Probiotics fermentation enhanced the bioactive properties of Gnaphalium affine water extract and improved regulation ability of gut microbiota by Qin Zhang, Shiying Yan, YuanYuan Luo, Zixin Meng, Zhihao Yu, Jian Zhao, Xiaojuan Wu, Yiming Tian, Guzhen Cui, Zhenghong Chen, Daoyan Wu

Get full text

An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice by Xiaojuan Wang, Guohui Zhang, Zhiwei Bian, Vimanda Chow, Marina Grimaldi, Coralie Carivenc, Savannah Sirounian, Hao Li, Lucia Sladekova, Stefano Mott, Yulia Luperi, Yufeng Gong, Cait Costello, Linhao Li, Matthew Jachimowicz, Miao Guo, Shian Hu, Derek Wilson, Patrick Balaguer, William Bourguet, Sridhar Mani, Laura Bonati, Hui Peng, John March, Hongbing Wang, Shengpeng Wang, Henry M. Krause, Jiabao Liu

Get full text

Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases by Jialian Lv, Xinyue Song, Zixin Luo, Duoqin Huang, Li Xiao, Kang Zou

“…Therefore, although luteolin exhibits significant biological activity, its clinical application is limited by challenges associated with its poor water solubility and low bioavailability, which are critical factors for its efficacy and pharmacological application. …”
Get full text

Dexamethasone in Treatment of Comorbid SARS-CoV-2 Patients Aged over 50 Years with Lung Injury over 50 % by O. Yu. Zolnikova, R. V. Maslennikov, V. T. Ivashkin, N. L. Dzhakhaya, O. Yu. Kiseleva, N. D. Potskhverashvili, S. A. Shorokhova

“…A retrospective study of 158 SARS-CoV-2 patients hospitalised in April—June 2020 was conducted under the inclusion criteria: age over 50 years, chest computed tomography (CT) for COVID-19-asso-ciated pneumonia, C-reactive protein (CRP) >50 mg/L, anticoagulant therapy, no contraindications to steroids, no biologic therapy. Cohort 1 patients (n = 96) received dexamethasone 4–12 mg/day, cohort 2 (n = 62) — a standard non-dexamethasone therapy.Results. …”
Get full text

Chemo-proteomics reveals dihydrocaffeic acid exhibits anti-inflammation effects via Transaldolase 1 mediated PERK-NF-κB pathway by Guanjun Li, Huiying Li, Peili Wang, Xinzhou Zhang, Wenhua Kuang, Ling Huang, Ying Zhang, Wei Xiao, Qingfeng Du, Huan Tang, Jigang Wang

“…Dihydrocaffeic acid (DA), metabolite of chlorogenic acid, possesses potent pharmacologic activity for the therapy of a wide range of disorders and various biological properties, such as anti-inflammation. Nevertheless, the specific protein targets and potential molecular mechanisms of DA in acute pneumonia are still poorly understood. …”
Get full text

USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer by Zhongdong Xie, Hanbin Lin, Yuecheng Wu, Yanan Yu, Xintong Liu, Yating Zheng, Xiaojie Wang, Jiashu Wu, Meifang Xu, Yuting Han, Qiongying Zhang, Yu Deng, Lin Lin, Yan Linzhu, Li Qingyun, Xinjian Lin, Ying Huang, Pan Chi

“…Our subsequent goal was to identify potential genes associated with the autophagy panel and assess their prognostic significance, biological roles, and mechanisms in CRC metastasis. …”
Get full text

Host plants selection of Centranthera grandiflora Benth. and nontargeted metabolomics analysis of its parasitic and non-parasitic samples. by Song Jin, Yuchuan Li, Jun Ni, Haili Xie, Falin Lei, He Liu

“…The experiments of mixed sowing of C. grandiflora and 9 companion plants that might be hosts were conducted, and the growth, biological yield and other indexes were observed. The results showed that Cyperus iria L. was the best host for C. grandiflora, and when they were mixed sowed, C. grandiflora had a vigorous growth above ground and the haustoria connected obviously below ground, while C. grandiflora could achieve blossoming and fruiting in the same year. …”
Get full text

Microscale insight into the proton concentration during electrolytic reaction via an optical microfiber: potential for microcurrent monitoring by a dielectric probe by Yunyun Huang, Jiaxuan Liang, Haotian Wu, Pengwei Chen, Aoxiang Xiao, Bai-Ou Guan

“…Abstract Local microcurrent monitoring is of great significance for biological and battery systems, yet it poses a formidable challenge. …”
Get full text

Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress by Linmin Zhong, Qiling Yang, Yiming Shao, Shanwen Hu, Lianxian Guo

“…Herein, we hypothesize that H. pylori infection may exacerbate the intestinal flora imbalance and hepatic metabolic disturbances caused by arsenic exposure, which may disrupt enterohepatic homeostasis and potentially increase biological susceptibility to heavy metal toxicity.…”
Get full text

The First Saint Petersburg Regional Inflammatory Bowel Diseases Registry on the Basis of the Regional Health Information System: Principles of Functioning, Testing Results, Plan of... by Yu. P. Uspenskiy, A. M. Sarana, L. N. Melentyeva, A. V. Yazenok, S. V. Petrov, Yu. A. Fominykh, S. V. Ivanov, A. V. Shotik, A. M. Segal, T. V. Gorbacheva, S. D. Plotnikova, K. V. Dronov

“…The functioning of the Saint Petersburg IBD Registry allows to achieve following primary goals within region: assessment of the epidemiological features of IBD in Saint Petersburg; dynamic assessment of the disease features; assessment and planning of health care resources required to provide care to IBD patients; improvement of approaches to the treatment taking into account the specifics of the region; assessment of the effectiveness and tolerability of specific treatment including biologics.…”
Get full text

Chemical Composition of Cymbopogon flexuosus and C. winterianus Essential Oils and Their Insecticidal Potential Against the Coffee Berry Borer Hypothenemus hampei by Melally Giddegowda Venkatesha, Rudramuni Kiran

“…Among two concentrations of both essential oils, 100% mortality was observed at 500 and 1000 ppm within 48 and 24 hours of treatment, respectively. The significant biological activity of both Cymbopogon species oils indicated a potential source for further development of botanical pesticides as an effective, useful alternative for currently used toxic insecticides. …”
Get full text

Exploring shape diversity and sexual dimorphism in two populations of Nigma conducens through geometric morphometrics by Safa M. El-masry, Tarek G. Ismail, Asmaa N. Mustafa

“…Abstract Background Spiders are highly adaptable hunters found in nearly all terrestrial ecosystems and play an important role in biological control by preying on pest insects. Spiders’ body size and shape are vital for their survival, particularly in prey capture, and these morphological features are often utilized in cladistic analyses. …”
Get full text

The impact of PD-L1 polymorphisms on the efficacy of immune checkpoint inhibitors depends on the tumor proportion score: a retrospective study by Keiichiro Suminaga, Takashi Nomizo, Hironori Yoshida, Hiroaki Ozasa

“…Method Patients treated with immune checkpoint inhibitor monotherapy for non-small cell lung cancer at Kyoto University Hospital until January 2023, with TPS data and biological specimens available for SNP measurement, were eligible for this study. …”
Get full text

Cactus Bug, Chelinidea vittiger aequoris McAtee (Insecta: Hemiptera: Coreidae) by Frank W. Mead, J. R. Herring

“…DeVol and Goeden (1973) discussed the value of this species in biological weed control and reported that it was ineffective in controlling prickly pears in Australia and Santa Cruz Island, California. …”
Get full text

The role of the interleukin family in liver fibrosis by Zixin Zhang, Zixin Zhang, Jiahui Wang, Hui Li, Qun Niu, Qun Niu, Yujing Tao, Yujing Tao, Xin Zhao, Xin Zhao, Zijian Zeng, Zijian Zeng, Haijian Dong, Haijian Dong

“…It is a critical step in the progression from chronic liver disease to cirrhosis and hepatocellular carcinoma. No chemical or biological drugs have been approved for the treatment of liver fibrosis. …”
Get full text

Identification of the immune infiltration and biomarkers in ulcerative colitis based on liquid–liquid phase separation-related genes by Zhixing Hong, Shilin Fang, Haihang Nie, Jingkai Zhou, Yuntian Hong, Lan Liu, Qiu Zhao

“…Two distinct clusters were identified, in which cluster A displayed higher immune infiltration level compared with the cluster B. The top targeted biological pathways of two clusters were distinct, glutamate receptor antagonist ranked top for cluster A while HDAC inhibitor ranked top in cluster B. …”
Get full text

DIDACTIC TERMS OF USE OF BIOGRAPH INFINITI SPECIALIZED SOFTWARE IN UKRAINE’S HIGHER EDUCATION INSTITUTIONS by Olha M. Lunhol, Olha A. Haborets, Hanna M. Kolieva, Artur O. Voloboiev

“…Each laboratory work is created according to the principles of scientificity, integrity and professional orientation of education and includes 3 levels: general (basic), psychological and medical-biological. …”
Get full text

Heterologous expression of SpsTAC2 in Arabidopsis affected branch angle and secondary vascular system development by Fangshu Niu, Mengru Yuan, Hongxia Zhao, Zhi Pang, Jie Yan, RuiXie Ning, Lin Shi, Fengqiang Yu, Dongshan Wei, Rong Yang, Runming Zhang, Haifeng Yang

“…To investigate the biological functions of Tiller Angle Control 2 (TAC2) in Salix psammophila. …”
Get full text

The impaired response of nasal epithelial cells to microplastic stimulation in asthma and COPD by Magdalena Paplińska-Goryca, Paulina Misiukiewicz-Stępień, Monika Wróbel, Katarzyna Mycroft-Rzeszotarska, Dorota Adamska, Julia Rachowka, Milena Królikowska, Krzysztof Goryca, Rafał Krenke

“…This study aimed to evaluate the biological effects of polyamide fibres on nasal epithelium co-cultivated with macrophages in control, asthma, and COPD groups. …”
Get full text

Case Report: Combined Autoimmune Pancreatitis, Ulcerative Colitis and Sclerosing Cholangitis in 28-y.o. Patient by A. R. Khurmatullina, A. V. Okhlobystin, L. N. Androsova, R. T. Rzayev, A. S. Tertychnyy, A. P. Kiryukhin, O. Z. Okhlobystina, M. S. Zharkova, O. S. Shifrin, V. T. Ivashkin

“…The patient was recommended to receive biologic therapy for UC remission induction.Conclusion. …”
Get full text