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PRDM16 Enhances Osteoblastogenic RUNX2 via Canonical WNT10b/β-CATENIN Pathway in Testosterone-Treated Hypogonadal Men
Published 2025-01-01“…Our results suggest that T therapy activates PRDM16, leading to enhanced signaling in the canonical WNT10b—β-CATENIN-RUNX2 pathway, the pathway involved in osteoblastogenesis. …”
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THE COMPARATIVE ANALYSIS OF GUY DE MAUPASSANT’S TWO FRIENDS AND ARTURO ARIAS’ TOWARD PATZUN
Published 2019-03-01Subjects: Get full text
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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability
Published 2024-12-01“…Here, we describe the discovery and humanization of a human-mouse cross-reactive anti-programmed cell death (PD-1) monoclonal rabbit antibody, termed h1340.CC, which possesses this non-canonical disulfide bond. Initial removal of the non-canonical disulfide resulted in a loss of PD-1 affinity and cross-reactivity, which led us to explore protein engineering approaches to recover these. …”
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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway
Published 2025-02-01“…Mechanistically, the administration of Clo induced the interaction of P53 with STING, which activated the non-canonical STING-NFκB pathway; consequently, NF-κB directly bound to the promoter regions of its target genes, including CCL5, CXCL10, HLAs and BAX. …”
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A cultura do outro em Histórias de leves enganos e parecenças, de Conceição Evaristo
Published 2018-01-01Subjects: Get full text
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O avesso do direito à literatura: por uma definição de literatura indígena
Published 2018-01-01Subjects: Get full text
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Stability, performance and participatory evaluation of potato varieties under rain-fed and irrigation conditions at Southeast, Ethiopia
Published 2024-12-01Subjects: Get full text
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Género y participación de las mujeres en la gestión del agua en las subcuencas Río Sabinal y Cañón del Sumidero, Berriozábal, Chiapas
Published 2013-01-01“…Este estudio presenta un enfoque de género sobre participación feme - nina en comités comunitarios de gestión del agua en las subcuencas Río Sabinal y Cañón del Sumidero en Berriozábal, Chiapas. Se encon - tró que la división entre lo público-masculino y lo privado-femenino, limita la participación femenina, siendo ésta posible sólo cuando las actividades en los comités de agua son consideradas de bajo prestigio entre los hombres. …”
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L’Église au miroir. Visiter le musée ecclésial avec Pierre Legendre
Published 2013-08-01Subjects: Get full text
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Development of Stylistics and Rhetoric in Lithuania
Published 2024-03-01Subjects: Get full text
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Fausse extase et vrai fou : l'artifice revendiqué dans quelques poèmes de John Donne
Published 2009-12-01Subjects: Get full text
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Marie Spartali Stillman: le donne diventano protagoniste dell’iconografia dantesca
Published 2025-01-01Subjects: Get full text
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Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis
Published 2016-01-01“…The regulative role of RSV over canonical Wnt signal pathway and serum response factor- (SRF-) miR-1 axis and the functions of these two axes were further studied. …”
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