<i>Ex Vivo</i> Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study by Arijita Sarkar, Matthew C. Gallo, Jennifer A. Bell, Cory K. Mayfield, Jacob R. Ball, Mina Ayad, Elizabeth Lechtholz-Zey, Stephanie W. Chang, Osamu Sugiyama, Denis Evseenko, Jay R. Lieberman

“…Additionally, gene therapy was associated with an anti-inflammatory microenvironment; macrophages expressing canonical anti-inflammatory markers were more common in the gene therapy group. …”
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Linear Active Disturbance Rejection Control-Based Voltage Controller for Buck and Boost DC/DC Converters in DC Distribution Grids by Asimenia Korompili, Oemer Ekin, Marija Stevic, Veit Hagenmeyer, Antonello Monti

“…The formulation of the proposed L-ADRC model in the non-canonical form facilitates the employment of model-based estimation and feedback control methods, whose performance is determined through the design of several parameters. …”
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‘What a perennial delight is in hearing the French language spoken!’: Class, Language and Taste in the Maison de Molière’s French Performances in London (1871–1893) by Ignacio Ramos Gay

“…Through an examination of the reviews and impressions published by an array of professionals, including leading theatre critics at the time, dramatists, actors and aficionados, the research analyses the sociological, political, and aesthetic implications associated with the firm presence of the French language and French canonical plays in late Victorian London. The responses of theatre professionals inevitably raise the matter of high art by implicitly questioning which of the two theatrical traditions best reflect and recreate, through their language, such cultural standards: How is a language stylized to answer simultaneously to dramatic conventions and to expectations related to national sentiment? …”
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New York as Shadow-Line in Philip Roth's Exit Ghost by Ellen Levy

“…Pour Nathan, désormais étranger, la réalité de la ville est une invitation à mesurer son aliénation dans le monde contemporain; mais aussi un encouragement à considérer les mots comme une alternative ou comme un reflet du monde dont il s'est retiré.Par une série de rencontres fortuites, Exit Ghost évoque aussi l'entrée de Nathan dans le canon de Roth une trentaine d'années auparavant (The Ghost Writer, 1979). …”
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Unveiling the signal valve specifically tuning the TGF-β1 suppression of osteogenesis: mediation through a SMAD1-SMAD2 complex by Ying-Wen Wang, Ching-Wei Luo

“…Results Distinct from the TGF-β1 inhibition on adipogenesis through canonical SMAD2/3 signaling, we clarified that TGF-β1 suppresses osteogenesis by inducing the formation of previously unidentified mixed SMADs mainly composed of SMAD1 and SMAD2, in which SMAD2 recruits more TGF-β1-induced co-repressors including HDAC1, TGIF1 and ATF3, whereas SMAD1 allows directing the whole transcriptional suppression complex to the cis-elements of osteogenic genes. …”
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Clinical Validation of the Defining Characteristics of the Nursing Diagnosis ‘Activity Intolerance’ in Patients With Acute Coronary Syndrome by Diana Isabel Cáceres Rivera, Luz Mileyde Jaimes Rojas, Luisa Yaneth Cristancho Zambrano, Jennifer Vanesa Acosta Barón, Diana Ivonne Cañon Gómez, Lyda Z. Rojas

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Variations in the composition and frequency of celiac disease epitopes among synthetic wheat lines by Rahman Ebrahimzadegan, Ghader Mirzaghaderi

“…By searching the previously identified 121 epitopes and those with one mismatch in our amplicons, we found 54 different α-gliadins epitopes across our genotypes, four of which were new variants. The canonical epitopes were present in all lines, although their expression patterns varied. …”
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Lecture poétique des langues locales : cas de Nyanndra Mun (Proverbes) du Roi Salomon by Koffi Samuel N’ZI & Kouamé Gilles YAO

“…Au plan littéraire et linguistique, le corpus se révèle être un ancrage des assises des canons de la littérature et mise en fonctionnement des attentes stylistique, lexicale et sémantico-structurale, qui au demeurant satisfait les attentes des approches méthodologiques convoquées. …”
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms by Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity

“…In fact, FNDC5 forms a co-precipitable complex with Chk1 alluding to possible intracellular actions for this canonically membrane-associated protein. Whereas FNDC5 overexpression in murine heart was cardioprotective, introduction of FNDC5-targeted shRNA into the myocardium was sufficient to trigger Bax up-regulation, ATR/Chk1 activation, oxidative stress, cardiac fibrosis, loss of ventricular function, and compromised animal survival. …”
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Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years by Christos Grigoroglou, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Salwa S Zghebi, Rosa Parisi, Brian McMillan

“…Objective To assess the diagnostic Read code usage for 18 conditions by examining their frequency and diversity in UK primary care between 2000 and 2013.Design Population-based cohort studySetting 684 UK general practices contributing data to the Clinical Practice Research Datalink (CPRD) GOLD.Participants Patients with clinical codes for at least one of asthma, chronic obstructive pulmonary disease, diabetes, hypertension (HT), coronary heart disease, atrial fibrillation (AF), heart failure, stroke, hypothyroidism, chronic kidney disease, learning disability (LD), depression, dementia, epilepsy, severe mental illness (SMI), osteoarthritis, osteoporosis and cancer.Primary and secondary outcome measures For the frequency ranking of clinical codes, canonical correlation analysis was applied to correlations of clinical code usage of 1, 3 and 5 years. …”
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Detection of Bartonella spp. in foxes' populations in Piedmont and Aosta Valley (NW Italy) coupling geospatially-based techniques by Annalisa Viani, Tommaso Orusa, Sara Divari, Stella Lovisolo, Stefania Zanet, Riccardo Orusa, Enrico Borgogno-Mondino, Enrico Bollo

“…The study found that Bartonella spp. infections in foxes were positively associated with higher TCW values (&gt;0.7). Canonical Correspondence Analysis further demonstrated a strong link between pathogen prevalence and municipal-level TCW, suggesting that TCW could be used as a parameter to facilitate disease management and control. …”
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Safety and Efficacy of Incorporating Actellic^® 300 CS into Soil Wall Plaster for Control of Malaria Vectors in Rural Northeastern Uganda by Tonny Jimmy Owalla, Emmanuel Okurut, Kenneth Ssaka, Gonsaga Apungia, Barbara Cemeri, Andrew Akileng, Basil Ojakol, Mark J. I. Paine, Hanafy M. Ismail, Thomas G. Egwang

“…In conclusion, HD4MC was safe and had comparable efficacy to canonical IRS.…”
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Integrin α8 is a useful cell surface marker of alveolar lipofibroblasts by Atsuki Fukada, Yasunori Enomoto, Ryo Horiguchi, Yoichiro Aoshima, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Takafumi Suda, Toshihide Iwashita

“…The transcriptome profile of ITGA8+ fibroblasts in adult mouse lungs, evaluated through two independent single-cell RNA-seq datasets, consistently showed higher expression of Tcf21 and Plin2, which are canonical markers of lipofibroblasts. ITGA8+ fibroblasts were primarily located in the alveolar area, particularly in the neighborhood of AT2. …”
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Dataset of microscale atmospheric flow and pollutant concentration large-eddy simulations for varying mesoscale meteorological forcing in an idealized urban environmentZenodo by Eliott Lumet, Thomas Jaravel, Mélanie C. Rochoux

“…These simulations reproduce the canonical MUST dispersion field campaign while perturbing the model's mesoscale meteorological forcing parameters. …”
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Midgut immune profiling and functional characterization of Aedes aegypti ABC transporter gene(s) using systemic and local bacterial challenges by Vikas Kumar, Shilpi Garg, Diksha Sisodia, Lalita Gupta, Sanjeev Kumar, Vishal Saxena

“…Studies on mosquito midgut transcriptome following pathogen exposure have revealed the presence of non-canonical immune genes, such as ABC transporters, whose function in insect immunity remains unexplored. …”
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Making Maoshan Great Again: Religious Rhetoric and Popular Mobilisation from Late Qing to Republican China (1864–1937) by Qijun Zheng

“…Through a detailed analysis of primary sources, including editions of the <i>Maoshan Gazetteer</i>, liturgical manuals such as the scripture (<i>jing</i> 經), litany (<i>chan</i> 懺), and performative texts such as the precious scroll (<i>baojuan</i> 寶卷) of the Three Mao Lords, this study identifies six key rhetoric strategies employed by Maoshan Daoists, using the acronym IMPACT: (1) Incorporation: Appending miracle tales (<i>lingyan ji</i> 靈驗記) and divine medicine (<i>xianfang</i> 仙方) to address immediate and practical needs of contemporary society; (2) Memory: Preserving doctrinal continuity while invoking cultural nostalgia to reinforce connections to traditional values and heritage; (3) Performance: Collaborating with professional storytellers to disseminate vernacularized texts through oral performances, thereby reaching broader audiences including the illiterate. (4) Abridgment: Condensing lengthy texts into concise and accessible formats; (5) Canonization: Elevating the divine status of deities through spirit-writing, thereby enhancing their religious authority; (6) Translation: Rendering classical texts into vernacular language for broader accessibility. …”
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CRISPR/Cas9-editing of PRNP in Alpine goats by Aurélie Allais-Bonnet, Christophe Richard, Marjolaine André, Valérie Gelin, Marie-Christine Deloche, Aurore Lamadon, Gwendoline Morin, Béatrice Mandon-Pépin, Eugénie Canon, Dominique Thépot, Johann Laubier, Katayoun Moazami-Goudarzi, Ludivine Laffont, Olivier Dubois, Thierry Fassier, Patrice Congar, Olivier Lasserre, Tiphaine Aguirre-Lavin, Jean-Luc Vilotte, Eric Pailhoux

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Modeling Coupled Nonlinear Multilayered Dynamics: Cyber Attack and Disruption of an Electric Grid by Marc Mangel, Jimmie McEver

“…Second, we illustrate one of the Electric Power Research Institute scenarios for the reverse engineering of Advanced Metering Infrastructure (AMI) by coupling the synchronous motor equations for the generator and utility to the model of compromise. We derive a canonical condition for grid failure that relates the level of compromise at the time of detection of compromise and the dissipation parameter in the synchronous motor model. …”
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Effects of Sewage Sludge Compost on Carbon, Nitrogen, Phosphorus, and Sulfur Ratios and Soil Enzyme Activities in a Long-Term Experiment by Csilla Almási, Viktória Orosz, Timea Tóth, Mostafa M. Mansour, Ibolya Demeter, István Henzsel, Zsolt Bogdányi, Tamás András Szegi, Marianna Makádi

“…The main factors of treatment effects were plant-available phosphorus (ammonium lactate (AL)-soluble P₂O₅), total P, and NO₃-NO₂-N, based on principal component analysis. The canonical correspondent analyses revealed that phosphatase activities were affected by C:N, C:P, and N:P ratios and β-glucosidase was correlated with P forms and the E4/E6 ratio, while the soil pH strongly affected all soil enzymes. …”
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The Role of β-Catenin in Th1 Immune Response against Tuberculosis and Profiles of Expression in Patients with Pulmonary Tuberculosis by Kunlong Xiong, Jinxia Niu, Ruijuan Zheng, Zhonghua Liu, Yanzheng Song, Lin Wang, Changtai Zhu, Lin Fan

“…β-Catenin is a key molecule of canonical Wnt/β-catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. …”
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