Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae by Wei Yu, Peiyao Jia, Xiaobing Chu, Shengjie Li, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Yingchun Xu, Qiwen Yang

“…The dual impact of these mutations on both antimicrobial resistance and immune activation not only underscores the challenges in treating infections but also advocates for heightened surveillance and innovative strategies to counteract the emerging threat of antimicrobial‐resistant K. pneumoniae.…”
Get full text

Evidence-based clinical standard for the diagnosis and treatment of candidemia in critically ill patients in the intensive care unit by Jorge Alberto Cortés, Martha Carolina Valderrama-Rios, Paula M. Peçanha-Pietrobom, Moacyr Silva Júnior, Cándida Diaz-Brochero, Rafael Ricardo Robles-Torres, Carmelo José Espinosa-Almanza, Laura Cristina Nocua-Báez, Marcio Nucci, Carlos Arturo Álvarez-Moreno, Flavio Queiroz-Telles, Ricardo Rabagliati, Rita Rojas-Fermín, Jorge L. Finquelievich, Fernando Riera, Patricia Cornejo-Juárez, Dora E. Corzo-León, Luis E. Cuéllar, Jeannete Zurita, Augusto Raúl Hernández, Arnaldo Lopes Colombo

Get full text

Antimicrobial Stewardship in the Pediatric Emergency Department: An Observational Pre-Post Study by Erika Silvestro, Ilaria Mussinatto, Antonia Versace, Marco Denina, Giulia Pruccoli, Raffaella Marino, Giulia Mazzetti, Lorenzo Scaglione, Federico Vigna, Alessandra Macciotta, Silvia Garazzino, Claudia Bondone

“…<b>Background/Objectives</b>: To face antimicrobial resistance, antimicrobial stewardship programs (ASPs) have been implemented in the pediatric age, but the area of urgency remains understudied. …”
Get full text

Standardization of the Agar Plate Method for Bacteriophage Production by Su Jin Jo, Young Min Lee, Kevin Cho, Seon Young Park, Hyemin Kwon, Sib Sankar Giri, Sung Bin Lee, Won Joon Jung, Jae Hong Park, Mae Hyun Hwang, Da Sol Park, Eun Jae Park, Sang Wha Kim, Jin Woo Jun, Sang Guen Kim, Ji Hyung Kim, Se Chang Park

“…The growing threat of antimicrobial resistance (AMR), exacerbated by the COVID-19 pandemic, highlights the urgent need for alternative treatments such as bacteriophage (phage) therapy. …”
Get full text

Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii group in Taiwan by Tran Lam Tu Quyen, Yu-Chia Hsieh, Shiao-Wen Li, Lii-Tzu Wu, Ya-Zhu Liu, Yi-Jiun Pan

“…We identified an A. seifertii strain carrying a Ti-type conjugative operon on a small plasmid that harbored genes encoding the NDM-1 carbapenemase alongside genes conferring resistance to aminoglycosides and bleomycin and closely resembled sequences detected in A. soli and A. pittii in Taiwan and China, respectively, suggesting its potential for transmitting multidrug resistance and contributing to the spread of antimicrobial resistance.…”
Get full text

Immunomodulatory and growth-promoting effects of Rauwolfia serpentina root powder in broiler chicks challenged with Salmonella Gallinarum by Yingyu Zhang, Hiba Rehman, Farina Khattak, Maryam Tariq, Bushra Nisar Khan, Sadia Chaman, Ayaesha Riaz, Muhammad Ovais Omer, Aqib Ali, Qamar un Nisa, Muhammad Muddassir Ali, Gulbeena Saleem

“…BackgroundAmid growing concern about antimicrobial resistance due to the irrational use of antibiotics in treating common poultry diseases, particularly Salmonella which is a foodborne pathogen in humans. …”
Get full text

Pathogenic potential of ornithogenic <i>Escherichia coli</i> strains detected in the Earth's polar regions by Batyrbek I. Aslanov, Daniil V. Azarov, Maria A. Makarova, Elizaveta G. Marysheva, Lyudmila A. Kraeva, Aleksey S. Mokhov, Ekaterina A. Lebedeva, Nikita E. Goncharov, Natalya V. Lebedeva, Dmitry A. Starikov, Victoria V. Kolodzhieva, Dmitry E. Polev, Artemy E. Goncharov

“…The annotation of the genomes focused on the identification of genes for pathogenicity factors and antimicrobial resistance, as well as the identification of strains belonging to individual genetic lineages using the cgMLST method. …”
Get full text

Comparative evaluation of sensititre YeastOne and VITEK2 antifungal susceptibility tests with CLSI broth microdilution method of clinical Cryptococcus isolates in Taiwan by Tzu-Ping Weng, Shin-Wei Wang, Shih-Ting Lo, Shu-Li Su, Ming-I Hsieh, Pei-Jane Tsai, Pei-Fang Tsai, Chi-Jung Wu, Nan-Yao Lee, Wen-Chien Ko, Po-Lin Chen

Get full text

Synthesis of silver Nanoparticles@Carbon Dot nanocomposites using Aegle marmelos and Euphorbia hirta: Anti vibriocidal and antioxidant properties by Gali Raman, Sirangu Joseph, D Ramachandran, Phanindra Babu Kasi, Abhinash Marukurti, Alavala Matta Reddy, P Vijaya Nirmala, V S Manikanta, R. Lohitha Kavya, K Sarojani, Anitha Kadimi, Silpa Rani Medapalli, S B Sonia Shankar, G Dinesh Ratna, K Gayathri, P Tirupathi Rao

“…In spite of the increasing Antimicrobial Resistance (AMR) in pathogenic organisms due to inappropriate usage of conventional antibiotics, there is an urgent need of alternative therapeutic antimicrobials. …”
Get full text

Emergence of invasive Streptococcus dysgalactiae subsp. equisimilis in Spain (2012-2022): genomic insights and clinical correlations by Guillem López de Egea, Aida González-Díaz, Randall J Olsen, Gérard Guédon, Dàmaris Berbel, Immaculada Grau, Jordi Càmara, Lucía Saiz-Escobedo, Sara Calvo-Silveria, Irene Cadenas-Jiménez, José María Marimón, Emilia Cercenado, Antonio Casabella, Sara Martí, M. Ángeles Domínguez, Nathalie Leblond-Bourget, James M Musser, Carmen Ardanuy

Get full text

Genomic interrogation of invasive group A Streptococcus (iGAS) epidemiology and COVID-19 impacts in Victoria, Australia: a 6-year retrospective studyResearch in context by Jacqueline M. Morris, Jake A. Lacey, Kerrie Stevens, Lamali Sadeesh Kumar, Mathilda Wilmot, Janet Strachan, Marion Easton, Daneeta Hennessy, Tony M. Korman, Andrew J. Daley, Katherine B. Gibney, Adam W.J. Jenney, Steven Y.C. Tong, Benjamin P. Howden, Norelle L. Sherry

“…Low levels of antimicrobial resistance were observed, primarily to macrolides and tetracyclines. …”
Get full text

Azithromycin to prevent acute lower respiratory infections among Australian and New Zealand First Nations and Timorese children (PETAL trial): study protocol for a multicentre, int... by Anne B Chang, Keith Grimwood, Yuejen Zhao, Gabrielle B McCallum, Catherine A Byrnes, Heidi Smith-Vaughan, Peter S Morris, Christine Connors, Adrian Trenholme, Shirley Lawrence, Joshua Francis, Kobi L Schutz, Mark D Chatfield, Nevio Sarmento, Robyn L. Marsh, Emily R Bowden, Nicholas Fancourt, Adriano Vieira, Kim M Hare, Dennis Bonney, Felicity Marwick, Bronwyn Karvonen, Carolyn Maclennan, Milena Santos Lay, Endang Soares da Silva

“…The secondary outcomes are the rates and proportions of children with ALRI-related hospitalisation, chronic symptoms/signs suggestive of underlying chronic suppurative lung disease or bronchiectasis, serious adverse events, and antimicrobial resistance in the upper airways, and cost-effectiveness analyses.Ethics and dissemination The Human Research Ethics Committees of the Northern Territory Department of Health and Menzies School of Health Research (Australia), Health and Disability Ethics Committee (New Zealand) and the Institute National of Health-Research Technical Committee (Timor-Leste) approved this study. …”
Get full text

PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label,... by David Taylor-Robinson, Steve Goodacre, Neil French, Richard Body, Kerenza Hood, Emma Thomas-Jones, Jane Daniels, Sarah Walker, Ingeborg Welters, Mike Bradburn, Paul Schmidt, Enitan Carrol, Lucy Brookes-Howell, Sarah Milosevic, Andrew Tabner, Philip Pallmann, Stephen Aston, Gavin Barlow, Emma Richards, Emmanuel Nsutebu, Philip Howard, Matthew Inada-Kim, Stacy Todd, Fiona McGill, Martin Llewelyn, Louis Wihelmus Niessen, Joanne Euden, Julie Carman, Stephanie Gilbert, Sam Clarkstone, Jacqui Hughes, Lena Meister, Angela Brain, Matthew Scarborough, Sian O'Shea, Claire James

“…Despite this, there is a tendency to overemphasise the score in isolation in patients with suspected infection, leading to the overprescription of antibiotics and potentially treatment-related complications and rising antimicrobial resistance. The biomarker procalcitonin (PCT) has been shown to be useful in specific circumstances to support appropriate antibiotics prescribing by identifying bacterial infection. …”
Get full text

Gaps in U.S. livestock data are a barrier to effective environmental and disease management by Rebecca Logsdon Muenich, Sanskriti Aryal, Amanda J Ashworth, Michelle L Bell, Melanie R Boudreau, Stephanie A Cunningham, K Colton Flynn, Kerry A Hamilton, Ting Liu, Michael L Mashtare, Natalie G Nelson, Barira Rashid, Arghajeet Saha, Danica Schaffer-Smith, Callie Showalter, Aureliane Tchamdja, Jada Thompson

“…Issues such as soil, water, and air pollution, greenhouse gas emissions, aquifer depletion, antimicrobial resistance genes, and zoonotic disease outbreaks have all been linked to livestock operations. …”
Get full text

Community-Acquired Antibiotic Resistance in Urinary Isolates from Adult Women in Canada by Warren J McIsaac, Tony Mazzulli, Joanne Permaul, Rahim Moineddin, Donald E Low

“…BACKGROUND: There are currently limited data regarding the prevalence of antimicrobial-resistant organisms causing community-acquired urinary tract infections among adult women in Canada. …”
Get full text

Antimicrobial Stewardship in Acute Care Centres: A Survey of 68 Hospitals in Quebec by Vincent Nault, Mathieu Beaudoin, Daniel JG Thirion, Michel Gosselin, Benoit Cossette, Louis Valiquette

“…BACKGROUND: Antimicrobial stewardship programs (ASPs) and quantitative monitoring of antimicrobial use are required to ensure that antimicrobials are used appropriately in the acute care setting, and have the potential to reduce costs and limit the spread of antimicrobial-resistant organisms and Clostridium difficile. …”
Get full text

Determination of antibiotic resistance patterns of Vibrio parahaemolyticus from shrimp and shellfish in Selangor, Malaysia by Vengadesh Letchumanan, Nurul-Syakima Ab Mutalib, Sunny Hei Wong, Kok-Gan Chan, Learn-Han Lee

“…The extensive use of antibiotics in aquaculture has been postulated to represent a major contributing factor in the rising incidence of antimicrobial resistant pathogenic bacteria in seafood; which may then lead to the spread of antimicrobial resistant bacteria in the environment as well as posing a significant threat to human health. …”
Get full text

CTX-M, SHV, TEM and VEB β-lactamases, and MCR-1 among multidrug-resistant Escherichia coli and Klebsiella isolates from environment near animal farms in Thailand by Arpasiri Srisrattakarn, Bhanubong Saiboonjan, Patcharaporn Tippayawat, Sunpetch Angkititrakul, Aroonwadee Chanawong, Chanakan Pornchoo, Chokdee Smithkittipol, Aroonlug Lulitanond

“…In this study we surveyed for 4 important antimicrobial-resistant bacteria: extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, Klebsiella pneumoniae and Salmonella spp., and methicillin-resistant Staphylococcus aureus (MRSA) from the environment around chicken and pig farms. …”
Get full text

Antibiotic resistances of enterococci isolated from bovine subclinical mastitis by Yahya Kuyucuoğlu

“…<p> <b>Conclusion:</b> This study showed a high prevalence of antimicrobial resistant E. faecalis, E. faecium and other Enterococci species isolated from CMT positive milk samples. …”
Get full text

Identification, resistance, and susceptibility of microorganisms on healthcare workers' hands: a systematic review and meta-analysis by Juan Jairo Vaca González, Nolbedir Saza Ramírez, Fernando Rojas Páez, Julieth Yadira Serrano Riaño

“…Background and Objectives: The aim of this study is to analyze, through a systematic review and meta-analysis, the identification, resistance and susceptibility of microorganisms present in healthcare workers’ hands, identifying the most relevant antimicrobial resistant bacteria and their prevalence. Methods: Several scientific databases were reviewed to summarize contributions of the past 10 years. …”
Get full text