Association of a non-synonymous substitution in the condensin NCAPG gene with traits of eggs in laying hens by O. Yu. Barkova, M. G. Smaragdov

“…The results obtained are discussed in connection with the role of the canonical condensin complex in the compaction of chromatin and segregation of chromosomes.…”
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Research note: Increased lipid accumulation within broiler preadipocytes during differentiation in vitro at atmospheric oxygen tension by Jéssica Moraes Cruvinel, Elizabeth S. Greene, Rachel W. Read, Kichoon Lee, Sami Dridi, Paula R. Chen

“…Culture at 1% O2 resulted in increased abundance of HIF1α, a canonical protein stabilized during hypoxia, thus confirming effectiveness of the treatment. …”
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From physical activity patterns to cognitive status: development and validation of novel digital biomarkers for cognitive assessment in older adults by Ling-Jie Fan, Feng-Yi Wang, Jun-Han Zhao, Jun-Jie Zhang, Yang-An Li, Jia Tang, Tao Lin, Quan Wei

“…Demographic characteristics were also incorporated, and multimodal data fusion was achieved through canonical correlation analysis. We then developed explainable machine learning models, primarily random forest, optimized with hyperparameters, to predict individual cognitive function status. …”
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Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source by Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer W. Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay

“…However, sustainable feedstocks pose a challenge due to incomplete high-resolution metabolic data for non-canonical carbon sources required to curate GSMM and identify implementable designs. …”
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Mapping the Discourse. Architecture Periodicals in/for the Teaching of Architecture History by Gaia Caramellino, Valeria Casali, Nicole De Togni

“…On the one hand, the cross-reading of “journal biographies” and the study of the “anatomy” of diverse genres of magazines contribute to question canonical interpretations and timeframes of a 20th century architectural history still centered on the European and North American editorial scene, offering a more nuanced understanding of the times and forms of production of architectural culture. …”
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Constelações pós-utópicas: sobre a poesia de Haroldo de Campos by Diana Junkes Bueno Martha

“…Si se ve desde la relación con el canon, el trabajo creativo de Haroldo de Campos va más allá de lo concreto, lo que sugiere la existencia de un vínculo entre la utopía vanguardista y un sentido más amplio centrado en el diálogo y la reinvención de la tradición, a lo que se le puede llamar la utopía fáustica y que pueden estar asociado con la post-utopía, presentada por el poeta en Poesia e modernidade, da morte do verso à constelação, o poema pós-utópico. …”
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X-ray emission from hot gas and XRBs in the NGC 5846 galaxy by Kyadampure Anil, Vagshette Nilkanth, Patil Madhav

“…Among 90, only one source exhibits an X-ray luminosity greater than 1039ergs−11{0}^{39}\hspace{0.33em}{\rm{erg}}\hspace{0.33em}{{\rm{s}}}^{-1}, exceeding the Eddington limit for a canonical mass of a neutron star and occupies a position in the hard region of the X-ray color–color plot. …”
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Powdery mildew resistance of Nordic spring bread wheat accessions from the collection of the Vavilov Institute (VIR) by T. V. Lebedeva, A. N. Brykova, E. V. Zuev

“…Swedish cultivars ‘Sunnan’ (k-58177), ‘Canon’ (k-60992), ‘Sober’ (k-61080) ‘Dragon’ (k-61515) and ‘Dacke’ (k-63479) preserved their resistance to the powdery mildew population beginning from 1993. …”
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TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms by Nicholas L. Calistri, Tiera A. Liby, Zhi Hu, Hongmei Zhang, Mark A. Dane, Sean M. Gross, Laura M. Heiser

“…Single-cell RNA sequencing (scRNA-seq) of TNBC cells after paclitaxel treatment revealed upregulation of innate immune programs canonically associated with interferon response and downregulation of cell cycle progression programs. …”
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NLRP3 Inflammasome Simultaneously Involved in Autophagy and Phagocytosis of THP-1 Cells to Clear Aged Erythrocytes by Qin Li, Fengyong Zhao, Jiamin Zhang, Ying Yang, Zhonghui Guo, Chen Wang, Qixiu Yang, Ying Sun, Ziyan Zhu

“…The occurrence of autophagy was dominated by microtubule-associated protein 1A/1B-light chain 3- (LC3-) associated phagocytosis accompanied by canonical autophagy. A negative correlation exists between the clearance of RBCs by THP-1 cells and the degree of autophagy. …”
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Unraveling TGF-β1’s Role in Mediating Fibrosis and Cell Death in Feline Kidney Cells by Chanyanuch Intachat, Phongsakorn Chuammitri, Benjaporn Sornpet, Prapas Patchanee, Nawin Manachai, Kakanang Piyarungsri

“…TGF-β1 signaling through the non-canonical/smad-independent pathway activates mitogen-activated protein kinase (MAPK) signaling, which is linked to fibrosis and apoptosis. …”
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Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…Mechanistically, we show that LRP1 regulates core non-canonical Wnt/planar cell polarity (PCP) components that may explain the malformation of long bones. …”
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Ethanol extract of Polygonatum cyrtonema Hua mitigates non-alcoholic steatohepatitis in mice by Dongliang Chen, Yue Shen, Yue Shen, Fang Huang, Bo Huang, Shangfu Xu, Shangfu Xu, Lisheng Li, Lisheng Li, Jie Liu, Zheng Li, Xia Li

“…Ingenuity pathway analysis of RNA-seq data revealed key canonical pathways and upstream molecules regulated by PCE.ConclusionOur findings confirm the ability of PCE in alleviating NASH and underscores AMPK/SIRT1 pathway as a potential theraputic target for NASH treatment.…”
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The correlation between coagulation biomarkers, bone turnover markers, and bone mineral density in Chinese adults aged ≥ 50 years by Zhengming Wang, Rui Wang, Haiya Ge, Yong Gu, Sicheng Xian, Laijun Yan, Guoqing Du, Zhibi Shen, Shuaijie Lv, Hongsheng Zhan, Zhengyan Li

“…The relationships between coagulation biomarkers, BTMs, and BMD were investigated by Spearman correlation analysis and canonical correlation analysis (CCA). Consequently, age, bone mass stage, 25-hydroxyvitamin D (25-(OH)D), and BMD were included as independent variables in the logistic regression model. …”
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Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion by Mehul Vora, Jonathan Dietz, Zachary Wing, Karen George, Jun Kelly Liu, Christopher Rongo, Cathy Savage-Dunn

“…In C. elegans, the BMP2/4 ortholog DBL-1 regulates multiple biological functions, including body size, via a canonical receptor-Smad signaling cascade. Here, we identify functional binding sites for SMA-3/Smad and its transcriptional partner SMA-9/Schnurri based on ChIP-seq peaks (identified by modEncode) and expression differences of nearby genes identified from RNA-seq analysis of corresponding mutants. …”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Genomic alterations were subdivided into canonical oncogenic pathways and noted for their involvement in homologous recombination deficiency (HRD). …”
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Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2 by Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huang

“…Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood. …”
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Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation by Xin Zhang, Jieling Li, Minyi Fu, Xijie Geng, Junjie Hu, Ke-Jing Tang, Pan Chen, Jianyong Zou, Xiaoman Liu, Bo Zeng

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis investigated shared pathways, and canonical correlation analysis assessed gene-metabolite relationships. …”
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Influence of lemongrass and oregano essential oils and their combination on in vitro ruminal fermentation and greenhouse gas emissions in total mixed ration for dairy cows by Sara Glorio Patrucco, Alessandro Lotto, Martina Dorigo, Rita Fornaciari, Antonio Sagliano, Nicola Martinelli, Alessandra Cosani, Khalil Abid, Salvatore Barbera, Hatsumi Kaihara, Sonia Tassone

“…LEO reduced pH (−0.6%, p=0.004), while OEO increased oxidation capacity (+4.2%, p=0.004), but both parameters remained within physiological ranges. Canonical discriminant analysis confirmed distinct EOs effects, highlighting their potential as natural additives for improving ruminal fermentation and mitigating ruminant environmental footprint.…”
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3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis by Sayan Deb Dutta, Jeong Man An, Jin Hexiu, Aayushi Randhawa, Keya Ganguly, Tejal V. Patil, Thavasyappan Thambi, Jangho Kim, Yong-kyu Lee, Ki-Taek Lim

“…In a subcutaneous wound model, the 3D bioprinted COL@d-ECM/M2-Exo hydrogel displayed robust wound remodeling and hair follicle (HF) induction while reducing canonical pro-inflammatory activation after 14 days, presenting a viable therapeutic strategy for skin-related disorders.…”
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