YAT2150 is irresistible in Plasmodium falciparum and active against Plasmodium vivax and Leishmania clinical isolates by Inés Bouzón-Arnáiz, Mukul Rawat, Rachael Coyle, Lionel Brice Feufack-Donfack, Malen Ea, Agnes Orban, Jean Popovici, Lucía Román-Álamo, Antonino Nicolò Fallica, Bárbara Domínguez-Asenjo, Javier Moreno, Elsa M. Arce, Ana Mallo-Abreu, Diego Muñoz-Torrero, Marcus C. S. Lee, Xavier Fernàndez-Busquets

“…Using single-dose and ramping methods, assays were done to select Plasmodium falciparum parasites resistant to YAT2150 concentrations ranging from 3× to 0.25× the in vitro IC50 of the compound (in the two-digit nM range) and performed a cross-resistance assessment in P. falciparum lines harboring mutations that make them resistant to a variety of antimalarial drugs. Resistant parasites did not emerge in vitro after 60 days of incubation, which postulates YAT2150 as an ‘irresistible’ antimalarial. …”
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Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility by Amy Ibrahim, Franziska Mohring, Emilia Manko, Donelly A. van Schalkwyk, Jody E. Phelan, Debbie Nolder, Steffen Borrmann, Ayola A. Adegnika, Silvia Maria Di Santi, Mohammad Shafiul Alam, Dinesh Mondal, Francois Nosten, Colin J. Sutherland, Robert W. Moon, Taane G. Clark, Susana Campino

“…Amino acid substitutions were identified in orthologs of genes associated with antimalarial susceptibility including 2 amino acid substitutions in pmdhfr aligning with pyrimethamine resistance mutations in P. falciparum. …”
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Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil) by Cássio Braga e Braga, Antonio Camargo Martins, Athaid David Escalante Cayotopa, Wagner Werner Klein, Andreus Roberto Schlosser, Aline Ferreira da Silva, Mardelson Nery de Souza, Breno Wilson Benevides Andrade, José Alcântara Filgueira-Júnior, Wagner de Jesus Pinto, Mônica da Silva-Nunes

“…Side effects of antimalarial drug can overlap with malaria symptoms. …”
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A narrative review on inhibitory effects of edible mushrooms against malaria and tuberculosis-the world’s deadliest diseases by Ashaimaa Y. Moussa, Baojun Xu

“…The isolated secondary metabolites from 39 edible mushrooms are reported, among which 107 compounds were active, 61 demonstrated antitubercular activities with IC50 range of 0.2–50 µg/mL and 46 manifested antimalarial effects with IC50 range of 0.061–36 µg/mL. …”
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Attributable risk factors for asymptomatic malaria and anaemia and their association with cognitive and psychomotor functions in schoolchildren of north-eastern Tanzania. by Geofrey Makenga, Vito Baraka, Filbert Francis, Daniel T R Minja, Samwel Gesase, Edna Kyaruzi, George Mtove, Swabra Nakato, Rashid Madebe, Sif R Søeborg, Kathrine H Langhoff, Helle S Hansson, Michael Alifrangis, John P A Lusingu, Jean-Pierre Van Geertruyden

“…We explored the prevalence of antimalarial drug resistance as well as the association of asymptomatic malaria infection and anaemia on cognitive and psychomotor functions in school-aged children living in high endemic areas. …”
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Efficacy of Hydroxychloroquine for Improving Pregnancy Outcomes in a Female with Systemic Lupus Erythematosus and Antiphospholipid Syndrome by Yumika Takaki, Atsushi Daimon, Misa Nunode, Tomohito Tanaka, Daisuke Fujita, Masahide Ohmichi

“…Recently, the addition of a novel antimalarial, hydroxychloroquine (HCQ), to the conventional treatment has shown the potential to prevent obstetric complications. …”
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A Child with Severe Malaria Presenting with Acute Surgical Abdomen (Duodenal Perforation) by Tika Ram Bhandari, Sudha Shahi, Rajesh Poudel, Nagendra Chaudhary

“…Here, we report a case of a 5-year-old male child with falciparum malaria complicated by a duodenal perforation that was successively managed with appropriate antimalarial drugs and early surgical repair.…”
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Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa by Bridget Kamurai, Molly Mombeshora, Stanley Mukanganyama

“…The drugs used in this study were amodiaquine an antimalarial drug, probenecid used to prevent gout, ibuprofen a painkiller, 2-amino-5-chlorobenzaxazole used as a tool for assessing hepatic cytochrome P450 activity in rodents, ellargic acid an antioxidant, quercetin an antioxidant and anti-inflammatory drug, N–N diacryloylpiperazine used to crosslink polyacrylamide gel in 2D-protein electrophoresis, epicatechin an antioxidant and antiviral drug, curcumin an anticancer drug, and quinine an antimalarial drug. …”
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In Vivo Antiplasmodial Activity of Terminalia mantaly Stem Bark Aqueous Extract in Mice Infected by Plasmodium berghei by Mariscal Brice Tchatat Tali, Cedric Derick Jiatsa Mbouna, Lauve Rachel Yamthe Tchokouaha, Patrick Valere Tsouh Fokou, Jaures Marius Tsakem Nangap, Rodrigue Keumoe, Alvine Ngoutane Mfopa, Issakou Bakarnga-via, Raceline Gounoue Kamkumo, Fabrice Fekam Boyom

“…The results suggest that the stem bark extract of T. mantaly possesses antimalarial activity.…”
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Molecular identification of pfcytb, pfdhfr, and pvmrp1 mutations in imported malaria cases in Chile by Alan Oyarce, Lizbeth Huaccha, Esteban M. Cordero, Bárbara Parra, Jorge Fernández, Mario E. Soto-Marchant, Natalia T. Santis-Alay, María Isabel Jercic

“…Malaria-free countries must also address issues such as limited access to antimalarial drugs and treatment failures caused by drug resistance. …”
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Myocarditis in malaria—current evidence and future directions: a literature review by Gbolahan Olatunji, Emmanuel Kokori, Ikponmwosa Jude Ogieuhi, Olumide Akinmoju, Oluwatobi Omoworare, Doyin Olatunji, David Timilehin Isarinade, God-dowell O. Odukudu, Israel Charles Abraham, Samuel Owolabi, Jamil Nasrallah, Emmanuel Egbunu, Babafemi Oluwadarasimi Jaiyeoba, Ismaila Ajayi Yusuf, Olawale Olanisa, Nicholas Aderinto

“…Addressing therapeutic challenges involves balancing antimalarial drugs, supportive care, and long-term monitoring. …”
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New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells by Lixian Lin, Zengqi Tang, Zhenrui Shi, Qing Guo, Hui Xiong

“…Artesunate, one of the derivatives of artemisinin (“qinghaosu” in Chinese), is known as an antimalarial drug with high efficiency and low toxicity. …”
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The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro by Yakubu Jibira, Elizabeth Cudjoe, Frederick M. Tei-Maya, Benjamin Ayensu, Linda E. Amoah

“…Drug resistance in malaria is a global problem, with reports of Plasmodium parasites resistant to the current first-line antimalarial drug, artemisinin, expanding from Southeast Asia to Africa. …”
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Malaysia’s Breakthrough in Modern Actinobacteria (MOD-ACTINO) Drug Discovery Research by Angel Yun-Kuan Thye, Vengadesh Letchumanan, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Learn-Han Lee

“…The Malaysian MOD-ACTINO strains are capable of exerting a wide range of bioactivities such as antimicrobial/anti-MRSA, anticancer, antioxidant, antifungal, and antimalarial. Research on MOD-ACTINO is highly encouraged to harness the benefits of actinobacteria and unravel important metabolites for various applications. …”
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Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla Del by Isma'il Shittu, Amlabu Emmanuel, Andrew Jonathan Nok

“…The antimalarial effect of the ethanolic stem bark extract of Ficus platyphylla Del was evaluated against Plasmodium berghei infection in mice. …”
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Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Victor Osoti, Kevin Wamae, Leonard Ndwiga, Paul M. Gichuki, Collins Okoyo, Stella Kepha, Kibor Keitany, Regina Kandie, Stephen Aricha, Rosebella Kiplagat, Charles Mwandawiro, Philip Bejon, Robert W. Snow, Lynette Isabella Ochola-Oyier

“…Abstract Background To understand the emergence and spread of drug-resistant parasites in malaria-endemic areas, accurate assessment and monitoring of antimalarial drug resistance markers is critical. Recent advances in next-generation sequencing (NGS) technologies have enabled the tracking of drug-resistant malaria parasites. …”
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Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells by J. I. Raji, C. K. Onwuamah, P. G. C. Odeigah

“…Artemisinin-based combination therapy is used to treat uncomplicated malaria disease in most endemic countries. Although most antimalarial drugs are effective in killing the parasite, there is a concern of induced toxicity to the cell. …”
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Coinfection of malaria and scrub typhus in a toddler: First report from South India by Nandini Vasudevan, Sawantharia Jaganathan, Priya Jose, Peter Prasanth Kumar Kommu

“…Rapid malarial antigen was positive, and started on antimalarial therapy. Fever was persisting after 48 h and doxycycline was started. …”
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N-Terminal Plasmodium vivax Merozoite Surface Protein-1, a Potential Subunit for Malaria Vivax Vaccine by Fernanda G. Versiani, Maria E. Almeida, Luis A. Mariuba, Patricia P. Orlandi, Paulo A. Nogueira

“…One of the major candidates to antimalarial vaccine is the merozoite surface protein-1 (MSP1), which is expressed abundantly on the merozoite surface and capable of activating the host protective immunity. …”
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Rapid Diagnosis of Malaria by Clinton K. Murray, Jason W. Bennett

“…Implementation of prompt and accurate diagnosis is needed to curb the expanding global impact of malaria associated with ever-increasing antimalarial drug resistance. Traditionally, malaria is diagnosed using clinical criteria and/or light microscopy even though both strategies are clearly inadequate in many healthcare settings. …”
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