An artificial transcription factor that activates potent interferon-γ expression in human Jurkat T Cells by Ashley King, Davis Noblitt, Olivia Sherron, Olivia Sherron, Clara Kjerfve, Lydia Pless, Nicholas L. Truex

“…Biological studies with human Jurkat T cells reveal that the ATF amplifies IFNG gene transcription and translation, and also stimulates gene transcription for multiple class I and II HLA alleles and interferon-stimulated genes (ISGs). Biophysical characterization showed the recombinant ATF protein recognizes the human IFNG gene with nanomolar affinity (KD = 5.27 ± 0.3 nM), adopts a protein secondary structure associated with the ββα-fold of zinc finger domains, and is resistant to thermal denaturation. …”
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Spatial Dynamics and Risk Mapping of Forest Fires in Madhesh Province, Nepal: A Multi-Criteria Decision Approach by Gunjan Adhikari, Khagendra Prasad Joshi, Dristee Chad, Ashish Ghimire, Sandeep Mahara

“…Following the analytic hierarchy process (AHP) approach, this research investigates topographic, climatic, biophysical, and anthropogenic variables to create a fire risk map. …”
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Effects of Deer Settling Stimulus and Deer Density on Regeneration in a Harvested Southern New England Forest by Kevin J. Barrett, Oswald J. Schmitz

“…However, there is growing evidence that the biophysical conditions of a forest that make it attractive to deer may be a contributing factor in determining browsing levels. …”
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Prospective de novo drug design with deep interactome learning by Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F. Nippa, Michael Iff, Jann Ledergerber, Carl C. G. Schiebroek, Valentina Romeo, Jan A. Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider

“…The top-ranking designs are chemically synthesized and computationally, biophysically, and biochemically characterized. Potent PPAR partial agonists are identified, demonstrating favorable activity and the desired selectivity profiles for both nuclear receptors and off-target interactions. …”
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Cultured Human Airway Epithelial Cells (Calu-3): A Model of Human Respiratory Function, Structure, and Inflammatory Responses by Yan Zhu, Aaron Chidekel, Thomas H. Shaffer

“…This article reviews the application of the human airway Calu-3 cell line as a respiratory model for studying the effects of gas concentrations, exposure time, biophysical stress, and biological agents on human airway epithelial cells. …”
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Dinâmica territorial dos Sistemas Agroflorestais em áreas de várzea e terra firme, na Amazônia oriental by Wagner Luiz Nascimento do Nascimento, Roberta de Fátima Rodrigues Coelho, François Laurent

“…The analysis shows that the adoption of SAFs in the territories depends on the biophysical environment, because although there are similarities between the productive dynamics, the territories have natural specificities that differentiate between SAFs established in open fields (type A), in terra firme areas, and those established in flooded forests (type F). …”
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Remote Sensing of Aboveground Biomass in Tropical Secondary Forests: A Review by J. M. Barbosa, E. N. Broadbent, M. D. Bitencourt

“…New remote sensing methods, including sensors, image processing, statistical methods, and uncertainty evaluations, are constantly being developed to estimate biophysical forest changes. We review 318 peer-reviewed studies related to the use of remotely sensed AGB estimations in tropical forest succession studies and summarize their geographic distribution, sensors and methods used, and their most frequent ecological inferences. …”
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Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae by Isabel Ramón Roth, Pavel Kats, Timm Fiebig, Françoise Routier, Roman Fedorov, Larissa Dirr, Jana I. Führing

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Du calcul biophysique à l’évaluation des risques financiers by Sylvain Maechler, Valérie Boisvert

“…The first is public accounting expressed in biophysical, material and energy units, with the aim of exposing the exploitation and unequal exchange of natural resources as an extension of unbalanced trading relations. …”
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Growth Rates of  Morphometric Variables in Approximately Linear Sections Using Lines in R3 by Aquiles E. Darghan, Enrique Quevedo García, Sergio Esteban Gamboa Muñoz, Carlos Armando Rivera Moreno

“…Morphometric analyses have great potential for application in fruit crops, especially in the construction of indices that can be linked to biophysical and/or biochemical quantities of a physiological nature. …”
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A filter inspired by deep-sea glass sponges for oil cleanup under turbulent flow by Yuan Yu, Chi Ding, Jinna Zhang, Nanqi Ren, Chuyang Y. Tang, Shijie You

“…This study not only highlights the importance of vortex-anchored mechanism in enhancing interfacial mass transfer and hydrodynamic stability during oil capture beyond previously known benefits of increased residence time, but also represents a paradigm shift to advance biophysically inspired strategies for in-situ, dynamic and robust cleanup of spilled oil, environmental remediation and resource recovery.…”
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Bionic Silk Fibroin Film Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells by Activating Focal Adhesion Kinase by Kang Lu, Xiaodie Chen, Hong Tang, Mei Zhou, Gang He, Zhisong Lu, Kanglai Tang

“…SF films with a bionic microstructure may serve as a scaffold, provide biophysical cues to alter the cellular adherence arrangement and cell morphology, and enhance the tenogenic gene and protein expression in TSPCs. …”
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Ginkgetin Alleviates Inflammation and Senescence by Targeting STING by Yadan Liu, Jialin Ye, Zisheng Fan, Xiaolong Wu, Yinghui Zhang, Ruirui Yang, Bing Jiang, Yajie Wang, Min Wu, Jingyi Zhou, Jingyi Meng, Zhiming Ge, Guizhen Zhou, Yuan Zhu, Yichuan Xiao, Mingyue Zheng, Sulin Zhang

“…Subsequent cell biological and biophysical data confirmed that Ginkgetin directly binds to the carboxy‐terminal domain of STING protein, thereby inhibiting STING activation and signal transduction. …”
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The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells by Magdalena Maj, Gregor Hoermann, Sazan Rasul, Wolfgang Base, Ludwig Wagner, Johannes Attems

“…We have previously shown that MAPT is present in human islets of Langerhans, human insulinomas, and pancreatic beta-cell line models, with biophysical similarities to the pathological MAPT in the brain. …”
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The Stability of a Model Substrate for Topoisomerase 1-Mediated DNA Religation Depends on the Presence of Mismatched Base Pairs by William H. Gmeiner, Freddie Salsbury, Chris M. Olsen, Luis A. Marky

“…These results provide a biophysical rationale for the inhibition of Top1-mediated DNA religation by nucleotide analog substitution.…”
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Synthesis, Structural Characterization, and Preclinical Efficacy of a Novel Paclitaxel-Loaded Alginate Nanoparticle for Breast Cancer Treatment by Ahmed A. Markeb, Nagwa A. El-Maali, Douaa M. Sayed, Amany Osama, Mohamed A. Y. Abdel-Malek, Amen H. Zaki, Mostafa E. A. Elwanis, James J. Driscoll

“…PTX-ALG nanoparticles were first synthesized by nanoemulsification polymer cross-linking methods that improved the aqueous solubility. Structural and biophysical properties of the PTX-ALG nanoparticles were then determined by transmission electron microscopy (TEM) and high performance liquid chromatography (HPLC) fluorescence. …”
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Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperve... by Ronnie Wirestam, Arthur Chakwizira, Peter Reinstrup

“…The established mean transit time (MTT) estimate was supplemented by biophysical modelling for extraction of the oxygen extraction capacity, quantified in terms of an apparent oxygen extraction fraction (AOEF) index. …”
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With great power, comes great responsibility: the importance of broadly measuring Fc-mediated effector function early in the antibody development process by Silvia Crescioli, Shashi Jatiani, Lenny Moise

“…Given the breadth of effector functions antibodies can deploy and the close interplay between the antibody Fab and Fc functional domains, it is important to conduct a comprehensive evaluation of Fc-mediated functions using an array of antigen-specific biophysical and cell-mediated functional assays. Here, we review antibody and Fc receptor properties that influence Fc effector functions and discuss their implications on development of safe and efficacious antibody therapeutics.…”
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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. by Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman

“…Herein, we developed biochemical and biophysical assays to enable the discovery of small molecules that perturb the interaction between the FCER1G p-ITAM and SYK-tSH2. …”
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Acute and Chronic Fetal Anemia as a Result of Fetomaternal Hemorrhage by Paul Singh, Tara Swanson

“…On the other hand, signs of acute fetal decompensation such as deterioration of the fetal heart tracing, diminished biophysical score, decreased cord pH, and increased cord base deficit were noted. …”
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