p57 Suppresses the Pluripotency and Proliferation of Mouse Embryonic Stem Cells by Positively Regulating p53 Activation by Na Li, Zhaoyu Du, Yunxiang Li, Wenjing Xu, Yumei Yang, Haodong Peng, Tianxiang Song, Qihua Qin, Huining Lei, Jinlian Hua

“…Herein, we discovered that p57Kip2 (p57), a cyclin-dependent kinase inhibitor canonically inhibiting cell proliferation, played a role in suppressing the pluripotency state of mouse ESCs (mESCs). p57 knockdown significantly stimulated the expressions of core pluripotency factors NANOG, OCT4, and SOX2, while p57 overexpression inhibited the expressions of these factors in mESCs. …”
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Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism by Jie An, Inna Astapova, Guofang Zhang, Andrew L. Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J. Muehlbauer, Tabitha George, Joseph Brozinick, Mark A. Herman, Christopher B. Newgard

“…In sum, our study reveals functions of ChREBP beyond its canonical roles in carbohydrate and lipid metabolism to include regulation of substrate transport, mitochondrial function, and energy balance.…”
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Forecast generation model of municipal solid waste using multiple linear regression by J.A. Araiza-Aguilar, M.N. Rojas-Valencia, R.A. Aguilar-Vera

“…The objective of this study was to develop a forecast model to determine the rate of generation of municipal solid waste in the municipalities of the Cuenca del Cañón del Sumidero, Chiapas, Mexico. Multiple linear regression was used with social and demographic explanatory variables. …”
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PDPN+ cancer‐associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF‐κB activation and the CCL2‐ACKR1 axis by Zhenxiong Zhao, Hui Sun, Yingxue Liu, Yanqiu Zhang, Xin Wang, Xu Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Wenchao Gu, Jinjia Chang, Weiqi Sheng, Mi‐die Xu

“…Mechanistically, PDPN(+) CAFs enhance angiogenesis by activating the AKT/NF‐κB signaling pathway. The canonical NF‐κB signaling protein P65 binds to the promoter region of CCL2, inducing its expression. …”
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Executioner caspases degrade essential mediators of pathogen-host interactions to inhibit growth of intracellular Listeria monocytogenes by Marilyne Lavergne, Raffael Schaerer, Sara De Grandis, Safaa Bouheraoua, Oluwadamilola Adenuga, Tanja Muralt, Tiffany Schaerer, Léa Chèvre, Alessandro Failla, Patricia Matthey, Michael Stumpe, Dieter Kressler, Pierre-Yves Mantel, Michael Walch

“…With that, we uncovered an underappreciated defense barrier and a non-canonical role of executioner caspases to degrade virulence mediators, thus impairing intracellular Listeria growth.…”
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Daily Activity Monitoring and Fall Detection Based on Surface Electromyography and Plantar Pressure by Xugang Xi, Wenjun Jiang, Zhong Lü, Seyed M. Miran, Zhi-Zeng Luo

“…A feature-level fusion method, named as the global canonical correlation analysis of weighting genetic algorithm, was proposed to reduce dimensions. …”
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Classical eikonal from Magnus expansion by Joon-Hwi Kim, Jung-Wook Kim, Sungsoo Kim, Sangmin Lee

“…Abstract In a classical scattering problem, the classical eikonal is defined as the generator of the canonical transformation that maps in-states to out-states. …”
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Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3 by Ling Ye, Shengqi Shen, Qiankun Mao, Hui Lu, Haiying Liu, Pinggen Zhang, Zetan Jiang, Wenhao Ma, Yuchen Sun, Yiyang Chu, Zilong Zhou, Rui Liu, Jian Li, Shi-ting Li, Ping Gao, Huafeng Zhang

“…Summary: Metabolic enzymes play significant roles in the pathogenesis of various cancers through both canonical and noncanonical functions. Hexokinase domain-containing protein 1 (HKDC1) functions beyond glucose metabolism, but its underlying mechanisms in tumorigenesis are not fully understood. …”
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The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway by Danilo Figueiredo Soave, Marina Pacheco Miguel, Fernanda Dias Tomé, Liliana Borges de Menezes, Patrícia Resende Alo Nagib, Mara Rúbia Nunes Celes

“…Biologically, two forms of activated macrophages can be observed: classically activated macrophages (M1) and alternative activated macrophages (M2). Despite the canonical pathways that control this puzzle of macrophages polarization, recently, mTOR signaling pathway has been implicated as an important piece in determining the metabolic and functional differentiation of M1 and M2 profiles. …”
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Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease by Daisuke Yoshihara, Masanori Kugita, Tamio Yamaguchi, Harold M. Aukema, Hiroki Kurahashi, Miwa Morita, Yoshiyuki Hiki, James P. Calvet, Darren P. Wallace, Takafumi Toyohara, Takaaki Abe, Shizuko Nagao

“…By Gene Set Enrichment Analysis of 30655 genes, 13 of the top 20 downregulated gene ontology biological process gene sets and six of the top 20 curated gene set canonical pathways identified to be downregulated by PIOtreatment were related to cell cycle and proliferation, including EGF, PDGF and JNK pathways. …”
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Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai by Juan-José Escuder-Rodríguez, Andrea Rodríguez-Alonso, Lía Jove, Macarena Quiroga, Gloria Alfonsín, Angélica Figueroa

“…Most of the knowledge about the protein was associated to its E3 ubiquitin ligase canonical role. However, important recent published research has highlighted the noncanonical role of Hakai, independent of its E3 ubiquitin ligase activity, underscoring its involvement in the N 6-methyladenosine (m6A) writer complex and its impact on the methylation of RNA. …”
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Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression by Divya Khandige Sharma, Kamiko Bressler, Harshil Patel, Nirujah Balasingam, Nehal Thakor

“…In this review, we will focus on this context by describing both canonical and noncanonical roles of eIFs, which alter mRNA translation.…”
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Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with Extradenticle and Homothorax. by Jesús R Curt, Paloma Martín, David Foronda, Bruno Hudry, Ramakrishnan Kannan, Srividya Shetty, Samir Merabet, Andrew J Saurin, Yacine Graba, Ernesto Sánchez-Herrero

“…They strongly diverge from anterior and central class Hox proteins, with a low degree of HD sequence conservation and the absence of a core canonical Pbc interaction motif. Here we explore how Abd-B function interface with that of Exd/Hth using several developmental contexts, studying mutual expression control, functional dependency and intrinsic protein requirements. …”
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Fast Random Permutation Tests Enable Objective Evaluation of Methods for Single-Subject fMRI Analysis by Anders Eklund, Mats Andersson, Hans Knutsson

“…To exemplify the permutation-based approach, brain activity maps generated by the general linear model (GLM) and canonical correlation analysis (CCA) are compared at the same significance level.…”
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Un instante en el infierno: memoria de la eternidad en Farabeuf de Salvador Elizondo by Evelyn Yaneli Garfias Varela

“…A partir de esta generalidad se puede establecer que la escritura de Elizondo, particularmente en Farabeuf, constituye un experimento para abandonar el canon y acariciar atisbos de lo continuo y lo mudable, pues no hay límites reales en ella, es decir, conforma una visión prismática que envuelve al observador en un desfile interminable de sensaciones, así alcanza un carácter vivencial, una experiencia latente en cada rincón de la narración.…”
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Plant community formation and species distribution pattern in relation to environmental variables in Endiras Natural Forest, northwest Ethiopia by Getinet Masresha, Worku Misganaw, Endale Adamu

“…The relationships between species and environmental variables were evaluated using canonical correspondence analysis (CCA). Seventy-three woody plant species, distributed in 40 families, were documented. …”
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Barrancas de Barrujón (Toledo, España, 2019) by Íñigo Yvorra

“…La peculiaridad del entorno se debe a las tonalidades rojizas del espectacular escarpe, llegando a superar los 120 m, que contrastan con las aguas del embalse del Tajo y confieren al conjunto un valor paisajístico que recuerda vagamente, al Gran Cañón del Colorado. En 2010 fueron declaradas Monumento Natural, por la Junta de Castilla La Mancha. …”
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Integrated Multiscale Latent Variable Regression and Application to Distillation Columns by Muddu Madakyaru, Mohamed N. Nounou, Hazem N. Nounou

“…Commonly used inferential models include latent variable regression (LVR) techniques, such as principal component regression (PCR), partial least squares (PLS), and regularized canonical correlation analysis (RCCA). Unfortunately, measured practical data are usually contaminated with errors, which degrade the prediction abilities of inferential models. …”
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Saberes contemporáneos y tradición oral frente al maíz transgénico en Tenosique, Tabasco. México by Adriana Tapia Hernández, Elda Miriam Aldasoro Maya

“…Se reflexiona sobre qué se puede hacer en caso de sospecha o presencia de maíz transgénico en los territorios, de acuerdo al saber contemporáneo y la tradición oral de las familias campesinas indígenas y mestizas del Área de Protección de Flora y Fauna Cañón del Usumacinta (apffcu) en Tenosique, Tabasco, confirmada como tal en 2021 y 2022. …”
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CALCULATION OF A GLARE STOP FOR TWO-MIRROR EXTRA-FOCAL OBJECTIVE by L. F. Zambrano, N. K. Artyukhina, L. V. Peroza

“…Recently, efforts to improve optical characteristics in canonical mirror systems, including aspherical surfaces and corrective aberration capabilities. …”
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