Physiochemical and functional evaluation of the first-in-class anti-cancer IgE antibody drug, MOv18, through process development and good manufacturing practice production by Heather J Bax, Jitesh Chauhan, Alexandra J McCraw, Melanie Grandits, Chara Stavraka, Heike Lentfer, Tim Hillyer, Simon Carroll, Kim Vigor, Chris Selkirk, Mariangela Figini, Jack Cheeseman, Paulina A Urbanowicz, Richard A Gardner, Daniel I R Spencer, Nigel Westwood, Sarah Mellor, James Spicer, Debra H Josephs, Sophia N Karagiannis

“…During the process development and scaled Good Manufacturing Practice production, we demonstrate the retention of glycosylation state, biophysical profile, and functional characteristics of MOv18 IgE, including Fc-mediated mast cell degranulation and tumor cell killing. …”
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LAND SUITABILITY ASSESSMENT FOR SOYBEAN (GLYCINE MAX) IN BARDAGHAT MUNICIPALITY USING GIS TECHNIQUES by Birendra Tiwar, Amrit Dumre, Mahesh Jaishi

“…The research employed a comprehensive methodology, combining Pair-wise Comparison Matrix (PWCM) and Weighted Multi-Criteria Analysis via Analytical Hierarchy Process (AHP) to consider various biophysical criteria. Thematic maps were generated using Remote Sensing, Geostatistics, and Geographic Information Systems (GIS). …”
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Truffle Species Discrimination Based on Their Chemical Composition, Chromaticity Coordinates and Antioxidant Capacity by Cristina Valencia-Sullca, Anja Rakotondramavo, Catherine Verret, Jean-Philippe Blondeau, Sullivan Renouard

“…Total phenolic content and antioxidant capacity analyses allowed to discriminate most of the six-truffle species but not each of the species. Thus, biophysical approaches and, to a lesser extent, the antioxidant activity assays, and total phenolic content are credible means of identifying truffle species found in France.…”
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Soil Physicochemical Properties Variation under Annual Crop and Coffee Landuse in the Chentale Watershed, Upper Blue Nile Basin, Ethiopia by Feven Azene Tebekew, Teshome Betru Tadesse, Desta Adane Alemu, Amsalu Awoke Ayalew

“…In this line, several studies were conducted to enable informed decisions; however, monitoring soil property dynamics in different biophysical, climatic, and cropping systems is yet to be adequate to support and influence decision and policymakers. …”
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Synthesis, Characterization, and Application of Fe2O3 Nanophotocatalyst for the Treatment of Various Pollutants in Aqueous Phase: A Systematic Review by Aya Khalaf, Duaa Abu-Dalo, Ehab AlShamaileh

“…Many techniques are used for the treatment of wastewater, including physical, chemical, biological, physiochemical, and biophysical methods. Advanced oxidation processes (AOPs), a chemical approach, are a key procedure for wastewater treatment. …”
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Navigating dynamics of farm household livelihood vulnerability to climate-related risks in southern Ethiopia: An agroecology-based comparative analysis by Daniel Dalle, Yishak Gecho, Sisay Belay Bedeke

“…Secondary data, notably climatic data, was accessed for the years 1991 to 2022. Data on biophysical features were also collected and incorporated into indices. …”
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Integrating cellular automata Markov model to simulate future land use change of a tropical basin by M. Camara, N.R.B. Jamil, A.F.B. Abdullah, R.B. Hashim

“…The study however, suggests future research to integrate geospatial techniques with biophysical and socio-economic factors in simulating land use trends.…”
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Study on SHP2 Conformational Transition and Structural Characterization of Its High-Potency Allosteric Inhibitors by Molecular Dynamics Simulations Combined with Machine Learning by Baerlike Wujieti, Mingtian Hao, Erxia Liu, Luqi Zhou, Huanchao Wang, Yu Zhang, Wei Cui, Bozhen Chen

“…Meanwhile, we explored the free energy landscape of SHP2 activation using enhanced sampling technique (meta-dynamics simulations), which provides insights into its conformational changes and activation mechanism. Furthermore, to biophysically interpret high-dimensional simulation trajectories, we employed interpretable machine learning methods, specifically extreme gradient boosting (XGBoost) with Shapley additive explanations (SHAP), to comprehensively analyze the simulation data. …”
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SISTEMAS FISIOGRÁFICOS DEL ÁREA NATURAL PROTEGIDA “VALLE CRETÁCICO”, PROVINCIA DE RÍO NEGRO by Romina Solorza, Marcos D. Mare

“…This paper is a revised and shortened version of the biophysical studies of carried out as a part of the interdisciplinary technical reports for the "Management Plan of the Protected Natural Area (PNA) Cretaceous Valley" of the Rio Negro Province. …”
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Assessing vulnerability and climate risk to agriculture for developing resilient farming strategies in the Ganges Delta by Uttam Kumar Mandal, Fazlul Karim, Yingying Yu, Amit Ghosh, Taslima Zahan, Sonali Mallick, Mohammad Kamruzzaman, Priya Lal Chandra Paul, Mohammed Mainuddin

“…Through an extensive literature review, 18 biophysical and socio-economic variables were identified as critical and policy-relevant, including three related to exposure and 15 to vulnerability. …”
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Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (H... by Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink, Stephan Scheidegger

“…In this context, in-silico biophysical models that translate deviations in the treatment conditions into clinical outcome variations may be used to study the extent of such processes and their influence on combined hyperthermia plus radiotherapy (HT + RT) treatments under varying conditions.Methods An extended linear-quadratic model calibrated for SiHa and HeLa cell lines (cervical cancer) was used to theoretically study the impact of varying HT treatment conditions on radiosensitization and direct HT cell killing effect. …”
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Influence of Polymorphism on Glycosylation of Serum Amyloid A4 Protein by Toshiyuki Yamada, Jyunji Sato, Kazuhiko Kotani, Masafumi Tanaka

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Land Use/Land Cover Change and Its Driving Forces in Shenkolla Watershed, South Central Ethiopia by Belayneh Bufebo, Eyasu Elias

“…Agricultural expansion, policy change and social unrest, population pressure, shortage of farm land, and biophysical factors were major driving forces of the LU/LC changes. …”
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A Clinically-Reasoned Approach to Manual Therapy in Sports Physical Therapy by Steven Short, Matthew Tuttle, Dillon Youngman

“…Given the risks associated with pharmacological pain management, the cost of passive modalities like biophysical agents (electrical stimulation, photobiomodulation, ultrasound, etc), and the indications from the evidence-base when combined with active therapies, manual therapy can be a safe and effective treatment strategy to keep athletes active…”
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Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3 by Alexander J. D. Snow, Tharushi Wijesiriwardena, Benjamin J. Lane, Brendan Farrell, Polly C. Dowdle, Matilda Katan, Stephen P. Muench, Alexander L. Breeze

“…Abstract Despite their high clinical relevance, obtaining structural and biophysical data on transmembrane proteins has been hindered by challenges involved in their expression and extraction in a homogeneous, functionally-active form. …”
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The effects of vessel speed and size on the lethality of strikes of large whales in U.S. waters by Lance P. Garrison, Niki E. Lisi, Meghan Gahm, Eric M. Patterson, Hannah Blondin, Hannah Blondin, Caroline P. Good

“…The model is consistent with biophysical models that demonstrate a high rate of strike lethality for large vessels with high masses. …”
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AI-powered estimation of tree covered area and number of trees over the Mediterranean island of Cyprus by Anna Zenonos, Sizhuo Li, Martin Brandt, Jean Sciare, Philippe Ciais

“…Trees play a crucial role in mitigating climate change by absorbing CO2 and providing biophysical cooling. The European Commission’s climate policies underscore the importance of forest monitoring systems to achieve substantial greenhouse gas reductions by 2030. …”
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A multivalent binding model infers antibody Fc species from systems serology. by Armaan A Abraham, Zhixin Cyrillus Tan, Priyanka Shrestha, Emily R Bozich, Aaron S Meyer

“…Systems serology aims to broadly profile the antigen binding, Fc biophysical features, immune receptor engagement, and effector functions of antibodies. …”
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Performance of vermicomposted wastes for tomato (Lycopersicon Esculentum Mill.), production: A case study of Embu, Kenya by Miriam Mochache, Rebecca Yegon, Onesmus Ngetich

“…Data obtained were analyzed using SAS version 9.4 by subjecting to one-way Analysis of Variance (ANOVA). Biophysical crop data means were separated using Tukey’s Studentized Range (HSD) test at p=0.05 significance level. …”
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Major individual and regional variations in unit entrainment by oscillations of different frequencies by Mohamed Badawy, Ian T. Kim, Alon Amir, Mohammad M. Herzallah, Luisa F. Gomez-Alatorre, Drew B. Headley, Denis Paré

“…In contrast, network activity in vivo can entrain neurons to rhythms that their biophysical properties do not predispose them to favor. …”
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