A landscape of checkpoint blockade resistance in cancer: underlying mechanisms and current strategies to overcome resistance by Ginette S. Santiago-Sánchez, Kellsye P. Fabian, James W. Hodge

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Cytoplasmic HMGB2 orchestrates CALR translocation in the course of immunogenic cell death by Peng Liu, Liwei Zhao, Oliver Kepp, Guido Kroemer

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Mutation of isocitrate dehydrogenase indicates favorable outcomes in pan-cancer immune checkpoint blockade by Zhiyang Huang, Yingying Li, Hong Zhao, Bin Zhao

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Thioredoxin: a key factor in cold tumor formation and a promising biomarker for immunotherapy resistance in NSCLC by Jiayi Hu, Yilimunuer Abulimiti, Haiyang Wang, Dianyu Yang, Xu Wang, Yang Wang, Ping Ji

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Dendritic cell effector mechanisms and tumor immune microenvironment infiltration define TLR8 modulation and PD-1 blockade by Daniel A. Ruiz-Torres, Daniel A. Ruiz-Torres, Daniel A. Ruiz-Torres, Daniel A. Ruiz-Torres, Jillian F. Wise, Jillian F. Wise, Jillian F. Wise, Jillian F. Wise, Jillian F. Wise, Brian Yinge Zhao, Joao Paulo Oliveira-Costa, Joao Paulo Oliveira-Costa, Joao Paulo Oliveira-Costa, Sara Cavallaro, Sara Cavallaro, Sara Cavallaro, Peter M. Sadow, Peter M. Sadow, Jacy Fang, Jacy Fang, Osman Yilmaz, Amar Patel, Christopher Loosbroock, Moshe Sade-Feldman, Moshe Sade-Feldman, Moshe Sade-Feldman, Daniel L. Faden, Daniel L. Faden, Daniel L. Faden, Shannon L. Stott, Shannon L. Stott, Shannon L. Stott, Shannon L. Stott

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Potentiation of immune checkpoint blockade with an ITPP radiosensitizer studied with oxygen saturation measurements from photoacoustic imaging by Renee L. Tran, Xiaofei Liang, Jorge de la Cerda, F. William Schuler, Mark D. Pagel

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Cryoablation combined with dual immune checkpoint blockade enhances antitumor efficacy in hepatocellular carcinoma model mice by Jun Gu, Zepeng Yu, Xiangxiang Tang, Wenying Chen, Xuedong Deng, Xiaoli Zhu

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Injectable celastrol-loading emulsion hydrogel for immunotherapy of low-immunogenic cancer by Yu Liu, Jia Zhang, Chunyu Lai, Wenjun Wang, Yangyue Huang, Xuanwen Bao, Haimeng Yan, Xuqi Sun, Qiqi Liu, Dong Chen, Xiaomeng Dai, Xinyu Qian, Peng Zhao

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M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance by Naisheng Zheng, Tingting Wang, Qin Luo, Yi Liu, Junyao Yang, Yunlan Zhou, Guohua Xie, Yanhui Ma, Xiangliang Yuan, Lisong Shen

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Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression by Paul G. Pavicic, Patricia A. Rayman, Shadi Swaidani, Amit Rupani, Vladimir Makarov, Charles S. Tannenbaum, Robert P. Edwards, Anda M. Vlad, C. Marcela Diaz-Montero, Haider Mahdi

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An immune activator encapsulating PD-L1 siRNA for augmented immune checkpoint blockade immunotherapy through Zn2+ overload triggered pyroptosis by Liming Gong, Yanhong Liu, Jing Feng, Congcong Xiao, Chenfei Liu, Bohan Chen, Liqing Chen, Mingji Jin, Youyan Guan, Zhonggao Gao, Wei Huang

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Concurrent treatment with transarterial immunoembolization of hepatic metastases and systemic immune checkpoint inhibitors to overcome immune evasion in patients with metastatic uv... by Natalie J. Miller, Sharon W. Kwan, Jacob B. Leary, Daniel S. Hippe, William McCamy, Joshua R. Veatch, Evan T. Hall, Wayne L. Monsky, Shailender Bhatia

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Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer by Marion Thibaudin, Francois Ghiringhelli

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Editorial: Tumor-associated tertiary lymphoid structures response during immunotherapy by Ileana Soto Mauldin, Christine Mall Minnar, Antoine Italiano, Antoine Italiano

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Circulating cytokine associations with clinical outcomes in melanoma patients treated with combination nivolumab plus ipilimumab by Jiajia Chen, Giuseppe Tarantino, Mariano Severgnini, Joanna Baginska, Anita Giobbie-Hurder, Jason L. Weirather, Michael Manos, Janice D. Russell, Kathleen L. Pfaff, Scott J. Rodig, Amy Y. Huang, Ryan Brennick, Matthew Nazzaro, Emma Hathaway, Marta Holovatska, Claire Manuszak, Srinika Ranasinghe, David Liu, F. Stephen Hodi

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A novel nanomedicine integrating ferroptosis and photothermal therapy, well-suitable for PD-L1-mediated immune checkpoint blockade by Yujun Bao, Guanghao Li, Siqi Li, Haishui Zhou, Ziqing Yang, Zhiqiang Wang, Rui Yan, Changhong Guo, Yingxue Jin

Subjects: “…Immune checkpoint blockade…”
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PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors by Anna D. Staniszewska, Joshua Armenia, Matthew King, Chrysiis Michaloglou, Avinash Reddy, Maneesh Singh, Maryann San Martin, Laura Prickett, Zena Wilson, Theresa Proia, Deanna Russell, Morgan Thomas, Oona Delpuech, Mark J. O’Connor, Elisabetta Leo, Helen Angell, Viia Valge-Archer

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Immunosuppressive mechanisms and therapeutic targeting of regulatory T cells in ovarian cancer by Jing Li, Haojun Huang, Renxian Xie, Rongying Yang, Haitao Wang, Li Wan

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iMLGAM: Integrated Machine Learning and Genetic Algorithm‐driven Multiomics analysis for pan‐cancer immunotherapy response prediction by Bicheng Ye, Jun Fan, Lei Xue, Yu Zhuang, Peng Luo, Aimin Jiang, Jiaheng Xie, Qifan Li, Xiaoqing Liang, Jiaxiong Tan, Songyun Zhao, Wenhang Zhou, Chuanli Ren, Haoran Lin, Pengpeng Zhang

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Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

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