Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella by Yajun Zhai, Peiyi Liu, Xueqin Hu, Changjian Fan, Xiaodie Cui, Qibiao He, Dandan He, Xiaoyuan Ma, Gongzheng Hu

“…Collectively, our work opens new avenues toward the potentiation of COL and reveals an alternative drug combination strategy to overcome COL-resistant bacterial infections.…”
Get full text

Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency by Jungnam Lee, Naweed Mohammad, Kyudong Han, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban, Karina A. Serban

“…Despite the antimicrobial activities of α-defensins by direct bacterial killing and by modulation of immune responses, AATD individuals are paradoxically burdened by recurrent exacerbation triggered by bacterial infections, frequently with nontypeable Haemophilus influenzae (NTHi). …”
Get full text

Carbapenem-resistant Enterobacterales infection and colonization in patients with severe burns: a retrospective cohort study in a single burn center by Myongjin Kim, Kibum Jeon, Dohern Kym, Jinsun Jung, Yu Jin Jang, Seung Beom Han

“…Abstract Background Clinical characteristics and outcomes of carbapenem-resistant Enterobacterales (CRE) infection and colonization have rarely been reported in patients with severe burns, who are prone to severe bacterial infections. This study aimed to evaluate clinical characteristics and outcomes of CRE infection and colonization in patients with severe burns. …”
Get full text

Airborne Escherichia coli bacteria biosynthesize lipids in response to aerosolization stress by Brooke L. Smith, Meiyi Zhang, Maria D. King

“…Understanding the relationship between environmental conditions in ventilated spaces, lipid biosynthesis, and cellular responses is crucial for developing effective strategies to combat bacterial infections and antibiotic resistance. By elucidating the repair mechanisms initiated by E. coli in response to aerosolization, this study contributes to the broader understanding of bacterial adaptation and vulnerability under specific environmental pressures. …”
Get full text

Clinical Predictors of Pseudomonas aeruginosa Bacteremia in Emergency Department by Yongsoon Choi, Jin Hui Paik, Ji Hye Kim, Seung Baik Han, Areum Durey

“…Pseudomonas aeruginosa shows higher mortality rate compared to other bacterial infections and is susceptible to a limited number of antimicrobial agents. …”
Get full text

Implementation of a rapid host-protein diagnostic test for distinguishing bacterial and viral infections in adults presenting to urgent care centers: a pragmatic cohort study by Boaz Kalmovich, Daniella Rahamim-Cohen, Ilan Yehoshua, Sara Kivity, Noam Orvieto, Shirley Shapiro Ben David

“…MMBV indicated 405/3262 (12.4%) cases of potentially missed bacterial infections. Physicians prescribed antibiotics to 283/405 (69.9%). …”
Get full text

Assessment of the Bacteriological Profile and Antibiotic Susceptibility Patterns of Wastewater in Health Facilities of Ethiopia by Belayneh Regasa Dadi, Eyayu Girma, Mheret Tesfaye, Mohamed Seid

“…Antimicrobials used for the treatment and prevention of bacterial infections are mainly released nonmetabolized into the aquatic environment via wastewater. …”
Get full text

Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Aframomum melegueta K. Schum. against Multidrug-Resistant Bacteria of Clinical Importance by Olufunmiso Olusola Olajuyigbe, Otunola Adedayo, Roger Murugas Coopoosamy

“…This study indicated that DME was more active with higher antibacterial activity than the NDME of this plant, and extracting the fatty portion of plant materials prior susceptibility testing would allow plant extracts to be more effective as well as justifying the use of Aframomum melegueta in traditional medicine for the treatment of bacterial infections.…”
Get full text

Veterinary Drug Prescribing Practices at Selected District Veterinary Clinics of Rift Valley Areas of Ethiopia by Monenus Etefa, Ashenafi Feyisa Beyi, Dinka Ayana, Tariku Jibat Beyene, Takele Beyene Tufa

“…Similarly, 40.5% ivermectin and 17.7% albendazole were prescribed for bacterial infections. In conclusion, this study revealed problems in antibiotics and anthelmintics use, description of routes of administration and length of treatment, and shortage of laboratory diagnostic facilities. …”
Get full text

Characterization of patients admitted with pneumonia and a negative diagnostic test for COVID-19 in the intensive care unit by Rodolfo Javier Rivero Morey, Lietter Aguilar Jure, Yenisel Chang Cuesta, Inte Santana Carballosa, Victor René Navarro Machado, Lya del Rosario Magariño Abreus

“…<p><strong>Background</strong>: in the wide context of the COVID-19 epidemic, secondary bacterial infections represent an important risk factor for the entity's adverse outcomes.…”
Get full text

Th1/17-Biased Inflammatory Environment Associated with COPD Alters the Response of Airway Epithelial Cells to Viral and Bacterial Stimuli by Yifan Chen, Rakesh K. Kumar, Paul S. Thomas, Cristan Herbert

“…These findings suggest that the Th1/17-biased environment associated with COPD may enhance the proinflammatory cytokine response of AECs to viral and bacterial infections and that increased signaling via upregulated receptors may contribute to exaggerated inflammation in virus-induced AECOPD.…”
Get full text

Chloramphenicol-infused N-vinyl-based soft contact lenses for therapeutic and optical applications by Lina M. Shaker, Ahmed Alamiery, Abdulamier Ahmed Abdulamier, Wan Nor Roslam Wan Isahak

“…This work is exploring the development of antibacterial contact lenses (CLs) by implementing the silicon-N-vinyl pyrrolidone-2-hydroxyethyl methacrylate (Si-NVP-HEMA) base to combat the corneal bacterial infections. Due to its hydrophilic and flexible properties, Si-NVP-HEMA enhances oxygen permeability and allows for more effective pairing with antibacterial agents. …”
Get full text

Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition by Suad A Al-Hilu, Wisam H Al-Shujairi

“…These changes come from several reasons, including smoking, drinking alcohol, sunlight, exposure to chemical or physical factors, and finally chronic infection with microorganisms, including bacteria. In fact, bacterial infections are not carcinogenic, but recently it was discovered that the association between bacteria and cancer is through two mechanisms, the first stimulating chronic inflammation and the second producing carcinogenic metabolites. …”
Get full text

Design and assessment of lipase-CuO nanoparticle conjugates for enhanced antimicrobial efficacy against clinical pathogens by Eman M. Handak, Dina H. Amin, Mai M. Elhateir

“…These findings suggest that Lipase-CuO nanoparticle conjugates hold great promise as a novel antimicrobial strategy, offering a potential solution to combat bacterial infections, especially those caused by multidrug-resistant strains. …”
Get full text

Characterization of Pathogenic Bacteria Isolated from Sudanese Banknotes and Determination of Their Resistance Profile by Noha Ahmed Abd Alfadil, Malik Suliman Mohamed, Manal M. Ali, El Amin Ibrahim El Nima

“…All studied Sudanese banknotes were contaminated with pathogenic bacteria, including multidrug-resistant strains, and may play a significant role in the transmission of bacterial infections.…”
Get full text

Improved Antibacterial Properties of Fermented and Enzymatically Hydrolyzed Bee Pollen and Its Combined Effect with Antibiotics by Vaida Damulienė, Vilma Kaškonienė, Paulius Kaškonas, Rūta Mickienė, Audrius Maruška

“…These findings provide new insights into the potential use of bee pollen in combating bacterial infections.…”
Get full text

The liver’s dilemma: sensing real danger in a sea of PAMPs: the (arterial) sinusoidal segment theory by Andrea Henriques-Pons, Natália Vacani-Martins, Carina de Lima Pereira dos Santos, Marcelo Meuser-Batista

“…The liver is susceptible to viruses and bacterial infections, tumors, and sterile tissue damage, but immunological danger recognition in the liver is highly unconventional. …”
Get full text

An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…Detection of Ribonucleic acids (RNA) is a critical step in the identification of viral or bacterial infections in humans and animals. Reverse transcriptase-polymerase chain reaction (RT-PCR) remains the gold standard, but clustered regularly interspaced short palindromic repeats linked to a Cas endoribonuclease particle (CRISPR/Cas) have recently revolutionized the recognition step of two RNAs, i.e. the CRISPR-RNA (crRNA) and the target, providing a much better selectivity compared to the naked hybridization on which RT-PCR is based. …”
Get full text

Characterization of the C5H11ORF96 gene in chickens: cloning, tissue distribution and investigation of its potential function in stress response regulation by Yiping Wan, Jiannan Zhang, Xiao Zhang, Jiliang He, Ningkun Shi, Yuanyou Li, Juan Li, Yajun Wang

“…Chicken is an important economic animal that encounter various stressors including high temperature, high stocking density, bacterial infections and transportation, etc. affecting the poultry production with serious economic loss. …”
Get full text

Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins by Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu

“…Antivirulence drugs offer a new approach to treating bacterial infections by targeting specific virulence factors without affecting bacterial growth, thus helping to combat infection without exerting selective pressure on bacteria or inducing resistance. …”
Get full text