Association of uveitis with pediatric autoimmune diseases based on a TriNetX study by Alan Y. Hsu, Hou-Ting Kuo, Chun-Ju Lin, Chang-Ching Wei, Ning-Yi Hsia, James Cheng-Chung Wei, Yu-Hsun Wang, You-Ling Li, Chun-Ting Lai, Huan-Sheng Chen, Yi-Yu Tsai

“…Conditions include inflammatory arthritis, systemic autoimmune rheumatic diseases, systemic vasculitis, inflammatory bowel disease, psoriasis, multiple sclerosis, and immune thrombocytopenic purpura. …”
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The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

“…Therefore, this review not only summarizes the immunomodulatory and therapeutic effects of SCO on immune-based inflammatory diseases (IMIDs), such as inflammatory bowel disease, osteoarthritis, allergic rhinitis, acute lung injury, type 1 diabetes and neuroinflammatory diseases etc., but also provides a comprehensive summary of its therapeutic effects on hepatic diseases, including non-alcoholic steatohepatitis, fulminant hepatic failure and hepatic fibrosis. …”
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Polydatin protects against DSS-induced ulcerative colitis via Nrf2/Slc7a11/Gpx4-dependent inhibition of ferroptosis signalling activation by Shimin Zheng, Jianbin Yin, Bingbing Wang, Qiujuan Ye, Jialuo Huang, Xinzhi Liang, Junfeng Wu, Hui Yue, Ting Zhang

“…IntroductionUlcerative colitis (UC), a form of inflammatory irritable bowel disease, is characterized by a recurrent and persistent nonspecific inflammatory response. …”
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Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPARα by Bianca Knoch, Matthew P. G. Barnett, Janine Cooney, Warren C. McNabb, Diane Barraclough, William Laing, Shuotun Zhu, Zaneta A. Park, Paul MacLean, Scott O. Knowles, Nicole C. Roy

“…The interleukin-10 gene-deficient (Il10-/-) mouse is a model of human inflammatory bowel disease and Ppara has been identified as one of the key genes involved in regulation of colitis in the bacterially inoculated Il10-/- model. …”
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Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

“…Xiping Liao,1,2 Hengqian Liu,3 Yuanyuan Li,1,4 Wei Zhang,1 Qian Dai,1 Haoqi Wei,5 Jianyun Zhou,1 Xia Xie,2 Hongli Zhou1 1Clinical Medical Research Center, The Second Affiliated Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of Gastroenterology, The Second Affiliated Hospital, Army Medical University, Chongqing, People’s Republic of China; 3School of Medicine, Chongqing University, Chongqing, People’s Republic of China; 4Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center, Ministry of Education of the People’s Republic of China, Chongqing, People’s Republic of China; 5Department of General Surgery, The PLA 77th Group Army Hospital, Leshan City, People’s Republic of ChinaCorrespondence: Xia Xie, Department of Gastroenterology, The Second Affiliated Hospital, Army Medical University, No. 83 Xinqiao Main Street, Shapingba District, Chongqing, 400037, People’s Republic of China, Email xiexia0128@tmmu.edu.cn Hongli Zhou, Clinical Medical Research Center, The Second Affiliated Hospital, Army Medical University, No. 83 Xinqiao Main Street, Shapingba District, Chongqing, 400037, People’s Republic of China, Email zhouhongli@tmmu.edu.cnBackground: Inflammatory bowel disease (IBD) comprises a group of autoimmune disorders characterized by chronicity and resistance to cure, with an unknown etiology. …”
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Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders by Huanxin Ding, Yue Jiang, Qing Sun, Yingchao Song, Shuohui Dong, Qian Xu, Linzehao Li, Chuxuan Liu, Bingjun Li, Hengxuan Jiang, Bichen Peng, Shi Peng, Chumeng Zhang, Jiankang Zhu, Mingwei Zhong, Guangyong Zhang, Xiao Chang

“…Significant genetic correlations were found between these disorders, especially in irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), depression (DEP), and neuroticism (NE). …”
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Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis by Liming Liu, Cuiqing Zhao, Ying Yang, Xiaoxia Kong, Tuo Shao, Li Ren, Xinyu Zhuang, Baishuang Yin, Gerald Dryden, Craig McClain, Weimin Luan, Wenke Feng

“…Nutrient deficiencies are common in patients with inflammatory bowel disease (IBD). Adipose tissue plays a critical role in regulating energy balance. …”
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Lethal necrotizing granulomatous vasculitis after bariatric surgery and bilateral mammaplasty by O. V. Blagova, D. Kh. Aynetdinova, A. V. Nedostup, N. A. Novikova, Ye. A. Kogan, Yu. V. Lerner, L. V. Kozlovskaya, V. V. Rameyev, N. A. Mukhin

“…Autopsy revealed the signs of vasculitis with involvement of the brain, skin, mediastinal lymphnodes, lungs, as well as the signs of chronic inflammation, atrophy of breast gland lobules, embolization of the focal lymphatics by the implant substance, ulceronecrotic enteritis of defunctioning bowel, severe liver steatosis with the chronic vitamin deficiency. …”
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Mendelian randomization analysis does not support a causal influence between lipoprotein(A) and immune-mediated inflammatory diseases by Yun Ti, Dan Xu, Xiaoning Qin, Yang Hu, Yuru Xu, Qingzhao Zhao, Peili Bu, Jingyuan Li

“…We performed a bidirectional two-sample mendelian randomization analyses based on genome-wide association study (GWAS) summary statistics of Lp(a) and nine IMIDs, specifically celiac disease (CeD), Crohn’s disease (CD), ulcerative colitis (UC), inflammatory bowel disease (IBD), multiple sclerosis (MS), psoriasis (Pso), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), and summary-level data for lipid traits. …”
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Altered functional network topology properties to detect anxiety and depression caused by Crohn’s disease and disease severity by Jiaxing Yang, Kechen Yue, Jingwen Sun, Changjie Pan, Xintong Wu, Yongjun Cheng, Xiaomeng Wu, Haifeng Shi

“…Methods: In total, 31 individuals with CD, 21 with irritable bowel syndrome (IBS), and 20 healthy controls underwent functional magnetic resonance imaging. …”
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Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway by Yumei Rong, Yumei Rong, Yumei Rong, Yumei Rong, Yumei Rong, Minghui Zhu, Minghui Zhu, Minghui Zhu, Minghui Zhu, Nan Wang, Nan Wang, Nan Wang, Nan Wang, Feiyu Zhang, Feiyu Zhang, Feiyu Zhang, Feiyu Zhang, Tianjun Liu

“…IntroductionUlcerative colitis (UC) is an inflammatory bowel disease characterized by inflammation and ulceration of the digestive tract.MethodsPhotodynamic therapy (PDT) with a novel photosensitizer LD4 was used to treat UC rat models to explore the therapeutic effect and mechanism of LD4-PDT on UC. 16S ribosomal RNA was used to detect the composition of Gut microbiota.ResultsOur findings indicate that LD4-PDT could protect the integrity of the colonic mucosa, alleviate the inflammatory response and promote the healing of colonic mucosa. …”
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Duodenal obstruction due to two congenital bands: a case report and literature review by Shiqiu Xiong, Kuku Ge, Chongzhi Hou, Hongbin Yang, Hanhua Zhang, Sheng Zhang, Bailing Liu, Yuewen Hao, Ying Fang, Xiaoxia Ren

“…Physical examination revealed abdominal tenderness and decreased bowel sounds. Contrast x-ray showed an obstructed passage of contrast through the third part of the duodenum. …”
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A comparative study between condensed polytetrafluoroethylene mesh versus other composite meshes in Endo-laparoscopic ventral herniorrhaphy by Meredeth Chin, James Lee Wai Kit, Sujith Wijerathne, Avelyn Aw, Daryl Chia Kai Ann, Sean Lee Kien Fatt, Tharun Ragupathi, Harry Ng Ho Man, Davide Lomanto

“…In intra-peritoneal onlay method (IPOM) a dual layer composite mesh with an absorbable barrier on the visceral surface is used for minimising bowel adhesions. Three most popular prosthetic mesh scaffolds are polypropylene (PP), polyester and expanded polytetrafluoroethylene (ePTFE). …”
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Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy by Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young

“…They also exacerbate pre-existing health issues, such as depression and inflammatory bowel disease. The normal inflammatory response to acute infection displays remarkable circadian rhythmicity in humans with increased inflammatory activity during the normal night or rest period. …”
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Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status by S. Nooij, N. Plomp, I. M. J. G. Sanders, L. Schout, A. E. van der Meulen, E. M. Terveer, J. M. Norman, N. Karcher, M. F. Larralde, R. H. A. M. Vossen, S. L. Kloet, K. N. Faber, H. J. M. Harmsen, G. F. Zeller, E. J. Kuijper, W. K. Smits, Q. R. Ducarmon

“…By surveying 12,791 gut metagenomes, we recapitulated known associations with metabolic diseases and inflammatory bowel disease. We uncovered a higher prevalence and abundance of R. gnavus in Westernized populations and observed bacterial relative abundances up to 83% in newborns. …”
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Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…It was delivered in three face-to-face counselling sessions (plus nine phone calls) by lifestyle coaches over three phases (1: presurgery, 2: surgical recovery and 3: post-treatment recovery).Primary outcome Feasibility measures (recruitment, retention, programme implementation, achieved measures, fidelity, factors affecting protocol adherence and acceptability).Secondary outcomes Measured changes in body weight, waist circumference, walking and self-reported physical activity, diet, smoking, alcohol intake, fatigue, bowel function and quality of life.Results Of 84 patients diagnosed, 22 (26%) were recruited and 15 (18%) completed the study. …”
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Correction of Dysbiosis in Diversion Proctitis: Possibilities of Intraluminal Sanitation and the Prevention of Complications after Reconstructive Surgery by V. S. Groshilin, D. V. Martynov, Yu. L. Naboka, M. Yu. Bakulyarov, G. A. Mrykhin

“…Pronounced dysbiotic changes, the progression of catarrhal or erosive diversion colitis and proctosigmoiditis are the risk factors for anastomotic leakage and postoperative bowel dysfunction. This determines the need for a therapeutic algorithm of intestine sanitation and the introduction of methods for preventing the anastomotic leakage after obstructive resection of the distal colon (Hartmann’s operation). …”
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Imbalance of Microbacterial Diversity Is Associated with Functional Prognosis of Stroke by Xintong Zhang, Xiangyu Wang, Hong Zhao, Risheng Cao, Yini Dang, Binbin Yu

“…In addition, the Neurogenic Bowel Dysfunction score (r=0.495, P=0.026), Barthel index (r=−0.531, P=0.015), Fugl-Meyer Assessment score (r=−0.565, P=0.009), Visual Analogue Scale score (r=0.605, P=0.005), and Brief Pain Inventory score (r=0.507, P=0.023) were significantly associated with alterations of distinctive gut microbiota. …”
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Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis by Shuji Kanmura, Akihito Tanaka, Kazuki Yutsudou, Kosuke Kuwazuru, Fukiko Komaki, Yuga Komaki, Hiromichi Iwaya, Shiho Arima, Fumisato Sasaki, Shiroh Tanoue, Shinichi Hashimoto, Akio Ido

“…Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology. Recently, mucosal healing has emerged as an important therapeutic endpoint in UC. …”
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Safety and feasibility evaluation of a novel robotic surgical system in gynecological surgery application by Yuanbo Tao, Jun Wang, ShiChao Han, Jing Na, Ya Li

“…The average surgical time was (134.15 ​± ​82.44) min, the average intraoperative blood loss was (29.16 ​± ​29.35) mL, the average time for postoperative bowel motility recovery was (27.0 ​± ​11.5) h, and the average hospital stay after surgery was (3.1 ​± ​1.3) d. …”
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