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Interpreting IGF-1 in children treated with recombinant growth hormone: challenges during early puberty
Published 2025-01-01“…Levels of estradiol in girls and testosterone in boys were analyzed from previously collected frozen samples.ResultsNine of 58 (15.5%) estradiol samples in girls with Tanner breast stage 1 had pubertal levels of estradiol ≥25 pmol/L. …”
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CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens
Published 2025-02-01“…The molecule, termed mSA2-CD8h-tILCD32B1, was also successfully expressed in T cells, readily and stably bound biotinylated IgG mAbs in vitro and once decorated with the biotin labeled mAbs, conferred the T cells with high adhesiveness to multiple surface-coated antigens. mSA2-CD8h-tILCD32B1 expressing human T cells decorated ex vivo with a biotin-labeled mAb retained the antibody for hours after accumulation inside breast tumors implanted in immunodeficient recipient mice. …”
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Understanding the Molecular Mechanisms of Incomptine A in Treating Non-Hodgkin Lymphoma Associated with U-937 Cells: Bioinformatics Approaches, Part I
Published 2024-12-01“…Also, <b>IA</b> has cytotoxic activity in the triple-negative subtypes, HER2+, and luminal A of breast cancer cells, with its properties being associated with an effect on the antiapoptotic function of Hexokinase II (HKII). …”
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Relationship between mucin gene polymorphisms and different types of gallbladder stones
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Evaluating the effects of dietary glutamine on performance, carcass traits, blood biochemistry, and intestine morphology in laying quail
Published 2025-03-01“…Supplementation with 0.5% Gln significantly enhanced the laying rate after 12 weeks; daily feed intake and feed efficiency varied over time but were not consistently affected by Gln. Breast muscle weight was highest in quail supplemented with 1.5% Gln after 6 weeks. …”
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Dietary calcium intake in primary hyperparathyroidism and in its normocalcemic variant: a case-control study
Published 2025-02-01“…Whether dietary calcium intake might affect the clinical presentation of PHPT or NHPT has never been addressed consistently.ObjectiveTo describe patients with a diagnosis of NHPT or PHPT in relation to their calcium intake, through three standard validated questionnaires; to describe clinical, biochemical and radiological features of NHPT and PHPT patients compared to each other and to a control group.DesignCross-sectional study.SettingOutpatient, single academic medical center.Patients109 consecutive women recruited from February 2021 through April 2023. 54 patients with mild primary hyperparathyroidism (PHPT or NHPT) were age-matched with 55 unselected women undergoing bone density test screening due to recently diagnosed hormone-positive breast cancer. NHPT diagnosis was based on multiple determinations of both total and albumin-corrected serum calcium.InterventionsAdministration of all the following during routine endocrine consultation: a country-specific food-frequency questionnaire (LOC), the International Osteoporosis Foundation Calcium Calculator (IOF) and the National Osteoporosis Foundation calcium questionnaire (NOF).Main outcome measuresAny association between dietary calcium intake and clinical, radiological, or biochemical features.ResultsAll three questionnaires confirmed that NHPT patients had similar calcium intake as those with PHPT or controls. …”
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Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy
Published 2022-03-01“…In vivo antitumor activity was investigated in a triple-negative breast cancer (TNBC) model and primary melanoma tumor model in immunocompromised mice.Results Monoclonal antibody 2D2 identified from phage-displayed library specifically bound to NY-ESO-1157-165 in the context of human leukocyte antigen HLA-A*02:01 but not to non-A2 or NY-ESO-1 negative cells. …”
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Longitudinal Changes in Body Weight of Breastfeeding Mothers in the First Year after Delivery and its Relationship with Human Milk Composition: a Combined Longitudinal and Cross-se...
Published 2024-01-01“…Leptin and adiponectin in breast milk and leptin in plasma are associated with the maternal body composition. …”
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Changes in cancer incidence and stage during the COVID-19 pandemic in 2020–2021 in the Nordic countries
Published 2025-02-01“…Incidence rates also declined in the second pandemic wave (Q1 2021), ranging from –8.6% [–10.2%; –6.9%] (Sweden) to –2.3% [–4.6%; 0.1%] (Norway), and in Sweden also by –3.1% [–4.8%; –1.3%] in the third pandemic wave (Q4 2021). Stage I breast cancer incidence declined during 2020 in Denmark/Norway/Sweden, with some catch-up in stage II incidence in 2021. …”
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Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function
Published 2025-02-01“…The gut and blood-brain barrier are essential components of the microbiota-gut-brain axis and are influenced by diet, particularly in infancy. Breast milk supports gut and brain barrier function, but infant formulas often lack key protective components. …”
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Estimation of mangrove carbon stocks using unmanned aerial vehicle over coastal vegetation
Published 2024-07-01“…Field surveys were conducted to determine the species composition of each mangrove stand and measure their diameter at breast height. The allometric formula was then used to calculate mangrove biomass, which was subsequently converted into carbon stock values. …”
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TP53 germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate
Published 2025-01-01“…Methods TP53 was analyzed in 6161 suspected hereditary cancer non-related patients categorized into three subgroups: (1) 495 patients fulfilling any LFS/Chompret clinical criteria; (2) 2481 patients diagnosed with early-onset breast/colorectal cancer; (3) 3185 patients without clinical criteria suggestive of hTP53rc. …”
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Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens
Published 2025-01-01“…Dietary SEC + SEY and SEY supplementation increased (P < 0.05) Se content in egg yolk and breast muscle compared to CON diet. Dietary SEC, SEY or SEC + SEY supplementation increased (P < 0.05) the activity of antioxidant enzymes (GSH-PX, T-AOC and T-SOD) in the plasma and liver and decreased (P < 0.05) MDA content in the plasma compared to CON diet. …”
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Investigating the Effect of Solanum lycopersicum L. (Tomato) Pomace on Growth Performance and some Blood Indices of Broiler Chickens by Meta-Analysis Method
Published 2024-12-01“…The effect of inclusion of tomato pomace on weight gain during the growth period, feed intake in all periods and FCR in the starter, grower, and finisher period, the blood concentration of triglyceride, glucose, and the percentage of abdominal fat, liver, heart, pancreas and gall bladder, also breast was not significantly affected by tomato pomace. …”
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Derivation of allometric equations and carbon content estimation in mangrove forests of Malaysia
Published 2025-06-01“…We measured 1403 trees across ten species, with Rhizophora apiculata identified as the dominant species. Using diameter at breast height (DBH) and tree height, we developed site species-specific allometric equations to estimate aboveground biomass. …”
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