing mRNA translation. …”
Get full text

Integrated analysis of ATAC-seq and RNA-seq reveals ADSCP2 regulates oxidative phosphorylation pathway in hypertrophic scar fibroblasts by Qian Li, Zhe Quan, Ling Chen, Yiliang Yin, Xin Chen, Jingyun Li

“…Consequently, this study sought to elucidate the potential mechanism associated with ADSCP2 by examining genome-wide transcriptional alterations and changes in chromatin accessibility in fibroblasts. This was achieved through the integrated analysis of assay for transposase accessible chromatin using sequencing (ATAC-seq) and RNA sequencing (RNA-seq). …”
Get full text

KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition by Deniz Gökbuget, Liana Goehring, Ryan M. Boileau, Kayla Lenshoek, Tony T. Huang, Robert Blelloch

“…Using machine learning, we quantify 21 chromatin features predicting local RT and RT changes during differentiation in embryonic stem cells (ESCs). …”
Get full text

Genomic and Computational Analysis of Novel SNPs in TNP1 Gene Promoter Region of Bos indicus Breeding Bulls by Kashif Hameed Anjum, Asif Nadeem, Maryam Javed, Hafiz Ishfaq Ahmad, Amjad Riaz, Wasim Shehzad, Jahanzaib Azhar, Muhammad Fahad Bhutta

“…Transition nuclear proteins (TNPs), the principal proteins identified in the condensing spermatids chromatin, have been found to play a key role in histone displacement and chromatin condensation during mammalian spermatogenesis. …”
Get full text

Droplet-based high-throughput 3D genome structure mapping of single cells with simultaneous transcriptomics by Honggui Wu, Maoxu Wang, Yinghui Zheng, X. Sunney Xie

“…Abstract Single-cell three-dimensional (3D) genome techniques have advanced our understanding of cell-type-specific chromatin structures in complex tissues, yet current methodologies are limited in cell throughput. …”
Get full text

Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis by Alireza Lorzadeh, George Ye, Sweta Sharma, Unmesh Jadhav

“…Abstract Transcription factors guide tissue development by binding to developmental stage-specific targets and establishing an appropriate enhancer landscape. In turn, DNA and chromatin modifications direct the genomic binding of transcription factors. …”
Get full text

In vivo Study of the Histone Chaperone Activity of Nucleolin by FRAP by Xavier Gaume, Karine Monier, Françoise Argoul, Fabien Mongelard, Philippe Bouvet

“…Thus, in live cells, nucleolin could play a role in chromatin accessibility by its histone chaperone and co-remodeling activities.…”
Get full text

Ubiquitin Proteasome System in Stress and Disease by Dmitry Karpov, Michael H. Glickman, Shoshana Bar-Nun, Philip Coffino

Get full text

Characterization and functional analysis of conserved non-coding sequences among poaceae: insights into gene regulation and phenotypic variation in maize by Yi Luo, Hang Zhai, Xiu Zhong, Bo Yang, Yang Xu, Tianhong Liu, Qi Wang, Yang Zhou, Yan Mao, Yaxi Liu, Qi Tang, Yanli Lu, Yao Wang, Jie Xu

“…To explore the regulatory characteristics of the CNS identified, the flanking regions of CNS were compared with the peaks called using both transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) and chromatin immunoprecipitation with high-throughput sequencing (ChIP-Seq) data of histone modifications. …”
Get full text

JUNB O‐GlcNAcylation‐Mediated Promoter Accessibility of Metabolic Genes Modulates Distinct Epithelial Lineage in Pulmonary Fibrosis by Marie‐Therese Bammert, Meshal Ansari, Leoni Haag, Zuhdi Ahmad, Victoria Schröder, Joseph Birch, Diana Santacruz, Werner Rust, Coralie Viollet, Benjamin Strobel, Alec Dick, Florian Gantner, Holger Schlüter, Fidel Ramirez, Muriel Lizé, Matthew J. Thomas, Huy Q. Le

“…This remodeling is characterized by an increase in chromatin accessibility, particularly at JUNB motif‐enriched promoter regions proximal to transcription start sites of metabolic and pro‐fibrotic genes. …”
Get full text

Igf2/H19 Imprinting Control Region (ICR): An Insulator or a Position-Dependent Silencer? by Subhasis Banerjee, Alan Smallwood, Scott Lamond, Stuart Campbell, Geeta Nargund

“…This repression of maternal Igf2 has recently been postulated to be due to a chromatin boundary or insulator function of the unmethylated ICR. …”
Get full text

<i>Triticum durum</i> Desf. is a valuable source for spring bread wheat genetic diversity enhancement by A. E. Druzhin, S. N. Sibikeev, E. I. Gultyaeva, L. B. Andreeva

“…Enhancement of the Triticum aestivum L. genetic diversity by means of alien chromatin, including that from Triticum durum Desf., is an important element in the breeding of bread wheat cultivars that meet modern requirements.Materials and methods. …”
Get full text

Role of sirtuins in epigenetic regulation and aging control by E. M. Samoilova, S. E. Romanov, D.  A. Chudakova, P. P. Laktionov

“…In addition to a brief description of the main SIRT enzymatic and biological activity, the review discusses its role in the epigenetic regulation of chromatin structure, including the context of the development of genome instability associated with aging. …”
Get full text

Genotoxic consequences of viral infections by Olga Szewczyk-Roszczenko, Piotr Roszczenko, Yegor Vassetzky, Nikolajs Sjakste

Get full text

Comprehensive Analysis of Transcriptome Sequencing Data in the Lung Tissues of COPD Subjects by Woo Jin Kim, Jae Hyun Lim, Jae Seung Lee, Sang-Do Lee, Ju Han Kim, Yeon-Mok Oh

“…Oxidative phosphorylation, protein degradation, and chromatin modification were the most dysregulated pathways in the lung tissues of COPD subjects. …”
Get full text