Safety Profile of the New 5-ASA Based Compounds by Vinod K Sharma

“…Diarrhea is more common with olsalazine, and it is due to the effect of olsalazine itself on the small bowel. not the 5-ASA component. There are case reports of pancreatitis, pericarditis and bronchospasm, retrosternal chest pain, mild neutropenia, nephrotic syndrome and hair loss associated with 5-ASA treatment. …”
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Portulaca oleracea L. (purslane) extract ameliorates intestinal inflammation in diet-induced obese mice by inhibiting the TLR4/NF-κB signaling pathway by Lingchao Miao, Meng Sam Cheong, Haolin Zhang, Haroon Khan, Haroon Khan, Hongxun Tao, Yuxiao Wang, Wai San Cheang

“…Chronic oral administration of purslane extract ameliorated colon shortening syndrome and reduced bowel inflammation in HFD-induced obese mice through suppression of the toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling pathway to downregulate TLR4, myeloid differentiation factor 88 (MyD88), Ser32 phosphorylation of NF-κB inhibitor alpha (IκBα), and Ser536 phosphorylation of NF-κB p65 expression levels, thereby inhibiting the pro-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels.ConclusionThe present study supports the anti-inflammatory potential of purslane extract for modulating bowel inflammation under obesity through inhibition of the TLR4/NF-κB signaling pathway.…”
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Short- and Long-term Outcomes of One-stage Radical Resection and Anastomosis without Preoperative Decompression and Diverting Stoma between Incomplete Obstructive and Non-obstructi... by Kentaro Sato, Yosuke Fukunaga, Manabu Takamatsu, Tatsuki Noguchi, Takashi Sakamoto, Shimpei Matsui, Toshiki Mukai, Tomohiro Yamaguchi, Takashi Akiyoshi

“…This management strategy appears feasible and safe with appropriate preoperative bowel preparation.…”
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Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients by Sanja Dragasevic, Aleksandra Sokic-Milutinovic, Milica Stojkovic Lalosevic, Tamara Milovanovic, Srdjan Djuranovic, Ivan Jovanovic, Sanja Rajic, Mirjana Stojkovic, Biljana Milicic, Stefan Kmezic, Branislav Oluic, Marko Aleksic, Aleksandra Pavlovic Markovic, Dragan Popovic

“…Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. …”
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Efficacy and Prognostic Factors for Y-90 Radioembolization (Y-90) in Metastatic Neuroendocrine Tumors with Liver Metastases by Erica S. Tsang, Jonathan M. Loree, Janine M. Davies, Sharlene Gill, David Liu, Stephen Ho, Daniel J. Renouf, Howard J. Lim, Hagen F. Kennecke

“…The primary location of the NET included pancreas (31%), small bowel (41%), large bowel (6%), unknown (14%), and others (12%). 69% of these patients had liver metastases alone, and tumors were graded as G1 (61%), G2 (25%), G3 (2%), and unknown (12%). …”
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Twenty years’ experience of midgut malrotation and volvulus in a tertiary center in northern Taiwan: A retrospective study by Wen-Yu Tseng, Ming-Wei Lai, Jin-Yao Lai, Chien-Chang Chen, Hsun-Chin Chao, Jeng-Chang Chen, Shih-Yen Chen, Yung-Ching Ming, Hung-Yu Yeh, Hung-Hsiang Lai, Sze-Ya Ting, Pai-Jui Yeh

“…Background: Early diagnosis and surgical intervention for midgut malrotation with bowel obstruction are crucial. We aimed to identify risk factors for adverse outcomes in infants with midgut malrotation and to develop a prediction model. …”
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QALYs: The Math Doesn’t Work by Tia G. Sawhney, Angela Dobes, Sirimon O'Charoen

“…Furthermore, our review of the mathematical properties of QALYs, including an analysis of quality-of-life utility (QOL utility) data recently collected from patients with inflammatory bowel disease (IBD), has led us to conclude that QALYs are an inappropriate metric of drug and treatment cost-effectiveness for all people, both disabled and nondisabled, and should not be the basis for US healthcare policy decisions.…”
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Inflammasome in Intestinal Inflammation and Cancer by Tiago Nunes, Heitor S. de Souza

“…In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer. Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens.…”
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A 26-Year-Old Retained Demised Abdominal Pregnancy Presenting with Umbilical Fistula by Nnadi Daniel, Bello Bashir, Ango Ibrahim, Singh Swati

“…She subsequently had exploratory laparotomy, evacuation of the abdominal pregnancy, hysterectomy, and bowel resection. The patient’s condition remained unstable throughout the postoperative period and she died from septicemia on the eleventh day.…”
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Cerebral Arterial Thrombosis in Ulcerative Colitis by Giovanni Casella, Claudio Camillo Cortelezzi, DeLodovici Marialuisa, Princiotta Cariddi Lucia, Verrengia Elena Pinuccia, Vittorio Baldini, Sergio Segato

“…Thrombosis, mainly venous, is a rare and well-recognized extraintestinal manifestation of inflammatory bowel disease (IBD). We describe a 25-year-old Caucasian man affected by ulcerative colitis and sclerosing cholangitis with an episode of right middle cerebral arterial thrombosis resolved by intraarterial thrombolysis. …”
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Congenital Tufting Enteropathy, a Rare Cause of Diarrhea and Malnourishment in Arab Child with Genetic and Histopathology Investigations by Shooq Alkhalifa, Aysha Darwish, Mohamed Awadh, Salman M. Alkhalifa, Abdulla Darwish

“…It is a rare congenital enteropathy that presents in early infancy as an intractable diarrhea that is independent of breast formula feeding that requires life-long total parental nutrition (TPN) to acquire adequate calories and fluid intake or small bowel transplantation in severe cases. Here, we report a case of intestinal failure due to congenital tufting enteropathy in a 3-year-old girl who presented with loose stools and failure to thrive. …”
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Medical Therapy of Steroid-Resistant Crohn's Disease by Bruce E Sands

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A 41-Year-Old Patient with a Rare Cause of Severe Abdominal Sepsis Misdiagnosed as PID by Anastasia Mikuscheva, David Becker, Mark Thompson-Fawcett

“…Here, we present a case of a 41-year-old woman who was misdiagnosed with infectious pelvic inflammatory disease and treated ineffectively with antibiotics when the underlying condition of her persistent abdominal pain was a midgut neuroendocrine tumor that had caused bowel perforation and formation of an abscess in the pouch of Douglas.…”
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Strangulated Morgagni’s Hernia: A Rare Diagnosis and Management by Malav Modi, Amit Kumar Dey, Ajay Mate, Samir Rege

“…An exploratory laparotomy was performed with resection of the ischemic bowel segment with anastomosis and a primary repair of the diaphragmatic defect. …”
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Futuristic Developments and Applications in Endoluminal Stenting by Joel Ferreira-Silva, Renato Medas, Mohit Girotra, Monique Barakat, James H. Tabibian, Eduardo Rodrigues-Pinto

“…Our discussion specifically focuses on (i) biodegradable as well as (ii) irradiating and drug-eluting stents for esophageal, gastroduodenal, biliary, and colonic indications, (iii) endoscopic stenting in inflammatory bowel disease, and (iv) lumen-apposing metal stent.…”
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What is true and what is new in esophageal microbiome in 2024? by M. Jauvain, E. Bessède

“…While the microbiota in the lower tract of the intestine, namely the small and large bowel, has been the core of scientific interest over the last 20 years, the resident microbial flora of the esophagus and its potential role in the pathogenesis of esophageal diseases have been neglected. …”
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Neurilemoma of the small intestine (<i>Clinical case presentation</i>) by I. D. Kalganov, A. P. Zhuchenko, I. V. Zarodnyuk, Ye. V. Markova

“…To draw attention of specialists to rare neoplastic bowel diseases.Original points. Article presents the case of small intestinal neurilemoma in 69 years-old woman with incidental abdominal pain. …”
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Fulminant Pseudomembranous Colitis Presenting as Sigmoid Stricture and Severe Polyposis with Clinical Response to Intracolonic Vancomycin by Sai Wah Cheung, Kin Kong Li

“…Severe diseases carry significant morbidities such as septic shock, acute kidney injury, bowel perforation, and mortality. Immunocompromising conditions increase the risk of developing the disease but whether these individuals suffer a more fulminant course or warrant a more potent first-line treatment is still controversial issue. …”
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The Enteric Nervous System in Intestinal Inflammation by Keith A Sharkey, Edward J Parr

“…Since about the 1950s nerves in the wall of the intestine have been postulated to play a role in the pathogenesis of inflammatory bowel disease (IBD). Human and animal studies examining the role of nerves in intestinal inflammation are the focus of this review. …”
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Effects of Anti-Cytokine Antibodies on Gut Barrier Function by Fang Liu, Seul A. Lee, Stephen M. Riordan, Li Zhang, Lixin Zhu

“…Anti-cytokine antibodies are used in treating chronic inflammatory diseases and autoimmune diseases such as inflammatory bowel disease and rheumatic diseases. Patients with these diseases often have a compromised gut barrier function, suggesting that anti-cytokine antibodies may contribute to the re-establishment of gut barrier integrity, in addition to their immunomodulatory effects. …”
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