Azidothymidine Sensitizes Primary Effusion Lymphoma Cells to Kaposi Sarcoma-Associated Herpesvirus-Specific CD4+ T Cell Control and Inhibits vIRF3 Function. by Samantha J Williamson, Samantha M Nicol, Michael Stürzl, Shereen Sabbah, Andrew D Hislop

“…To make KSHV-infected cells more sensitive to T cell control we treated PEL cells with the thymidine analogue azidothymidine (AZT), which sensitizes PEL lines to Fas-ligand and TRAIL challenge; effector mechanisms which T cells use. …”
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Comparison Anticancer Effects of Platinum Ribavirin with Platinum Azidothymidine via Telomerase, Bcl-2, miRNA-21 and miRNA-122 Biomarkers Genes Expression on HepG2 Cancer Cell Lines by Abdolreza Sabokrouh, Nasim Ghaffari, Soheila Hajivand, Fereshteh Atabi, Reza Saghiri, Zohreh Sharifi

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Pharmacoeconomic analysis of antiretroviral therapy regimes in the Syrian Arab Republic by Yu. Sh. Gushchina, А. Yu. Abramov, Y. J. Haitham

“…As a result of the analysis of the cost of second-line and third-line regimens, it was revealed that the average cost of second-line therapy per month exceeded the average cost of first-line therapy by 4 times (40,154.2 rubles/month). The initial “azidothymidine, zidovudine / lamivudine + efavirenz” group had fewer hospitalizations, lower mortality, and fewer years of life expectancy lost than on “azidothymidine, zidovudine / lamivudine + atazanavir, ritonavir” and “phosphazide + didanosine + efavirenz” regimens.Conclusion. …”
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Drug-Induced Oxidative Stress and Toxicity by Damian G. Deavall, Elizabeth A. Martin, Judith M. Horner, Ruth Roberts

“…We also review evidence implicating ROS in clinically relevant, drug-related side effects including doxorubicin-induced cardiac damage, azidothymidine-induced myopathy, and cisplatin-induced ototoxicity.…”
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Impact of Antiretroviral Agents on Blood Cell Parameters by Onukak, E.E. *, Onukak, A.E. , Akwiwu, E.C. , Akpotuzor, J.O.

“…Some antiretroviral agents such as zidovudine are associated with bone marrow suppression and an increased risk of developing anaemia Stavudine, azidothymidine and lamivudine have been linked with macrocytic anaemia in patients taking them. …”
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The YoaA-χ helicase modulates the dynamics of single-stranded DNA binding protein on DNA by Savannah J. Weeks-Pollenz, Matthew J. Petrides, Kaylie A. Padgett-Pagliai, Robert Davis, Kathryn K. Harris, Linda B. Bloom

“…Abstract The Escherichia coli helicase, YoaA, and DNA polymerase III subunit, χ, form a complex (YoaA-χ) that promotes tolerance to the DNA chain-terminator 3ˈ-azidothymidine (AZT). Single-stranded DNA binding protein (SSB), which accumulates at stalled replication forks, also contributes to AZT tolerance through interactions with χ. …”
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Persistent Infections in Tick Cell Lines: The Role of Viral-Derived DNA Forms in Hazara Virus Replication and Cellular Survival by Eva Dias, Filipe Tomaz, Silvia Fabi, Cristiano Salata, Ana Domingos, Gonçalo Seixas

“…The experiments characterized vDNAs production, viral titers, and subcellular localization, and they examined the effect of the reverse transcriptase inhibitor azidothymidine triphosphate (AZT). The results showed that all tested tick cell lines supported HAZV replication, achieving persistent infections without cytopathic effects. vDNAs was detected in both the cytoplasm and nucleus, and its formation was dependent on HAZV infection. …”
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Identification of a novel small-molecule inhibitor of the HIV-1 reverse transcriptase activity with a non-nucleoside mode of action by Kyung-Lee Yu, YoungHyun Shin, Dong-Eun Kim, Jeong-Ah Kim, Jeong-Eun Kang, Pooja Singh, Keun Woo Lee, Chul Min Park, Hojin Kwon, Sunwoo Kim, Songmee Bae, Cheol-Hee Yoon

“…In experiments with various HIV-1 strains and cell types, the potency of BPPT was found to be comparable to that of commercial antiretroviral agents (azidothymidine, nevirapine, and others). Further analysis of the mode of action demonstrated that BPPT is a novel type of HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). …”
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