Bioinformatics Analysis of Transcriptomic Data Reveals Refined Functional Networks for the Self-Renewal of Mouse Spermatogonial Stem Cells by Min Wang, Wene Zhao, Fuqiang Wang, Xiufeng Ling, Daozhen Chen, Tao Zhou, Ying Wang

“…Using a dynamic statistical model, we identified a list of 1119 candidate genes for SSC self-renewal with the best enrichment of canonical markers. Finally, based on interaction relations, we further optimized the list and constructed a refined network containing integrated information of interactions, expression alternations, biological functions, and disease associations. …”
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Application of Box-Behnken Design in Optimization of Glucose Production from Oil Palm Empty Fruit Bunch Cellulose by Satriani Aga Pasma, Rusli Daik, Mohamad Yusof Maskat, Osman Hassan

“…A three-level Box-Behnken design combined with the canonical and ridge analysis was employed to optimize the process parameters for glucose production from OPEFB cellulose using enzymatic hydrolysis. …”
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Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis by Yewei Jia, Rui Li, Yixuan Li, Katerina Kachler, Xianyi Meng, Andreas Gießl, Yi Qin, Fulin Zhang, Ning Liu, Darja Andreev, Georg Schett, Aline Bozec

“…HMOX1 was identified as a crucial regulatory factor in this process, directly involved in inducing ferroptosis and affecting osteocyte viability. We uncover a non-canonical pathway that involves excessive autophagy-mediated ferritin degradation, highlighting the complex relationship between autophagy and ferroptosis in melanoma-induced osteocyte death. …”
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Change detection in the dynamics of an intracellular protein synthesis model using nonlinear Kalman filtering by Gerasimos G. Rigatos, Efthymia G. Rigatou, Jean Daniel Djida

“…It is shown that such a dynamical system satisfies differential flatness properties and this allows to transform it, through a change of variables (diffeomorphism), to the so-called linear canonical form. For the linearized equivalent of the dynamical system, state estimation can be performed using the Kalman Filter recursion. …”
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Monocyte eukaryotic initiation factor 2 signaling differentiates 17-hydroxy-docosahexaenoic acid levels and pain by Peter R.W. Gowler, Asta Arendt-Tranholm, James Turnbull, Rakesh R. Jha, David Onion, Tony Kelly, Afroditi Kouraki, Paul Millns, Sameer Gohir, Susan Franks, David A. Barrett, Ana M. Valdes, Victoria Chapman

“…QIAGEN ingenuity pathway analysis identified the top ranked canonical biological pathway to be eukaryotic initiation factor 2 (EIF2) signaling (lower activation level in the low 17-HDHA-high pain group compared to the high 17-HDHA-low pain group (Z score −3)), followed by EIF4 and P70S6K signaling pathways and mTOR signaling. …”
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Analysis of Five Earthy-Musty Odorants in Environmental Water by HS-SPME/GC-MS by Zhen Ding, Shifu Peng, Weiwen Xia, Hao Zheng, Xiaodong Chen, Lihong Yin

“…In addition, the storage time experiment indicated that the concentrations did not change significantly for GSM and 2-MIB if they were stored in canonical environment. In conclusion, the method in this study could be applied for monitoring these five odorants in natural waters.…”
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Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5′-dithioacetates by Miklós Bege, Miklós Lovas, Dániel Priksz, Brigitta Bernát, Ilona Bereczki, Rasha Ghanem Kattoub, Richárd Kajtár, Simon Eskeif, Levente Novák, Jan Hodek, Jan Weber, Pál Herczegh, István Lekli, Anikó Borbás

“…In this work, new cysteine-selective nucleoside-H2S-donor hybrid molecules were prepared by conjugating nucleoside biomolecules with a thiol-activatable dithioacetyl group. 5′-Dithioacetate derivatives were synthesized from the canonical nucleosides (uridine, adenosine, cytidine, guanosine and thymidine), and the putative 5′-thio metabolites were also produced from uridine and adenosine. …”
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« Appelsinpiken » et le tourisme expérientiel en Andalousie : Géographie de l’émotion by Maria del Carmen Puche Ruiz

“…L’apparition colorée de ce dernier pays dans le film se limitait à promouvoir Séville en tant que destination touristique, d’après les canons du « tourisme expérientiel » : une vision émotionnelle du phénomène du voyage, dont la campagne pionnière fut « Andalucía te quiere » (« L’Andalousie t’aime »), en 2003. …”
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Decolonizar la Retórica Monumental. by Rakel Vazquez

“…Para profundizar después, a través de Canon, obra de Mateo Maté, en la que puede ser la génesis estética de este discurso hegemónico.Trazando a partir de ella un recorrido que vincula las implicaciones históricas de El Discóbolo de Mirón con el ideario supremacista y nuestro gusto esculpido por la estética incolora de lo blanco. …”
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Barrancas de Barrujón (Toledo, España, 2019) by Íñigo Yvorra

“…La peculiaridad del entorno se debe a las tonalidades rojizas del espectacular escarpe, llegando a superar los 120 m, que contrastan con las aguas del embalse del Tajo y confieren al conjunto un valor paisajístico que recuerda vagamente, al Gran Cañón del Colorado. En 2010 fueron declaradas Monumento Natural, por la Junta de Castilla La Mancha. …”
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Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution by Xiaohui Tong, Nianjun Yu, Rongchun Han, Tongsheng Wang

“…Moreover, by influencing canonical energy sensors like adenosine monophosphate-activated protein kinase (AMPK) or mammalian target of rapamycin (mTOR), Dicer favors catabolism in the periphery. …”
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Classification of Speech Emotion State Based on Feature Map Fusion of TCN and Pretrained CNN Model From Korean Speech Emotion Data by A-Hyeon Jo, Keun-Chang Kwak

“…In the third stage, we perform feature-map fusion using canonical correlation analysis (CCA), stationary wavelet transform (SWT), and fuzzy c-means-based principal component averaging (FCMPCA), respectively. …”
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Locally conformal symplectic manifolds by Izu Vaisman

“…L. c. s. manifolds can be seen as generalized phase spaces of Hamiltonian dynamical systems since the form of the Hamilton equations is, in fact, preserved by homothetic canonical transformations. The paper discusses first Hamiltonian vector fields, and infinitesimal automorphisms (i. a.) on l. c. s. manifolds. …”
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Exploring shape diversity and sexual dimorphism in two populations of Nigma conducens through geometric morphometrics by Safa M. El-masry, Tarek G. Ismail, Asmaa N. Mustafa

“…Principal Component Analysis (PCA) explored shape variation, while Canonical Variate Analysis (CVA) compared shape differences between populations and sexes. …”
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Suboptimal but intact integration of Bayesian components during perceptual decision-making in autism by Laurina Fazioli, Bat-Sheva Hadad, Rachel N. Denison, Amit Yashar

“…This hypothesis has gained momentum in recent years, partly because it can be implemented both at the computational level, as in Bayesian perception, and at the level of canonical neural microcircuitry, as in predictive coding. …”
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PIWI proteins and piRNAs: key regulators of stem cell biology by Fernando Claro-Linares, Patricia Rojas-Ríos

“…Together, PIWI proteins and piRNAs demonstrate evolutionary conservation in stem cell regulation, integrating TE silencing and gene expression regulation at chromatin and mRNA levels in somatic and germline lineages. Beyond their canonical roles, emerging evidence reveal their broader significance in maintaining stem cell properties and organismal health under physiological and pathological conditions.…”
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Human, too human? Experience, Learning, Interaction with AI by Eleonora Sparano

“…Thus, from the scenario outlined emerges the need to review the canonical theoretical frameworks of the sociological tradition, founded on the study of relations between human beings, as a horizon rich in epistemic opportunities is discovered from the emergence of new forms of interaction between human and non-human. …”
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Transgenic plants as a model for studying еpigenetic regulation of gene expression by T. V. Marenkova, E. V. Deineko

“…In plants, in addition to the canonical pathway, RdDM, more mechanisms exist, which include components for posttranscriptional gene inactivation, specific proteins and other types of small RNAs. …”
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Host RNA-Binding Proteins as Regulators of HIV-1 Replication by Sebastian Giraldo-Ocampo, Fernando Valiente-Echeverría, Ricardo Soto-Rifo

“…Strikingly, several of the RBPs found through interactome capture are not canonical RBPs, meaning that they do not have conventional RNA-binding domains and are therefore not readily predicted as being RBPs. …”
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Adsorption Behaviors of Cobalt on the Graphite and SiC Surface: A First-Principles Study by Wenyi Wang, Chuan Li, Jianzhu Cao, Chao Fang

“…Furthermore, the variation of adsorption ratios of Co on different substrate is obtained by a model of grand canonical ensemble, and it is found that when the temperature is close to 650 K and 1700 K for graphite surface and SiC surface, respectively, the Co adatom on the substrate will desorb dramatically. …”
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