Enhanced Expression of ABCB1 and Nrf2 in CD133-Positive Cancer Stem Cells Associates with Doxorubicin Resistance by Shinji Goto, Tsuyoshi Kawabata, Tao-Sheng Li

“…The precise mechanism about drug resistance of cancer stem cells (CSCs) has not yet been completely understood. …”
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MicroRNA-28-5p Regulates Liver Cancer Stem Cell Expansion via IGF-1 Pathway by Qing Xia, Tao Han, Pinghua Yang, Ruoyu Wang, Hengyu Li, Jin Zhang, Xinfeng Zhou

“…MicroRNAs (miRNAs) play a critical role in the regulation of cancer stem cells (CSCs). However, the role of miRNAs in liver CSCs has not been fully elucidated. …”
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Patient-derived xenografts from circulating cancer stem cells as a preclinical model for personalized pancreatic cancer research by Benedikt J. Wagner, Andreas Ettner-Sitter, Nicolas A. Ihlo, Merle Behr, Sebastian Koelbl, Stefan M. Brunner, Florian Weber, Bettina M. Rau, Hans J. Schlitt, Christoph Brochhausen, Rebecca Schoenmehl, Annalena Artinger, Dorothea Schott, Monika Pizon, Katharina Pachmann, Thiha Aung, Silke Haerteis, Christina Hackl

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Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells by Minkoo Seo, Seung Min Kim, Eun Young Woo, Ki-Cheol Han, Eun Joo Park, Seongyeol Ko, Eun wook Choi, Mihue Jang

“…Cancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence. …”
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Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma by Jian‐Hua Wang, Shu‐Ting Huang, Lan Zhang, Zi‐Gang Liu, Rong‐Xin Liang, Sen‐Wei Jiang, Yi‐Nan Jiang, Xing‐Juan Yu, Yu‐Chuan Jiang, Xi‐Zhao Li, Pei‐Fen Zhang, Zhe‐Sheng Wen, Min Zheng

“…Abstract Background Treatments based on the inhibition of pivotal signals of cancer stem cells (CSCs) are on a promising track. Recent studies have shown that targeting CSCs with broader immune‐based therapeutic methods, for example, the anti‐CD47 treatment, may serve as a more potent strategy for eliminating these intractable cells. …”
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Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog by Ting Ye, Jingyuan Li, Zhiwei Sun, Yongli Liu, Liangsheng Kong, Shixia Zhou, Junlin Tang, Jianyu Wang, H. Rosie Xing

Subjects: “…cancer stem cell…”
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FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A by Xing Wang, Ying Li, Yongning Li, Peng Liu, Songbai Liu, Yaozhen Pan

“…Cancer stem cells (CSCs) comprise a subset of tumor cells that can initiate tumorigenesis and promote tumor advance. …”
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Retracted: A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production by Bioinorganic Chemistry and Applications

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New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite by Eman M. Ragab, Doaa M. El Gamal, Fares F. El-najjar, Hager A. Elkomy, Mahmoud A. Ragab, Mariam A. Elantary, Omar M. Basyouni, Sherif M. Moustafa, Shimaa A. EL-Naggar, Abeer S. Elsherbiny

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Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells by Alaleh Rezalotfi, Ghasem Solgi, Marzieh Ebrahimi

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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

Subjects: “…cancer stem cells…”
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Cytoplasmic SALL4-A isoform expression as a diagnostic marker of less aggressive tumor behavior in gastric cancer by Saeed Rahmani, Amirhesam Babajani, Maryam Abolhasani, Roya Ghods, Elham Kalantari, Zahra Madjd

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Cancer Stem Cell Marker Endoglin (CD105) Induces Epithelial Mesenchymal Transition (EMT) but Not Metastasis in Clear Cell Renal Cell Carcinoma by Junhui Hu, Wei Guan, Libin Yan, Zhangqun Ye, Lily Wu, Hua Xu

“…Our work suggests that the ability to metastasize does not coincide with the cancer stem cell or EMT function of CD105.…”
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BMI1, ALDH1A1, and CD133 Transcripts Connect Epithelial-Mesenchymal Transition to Cancer Stem Cells in Lung Carcinoma by Ana Koren, Matija Rijavec, Izidor Kern, Eva Sodja, Peter Korosec, Tanja Cufer

“…Evidences from lung cancer cellular models show EMT can trigger conversion to a cancer stem cell (CSC) phenotype. In this study, we assessed mRNA expression levels of EMT-inducing transcription factors (BMI1, TWIST1), CSC (CD133, ALDH1A1), and epithelial (EpCAM) markers in primary tumor and whole blood samples obtained from 57 patients with operable non-small-cell lung cancer (NSCLC) as well as in circulating tumor cells (CTCs) of 13 patients with metastatic disease; then possible associations between marker expressions were evaluated. …”
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Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway by Jiali Yang, Kangjian Zhang, Jing Wu, Juan Shi, Jing Xue, Jing Li, Juan Chen, Yongzhao Zhu, Jun Wei, Jinxi He, Xiaoming Liu

“…Interestingly, an inhibition of Wnt/PKC signaling pathway could reduce properties of lung cancer stem cells, promote cell apoptosis, and resensitize cisplatin-resistant cells to cisplatin via a caspase/AIF-dependent pathway. …”
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In vitro effects of ascorbic acid on viability and metabolism of patients’ osteosarcoma stem cells by Jovičić Marijana Šimić, Pušić Maja, Antunović Maja, Ledinski Maja, Librenjak Lucija, Kolundžić Robert, Ribičić Tomislav, Trkulja Vladimir, Urlić Inga

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Establishment and Characterization of a Human Small Cell Osteosarcoma Cancer Stem Cell Line: A New Possible In Vitro Model for Discovering Small Cell Osteosarcoma Biology by Gaia Palmini, Roberto Zonefrati, Cecilia Romagnoli, Alessandra Aldinucci, Carmelo Mavilia, Gigliola Leoncini, Alessandro Franchi, Rodolfo Capanna, Maria Luisa Brandi

“…In this study, for the first time, we have isolated, established, and characterized a cell line of cancer stem cells (CSCs) from a human SCO. First of all, we have established a primary finite cell line of SCO, from which we have isolated the CSCs by the sphere formation assay. …”
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Cancer Stem Cells from Tumor Cell Lines Activate the DNA Damage Response Pathway after Ionizing Radiation More Efficiently Than Noncancer Stem Cells by Heriberto Abraham Valencia-González, Graciela Ruíz, Elizabeth Ortiz-Sánchez, Alejandro García-Carrancá

“…Recently, a subpopulation of tumor cells, called cancer stem cells (CSC), has been characterized, and these have emerged as a major topic in cancer research. …”
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Enhancers of cancer stem cells and epithelial–mesenchymal transition: Lin28, MUC1, and lipocalin-2 as a new prognostic axis in classical invasive lobular carcinoma of the breast by Mohamed Alabiad, Raja Aljafil, Amany Shalaby, Ahmed M. Yehia, Mohammed Alorini, Basma Hamed Ibrahim

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PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells by Xiao-Fang Guo, Ling-Ling Wang, Fei-Meng Zheng, He-Ping Li

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