Molecular investigation on active compounds in papaya leaves (Carica papaya Linn) as anti-malaria using network pharmacology, molecular docking, clustering-based analysis and molec... by Arwansyah Arwansyah, Sitti Rahmawati, Siti Nuryanti, Yenni Yusuf, Hartono, Abdur Rahman Arif

“…However, limited access to healthcare services in remote areas and the emergence of resistance to antimalarial drugs pose significant challenges to malaria elimination efforts in Indonesia. …”
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Ecotope-Based Entomological Surveillance and Molecular Xenomonitoring of Multidrug Resistant Malaria Parasites in Anopheles Vectors by Prapa Sorosjinda-Nunthawarasilp, Adisak Bhumiratana

“…MDR malaria is the heritable and hypermutable property of human malarial parasite populations that can decrease in vitro and in vivo susceptibility to proven antimalarial drugs as they exhibit dose-dependent drug resistance and delayed parasite clearance time in treated patients. …”
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Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats by Ugochukwu Vincent, Igbokwe, Ejike, Daniel Eze, Moses Dele, Adams, Karimah Mohammed, Rabiu, Iliya, Ezekiel, Prisca Ojochogu, Ajeka, Peace Ogechukwu, Okpara

“…Animals in Groups B–E which were infected were given 500 mg/kg body weight (BW) of malanter DS (reference antimalarial drug), 500 mg/kg BW of BL, 250 mg/kg BW each of SL and BL as well as 250 mg/kg BW each of G, PP and UPA. …”
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Metformin in COVID-19: a magical role beyond the hyperglycemia by Gaurav Kumar Chaubey, Rahul Dilawari, Radheshyam Modanwal, Sharmila Talukdar, Asmita Dhiman, Manoj Raje

“…To date, there have been myriad reports ranging from the repurposing of the classical antimalarial drug hydroxychloroquine to several other antiviral and anti-bacterial agents like remdesivir, favipiravir, and most recently azithromycin, which has entered clinical use in many countries for combating COVID-19 infections. …”
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A Validated Volumetric Absorptive Microsampling-Liquid Chromatography Tandem Mass Spectrometry Method to Quantify Doxycycline Levels in Urine: An Application to Monitor the Malaria... by Mylène Penot, Cyril Linard, Nicolas Taudon

“…Because of logistics and cost constraints, monitoring of the compliance to antimalarial chemoprophylaxis by the quantitation of drugs in biological samples is not a simple operation on the field. …”
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Investigating the Presence of Falsified and Poor-Quality Fixed-Dose Combination Artemether-Lumefantrine Pharmaceutical Dosage Forms in Kumasi, Ghana by Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Denis Dekugmen Yar

“…However, ineffective regulatory systems in resource-limited settings can lead to the infiltration of poor-quality and counterfeit antimalarial medicines into the pharmaceutical supply chain, causing treatment failures, prolonged illness, and disease progression. …”
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Development of the RP-HPLC Method for Simultaneous Determination and Quantification of Artemether and Lumefantrine in Fixed-Dose Combination Pharmaceutical Dosage Forms by Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Desmond Asamoah Bruce Otu, Denis Dekugmen Yar, Yaa Asantewaa Osei

“…Developing countries face enormous challenges with substandard and falsified antimalarial drugs. One specific issue is the lack of a simple, cost-effective, and robust HPLC method to simultaneously determine and quantify the active pharmaceutical ingredients (APIs) in fixed-dose artemether-lumefantrine pharmaceutical dosage forms. …”
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A cluster randomized trial assessing the effect of a digital health algorithm on quality of care in Tanzania (DYNAMIC study). by Rainer Tan, Godfrey Kavishe, Alexandra V Kulinkina, Sabine Renggli, Lameck B Luwanda, Chacha Mangu, Geofrey Ashery, Margaret Jorram, Ibrahim Evans Mtebene, Peter Agrea, Humphrey Mhagama, Kristina Keitel, Marie-Annick Le Pogam, Nyanda Ntinginya, Honorati Masanja, Valérie D'Acremont

“…Secondary outcomes included antibiotic prescription, counseling provided, and the appropriateness of antimalarial and antibiotic prescriptions. A total of 450 consultations were observed in 9 intervention and 9 control health facilities. …”
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Diagnostic Performance between Histidine-Rich Protein 2 (HRP-2), a Rapid Malaria Diagnostic Test and Microscopic-Based Staining Techniques for Diagnosis of Malaria by Jean Baptiste Niyibizi, Emmanuel Kamana Gatera

“…The patients included in the study did not receive any antimalarial drug. The mean age of the study participants was 31.6 ± 12.4 with the majority of participants being between 25 and 44 years and the minority being above 65 years. …”
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Leveraging genomic insights from the neglected malaria parasites P. malariae and P. ovale using selective whole genome amplification (SWGA) approach by Fathia Ben-Rached, Amit Kumar Subudhi, Chang Li, Mariah Alawi, Rohit Satyam, Sui Xu, Guoding Zhu, Raeece Naeem, Sara Mfarrej, Di Liu, Zenaida Stead, Caroline Askonas, Yaobao Liu, Jun Cao, Arnab Pain

“…Consequently, the detection of thousands of additional SNPs not detectable in pre-SWGA samples was facilitated after SWGA, allowing more substantial downstream population genomics analysis, particularly for the polymorphic and antimalarial genes of great interest for all the species. …”
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EFFECT OF IRRIGATION INTERVAL ON GROWTH AND ARTEMISININ CONTENT OF WORMWOOD (Artemisia annua L.) CHEN YOUNG VARIETY IN SOKOTO by Lawal Gandi ABDULKADIR, Adamu Aliyu ALIERO, Hassan Muhammad MAISHANU, Abdullahi Yahaya ABBAS

“…Artemisinin is the main antimalarial compound in Artemisia annua, used in the formulation of artemisinin-based combined therapies (ACT) to treat malaria. …”
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Gedunin Mitigates <i>Cutibacterium acnes</i>-Induced Skin Inflammation by Inhibiting the NF-κB Pathway by Ju Kyoung Sim, Ye Ji Heo, Jin Hak Shin, Seon Sook Kim, Su Ryeon Seo

“…Gedunin, a limonoid derived from <i>Azadirachta indica</i> (commonly known as neem), is renowned for its antifungal, antimalarial, anticancer, anti-inflammatory, and neuroprotective effects. …”
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Endoplasmic reticulum stress in the salivary glands of patients with primary and associated Sjögren’s disease, and non-Sjögren’s sicca syndrome: a comparative analysis and the infl... by Graziela Vieira Cavalcanti, Fabiola Reis de Oliveira, Rafael Ferraz Bannitz, Natalia Aparecida de Paula, Ana Carolina Fragoso Motta, Eduardo Melani Rocha, John Chiorini, Hilton Marcos Alves Ricz, Denny Marcos Garcia, Maria Cristina Foss-Freitas, Luiz Carlos Conti de Freitas

“…Conclusions Altogether, the results suggest a greater activation of the ERS and UPR genes in patients with SD, especially in the pSD group. Antimalarial drugs, like CQ, used to treat RAD, may affect the ER function in exocrine glands.…”
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Can Ethiopia eliminate malaria? Malaria burden: insights from the pre-elimination era, current challenges and perspectives by Dagmawi Woldesenbet, Yalewayker Tegegne, Abdulhakim Mussema, Elias Tamene, Kemal Mohamed, Wagaw Abebe, Melese Mekuria, Kasahun Bogale, Habtamu Geremew, Mufta Muzemil Shifa, Mulugeta Aemero Tegegne

“…Other challenges include the spreading resistance to effective antimalarial drugs, socio-cultural barriers to malaria elimination, the challenge posed by Plasmodium vivax in elimination efforts, and the occurrence of imported cases in previously low burden areas. …”
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Effectiveness of an electronic clinical decision support system in improving the management of childhood illness in primary care in rural Nigeria: an observational study by Marek Kwiatkowski, Rodolfo Rossi, Torsten Schmitz, Fenella Beynon, Capucine Musard, Marco Landi, Daniel Ishaya, Jeremiah Zira, Muazu Muazu, Camille Renner, Edwin Emmanuel, Solomon Gideon Bulus

“…Secondary outcomes were antibiotic and antimalarial prescription, referral, and communication of diagnosis and follow-up advice, assessed at day 0 exit interview.Results We recruited 1929 children, of which 1021 (53%) attended ALMANACH facilities, between March and September 2020. …”
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Clinical characteristics of Plasmodium vivax malaria infection in children and adolescents in the Republic of Korea during the period 2000 to 2016: a retrospective study by Jung Ah Lee, Je Eun Song, Seong Yeon Park, Yoon Soo Park, Yoonseon Park, Yee Gyung Kwak, Sang-Eun Lee, Hyun-Il Shin, Joon-Sup Yeom

“…Conclusions Pediatric P. vivax malaria showed a low incidence of severe cases and no mortality in the ROK. Underdosing of antimalarial drugs was observed, underscoring the need for educating healthcare providers to ensure appropriate dosing. …”
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Plasmodium falciparum transcription factor AP2-06B is mutated at high frequency in Southeast Asia but does not associate with drug resistance by Qiyang Shi, Changhong Wang, Wenluan Yang, Xiaoqin Ma, Jianxia Tang, Jiayao Zhang, Guoding Zhu, Yinlong Wang, Yaobao Liu, Xiaoqin He

“…IntroductionA continuing challenge for malaria control is the ability of Plasmodium falciparum to develop resistance to antimalarial drugs. Members within the Plasmodium transcription factor family AP2 regulate the growth and development of the parasite, and are also thought to be involved in unclear aspects of drug resistance. …”
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Artemisinin supplementation in concentrated cottonseed protein basal diets enhances growth, antioxidant capacity, intestinal immunity and microbiota in hybrid grouper (Epinephelus... by Ling Pan, Qi Wang, Weikang Li, Xiaohui Dong, Shiwei Xie, Beiping Tan, Hongyu Liu, Yan Wang

“…Artemisinin is a natural compound extracted from Artemisia annua, widely used in traditional Chinese medicine, with various bioactivities including antimalarial, anti-inflammatory, antioxidant, and immunomodulatory effects. …”
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Voacanga africana-artesunate and Voacanga africana-amodiaquine combinations as effective anti-plasmodial agents in mice by Daniel Ampomah Frimpong, Aliu Moomin, Samuel Asare Nkansah, Aaron Opoku Antwi, Abubakar Ibn Sidik, Paa Kofi Tawiah Adu-Gyamfi, Kwesi Boadu Mensah

“…Conclusions: VA showed a moderate antimalarial activity when used in monotherapy, while a combination of VA and AT showed synergism against P. beighei infection by reducing parasitemia levels, preventing hemolysis, decreasing PCV, increasing body temperature and increasing body weights. …”
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Subclinical Plasmodium spp. Infections in a Community Setting in Bangui, Central African Republic by Nzoumbou-Boko R, Denissio Morissi Nalingbo MCI, Yambiyo BM, Detol R, Moussa ERF, Nalinga D, Namsenei-Dankpea LJVDLG, Manirakiza A, Ayong L, Boum II Y

“…Moreover, little is known about the extent of, and factors associated with subclinical Plasmodium infections, which are essential for guiding ongoing antimalarial interventions in the community. Subclinical infection is defined as an infection with no noticeable clinical symptoms.This study demonstrated that one out of three people living in Bangui is carrying malaria parasite without showing any symptoms. …”
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