EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury by Shuangfei Ni, Bo Yang, Lei Xia, Huafeng Zhang

“…Acute spinal cord injury (ASCI) is a severe traumatic disease of the central nervous system, the underlying mechanism of which is unclear. …”
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Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection by Timo Hautala, Terhi Partanen, Tarja Sironen, Saara-Mari Rajaniemi, Nina Hautala, Olli Vainio, Olli Vapalahti, Heikki Kauma, Antti Vaheri

“…These results reinforce the view that PUUV-HFRS is a general infection that affects the central nervous system and the blood-brain barrier.…”
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Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD

“…The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain’s resident macrophages, microglia. …”
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Diagnosis and treatment of descending optic neuritis developed as a manifestation of local viral encephalitis (a clinical case) by N.V. Korsakova, E.I. Korsakova

“…At the same time, in 45–75% of cases, optic neuritis affects the central nervous system causing its disorders of various severity. …”
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Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke by Weilin Xu, Weilin Xu, Jun Yan, Zachary D. Travis, Cameron Lenahan, Liansheng Gao, Liansheng Gao, Haijian Wu, Haijian Wu, Jingwei Zheng, Jingwei Zheng, Jianmin Zhang, Jianmin Zhang, Anwen Shao, Anwen Shao, Jun Yu, Jun Yu

“…The apelin/APJ system is widely expressed in the central nervous system (CNS). However, the distribution of the apelin/APJ system varies across different regions and subcellular organelles of the brain. …”
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Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control by Danyan Chen, Jiaying Lu, Hucheng Zhou, Jiehui Jiang, Ping Wu, Qihao Guo, Jingjie Ge, Huiwei Zhang, Kuangyu Shi, Chuantao Zuo

“…Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. …”
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A novel pulse-current waveform circuit for low-energy consumption and low-noise transcranial magnetic stimulation by Xinhua Tan, Ao Guo, Jiasheng Tian, Yingwei Li, Yingwei Li, Jian Shi

“…It utilizes a pulsed magnetic field to induce electric pulses that act on the central nervous system, altering the membrane potential of nerve cells in the cerebral cortex to treat certain mental diseases. …”
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RETRACTED ARTICLE: Construction and validation of a machine learning-based immune-related prognostic model for glioma by Qi Mao, Zhi Qiao, Qiang Wang, Wei Zhao, Haitao Ju

“…Abstract Background Glioma stands as the most prevalent primary brain tumor found within the central nervous system, characterized by high invasiveness and treatment resistance. …”
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Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation by Makenna Gargus, Benneth Ben-Azu, Benneth Ben-Azu, Antonia Landwehr, Jaclyn Dunn, Joseph P. Errico, Marie-Ève Tremblay, Marie-Ève Tremblay

“…In this review we examine the VN’s important role in modulating the immune system through the inflammatory reflex, which involves the cholinergic anti-inflammatory pathway, which releases acetylcholine. Within the central nervous system (CNS), the direct release of acetylcholine can also be triggered by VNS. …”
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Safety and Feasibility of Repeated Intrathecal Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells in Patients with Neurological Diseases by Kuang Pan, Lingna Deng, Peiying Chen, Qingxia Peng, Jingrui Pan, Yanfeng Wu, Yidong Wang

“…Intrathecal injection has unique feature which allows stem cells to directly migrate to the lesion site in patients with central nervous system (CNS) diseases. In this study, we evaluate the safety and feasibility of intrathecal allogeneic bone marrow-derived MSCs (BM-MSCs) in patients with neurological diseases. …”
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Is the Frequency in Somatosensory Electrical Stimulation the Key Parameter in Modulating the Corticospinal Excitability of Healthy Volunteers and Stroke Patients with Spasticity? by Marco Antonio Cavalcanti Garcia, João Marcos Yamasaki Catunda, Marcio Nogueira de Souza, Ana Paula Fontana, Sandro Sperandei, Claudia D. Vargas

“…None of the investigated frequencies of SES was able to operate as a key in switching modulatory effects in the central nervous system of healthy volunteers and stroke patients with spasticity.…”
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Impact of MMP2 rs243865 and MMP3 rs3025058 Polymorphisms on Clinical Findings in Alzheimer’s Disease Patients by Vladimira Durmanova, Juraj Javor, Zuzana Parnicka, Gabriel Minarik, Agata Ocenasova, Barbora Vaseckova, Veronika Reznakova, Maria Kralova, Tomas Hromadka, Ivana Shawkatova

“…Alzheimer’s disease (AD) is a chronic neurodegenerative disease of the central nervous system with higher prevalence in elderly people. …”
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Epidemiology of Lumbar Puncture and the Validity of Meningeal Signs in Predicting Meningitis in Children: A Cross-sectional Study by Mehjabin, Shiji Joseph, Arun Ravi, Kalyani Pillai

“…Introduction: Predictive models have been developed to estimate the likelihood of bacterial meningitis in patients with clinical features suggestive of Central Nervous System (CNS) involvement. Early diagnosis and prompt treatment of bacterial meningitis in children are crucial due to the severity and rapid progression of the disease. …”
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Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy by Rebecca F. Slykerman, Naomi Davies, Klara Vlckova, Kenneth J. O'Riordan, Shalome A. Bassett, James Dekker, Harriët Schellekens, Niall P. Hyland, Gerard Clarke, Elaine Patterson

“…This missing information on both sides of the therapeutic equation when treating central nervous system (CNS) conditions makes psychobiotic research challenging, especially when compared to other pharmaceutical or functional food approaches. …”
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Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5 by You Ning, Jianhua Huang, Bill Kalionis, Qin Bian, Jingcheng Dong, Junzhen Wu, Xiantao Tai, Shijin Xia, Ziyin Shen

“…NSCs open a new way of treatment of the injured central nervous system and neurodegenerative disorders. Thus far, few drugs have been developed for controlling NSC functions. …”
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Case report: Pseudoprogression mimicking neoplastic recurrence three months after completion of proton beam therapy for an IDH-mutant astrocytoma CNS WHO grade 3 by Liv Cathrine Heggebø, Liv Cathrine Heggebø, Ida Maria Henriksen Borgen, Ida Maria Henriksen Borgen, Hanne Blakstad, Hanne Blakstad, Cathrine Saxhaug, Pål André Rønning, Pitt Frederik Niehusmann, Katja Werlenius, Malin Blomstrand, Malin Blomstrand, Petter Brandal, Petter Brandal

“…BackgroundRadiation-induced changes following proton beam therapy in isocitrate dehydrogenase (IDH)-mutated diffuse central nervous system (CNS) World Health Organization (WHO) grade 2 and 3 gliomas are not well characterized. …”
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Severe fever with thrombocytopenia syndrome complicated with aspergillus endocarditis and multiple organ infarctions after glucocorticoid treatment in an immunocompetent man: a cas... by Yuxi Zhao, Xiaoxin Wu, Xinyu Wang, Lanjuan Li

“…Previous studies have reported cases of SFTS complicated with invasive pulmonary aspergillosis (IPA) and central nervous system aspergillosis. Here, we present the first case of an immunocompetent patient with SFTS who progressed to IPA and Aspergillus endocarditis after glucocorticoid treatment, and embolism of the vegetations from the left ventricle led to multiple infarctions in the brain, kidney, and spleen. …”
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iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…Its MIC against Cryptococcus was over eight times lower than conventional AmB, significantly reducing fungal burden in the mouse brain and lowering serum inflammatory factors.ConclusionThe iPSC-Exo/AmB complex is a promising therapeutic strategy that enhances AmB efficacy while reducing toxicity, offering new hope for treating CM and other refractory fungal infections of the central nervous system.…”
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Development and experimental validation of dephosphorylation-related biomarkers to assess prognosis and immunotherapeutic response in gliomas by Hui Tang, Xuping Yang, Xuping Yang, Guoqian Li, Ke Peng, Yang Sun, Longyang Jiang, Longyang Jiang, Yilan Huang, Yilan Huang

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Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review by Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel

“…However, those have yet to be explored aiding diagnosis for tumours of the central nervous system (CNS) other than high-grade gliomas (HGG). …”
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