Trichoderma collection from Brazilian soil reveals a new species: T. cerradensis Sp. nov. by Gustavo Henrique Silva Peixoto, Rildo Alexandre Fernandes da Silva, Ana Beatriz Zacaroni, Thais França Silva, Priscila Chaverri, Priscila Chaverri, Danilo Batista Pinho, Sueli Corrêa Marques de Mello

“…In this study, 97 Trichoderma isolates preserved at the EMBRAPA collection (an important source for biocontrol agents) and previously collected from several areas in Brazil were characterized which were identified using various molecular markers (internal transcribed spacers (its), translation elongation factor (tef1α), RNA polymerase II subunit (rpb2), actin (act), and calmodulin (cal). Of these, 54 isolates were found to group in the Harzianum species complex and 32 in Sect. …”
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Germline deletion of Rgs2 and/or Rgs5 in male mice does not exacerbate left ventricular remodeling induced by subchronic isoproterenol infusion by Shelby Dahlen, Ipsita Mohanty, Bo Sun, Sanjana Nallapaneni, Patrick Osei‐Owusu

“…ISO induced cardiac hypertrophy and interstitial fibrosis in Rgs2/5 dbKO mice without increasing cardiomyocyte size or LV dilation but increased expression of cardiac fetal gene Nppa, α‐actinin, and Ca2+‐/calmodulin‐dependent kinase II. Single Rgs2 and Rgs5 KO mice had markedly increased CD45+ cells, whereas tissue from Rgs5 KO mice showed increased CD68+ cells, as revealed by immunohistochemistry. …”
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Proteomic Analysis Reveals the Vital Role of Synaptic Plasticity in the Pathogenesis of Temporal Lobe Epilepsy by Xu Qian, Ji-Qiang Ding, Xin Zhao, Xin-Wen Sheng, Zhao-Rui Wang, Qi-xing Yang, Jing-Jun Zheng, Jia-Gui Zhong, Teng-Yue Zhang, Shu-Qiao He, Wei-Dong Ji, Wei Li, Mei Zhang

“…Bioinformatics analysis indicated 27 DEPs were mainly enriched in “regulation of synaptic plasticity and structure” and “calmodulin-dependent protein kinase activity,” which implicate synaptic remodeling may play a vital role in the pathogenesis of TLE. …”
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Re-identification of Strains from Aspergillus Section Aspergillus and Description of Three Unrecorded Species from Korea by Anbazhagan Mageswari, Daseul Lee, Le Dinh Thao, Donghun Kang, Dong-Hyun Kim, Seung-Beom Hong

“…In this study, 108 strains from the section Aspergillus, originating from Korea and conserved at the Korean Agricultural Culture Collection, were subjected to re-identification using a combined dataset that included partial sequences of β-tubulin (BenA), Calmodulin (CaM), and RNA polymerase II second largest subunit (RPB2) genes, along with their morphological characteristics. …”
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Evaluation of GABAergic Transmission Modulation as a Novel Functional Target for Management of Multiple Sclerosis: Exploring Inhibitory Effect of GABA on Glutamate-Mediated Excitot... by Ankit A. Gilani, Ranjeet Prasad Dash, Mehul N. Jivrajani, Sandeep Kumar Thakur, Manish Nivsarkar

“…However, it has been observed that gamma-aminobutyric acid-A (GABAA) receptors located in the nerve terminals activate presynaptic Ca2+/calmodulin-dependent signaling to inhibit depolarization-evoked Ca2+ influx and glutamate release from isolated nerve terminals, which suggest a potential implication of GABAA receptor in management of MS. …”
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Loss of neuronal βPix isoforms impairs neuronal morphology in the hippocampus and causes behavioral defects by Younghee Kwon, Seung Joon Lee, Yoon Kyung Shin, June-Seek Choi, Dongeun Park, Jung Eun Shin

“…Loss of the neuronal βPix isoforms leads to reduced activity of Rac1 and Cdc42, decreased dendritic complexity and spine density, and increased GluN2B and Ca2+/calmodulin-dependent protein kinase IIα expression in the hippocampus. …”
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Identification of quantitative trait loci of pod dehiscence in a collection of soybean grown in the southeast of Kazakhstan by B. N. Doszhanova, A. K. Zatybekov, S. V. Didorenko, T. Suzuki, Y. Yamashita, Y. Turuspekov

“…Both minor QTLs for PD were associated with calmodulin-binding protein, which presumably plays an important role in regulating PD in dry areas. …”
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Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment by Yaling Dai, Yuhao Zhang, Minguang Yang, Huawei Lin, Yulu Liu, Wenshan Xu, Yanyi Ding, Jing Tao, Weilin Liu

“…In addition, the protein expression and phosphorylation levels of N-methyl-D-aspartate receptor 2B, α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor 1, and Ca2+-calmodulin-dependent protein kinase II increased to varying degrees in the hippocampus of VCI model rats. …”
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The tryptophan-aspartate (WD) repeat domain of bovine Coronin-1A promotes mycobacterial survival by inhibiting calcium signaling-mediated phagosome-lysosome fusion by Jing Yang, Zhunan Li, Aicong Li, Yayi Liu, Xinyan Zhang, Yong Zhang, Yuanpeng Gao

“…The WD repeat domain mediated a decrease in intracellular calcium levels, which reduced levels of calmodulin-dependent kinase II (CaMKII) and its activated forms, thereby inhibiting lysosomal delivery. …”
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Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism by Yuwen Sheng, Chong Qiao, Zhonghui Zhang, Xiaoke Shi, Linhan Yang, Ruiying Xi, Jialing Yu, Wanli Liu, Guolin Zhang, Fei Wang

“…Mechanistically, lacidipine targets calcium channels (CaV1.2/1.3) to inhibit Pyk2‐JAK1‐calmodulin complex‐mediated IDO1 transcription suppression, which suppresses the kynurenine pathway and maintains the total nicotinamide adenine dinucleotide (NAD) pool by regulating NAD biosynthesis. …”
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LIFU Alleviates Neuropathic Pain by Improving the KCC2 Expression and Inhibiting the CaMKIV–KCC2 Pathway in the L4–L5 Section of the Spinal Cord by Ye-Hui Liao, Bin Wang, Mo-Xian Chen, Yao Liu, Li-Juan Ao

“…Western blotting (WB) and immunofluorescence (IF) were used to calculate the expression of phosphorylated extracellular signal–regulated kinase 1/2 (p-ERK1/2), calcium/calmodulin-dependent protein kinase type IV (CaMKIV), phosphorylated cyclic adenosine monophosphate response element-binding protein (p-CREB), and KCC2 in the L4–L5 portion of the spinal cord after the last behavioral tests. …”
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Novel FRET‐Based Biosensors for Real‐Time Monitoring of Estrogen Receptor Dimerization and Translocation Dynamics in Living Cells by Kiseok Han, Jung‐Soo Suh, Gyuho Choi, Yoon‐Kwan Jang, Sanghyun Ahn, Yerim Lee, Tae‐Jin Kim

“…These biosensors are utilized to reveal interactions between ER α/β and calmodulin during dimer formation. Furthermore, by leveraging the ligand‐binding domain (LBD) of ER β, ER ββ LBD biosensor is designed for real‐time analysis of ER ββ homodimerization in the cytoplasm, enhancing the ability to screen ER dimerization‐related drugs. …”
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Plant Coping with Cold Stress: Molecular and Physiological Adaptive Mechanisms with Future Perspectives by Yan Feng, Zengqiang Li, Xiangjun Kong, Aziz Khan, Najeeb Ullah, Xin Zhang

“…Some transcription factors, such as AP2/ERF, MYB, WRKY, NAC, and bZIP, not only act as calmodulin-binding proteins during cold perception but can also play important roles in the downstream chilling-signaling pathway. …”
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Effect of High-Fat Diet on Spatial Learning and Memory and Regulatory Role of N-Methyl-D-Aspartate Receptors in the Dentate Gyrus by LIU Huaying, DONG Wei, ZHANG Zihan, LI Yingshun, JIN Qinghua

“…The Morris water maze (MWM) test was used to evaluate the spatial learning and memory capacity of the rats; Western blot was used to detect the expression of phosphorylated Ca2+/calmodulin dependent protein kinase II (p-CaMKII) and cAMP-response element binding protein (p-CREB), pro-inflammatory cytokines, including interleukin-6 (IL-6) and IL-1β in the hippocampal dentate gyrus (DG); the expression of ionized calcium binding adapter molecule 1 (Iba1) in the DG were observed by Western blot and immunohistochemistry. …”
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Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1 by P. Rowart, P. Erpicum, J.-M. Krzesinski, M. Sebbagh, F. Jouret

“…Liver kinase-β1 (LKB1) and Ca2+-calmodulin-dependent protein kinase kinase (CaMKK) represent the main kinases that activate AMPK. …”
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Genome-wide identification of CAMTA gene family in teak (Tectona grandis) and functional characterization of TgCAMTA1 and TgCAMTA3 in cold tolerance by Wenlong Zhou, Jian Du, Runjie Jiao, Xianbang Wang, Tiansong Fang, Guihua Huang

“…Abstract Background Calmodulin-binding transcription activator (CAMTA) proteins play significant roles in signal transduction, growth and development, as well as abiotic stress responses, in plants. …”
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Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production by Yan Tian, Chenxia Zhou, Qun Yan, Ziyi Li, Da Chen, Bo Feng, Jun Song

“…In addition, the role of the β-hydroxybutyrate- Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (BHB-CaMKK2) axis in mediating dapagliflozin regulating ferroptosis was examined.Results Dapagliflozin significantly ameliorated kidney injury in mice with DKD. …”
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Genome-Wide Identification and Expression Analysis of the <i>CAMTA</i> Gene Family in Roses (<i>Rosa chinensis</i> Jacq.) by Wanyi Su, Yuzheng Deng, Xuejuan Pan, Ailing Li, Yongjie Zhu, Jitao Zhang, Siting Lu, Weibiao Liao

“…Calmodulin-binding transcription activator (<i>CAMTA</i>), as one of the transcription factors, is involved in performing important functions in modulating plant stress responses and development in a Ca²⁺/CaM-driven modus. …”
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Liraglutide alleviates high-fat diet-induced kidney injury in mice by regulating the CaMKKβ/AMPK pathway by Yingli Xuan, Ting-ting Ding, Xiao-lei Mao, Shiqing Pang, Ruibin He, Li Qin, Jiang zi Yuan

“…Besides, hematoxylin–eosin staining and periodic acid-Schiff staining were used to observe the pathological changes of kidney tissue; immunohistochemistry, western blot, and real-time quantitative PCR to assess the calmodulin-dependent protein kinase kinase beta (CaMKKβ)/AMPK signaling pathway activation.Results Liraglutide significantly reduced serum lipid loading, improved kidney function, and relieved kidney histopathological damage and glycogen deposition in the mouse model of obesity-related kidney disease induced by HFD. …”
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Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus by Han-Fang Wu, Yi-Ju Chen, Su-Zhen Wu, Chi-Wei Lee, I-Tuan Chen, Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, Hui-Ching Lin

“…TPPU- or 14,15-EET-facilitated FSK-mediated LTP can be potentiated by an A1 adenosine receptor antagonist and a phosphodiesterase inhibitor, but is prevented by a cAMP-dependent protein kinase (PKA) inhibitor. sEHI and 14,15-EET upregulated the activation of extracellular signal-regulated kinases (ERKs) and Ca2+/calmodulin- (CaM-) dependent protein kinase II (CaMKII). …”
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