Levo-Tetrahydropalmatine Attenuates Bone Cancer Pain by Inhibiting Microglial Cells Activation by Mao-yin Zhang, Yue-peng Liu, Lian-yi Zhang, Dong-mei Yue, Dun-yi Qi, Gong-jian Liu, Su Liu

“…The present study is to investigate the analgesic roles of L-THP in rats with bone cancer pain caused by tumor cell implantation (TCI). …”
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The Impact of Metastatic Bone Cancers on Serum Calcium Levels: A Focused Analysis of Patient Outcomes by Muhammad Khizar Memon, Syed Uzair Mahmood, Sidra Memon, Azhar Rashid, Muhammad Ali Memon, Shahzad Ali Jiskani

Subjects: “…Metastatic Bone Cancer…”
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Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer pain by Liqun Duan, Qianliang Wang, Jianpeng Chen, Zelin Fan, Wenzhi Zhang, Jun Yan

Subjects: “…Bone cancer pain…”
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ZC3H15 suppression ameliorates bone cancer pain through inhibiting neuronal oxidative stress and microglial inflammation by Li-Quan Huang, Ting-Xuan Yan, Bao-Sheng Wang, Hao Li, Nai-Bao Zhou

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Inducible Lentivirus-Mediated siRNA against TLR4 Reduces Nociception in a Rat Model of Bone Cancer Pain by Ruirui Pan, Huiting Di, Jinming Zhang, Zhangxiang Huang, Yuming Sun, Weifeng Yu, Feixiang Wu

“…Although bone cancer pain is still not fully understood by scientists and clinicians alike, studies suggest that toll like receptor 4 (TLR4) plays an important role in the initiation and/or maintenance of pathological pain state in bone cancer pain. …”
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Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord by Guiqin Zhu, Yanbin Dong, Xueming He, Ping Zhao, Aixing Yang, Rubing Zhou, Jianhua Ma, Zhong Xie, Xue-Jun Song

“…Radiotherapy is one of the major clinical approaches for treatment of bone cancer pain. Activation of cAMP-PKA signaling pathway plays important roles in bone cancer pain. …”
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JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation by Shuyan Wu, Jundan Jiang, Danfeng Wang, Daoyi Lin, Mingxue Lin, Pinzhong Chen, Jianghu Chen, Honghong Zhang, Ying Wang, Xiaohui Chen, Xiaochun Zheng

Subjects: “…Bone cancer pain…”
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Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-γ to Inhibit the NF-κB/NLRP3 Inflammatory Axis in Spinal Cord Neurons by Jie Fu, Baoxia Zhao, Chaobo Ni, Huadong Ni, Longsheng Xu, Qiuli He, Miao Xu, Chengfei Xu, Ge Luo, Jianjun Zhu, Jiachun Tao, Ming Yao

“…Bone cancer pain (BCP) is a serious clinical problem that affects the quality of life of cancer patients. …”
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Novel Approaches to Monitor Pharmacokinetics and Metabolism of Gemcitabine-Ibandronate Conjugate in Mice and Dogs by Jost Klawitter, Mckay Easton, Alexander Karpeisky, Kristen B. Farrell, Douglas H. Thamm, Touraj Shokati, Uwe Christians, Shawn Patrick Zinnen

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A new effLuc/Kate dual reporter allele for tumor imaging in mice by Latifa Bakiri, Mélanie Tichet, Carolina Marques, Martin K. Thomsen, Elizabeth A. Allen, Stefanie Stolzlechner, Ke Cheng, Kazuhiko Matsuoka, Massimo Squatrito, Douglas Hanahan, Erwin F. Wagner

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‘If I Can, We Can’ by Jennifer N. Fish

“…For 52 years she advocated for the rights of domestic workers, upholding her presidency in both South Africa’s national union of domestic workers and the International Domestic Workers Federation, throughout her struggle with a rare form of bone cancer. Ms. Witbooi’s experience as a domestic worker under apartheid guided her life on the front lines of both a national and global movement to recognise and protect women once considered ‘servants’ without rights. …”
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P2X7 Receptor Function in Bone-Related Cancer by Elena Adinolfi, Francesca Amoroso, Anna Lisa Giuliani

“…Taken together these data point to a pivotal role for the P2X7 receptor in bone cancer biology.…”
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Relaxin inhibits 177Lu-EDTMP associated cell death in osteosarcoma cells through notch-1 pathway by Xu Junhua, Wan Song, Chen Wei, Zhang Yi, Ji Zhenzhong

“…177Lu-EDTMP (Ethylenediamine tetramethylene phosphonic acid) is the most used radioactive agent for pain palliation in bone cancer patients. The present study aims to study the impact of relaxin-2 on the 177Lu-EDTMP associated cell toxicity and death in osteosarcoma cells. …”
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Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy by Fangzhou He, Jiuhui Xu, Fanwei Zeng, Boyang Wang, Yi Yang, Jie Xu, Xin Sun, Tingting Ren, Xiaodong Tang

“…Abstract Background Ewing’s sarcoma (EwS), a common pediatric bone cancer, is associated with poor survival due to a lack of therapeutic targets for immunotherapy or targeted therapy. …”
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A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma by Shihao Li, Lina Zhang, Haiyang Zhang

“…ObjectiveOsteosarcoma is the most common primary bone cancer with a high propensity for local invasion and metastasis. …”
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The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma by Shahid Banday, Alok K. Mishra, Romana Rashid, Tianyi Ye, Amjad Ali, Junhui Li, Jason T. Yustein, Michelle A. Kelliher, Lihua Julie Zhu, Sara K. Deibler, Sunil K. Malonia, Michael R. Green

“…Abstract Ewing sarcoma (ES) is an aggressive bone cancer driven by the oncogenic fusion-protein EWSR1::FLI1, which is not present in normal cells and is therefore an attractive therapeutic target. …”
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An Unusual Cervical Mass in the Hyoid Bone: Intermediate-Grade Chondrosarcoma by Ozge Caglar, O. Karatag, A. Avci, Sefa Dereköy

“…Chondrosarcomas account for 11% of all bone cancers. Primary sites of the head and the neck include the nasal cavity, the skull base, the maxilla, the mandible. …”
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Therapeutic Mechanism and Effect of Camptothecin on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice by Yizhuo Wang, Kunjian Liu, Zhiyong Qi, Tong Chen, Wei Yu, Yang Jiang, Guofeng Li, Huijie Xiao

“…It possesses various antitumor activities and is mainly used in the treatment of colon, ovarian, liver, and bone cancers as well as leukemia. CPT inhibits the expressions of inflammatory genes and can prevent death from chronic inflammation. …”
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THE RESULTS OF MODULAR ENDOPROSTHESIS OF PERIACETABULAR REGION IN TUMOR LESIONS OF THE ACETABULUM AND HIP JOINT by G. D. Iluridze, V. Yu. Karpenko, V. A. Derzhavin, A. V. Bukharov

“…The median age was 45 years (23–63 years). Primary bone cancers were in 19 (63%) patients, giant cell tumors in 5 (17%), locally advanced soft tissue sarcoma in 1 (3%), solitary metastases of kidney cancer in 2 (7%), and recurrent sarcomas after previous surgical treatment in 3 (10%) patients.Results. …”
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