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61
Trafficked Proteins—Druggable in Plasmodium falciparum?
Published 2013-01-01“…However, drug resistance is spreading, and the identification of new drug targets as well as the development of new antimalarials is urgently required. Attention has been drawn to a variety of essential plasmodial proteins, which are targeted to intra- or extracellular destinations, such as the digestive vacuole, the apicoplast, or into the host cell. …”
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62
Use of Artemisinin- Combination Therapies in Port Harcourt
Published 2013-07-01“…@JASEM Keywords: Artemisinin-based combination therapy (ACT), Malaria, Antimalarial …”
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63
Use of Artemisinin- Combination Therapies in Port Harcourt
Published 2013-07-01“…@JASEM Keywords: Artemisinin-based combination therapy (ACT), Malaria, Antimalarial …”
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64
Isotretinoin – Induced AGEP: A Case Report
Published 2025-02-01“…Agents commonly implicated in triggering AGEP include antibiotics, antifungals, antimalarials, and diltiazem. We present a case of a isotretinoin induced AGEP in a young female patient known to have guttate psoriasis, inverse and scalp psoriasis. …”
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65
Epidemiological, Clinical and Paraclinical Profile of Paediatric Malaria at University Hospital Centre Amissa Bongo in Franceville, Gabon
Published 2024-12-01“…Conclusion: Non-compliance with preventive measures and the misuse of antimalarials further complicate the clinical picture, requiring parenteral management for the most part.…”
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66
Emerging trends and new developments in global research on artemisinin and its derivatives
Published 2025-01-01“…Nevertheless, ongoing antimalarial treatment efforts have been significantly hindered by the emergence of drug resistance. …”
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67
Challenges in Diagnosis and Management of SLE in Africa: An Online Survey
Published 2025-01-01“…Glucocorticoids and antimalarials were readily available across all regions, with variable availability of immunosuppressants from 93.7% for methotrexate to 65% for calcineurin inhibitors and only 58.4% for the biologic rituximab. …”
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68
Ocular Findings in COVID-19 Patients: A Review of Direct Manifestations and Indirect Effects on the Eye
Published 2020-01-01“…However, the risk of retinal toxicity with short-term high-dose use of antimalarials is still unknown. Ocular side effects have also been reported with other investigational drugs like lopinavir-ritonavir, interferons, and interleukin-1 and interleukin-6 inhibitors. …”
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69
Assessing the efficacy of iso-mukaadial acetate and betulinic acid against selected Plasmodium falciparum glycolytic pathway proteins: in silico and in vitro studies
Published 2025-01-01“…Parasite inhibition studies confirmed potent antimalarial activity against the P. falciparum NF54 strains, with BA and IMA showing IC50 values of 1.27 µg/ml and 1.03 µg/ml against the asexual stage of P. falciparum, respectively. …”
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70
Long-Term Safety and Efficacy of Lenabasum, a Cannabinoid Receptor Type 2 Agonist, in Patients with Dermatomyositis with Refractory Skin Disease: Follow-Up Data from a 3-Year Open-...
Published 2025-01-01“…Background: Dermatomyositis (DM) is a rare autoimmune condition involving skin manifestations often resistant to standard treatments such as immunosuppressants and antimalarials. Biopsies show elevated inflammatory cells such as CD4+ T cells, dendritic cells, and cytokines. …”
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71
The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice
Published 2013-01-01“…Xylopic acid therefore possesses prophylactic and curative antimalarial as well as antipyretic properties which makes it an ideal antimalarial agent.…”
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72
Exploring the Infectious Drug Target Glutathione S-Transferase in Plasmodium falciparum with the Inhibitory Potential of Azadirachta indica Phytocompounds
Published 2024-01-01“…Neem compounds are being studied for their potential as new and effective antimalarial drugs, and there is mounting evidence that they may help treat malaria. …”
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73
Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice
Published 2022-01-01“…Currently, the presence of antimalarial drug resistance has become a major obstacle in the treatment of malaria. …”
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74
Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum
Published 2014-01-01“…For more comprehensive analysis, antimalarial drug-protein interaction has been covered.…”
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75
Effect of Allicin and Artesunate Combination Treatment on Experimental Mice Infected with Plasmodium berghei
Published 2022-01-01“…Malaria is still a significant health problem in endemic countries and increases Plasmodium resistance to the available antimalarial drugs. Hence, this study aimed to investigate the antimalarial activity of allicin and its combination with artesunate (ART) against rodent malaria Plasmodium berghei ANKA (PbANKA) infected mice. …”
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76
Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives
Published 2015-01-01“…Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. …”
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77
In Vivo Antiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts of Haematostaphis barteri Hook F. (Anacardiaceae)
Published 2015-01-01“…Malaria is an endemic disease globally and the conundrum of drug resistance has led to the search for newer antimalarial agents. The root extract of H. barteri was evaluated for antimalarial, analgesic, and anti-inflammatory properties. …”
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78
New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation
Published 2021-01-01“…The biological evaluation of all target compounds as potential antimalarial, antileishmanial, antitrypanosomal, and antimicrobial agents was performed by various well-established cell-based methods. …”
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79
A Study of Synergy of Combination of Eosin B with Chloroquine, Artemisinin, and Sulphadoxine-Pyrimethamine on Plasmodium falciparum In Vitro and Plasmodium berghei In Vivo
Published 2020-01-01“…Artemisinin is the popular antimalarial medication, but it has to be used in combination with other drugs as its monotherapy causes resistance. …”
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80
Antiplasmodial and Cytotoxic Activities of Extracts of Selected Medicinal Plants Used to Treat Malaria in Embu County, Kenya
Published 2020-01-01“…The currently prescribed antimalarial drugs have been associated with adverse side effects ranging from intolerance to toxicity. …”
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