Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects by Selim Öğüt, Melikenur Türkol, Seydi Yıkmış, Esra Bozgeyik, Gholamreza Abdi, Emine Kocyigit, Rana Muhammad Aadil, Nilay Seyidoglu, Deniz Karakçı, Nazlı Tokatlı

“…In experiments on A549 (lung), MCF-7 (breast) and HT-29 (colon) cancer cell lines, ultrasound-treated vinegar increased apoptotic effects, suppressed cell migration and reduced necrosis rates in some cell lines. …”
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A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis by Mingyang Li, Tao Deng, Quan Chen, Shenghu Jiang, Hang Li, Jiayi Li, Shenglan You, Hui-qi Xie, Bin Shen

“…These applications include early and precise diagnosis of MMP activity via fluorescence probe technologies; acting as nanodrug carriers to enable on-demand drug release triggered by pathological microenvironments; and facilitating cartilage engineering through MMP-mediated degradation, which promotes cell migration, matrix synthesis, and tissue integration. …”
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A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan by Takamichi Ito, Yuka Tanaka, Dai Ogata, Haruto Nishida, Tatsushi Shiomi, Ryo Tanaka, Aya Kawaguchi, Azusa Miyashita, Satoshi Fukushima, Naoko Shojiguchi, Hiroyuki Goto, Yaei Togawa, Takahiro Kiyohara, Yoshinao Oda, Takeshi Nakahara

“…Knockdown of TROP2 reduced cell viability and cell migration, and caused slight upregulation of the apoptosis-related factors, together with downregulation of the epithelial-to-mesenchymal transition-related factors. …”
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APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs by Yong Wang, Xinping Liu, Zheng Liu, Shasha Hua, Kai Jiang

“…In addition, APC counteracts the major MT-stabilizer CLASPs at MT plus ends and promotes directional cell migration via modulating cell adhesion force. Reconstitution experiments demonstrate that APC potentiates KIF2A-induced MT catastrophes and antagonizes the stabilizing effect of CLASP2 in vitro. …”
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Effect of Pien Tze Huang on Lymphangiogenesis Mediated by LncRNA-ANRIL in Colorectal Cancer by Yao LU, Min ZHANG, Jie LIU, Qianqian MAO, Zhiyun CAO, Jiumao LIN

“…CCK-8 assay was used to detect cell proliferation, cell migration and invasion were evaluated by Transwell assay. …”
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Essential Oils from Citrus Peels Promote Calcium Overload-Induced Calcicoptosis in U251 Cells by Yurong Li, Juanjuan Wei, Zimao Ye, Chen Ji, Wenji Li, Li Xu, Zhiqin Zhou

“…Through wound healing assays and cell cycle and apoptosis analyses via flow cytometry, it was revealed that these CPEOs inhibited cell migration, arrested the cell cycle at G1/G0, and induced apoptosis with similar levels of inhibition. …”
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Utilizing bioinformatics and machine learning to identify CXCR4 gene-related therapeutic targets in diabetic foot ulcers by Hengyan Zhang, Ye Zhou, Heguo Yan, Changxing Huang, Licong Yang, Yangwen Liu

“…The CXCR4 gene is known to play a key role in cell migration, immunology response, and tissue repair, and thus may be an important target for DFU treatment.MethodsWe used the GEO database (Gene Expression Omnibus database) to obtain DFU-related gene expression data, identified differentially expressed genes (DEGs), and performed enrichment analysis to reveal the related biological pathways. …”
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An In Vitro Model of Diabetic Retinal Vascular Endothelial Dysfunction and Neuroretinal Degeneration by Qiyun Wang, Xinyuan Zhang, Kaiyue Wang, Ling Zhu, Bingjie Qiu, Xiaosi Chen, Xiao Lin, Yao Nie

“…Cell proliferation and viability were evaluated by the Cell Counting Kit-8. Cell migration was measured using a transwell migration assay. …”
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Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development by Yue-Wei Chen, Qiu-Rong Du, Yu-Juan He, Wen-Shu Chen, Wen-Yang Jiang, Qi Gui, Cheng-Cheng Xu, Wei Wang, Hong-Yun Cheng

“…Moreover, A549 and SPCA1 cell migration and invasion abilities were greatly repressed by circ_0044516 siRNA. …”
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FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region by Mian Liu, Pei Chen, Bo Wei, Hai-Long Tan, Ya-Xin Zhao, Lei Ai, Ning Li, Ying-Ke Jiang, Jing Lin, Shi-Jin Li, Shi Chang

“…Moreover, the alternative splicing EDB region of FN1 was modulated by p53-targeted protein ZMAT3 which activated cell migration and lymphoangiogenesis. Collectively, combined with p53-induced proteins, FN1 played both anti- and pro-cancer roles owing to EDB domain alternative splicing. …”
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Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism by Xin Liu, Junling Wang, Huiyun Zhang, Mengmeng Zhan, Hanqiu Chen, Zeman Fang, Chiyan Xu, Huifang Chen, Shaoheng He

“…Using mouse peritoneal model, cell migration assay, and flow cytometry analysis, we investigated role of tryptase in recruiting mast cells. …”
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Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4 by Zhe Huang, Ming Wang, Yitian Chen, Hua Tang, Kuo Tang, Mingkuan Zhao, Wei Yang, Zhengjun Zhou, Junjie Tian, Wei Xiang, Shenjie Li, Qinglian Luo, Luotong Liu, Yanru Zhao, Tao Li, Jie Zhou, Ligang Chen

“…Our experimental results suggest that migrasomes promote GBM cells migration by releasing such proteins into the extracellular space. …”
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Acoustic Transmitted Decellularized Fish Bladder for Tympanic Membrane Regeneration by Hong Chen, Hui Zhang, Guangjie Zhu, Long Cao, Chenjie Yu, Maoli Duan, Xiaoyun Qian, Xia Gao, Yuanjin Zhao

“…In addition, by loading mesenchymal stem cells on the DFB scaffolds, the resultant DFB@MSCs system exhibits remarkable anti-fibrotic and anti-inflammatory effects, together with the ability to promote cell migration and angiogenesis. In vivo experiments confirm that the prepared DFB@MSCs scaffolds can not only alleviate inflammatory response caused by TMP but also promote new vessel formation, TM repair, and hearing improvement. …”
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ZEB1 as a marker of metastasis in thyroid carcinomas: review of literature and own data by P.P. Zinych, V.M. Pushkarev, N.I. Levchuk, M. Tronko

“…ZEB1 is at the forefront of transcription factors involved in the EMT control and promotes tumor cell migration and diffusion, cell stemness, resistance to treatment, metastasizing and evasion of the immune response. …”
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Navigating the Collective: Nanoparticle-Assisted Identification of Leader Cancer Cells During Migration by Anastasia Alexandrova, Elizaveta Kontareva, Margarita Pustovalova, Sergey Leonov, Yulia Merkher

“…In most solid tumors, metastasis occurs through collective cell migration (CCM), guided by “cellular leaders”. These leader cells generate forces through actomyosin-mediated protrusion and contractility. …”
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Topical transdermal administration of lenalidomide nanosuspensions-based hydrogels against melanoma: In vitro and in vivo studies by Mengdi Zhang, Haiying Qiu, Zheyi Han, Yazhong Ma, Jingjing Hou, Jingwei Yuan, Haiyan Jia, Menglu Zhou, Hongjie Lu, Yan Wu

“…Lenalidomide could induce melanoma cells apoptosis, disrupt cell cycle progression, impede cell migration and invasion, and modify tumor microenvironment (TME). …”
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Identification and validation of CDK1 as a promising therapeutic target for Eriocitrin in colorectal cancer: a combined bioinformatics and experimental approach by Jiemiao Shen, Xing Gong, Haili Ren, Xia Tang, Hairong Yu, Yilu Tang, Shen Chen, Minghui Ji

“…CCK-8, colony formation, cell migration, cell invasion, and wound healing assays were employed to explore tumor-promoting role of CDK1. …”
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Expression and Function of Synthetic Dimeric Exercise-Induced Cytokine Irisin-Irisin by LIU Fengying, HUANG Yide, LIN Jia, CHEN Xuequn, WANG Qingshui, LIN Yao

“…The functions were verified in gastric cancer, colorectal cancer and other gastrointestinal tumors, and the activity and function of recombinant Irisin-Irisin and monomeric Irisin on tumor cells were compared.Results(1) Expression and purification of recombinant Irisin-Irisin: compared with the non-induced samples, the recombinant Irisin-Irisin was significantly expressed after IPTG induction; high purity recombinant Irisin-Irisin with a molecular weight of about 27 kDa was obtained by Ni Sepharose excel. (2) Detection of recombinant Irisin-Irisin activity: compared with the blank control group, both the recombinant Irisin-Irisin group and the Irisin group could up-regulate the expression of UCP-1 in C2C12 cells (<italic>P</italic>&lt;0.05); compared with the Irisin group, the recombinant Irisin-Irisin group had a more significant effect and stronger activity in inducing UCP-1 (<italic>P</italic>&lt;0.05). (3) Recombinant Irisin-Irisin on tumor function: compared with the blank control group, both the 100 ng/mL and 200 ng/mL Irisin-Irisin groups could inhibit the migration of gastric cancer cells and colorectal cancer cells(<italic>P</italic>&lt;0.05), but had no effect on their proliferation and clone formation; compared with the Irisin group, the recombinant Irisin-Irisin group had a more significant effect on cell migration inhibition (<italic>P</italic>&lt;0.05).ConclusionThe recombinant Irisin-Irisin expressed by <italic>Escherichia coli</italic> has activity, and the activity is higher than that of the monomeric Irisin; recombinant Irisin-Irisin has an effect on the migration of gastric cancer cells and colorectal cancer cells, and the effect was better than that of the monomeric Irisin.…”
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First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide by Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae-Jung Kang, Chun-Woong Park, Jongsung Lee, Won-Sang Seo

“…In wound-healing assays, L-PDRN demonstrated superior efficacy in promoting cell migration and wound closure, even under inflammatory conditions induced by tumor necrosis factor (TNF-α). …”
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TFE3 Regulates the Function of the Autophagy-Lysosome Pathway to Drive the Invasion and Metastasis of Papillary Thyroid Carcinoma by Hongsheng Lu, Chumeng Zhu, Yanyun Ruan, Lilong Fan, Kena Wei, Zhaohui Yang, Qi Chen

“…After inducing TFE3 overexpression by plasmid or TFE3 downregulation by small interfering RNA (siRNA) transfection, MTT, wound healing, and cell migration and invasion assays were used to verify the effects on invasion, migration, and the levels of autophagy-lysosome system-related proteins such as P62/SQSTM1, LC3, CTSL, and CTSB. …”
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