The time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force by Hélène Verdoux, Robert A. Bittner, Alkomiet Hasan, Mishal Qubad, Elias Wagner, Alexis Lepetit, Manuel Arrojo-Romero, Christian Bachmann, Marieke Beex-Oosterhuis, Jan Bogers, Andreja Celofiga, Dan Cohen, Domenico de Berardis, Marc de Hert, Carlos de Las Cuevas, Bjørn H. Ebdrup, Konstantinos N. Fountoulakis, Daniel Guinart, Dolores Keating, Miloslav Kopeček, John Lally, Judit Lazáry, Jurjen J. Luykx, Olalla Maronas Amigo, Espen Molden, Jimmi Nielsen, Brian O’Donoghue, Pierre Oswald, Flavian S. Radulescu, Christopher Rohde, Marina Sagud, Emilio J. Sanz, Ivona Šimunović Filipčić, Iris E. Sommer, Heidi Taipale, Jari Tiihonen, Heli Tuppurainen, Selene Veerman, Alina Wilkowska, Edoardo Spina, Peter Schulte

Get full text

Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021 by Gong Feng, Giovanni Targher, Christopher D. Byrne, Yusuf Yilmaz, Vincent Wai-Sun Wong, Cosmas Rinaldi Adithya Lesmana, Leon A. Adams, Jerome Boursier, George Papatheodoridis, Mohamed El-Kassas, Nahum Méndez-Sánchez, Silvia Sookoian, Laurent Castera, Wah-Kheong Chan, Feng Ye, Sombat Treeprasertsuk, Helena Cortez-Pinto, Hon Ho Yu, Won Kim, Manuel Romero-Gómez, Atsushi Nakajima, Khin Maung Win, Seung Up Kim, Adriaan G. Holleboom, Giada Sebastiani, Ponsiano Ocama, John D. Ryan, Monica Lupșor-Platon, Hasmik Ghazinyan, Mamun Al-Mahtab, Saeed Hamid, Nilanka Perera, Khalid A. Alswat, Qiuwei Pan, Michelle T. Long, Vasily Isakov, Man Mi, Marco Arrese, Arun J. Sanyal, Shiv Kumar Sarin, Nathalie Carvalho Leite, Luca Valenti, Philip N. Newsome, Hannes Hagström, Salvatore Petta, Hannele Yki-Järvinen, Jörn M. Schattenberg, Marlen I. Castellanos Fernández, Isabelle A. Leclercq, Gulnara Aghayeva, Abdel-Naser Elzouki, Ali Tumi, Ala I. Sharara, Asma Labidi, Faisal M. Sanai, Khaled Matar, Maen Al-Mattooq, Maisam Waid Akroush, Mustapha Benazzouz, Nabil Debzi, Maryam Alkhatry, Salma Barakat, Said A. Al-Busafi, John Rwegasha, Wah Yang, Agyei Adwoa, Christopher Kenneth Opio, Mohammadjavad Sotoudeheian, Yu Jun Wong, Jacob George, Ming-Hua Zheng

Get full text

Perceptions of science, science communication, and climate change attitudes in 68 countries – the TISP dataset by Niels G. Mede, Viktoria Cologna, Sebastian Berger, John Besley, Cameron Brick, Marina Joubert, Edward W. Maibach, Sabina Mihelj, Naomi Oreskes, Mike S. Schäfer, Sander van der Linden, Nor Izzatina Abdul Aziz, Suleiman Abdulsalam, Nurulaini Abu Shamsi, Balazs Aczel, Indro Adinugroho, Eleonora Alabrese, Alaa Aldoh, Mark Alfano, Innocent Mbulli Ali, Mohammed Alsobay, Marlene Altenmüller, R. Michael Alvarez, Richard Amoako, Tabitha Amollo, Patrick Ansah, Denisa Apriliawati, Flavio Azevedo, Ani Bajrami, Ronita Bardhan, Keagile Bati, Eri Bertsou, Cornelia Betsch, Apurav Yash Bhatiya, Rahul Bhui, Olga Białobrzeska, Michał Bilewicz, Ayoub Bouguettaya, Katherine Breeden, Amélie Bret, Ondrej Buchel, Pablo Cabrera-Álvarez, Federica Cagnoli, André Calero Valdez, Timothy Callaghan, Rizza Kaye Cases, Sami Çoksan, Gabriela Czarnek, Steven De Peuter, Ramit Debnath, Sylvain Delouvée, Lucia Di Stefano, Celia Díaz-Catalán, Kimberly C. Doell, Simone Dohle, Karen M. Douglas, Charlotte Dries, Dmitrii Dubrov, Małgorzata Dzimińska, Ullrich K. H. Ecker, Christian T. Elbaek, Mahmoud Elsherif, Benjamin Enke, Tom W. Etienne, Matthew Facciani, Antoinette Fage-Butler, Md. Zaki Faisal, Xiaoli Fan, Christina Farhart, Christoph Feldhaus, Marinus Ferreira, Stefan Feuerriegel, Helen Fischer, Jana Freundt, Malte Friese, Simon Fuglsang, Albina Gallyamova, Patricia Garrido-Vásquez, Mauricio E. Garrido Vásquez, Winfred Gatua, Oliver Genschow, Omid Ghasemi, Theofilos Gkinopoulos, Jamie L. Gloor, Ellen Goddard, Mario Gollwitzer, Claudia González-Brambila, Hazel Gordon, Dmitry Grigoryev, Gina M. Grimshaw, Lars Guenther, Håvard Haarstad, Dana Harari, Lelia N. Hawkins, Przemysław Hensel, Alma Cristal Hernández-Mondragón, Atar Herziger, Guanxiong Huang, Markus Huff, Mairéad Hurley, Nygmet Ibadildin, Maho Ishibashi, Mohammad Tarikul Islam, Younes Jeddi, Tao Jin, Charlotte A. Jones, Sebastian Jungkunz, Dominika Jurgiel, Zhangir Kabdulkair, Jo-Ju Kao, Sarah Kavassalis, John R. Kerr, Mariana Kitsa, Tereza Klabíková Rábová, Olivier Klein, Hoyoun Koh, Aki Koivula, Lilian Kojan, Elizaveta Komyaginskaya, Laura König, Lina Koppel, Kochav Koren Nobre Cavalcante, Alexandra Kosachenko, John Kotcher, Laura S. Kranz, Pradeep Krishnan, Silje Kristiansen, André Krouwel, Toon Kuppens, Eleni A. Kyza, Claus Lamm, Anthony Lantian, Aleksandra Lazić, Oscar Lecuona, Jean-Baptiste Légal, Zoe Leviston, Neil Levy, Amanda M. Lindkvist, Grégoire Lits, Andreas Löschel, Alberto López-Ortega, Carlos Lopez-Villavicencio, Nigel Mantou Lou, Chloe H. Lucas, Kristin Lunz-Trujillo, Mathew D. Marques, Sabrina J. Mayer, Ryan McKay, Hugo Mercier, Julia Metag, Taciano L. Milfont, Joanne M. Miller, Panagiotis Mitkidis, Fredy Monge-Rodríguez, Matt Motta, Iryna Mudra, Zarja Muršič, Jennifer Namutebi, Eryn J. Newman, Jonas P. Nitschke, Ntui-Njock Vincent Ntui, Daniel Nwogwugwu, Thomas Ostermann, Tobias Otterbring, Jaime Palmer-Hague, Myrto Pantazi, Philip Pärnamets, Paolo Parra Saiani, Mariola Paruzel-Czachura, Michal Parzuchowski, Yuri G. Pavlov, Adam R. Pearson, Myron A. Penner, Charlotte R. Pennington, Katerina Petkanopoulou, Marija M. Petrović, Jan Pfänder, Dinara Pisareva, Adam Ploszaj, Karolína Poliaková, Ekaterina Pronizius, Katarzyna Pypno-Blajda, Diwa Malaya A. Quiñones, Pekka Räsänen, Adrian Rauchfleisch, Felix G. Rebitschek, Cintia Refojo Seronero, Gabriel Rêgo, James P. Reynolds, Joseph Roche, Simone Rödder, Jan Philipp Röer, Robert M. Ross, Isabelle Ruin, Osvaldo Santos, Ricardo R. Santos, Philipp Schmid, Stefan Schulreich, Bermond Scoggins, Amena Sharaf, Justin Sheria Nfundiko, Emily Shuckburgh, Johan Six, Nevin Solak, Leonhard Späth, Bram Spruyt, Olivier Standaert, Samantha K. Stanley, Gert Storms, Noel Strahm, Stylianos Syropoulos, Barnabas Szaszi, Ewa Szumowska, Mikihito Tanaka, Claudia Teran-Escobar, Boryana Todorova, Abdoul Kafid Toko, Renata Tokrri, Daniel Toribio-Florez, Manos Tsakiris, Michael Tyrala, Özden Melis Uluğ, Ijeoma Chinwe Uzoma, Jochem van Noord, Christiana Varda, Steven Verheyen, Iris Vilares, Madalina Vlasceanu, Andreas von Bubnoff, Iain Walker, Izabela Warwas, Marcel Weber, Tim Weninger, Mareike Westfal, Florian Wintterlin, Adrian Dominik Wojcik, Ziqian Xia, Jinliang Xie, Ewa Zegler-Poleska, Amber Zenklusen, Rolf A. Zwaan

Get full text

Medical Assistance in Dying for Persons Suffering Solely from Mental Illness in Canada by Chloe Eunice Panganiban, Srushhti Trivedi

“…Yet despite these worldwide efforts, many argue through the theory of utilitarianism that the inability to see long-term consequences renders MAiD a premature solution, particularly for those who are unable or unwilling to seek other forms of potentially healing treatment or for those who may undergo MAiD only for a technological innovation or biomedical advancement to later come along as a potential cure.[30] While it is true that MAiD does not prevent these “premature deaths,” it is also true that it does not claim to.[31] MAiD provides an option to alleviate intolerable suffering. …”
Get full text

Development of sustained-release extemporaneous moxifloxacin loaded commercial soft hydrogel contact lenses by Duy Toan Pham, Pratthana Chomchalao, Kunasin Bunneramit, Phurichaya Kladcharoen, Rossukon Khotcharrat, Waree Tiyaboonchai

“…The simple soaking method was employed on five common available contact lenses of Acuvue, Biomedics, Maxim, Soflens, and Biotrue, which were immersed in the standard moxifloxacin eye drops solutions. …”
Get full text

Comparative Ethics of Modern Payment Models by Jacob Riegler

“…Acad Emerg Med. 2019;26(8):856-866. doi:10.1111/ACEM.13635 [6] Beauchamp T, Childress J. Principles of Biomedical Ethics. 8th ed. Oxford University Press; 2019…”
Get full text

Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology by Elliot Gould, Hannah S. Fraser, Timothy H. Parker, Shinichi Nakagawa, Simon C. Griffith, Peter A. Vesk, Fiona Fidler, Daniel G. Hamilton, Robin N. Abbey-Lee, Jessica K. Abbott, Luis A. Aguirre, Carles Alcaraz, Irith Aloni, Drew Altschul, Kunal Arekar, Jeff W. Atkins, Joe Atkinson, Christopher M. Baker, Meghan Barrett, Kristian Bell, Suleiman Kehinde Bello, Iván Beltrán, Bernd J. Berauer, Michael Grant Bertram, Peter D. Billman, Charlie K. Blake, Shannon Blake, Louis Bliard, Andrea Bonisoli-Alquati, Timothée Bonnet, Camille Nina Marion Bordes, Aneesh P. H. Bose, Thomas Botterill-James, Melissa Anna Boyd, Sarah A. Boyle, Tom Bradfer-Lawrence, Jennifer Bradham, Jack A. Brand, Martin I. Brengdahl, Martin Bulla, Luc Bussière, Ettore Camerlenghi, Sara E. Campbell, Leonardo L. F. Campos, Anthony Caravaggi, Pedro Cardoso, Charles J. W. Carroll, Therese A. Catanach, Xuan Chen, Heung Ying Janet Chik, Emily Sarah Choy, Alec Philip Christie, Angela Chuang, Amanda J. Chunco, Bethany L. Clark, Andrea Contina, Garth A. Covernton, Murray P. Cox, Kimberly A. Cressman, Marco Crotti, Connor Davidson Crouch, Pietro B. D’Amelio, Alexandra Allison de Sousa, Timm Fabian Döbert, Ralph Dobler, Adam J. Dobson, Tim S. Doherty, Szymon Marian Drobniak, Alexandra Grace Duffy, Alison B. Duncan, Robert P. Dunn, Jamie Dunning, Trishna Dutta, Luke Eberhart-Hertel, Jared Alan Elmore, Mahmoud Medhat Elsherif, Holly M. English, David C. Ensminger, Ulrich Rainer Ernst, Stephen M. Ferguson, Esteban Fernandez-Juricic, Thalita Ferreira-Arruda, John Fieberg, Elizabeth A. Finch, Evan A. Fiorenza, David N. Fisher, Amélie Fontaine, Wolfgang Forstmeier, Yoan Fourcade, Graham S. Frank, Cathryn A. Freund, Eduardo Fuentes-Lillo, Sara L. Gandy, Dustin G. Gannon, Ana I. García-Cervigón, Alexis C. Garretson, Xuezhen Ge, William L. Geary, Charly Géron, Marc Gilles, Antje Girndt, Daniel Gliksman, Harrison B. Goldspiel, Dylan G. E. Gomes, Megan Kate Good, Sarah C. Goslee, J. Stephen Gosnell, Eliza M. Grames, Paolo Gratton, Nicholas M. Grebe, Skye M. Greenler, Maaike Griffioen, Daniel M. Griffith, Frances J. Griffith, Jake J. Grossman, Ali Güncan, Stef Haesen, James G. Hagan, Heather A. Hager, Jonathan Philo Harris, Natasha Dean Harrison, Sarah Syedia Hasnain, Justin Chase Havird, Andrew J. Heaton, María Laura Herrera-Chaustre, Tanner J. Howard, Bin-Yan Hsu, Fabiola Iannarilli, Esperanza C. Iranzo, Erik N. K. Iverson, Saheed Olaide Jimoh, Douglas H. Johnson, Martin Johnsson, Jesse Jorna, Tommaso Jucker, Martin Jung, Ineta Kačergytė, Oliver Kaltz, Alison Ke, Clint D. Kelly, Katharine Keogan, Friedrich Wolfgang Keppeler, Alexander K. Killion, Dongmin Kim, David P. Kochan, Peter Korsten, Shan Kothari, Jonas Kuppler, Jillian M. Kusch, Malgorzata Lagisz, Kristen Marianne Lalla, Daniel J. Larkin, Courtney L. Larson, Katherine S. Lauck, M. Elise Lauterbur, Alan Law, Don-Jean Léandri-Breton, Jonas J. Lembrechts, Kiara L’Herpiniere, Eva J. P. Lievens, Daniela Oliveira de Lima, Shane Lindsay, Martin Luquet, Ross MacLeod, Kirsty H. Macphie, Kit Magellan, Magdalena M. Mair, Lisa E. Malm, Stefano Mammola, Caitlin P. Mandeville, Michael Manhart, Laura Milena Manrique-Garzon, Elina Mäntylä, Philippe Marchand, Benjamin Michael Marshall, Charles A. Martin, Dominic Andreas Martin, Jake Mitchell Martin, April Robin Martinig, Erin S. McCallum, Mark McCauley, Sabrina M. McNew, Scott J. Meiners, Thomas Merkling, Marcus Michelangeli, Maria Moiron, Bruno Moreira, Jennifer Mortensen, Benjamin Mos, Taofeek Olatunbosun Muraina, Penelope Wrenn Murphy, Luca Nelli, Petri Niemelä, Josh Nightingale, Gustav Nilsonne, Sergio Nolazco, Sabine S. Nooten, Jessie Lanterman Novotny, Agnes Birgitta Olin, Chris L. Organ, Kate L. Ostevik, Facundo Xavier Palacio, Matthieu Paquet, Darren James Parker, David J. Pascall, Valerie J. Pasquarella, John Harold Paterson, Ana Payo-Payo, Karen Marie Pedersen, Grégoire Perez, Kayla I. Perry, Patrice Pottier, Michael J. Proulx, Raphaël Proulx, Jessica L Pruett, Veronarindra Ramananjato, Finaritra Tolotra Randimbiarison, Onja H. Razafindratsima, Diana J. Rennison, Federico Riva, Sepand Riyahi, Michael James Roast, Felipe Pereira Rocha, Dominique G. Roche, Cristian Román-Palacios, Michael S. Rosenberg, Jessica Ross, Freya E. Rowland, Deusdedith Rugemalila, Avery L. Russell, Suvi Ruuskanen, Patrick Saccone, Asaf Sadeh, Stephen M. Salazar, Kris Sales, Pablo Salmón, Alfredo Sánchez-Tójar, Leticia Pereira Santos, Francesca Santostefano, Hayden T. Schilling, Marcus Schmidt, Tim Schmoll, Adam C. Schneider, Allie E. Schrock, Julia Schroeder, Nicolas Schtickzelle, Nick L. Schultz, Drew A. Scott, Michael Peter Scroggie, Julie Teresa Shapiro, Nitika Sharma, Caroline L. Shearer, Diego Simón, Michael I. Sitvarin, Fabrício Luiz Skupien, Heather Lea Slinn, Grania Polly Smith, Jeremy A. Smith, Rahel Sollmann, Kaitlin Stack Whitney, Shannon Michael Still, Erica F. Stuber, Guy F. Sutton, Ben Swallow, Conor Claverie Taff, Elina Takola, Andrew J. Tanentzap, Rocío Tarjuelo, Richard J. Telford, Christopher J. Thawley, Hugo Thierry, Jacqueline Thomson, Svenja Tidau, Emily M. Tompkins, Claire Marie Tortorelli, Andrew Trlica, Biz R. Turnell, Lara Urban, Stijn Van de Vondel, Jessica Eva Megan van der Wal, Jens Van Eeckhoven, Francis van Oordt, K. Michelle Vanderwel, Mark C. Vanderwel, Karen J. Vanderwolf, Juliana Vélez, Diana Carolina Vergara-Florez, Brian C. Verrelli, Marcus Vinícius Vieira, Nora Villamil, Valerio Vitali, Julien Vollering, Jeffrey Walker, Xanthe J. Walker, Jonathan A. Walter, Pawel Waryszak, Ryan J. Weaver, Ronja E. M. Wedegärtner, Daniel L. Weller, Shannon Whelan, Rachel Louise White, David William Wolfson, Andrew Wood, Scott W. Yanco, Jian D. L. Yen, Casey Youngflesh, Giacomo Zilio, Cédric Zimmer, Gregory Mark Zimmerman, Rachel A. Zitomer

Get full text

“But when I come home…”: How patients with chronic musculoskeletal pain account for their absent pain during naturally occurring clinical consultations by Trine C.B. Andersen, Olaug S. Lian

“…These findings may have general relevance for clinical consultations where patients’ symptoms are difficult to measure and validate biomedically. Understanding how patients account for absent pain can enhance clinician-patient communication and improve clinicians’ understanding of patients’ everyday circumstances and thereby improve the outcome of consultations. …”
Get full text

Overcrowding in emergency departments: Revealing the social perspectives through a medical sociological analysis by Jeffrey Yuk Chiu YIP

“…Many of the perspectives, however, have emerged from a biomedically centered conceptual framework. An explanatory model that integrates the concepts and views of medical sociology is generally lacking. …”

Sociocultural Determinants of the Utilization of Maternal Health Care Services in the Tallensi District in the Upper East Region of Ghana by Jonathan Mensah Dapaah, John Onzaberigu Nachinaab

“…To a large extent, these factors influence choice for traditional birth attendants over biomedically-based maternal health care services. Conclusion. …”
Get full text

MINIMUM INHIBITORY CONCENTRATION OF PURPLE LEAF EXTRACT (GRAPTOPHYLLUM PICTUM L. GRIFF) AGAINST LACTOBACILLUS ACIDOPHILUS ATCC 4356 by Shafira Indriyani Chusnadia, Atik Kurniawati, Sari Setyaningsih, Erawati Wulandari, Pudji Astuti

Get full text

Comparison of DNA Extraction Methods for the Detection of Canned Tuna Species with DNA Mini-Barcoding by Aubrey J. Emmi, Biola Fatusin, Rosalee S. Hellberg

“…In comparison, the MP Biomedicals FastPrep-24 + Machery-Nagel NucleoSpin Tissue Kit resulted in species identification for 30% of the samples and the Qiagen DNeasy Blood and Tissue Kit + PowerClean Pro Cleanup Kit resulted in species identification for 21% of the samples. …”
Get full text

Clostridioides difficile infection and recurrence in cancer patients (CIRCA): A multicentre, international study by Pedro Puerta-Alcalde, Jessica O'Keefe, Rachel Woolstencroft, Shipraa Kaul, Néstor López, Katie Cronin, Andrew Lim, Nicole Garcia-Pouton, Míriam Álvarez, Lynette Chee, Mateu Espasa, Ignacio Grafia, Maria Suárez-Lledó, Olivia Smibert, Carolina Garcia-Vidal, Monica A. Slavin, Michelle K. Yong, Alex Soriano, Leon J. Worth

Get full text

Effect of pasak bumi (Eurycoma longifolia Jack), DHA, and seluang fish (Rasbora spp.) on neuroinflammation and neurotransmitter alterations in malnourished rats by Triawanti, Didik Dwi Sanyoto, Meitria Syahadatina Noor, Dimas Ikhsan Airlangga

Get full text

Successful Management of Thyrocervical Trunk Aneurysm Ruptured into the Thoracic Cavity After Cesarean Section in Nonstable Patient with Neurofibromatosis Type I by Nikola Mirković, Marko Prokić, Marija Novčić, Miloš Arsenijević, Snežana Sretenović, Dragan Knežević, Vojin Kovačević, Marija Šorak, Olivera Kostić

Get full text