Showing 1 - 20 results of 638 for search '"brain development"', query time: 0.16s Refine Results
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    Impact of ATF6 deletion on the embryonic brain development by Loc Dinh Nguyen, Ly Huong Nguyen, Dat Xuan Dao, Tsuyoshi Hattori, Mika Takarada-Iemata, Hiroshi Ishii, Takashi Tamatani, Hiroshi Kawasaki, Yohei Shinmyo, Kenta Onoue, Shigenobu Yonemura, Jun Zhang, Masato Miyake, Seiichi Oyadomari, Kazutoshi Mori, Osamu Hori

    Published 2025-06-01
    “…Summary: Although the unfolded protein response (UPR) is activated during brain development, its roles remain unclear. Here, we report that deletion of activating transcription factor 6 (ATF6), consisting of ATF6α and ATF6β, in the developing brain caused microcephaly and neonatal death in mice. …”
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    Transcriptomic sex differences in early human fetal brain development by Federica Buonocore, Jenifer P. Suntharalingham, Olumide K. Ogunbiyi, Aragorn Jones, Nadjeda Moreno, Paola Niola, Tony Brooks, Nita Solanky, Mehul T. Dattani, Ignacio del Valle, John C. Achermann

    Published 2025-04-01
    “…Taken together, our data suggest that limited but potentially important sex differences occur during early human fetal brain development.…”
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    Immunoglobulin superfamily 3 (Igsf3) function is dispensable for brain development by Carolina Cocito, Chaomei Xiang, Meng Huang, Tatyana Gongora, Pallavi Surana, Ramana Davuluri, Nadia Dahmane, Jeffrey P. Greenfield

    Published 2025-02-01
    “…Remaining unexplored is the physiological role of IGSF3 in regulating brain development, including neocortical development. We generated an Igsf3 knockout (KO) mouse using a CRISPR/Cas9-based approach and explored the function of Igsf3 in regulating cortical development. …”
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    Systemic stimulation of TLR2 impairs neonatal mouse brain development. by Xiaonan Du, Bobbi Fleiss, Hongfu Li, Barbara D'angelo, Yanyan Sun, Changlian Zhu, Henrik Hagberg, Ofer Levy, Carina Mallard, Xiaoyang Wang

    Published 2011-05-01
    “…The aim of this study was to investigate the potential effect of a TLR2 agonist on neonatal brain development.<h4>Methodology/principal findings</h4>Mice were injected intraperitoneally (i.p.) once a day from postnatal day (PND) 3 to PND11 with endotoxin-free saline, a TLR2 agonist Pam(3)CSK(4) (5 mg/kg) or Lipopolysaccharide (LPS, 0.3 mg/kg). …”
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    Prenatal environmental exposures and brain development: studies with baboons and other nonhuman primates by Igor Y. Iskusnykh, Shiwani Thapa, Victor V. Chizhikov, Anna N. Bukiya

    Published 2025-08-01
    “…We further examine the impact of environmental insults on fetal brain development, including air pollution, infection, ionizing radiation, and exposure to toxicants, and highlight the ways in which these factors can disrupt brain development and neural circuitry, leading to long-term cognitive and behavioral deficits. …”
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    LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules by Orly Reiner

    Published 2013-01-01
    “…Here, we will review normal processes of brain development and neuronal migration, describe neuronal migration diseases, and will focus on the microtubule-associated functions of LIS1 and DCX, which participate in the regulation of neuronal migration and are involved in the human developmental brain disease, lissencephaly.…”
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    FOXR1 regulates stress response pathways and is necessary for proper brain development. by Andressa Mota, Hannah K Waxman, Rui Hong, Gavin D Lagani, Sheng-Yong Niu, Féodora L Bertherat, Lynne Wolfe, Christine May Malicdan, Thomas C Markello, David R Adams, William A Gahl, Christine S Cheng, Uwe Beffert, Angela Ho

    Published 2021-11-01
    “…Further examination of newborn Foxr1 knockout brains revealed a decrease in cortical thickness and enlarged ventricles compared to littermate wild-type mice, suggesting that loss of Foxr1 leads to atypical brain development. Combined, these results suggest FOXR1 plays a role in cellular stress response pathways and is necessary for normal brain development.…”
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