No easy way out: towards a framework concept of long-term governance by Dirk Scheer, Sandra Venghaus, Stefania Sardo, Sascha Stark, Sophie Kuppler, Michael W. Schmidt, Carsten Hoyer-Klick

“…Main text We elaborate an analytical framework for long-term governance (LTG), based on five building blocks: the ‘environment’, which details the policy-making arena; the ‘policy issues’, which elaborates on the problems to be dealt with by LTG; the ‘key challenges and driving force’, revealing LTG mechanisms; the ‘key strategies’, in which promising approaches for LTG are identified; and the ‘policy cycle’, where governance impacts on different policy phases are discussed. …”
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Bi-level data-driven enterprise-wide optimization with mixed-integer nonlinear scheduling problems by Hasan Nikkhah, Zahir Aghayev, Amir Shahbazi, Vassilis M. Charitopoulos, Styliani Avraamidou, Burcu Beykal

“…We apply DOMINO to the continuous production of multi-product methyl methacrylate polymerization process formulated as a Traveling Salesman Problem and demonstrate its capability in achieving near-optimal guaranteed feasible solutions. Building on this foundation, we extend this strategy to solve a high-dimensional and highly constrained nonlinear crude oil refinery operation problem that has not been previously tackled in this context. …”
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A holistic review of nanomaterials in strain-hardening cementitious composites: Insights into micro- and macromechanical, deformation, smart, and durability properties by Isyaka Abdulkadir, Leong Sing Wong, Lee Woen Ean, G. Murali, Bashar S. Mohammed

“…Strain-hardening cementitious composites (SHCC) are rapidly gaining popularity as building materials because of their remarkable ductility, increased tensile strain capacity, and controlled saturated microcrack propagation with tight crack width. …”
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Advancing dental biofilm models: the integral role of pH in predicting S. mutans colonization by Jay S. Sangha, Valentina Gogulancea, Thomas P. Curtis, Nicholas S. Jakubovics, Paul Barrett, Aline Metris, Irina D. Ofiţeru

“…We have developed mathematical models to simulate the transition toward a cariogenic microbial biofilm, modeled as the overgrowth of Streptococcus mutans within a five-species dental community. This work builds on experimental data from a continuous flow reactor with hydroxyapatite coupons for biofilm growth, in a chemically defined medium with varying concentrations of glucose and lactic acid. …”
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Reducing personal protective equipment waste in the emergency department of a large regional hospital: codesign informed by system science by Mike Forrester, Rebecca Patrick, Steven Allender, Jaithri Ananthapavan, Urvi Thanekar, Hasini Gunasiri, Minoo Naebe, Maryam Naebe

“…Background This study aimed to bring together health workers from an emergency department (ED) and broader health system changemakers to cocreate a system-oriented understanding of the drivers of single-use personal protective equipment (PPE) waste, and recommend priority actions for government policy, and organisational change, to reduce PPE waste and transition towards a circular economy approach.Methods Participatory group model building was used with ED and PPE health service stakeholders to create a causal loop diagram of drivers of PPE waste and use this diagram to codesign actions to address this waste. …”
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Enabling regulatory policy globally will promote realization of the potential of animal biotechnology by Eric Hallerman, Justin Bredlau, Luiz Sergio A. Camargo, Maria Lucia Zaidan Dagli, Margaret Karembu, Daniel Kovich, Anne Ndanu Muia, Mariana L. Murrone, Pedro Jesus Rocha-Salavarrieta, Rhodora Romero-Aldemita, Mark Tizard, Mark Walton, Diane Wray-Cahen

“…Effective scientific public communication is crucial to build public trust in precision animal biotechnology and risk-proportionate regulatory approaches. …”
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Visual hermeneutics as a tool to introduce empathy and core physician attributes in doctor-patient relationship for first-year medical undergraduate students by Sushma Prabhath, Uma Kulkarni, Vani Lakshmi R., Bikash Patra, Eshwari K., Divya Arvind Prabhu, Kirtana R. Nayak

“…Reflective writing revealed the importance of building trust, demonstrating professional conduct, and maintaining empathy and compassion in clinical interactions. …”
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System Design and Optimisation Study on a Novel CCHP System Integrated with a Hybrid Energy Storage System and an ORC by Jie Ji, Zujun Ding, Xin Xia, Yeqin Wang, Hui Huang, Chu Zhang, Tian Peng, Xiaolu Wang, Muhammad Shahzad Nazir, Yue Zhang, Baolian Liu, Xiaoying Jia, Ruisheng Li, Yaodong Wang

“…The integrated system’s configuration, the model building process of several key components, the optimisation method, and the case studies are discussed and analysed in this study. …”
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Integrated Three-Dimensional Structural and Petrophysical Modeling for Assessment of CO2 Storage Potential in Gas Reservoir by Syed Yasir Ali Shah, Jiangfeng Du, Sayed Muhammad Iqbal, Linze Du, Umair Khan, Baoyi Zhang, Jingqiang Tan

“…Carbon dioxide (CO2) storage in oil and gas reservoirs is one of the most effective methods for enhancing hydrocarbon recovery efficiency and mitigating climate change by securely storing CO2. However, building a realistic three-dimensional (3D) geological model for these storage reservoirs poses a significant challenge. …”
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A bibliometric analysis of the top 100 most cited articles on corticospinal tract regeneration from 2004 to 2024 by Saijilafu, Saijilafu, Ling-Chen Ye, Huanyi Li, Haokun Li, Xinyi Lin, Kehui Hu, Zekai Huang, Chimedragchaa Chimedtseren, Linjun Fang, Saijilahu, Ren-Jie Xu

“…Our findings unveiled the dynamics and trends within the field of CST regeneration, providing a scientific foundation for advancing clinical applications. Building on this analysis, the clinical application of CST regeneration should be optimized through interdisciplinary collaboration, enabling the exploration and validation of a variety of therapeutic approaches, including the use of neurotrophic factors, stem cell therapies, biomaterials, and electrical stimulation. …”
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Using a co-design approach to develop a Preventative Online Mental Health Program for Youth (POMHPY): a quality improvement project by Elnaz Moghimi, Kimberly Belfry, Sarah Farr, Shavon Stafford, Arina Bogdan, Megan Brush, Christopher Canning, Soyeon Kim

“…Preventative intervention programs can address the psychological impact of the pandemic on youth and build resiliency. Co-design approaches to developing such programs actively involve young people, resulting in solutions tailored to their unique needs. …”
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Is the topical application of sesame oil (Sesamum indicum L.) combined with standard care valuable and safe for managing infusion-related phlebitis: Evidence from a systematic revi... by Morteza Nasiri, Leila Amirmohseni, Mohammad Farzollah Abbasi, Fatemeh Yarahmadi, Sahar Zonoori, Mahya Torkaman, Elham Sadeghi Moghimi, Mehrnaz Ardaneh, Masoomeh Asadi

“…However, uncertainty remains because the evidence quality was moderate, some RCTs needed better methodological rigor, and most required to address the safety of the intervention or independent verification of SO used in terms of purity and potency. Thus, to build a valid conclusion about the efficacy and safety of SO in managing IRP, more high-quality RCTs must be conducted considering an active placebo control intervention along with a well-designed randomization and blinding approach, as well as a better description of safety parameters and the quality control information of the SO used. …”
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Participation in a pre-registration student interprofessional education (IPE) society: influence on subsequent professional practice by Christine Hirsch, Emily Audet, Emily Audet, Ekrahh Dawood, Freya Beardmore, Nafeesa Hussain, Wing Chi Wong, Robert J. Barry, Sharon Buckley

“…Two further themes: time to build relationships; and informality and autonomy, suggested possible reasons for such influence.ConclusionEarly career health professionals considered that participation in the KASE student IPE society helped their transition into the healthcare work environment and encouraged them to adopt a more collaborative and patient-centered approach. …”
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Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…Physical activity data showed a positive trend towards increased activity overall, but no other changes in secondary outcomes were detected.Conclusions To make this intervention feasible for testing as a full trial, further research is required on (a) recruitment optimisation, (b) appropriate assessment tools, (c) protocols for phase 2 and 3, which can build in flexibility and (d) ways for NHS staff to facilitate the programme.Trial registration number ISRCTN52345929; Post-results.…”
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The paediatric liver transplant experience in Johannesburg, South Africa: A broad overview and update by K Kinandu, A Beeton, M Beretta, S Berkenfeld, L Brannigan, R Britz, D Demopoulos, L Doedens, M Duncan, P Gaylard, C Hajinicolaou, W Lowman, H Maher, T De Maayer, V Mudau, S Rambarran, M Reynders, F van der Schyff, B Ströbele, S Tager, E Wessels, J Fabian, J Loveland

“…Since then, significant progress has been made in capacity-building the unit, improving outcomes and enhancing service delivery. …”
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Experiences, perceptions and ethical considerations of the malaria infection study in Thailand by Bhensri Naemiratch, Natinee Kulpijit, Supanat Ruangkajorn, Nicholas P. J. Day, Jetsumon Prachumsri, Phaik Yeong Cheah

“…We found that although compensation was a motivation for participation, this was secondary to it being beneficial to self (health checks; link to health networks; building merit) and others (medical research contribution; altruism). …”
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Chronic lung lesions in COVID-19 survivors: predictive clinical model by Paulo A Lotufo, Juliana C Ferreira, Eloisa Bonfa, Anna S Levin, Rodrigo Caruso Chate, Marta Imamura, Esper G Kallas, Roger Chammas, Thais Mauad, Izabel Marcilio, Nelson Gouveia, Ricardo Nitrini, José Eduardo Krieger, Marcio Valente Yamada Sawamura, Michelle Louvaes Garcia, Cristiano Gomes, Guilherme Fonseca, Jorge Hallak, Luis Yu, Marcio Mancini, Maria Elizabeth Rossi, Thiago Avelino-Silva, Edivaldo M Utiyama, Aluisio C Segurado, Beatriz Perondi, Anna Miethke-Morais, Amanda C Montal, Leila Harima, Marjorie F Silva, Marcelo C Rocha, Maria Amélia de Jesus, Carolina Carmo, Clarice Tanaka, Julio F M Marchini, Thaís Guimarães, Ester Sabino, Carlos Roberto Ribeiro Carvalho, Celina Almeida Lamas, Diego Armando Cardona Cardenas, Daniel Mario Lima, Paula Gobi Scudeller, João Marcos Salge, Cesar Higa Nomura, Marco Antonio Gutierrez, Adriana L Araújo, Bruno F Guedes, Carolina S Lázari, Cassiano C Antonio, Claudia C Leite, Emmanuel A Burdmann, Euripedes C Miguel, Fabio R Pinna, Fabiane Y O Kawano, Geraldo F Busatto, Giovanni G Cerri, Heraldo P Souza, Izabel C Rios, Larissa S Oliveira, Linamara R Batisttella, Luiz Henrique M Castro, Marcello M C Magri, Maria Cassia J M Corrêa, Maria Cristina P B Francisco, Maura S Oliveira, Orestes V Forlenza, Ricardo F Bento, Rodolfo F Damiano, Rossana P Francisco, Solange R G Fusco, Tarcisio E P Barros-Filho, Wilson J Filho

“…Patients with abnormalities in at least one of these parameters underwent chest CT. mMRC scale, SpO2, FVC and CXR findings were used to build a machine learning model for lung lesion detection on CT.Setting A tertiary hospital in Sao Paulo, Brazil.Participants 749 eligible RT-PCR-confirmed SARS-CoV-2-infected patients aged ≥18 years.Primary outcome measure A predictive clinical model for lung lesion detection on chest CT.Results There were 470 patients (63%) that had at least one sign of pulmonary involvement and were eligible for CT. …”
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Mitigation of environmental impacts in ornamental rock and limestone aggregate quarries in arid and semi-arid areas by M.A. Peñaranda Barba, V. Alarcón Martínez, I. Gómez Lucas, J. Navarro Pedreño

“…In the Region of Murcia, in Spain, as well as other Mediterranean areas with similar climatic conditions, there is a great deal of mining activity linked to the building sector, in which mainly ornamental rock (marble and marble limestone) and limestone aggregates are used. …”
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Efek Pemberian Suntikan Subkutan Vitamin C Terhadap Luka Insisi Dermal by Surya Darma, Menker Manjas, Deddy Saputra, Salmiah Agus, Erkadius Erkadius

“…The enzyme functions in hydroxylase process that builds hydroxyproline and hydroxylysine bondsin fibroblast in the synthesis of collagen. …”
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Prediksi Mahasiswa Drop-Out Di Universitas XYZ by Tubagus Ahmad Marzuqi, Evelline Kristiani, Marcel

“…The Random Forest, Gradient Boosting, and Decision Tree algorithms were utilized to evaluate the accuracy of classification models in predicting potential dropouts using academic baseline data. Prior to model building, the SMOTE method was applied to address the issue of imbalanced data. …”
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