Case report: Patients with positive HER-2 amplification locally advanced gastroesophageal junction cancer achieved pathologic complete response with the addition of pembrolizumab to chemotherapy plus trastuzumab as neoadjuvant therapy by Huanhuan Li, Chao Ren, Donghai Cui, Tao Wu, Zhiyong Nie

“…The patient received three cycles of pembrolizumab plus trastuzumab and chemotherapy preoperatively and underwent radical surgery on November 22, 2022.ConclusionPatients with HER-2-positive locally advanced GEJ cancers received PD-1 immunotherapy combined with trastuzumab and neoadjuvant chemotherapy and achieved a complete pathological response. …”
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Efficacy and Safety of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting Transforming Growth Factor-β and Programmed Death-Ligand 1, Plus Chemotherapy in Patients With Stage IV NSCLC by Christian Rolfo, MD, PhD, Laurent Greillier, MD, PhD, Remi Veillon, MD, PhD, Firas Badin, MD, MBA, Francois Ghiringhelli, MD, PhD, Nicolas Isambert, MD, PhD, Astrid Paulus, MD, PhD, Surendra Pal Chaudhary, MD, Yulia Vugmeyster, PhD, Masashi Sato, MSc, Sandrine Hiret, MD, PhD

“…This study evaluated the safety and efficacy of bintrafusp alfa with chemotherapy in patients with stage IV NSCLC regardless of the programmed death-ligand 1 (PD-L1) expression status. …”
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Prognostic Value of Skull Base Foramen Invasion Subclassification in T Category Modification and Induction Chemotherapy Management for Nasopharyngeal Carcinoma: Post‐Hoc Analysis of a Dual‐Center Retrospective Cohort Study by Siyu Zhu, Shuqi Li, Di Cao, Chao Luo, Zhiying Liang, Shaobo Liang, Guoyi Zhang, Qin Zhao, Guangying Ruan, Lizhi Liu, Gui Fu, Haojiang Li

“…Additionally, patients in the severe SBFI group gain significant survival benefits from induction chemotherapy ((IC). Therefore, T3 NPC with severe SBFI is an independent negative predictor for OS and is classified into the T4 category. …”
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Research progress on medication literacy of elderly cancer patients during oral chemotherapy (老年肿瘤患者口服化疗药物期间药物素养研究进展) by LIU Yin (柳吟), SHI Ruchun (施如春), HUANG Jun (黄君), ZHAO Hongxia (赵红霞), QIU Minyan (邱敏燕), SHEN Xiaoyan (沈晓燕)

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Effects of perioperative treatment of resectable adenocarcinoma of esophagogastric junction by immunotherapy (Adebrelimab) combined with chemotherapy (XELOX): protocol for a single-center, open-labeled study (AEGIS trial, neoadjuvant immunochemotherapy) by Yingyi Li, Yuqin Cao, Xipeng Wang, Chengqiang Li, Liqin Zhao, Hecheng Li

“…Considering the differences in chemotherapy regimen tolerance between Asian and Western populations, this study intends to evaluate the suitability of Adebrelimab combined with XELOX chemotherapy for the Asian population. …”
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Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort Study by Xu Y, Wu J, Jiang Q, Lv Y, Zhou J, Wang Z, Zhao H, Du D

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Updated Bayesian network meta-analysis on the efficacy and safety of PD−1 versus PD−L1 inhibitors in first−line treatment with chemotherapy for extensive−stage small-cell lung cancer by Ke Wang, Ke Wang, Chuangjie Zheng, Chuangjie Zheng, Xinrong Chen, Xinrong Chen, Penghui Lin, Mengge Lin, Cuizhen Chen, Linzhu Zhai

“…ObjectiveTo compare the efficacy and safety of programmed cell death 1 inhibitors plus chemotherapy (PD-1 + Chemo) and programmed cell death ligand 1 inhibitors plus chemotherapy (PD-L1 + Chemo) for the treatment of extensive-stage small-cell lung cancer (ES-SCLC).MethodsWe performed a meta-analysis of relevant data using R software, considering overall survival (OS), progression-free survival (PFS), and grade ≥ 3 treatment-related adverse events (TRAES).ResultsPD-1 + Chemo (OS: hazard ratio [HR] 0.71; PFS: HR 0.59) and PD-L1 + Chemo (OS: HR 0.72; PFS: HR 0.73) significantly prolonged survival and did not increase the incidence of grade ≥3 TRAEs compared with chemotherapy. …”
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Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the TRIM25-CXCL13 axis by Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge, Zhenyu Ju, Shengkang Luo

“…Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication that affects an increasing number of cancer survivors. …”
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Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling by Kunlin Guo, Lei Gao, Ping Li, Shanwu Feng, Liping Zhao, Xian Wang

Subjects: “…Chemotherapy-induced neuropathic pain…”
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Aortic intimal sarcoma with abdominal metastasis: case report and management approach by Gongji Yao, Gongji Yao, Jianwei Xu, Jianwei Xu

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Saudi urologists’ treatment pattern for high-risk Bacillus Calmette–Guérin naïve and Bacillus Calmette–Guérin unresponsive nonmuscle invasive bladder cancer by Mohammad Alghafees, Mohamad Abou Chakra, Abdullah Alkhayal, Mohamad Moussa, Mohammad Alkhamees, Bader Alsaikhan, Ahmed Alasker, Abdulrahman Alsayyari, Abdullah Alsaghyir, Ali Alkahtani, Michael A. O'Donnell

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Impact of HER2 Expression on the Prognosis of Muscle-Invasive Bladder Cancer Patients Treated with Bladder-Preservation Comprehensive Therapy by Yatong Chen, Fei Luo, Tingji Zhang, Jian Li

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Effect of depression and empowerment on medication adherence in patients with breast cancer: a descriptive survey by Sookyung Jeong, Eun Jeong Kim

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Epithelial–Mesenchymal Transition Suppression by ML210 Enhances Gemcitabine Anti-Tumor Effects on PDAC Cells by Keisuke Takemura, Kyohei Ikeda, Hayato Miyake, Yoshio Sogame, Hiroaki Yasuda, Nobuhiro Okada, Kazumi Iwata, Junichi Sakagami, Kanji Yamaguchi, Yoshito Itoh, Atsushi Umemura

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Effects of Potentially Inappropriate Medications in Older Patients with Gastrointestinal System Cancer by Melike OZKAN, Irfan KARAHAN, Selim YALCIN, Gozde SENGUL AYCICEK

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Neoadjuvant chemoimmunotherapy for locally advanced squamous cell carcinoma of the head and neck: Systematic review and meta-analysis by Xiayi Zhu, Jie Qiu, Ya Zhang, Chunni Lin, Xiaohui Wang, Xiwei Shi, Siya Yang, Qiaoyan Wu, Li Cong

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Modern treatment methods of patients with liver metastases of colorectal cancer by Ye. N. Grebenkin, V. D. Chhikvadze, U. S. Stanoyevich, Ye. I. Dekhissi

Subjects: “…regional endarterial chemotherapy…”
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Breaking the shield of solid tumors: a combined approach for enhanced efficacy of CAR-T cells by Marat Khaliulin, Aygul Valiullina, Alexey Petukhov, Youyong Yuan, Sheila Spada, Emil Bulatov

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Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy by Wu Y, Liu Y, Wu H, Tong M, Du L, Ren S, Che Y

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Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases by Ami B. Shah, Katarzyna A. Rejniak, Jana L. Gevertz

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