Associations among circulating sphingolipids, β-cell function, and risk of developing type 2 diabetes: A population-based cohort study in China. by Huan Yun, Liang Sun, Qingqing Wu, Geng Zong, Qibin Qi, Huaixing Li, He Zheng, Rong Zeng, Liming Liang, Xu Lin

“…<h4>Background</h4>Animal studies suggest vital roles of sphingolipids, especially ceramides, in the pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell dysfunction, and inflammation, but human studies are limited. …”
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The use of bacterial culture for Leptospirosis di- agnosis in female water buffaloes by Rosaura Pérez-Gil, Oriana Gavidia, Juan Torres

“…For this, 18 blood samples (16 females and two males) were extracted by puncture of the jugular vein, and these were allowed to coagulate to obtain the serum and urine samples from 2 female buffaloes, one male buffalo, and semen from 2 other animals, were collected. Additionally, two fetuses of 120 and 75 days of gestation were collected. …”
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Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…And then, we adopted the quantitative real-time PCR (RT-qPCR) assay to validate the hub genes among several CKD animal models. Furthermore, we constructed a competitive endogenous RNA (ceRNA) network for the hub genes utilizing the ENCORI and miRDB databases, while also calculating Spearman correlation coefficients. …”
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Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination by Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang

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Effect of ocean acidification on the oxygen consumption of the sea urchins Paracentrotus lividus (Lamarck, 1816) and Arbacia lixula (Linnaeus, 1758) living in CO2 natural gradients by Robert Fernández-Vilert, Robert Fernández-Vilert, Vanessa Arranz, Vanessa Arranz, Marta Martín-Huete, Marta Martín-Huete, José Carlos Hernández, Sara González-Delgado, Sara González-Delgado, Rocío Pérez-Portela, Rocío Pérez-Portela

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Antioxidant, Anti-Tyrosinase, and Wound-Healing Capacities of Soy Protein Hydrolysates Obtained by Hydrolysis with Papaya and Cantaloupe Juices Showing Proteolytic Activity by Thi-Phuong Nguyen, Quang Thai Le, Mai Linh Thi Tran, Kim Nhung Ta, Khoa Thi Nguyen

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Assessment of point-of-care quantitative serum canine pancreatic lipase testing for diagnosing acute pancreatitis in dogs by Pin-Chen Liu, Pin-Chen Liu, Kendy Tzu-yun Teng, Kendy Tzu-yun Teng, Tsia-Lu Lin, Chi-Hsuan Sung, Tsun-Li Cheng, Chi-Chung Chou, Chi-Chung Chou

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Genomic Diversity and Potential Transmission and Persistence of Salmonella in the Cambodian Vegetable Supply Chain by Abimel Salazar, Navin Sreng, Chanthol Peng, Yehzi Fu, Erin M. Nawrocki, Taejung Chung, Jessie Vipham, Edward G. Dudley, Jasna Kovac

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PET imaging of 52Mn labeled DOTATATE and DOTAJR11 by James M. Omweri, Hailey A. Houson, Shannon E. Lynch, Volkan Tekin, Anna G. Sorace, Suzanne E. Lapi

“…A comparison of these two compounds was performed in in vitro and in vivo studies in animals with somatostatin receptor-positive xenografts to characterize differences in cell, tumor, and tissue uptake. …”
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The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw... by Fanfan Wang, Fanfan Wang, Jian Liu

“…Lastly, a co-culture system of RA patient-derived peripheral blood mononuclear cells (RA-PBMCs) and vascular endothelial cells (VECs) was established to mimic the in vivo microenvironment, and the anti-inflammatory and anticoagulant mechanisms of XFC were validated in vitro.ResultsData mining analysis revealed abnormally elevated levels of inflammatory and coagulation markers such as fibrinogen (FBG), erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (Hs-CRP), and rheumatoid factor (RF) in RA patients (p &lt; 0.001), and emphasized the close correlation between XFC treatment and the improvement of these markers including Hs-CRP, ESR, and RF (confidence &gt;60% and lift &gt;1). Animal experimental data indicated that XFC effectively reduced the levels of inflammatory and coagulant markers (IL-6, D-D, FBG, PAF, VEGF, and TF) in adjuvant-induced arthritis (AA) rats while enhancing the expression of anti-inflammatory factors (IL-10) (p &lt; 0.05). …”
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Unveiling the Microbial Symphony of Amasi: A Targeted Metagenomic 16S rRNA, ITS, and Metabolites Insights Using Bovine and Caprine Milk by Betty Olusola Ajibade, Titilayo Adenike Ajayeoba, Saheed Sabiu, Konstantin V. Moiseenko, Sizwe Vincent Mbona, Errol D. Cason, Tatyana V. Fedorova, Oluwatosin Ademola Ijabadeniyi

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Safety evaluation and whole genome sequencing for revealing the ability of Penicillium oxalicum WX-209 to safely and effectively degrade citrus segments by Xiao Hu, Yujiao Qian, Zhipeng Gao, Gaoyang Li, Fuhua Fu, Jiajing Guo, Yang Shan

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Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model by Haoshu Fang, Chuanfeng Hua, Stefanie Weiss, Anding Liu, Wenhui Cheng, Ralf Claus, Jürgen Rödel, Olaf Dirsch, Uta Dahmen

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Modulation of Caecal Microbiome in Obese Mice Associated with Administration of Amaranth or Soybean Protein Isolates by Diana Olguín-Calderón, Jorge L. González-Escobar, Rosalva Ríos-Villa, Elena Dibildox-Alvarado, Antonio De León-Rodríguez, Ana P. Barba de la Rosa

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Effects of supplementation with vitamin D3 on growth performance, lipid metabolism and cecal microbiota in broiler chickens by Jiawei Li, Ximei Li, Jiamin Tian, Linna Xu, Yan Chen, Susu Jiang, Guohua Zhang, Jianxiong Lu

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Colour Stability and Lipid Oxidation of Beef Longissimus Lumborum under Different Packaging Conditions by Bonny Dadji Stéphane Serge, Li Xin, Li Zheng, Li Meng, Du Manting, Gao Lingling, Zhang Dequan

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Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…Samples of dorsal skin from these animals were subjected to hematoxylin and eosin staining or Masson’s trichrome staining. …”
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Soil organic carbon and related properties under conservation agriculture and contrasting conventional fields in Northern Malawi by Muneta G. Manzeke-Kangara, Ivy S. Ligowe, Austin Tibu, Timothy N. Gondwe, Henry M. R. Greathead, Marcelo V. Galdos, Marcelo V. Galdos

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Egyptian Novel Goose Parvovirus in Immune Organs of Naturally Infected Ducks: Next-Generation Sequencing, Immunohistochemical Signals, and Comparative Analysis of Pathological Chan... by Mohamed A. Lebdah, Amal A. M. Eid, Reham M. ElBakrey, Abd Elgalil. El-Gohary, Mohamed G. Seadawy, Mohamed R. Mousa, Hagar F. Gouda, Nehal I. A. Goda, Mostafa F. El-Hosseny, Ahmed S. El-tahlawy, Rokayya Sami, Rasha A. Al-Eisa, Sarah S. Helal

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Association Between Weight-Adjusted Waist Index and Cognitive Function in Older Adults Without Diabetes: A Cross-Sectional Study by Wang Q, Yin Y, Liu W, Li L, Wang Z, Tian Y, Fan J

“…Qing Wang,1,&ast; Yishan Yin,2,&ast; Wei Liu,3,&ast; Lingyu Li,1 Zhen Wang,1 Yue Tian,1 Jing Fan1 1Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China; 2Department of Orthopedics, The Armed Police Forces Hospital of Shandong, Jinan, Shandong, 250000, People’s Republic of China; 3Department of Emergency Critical Care Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jing Fan, Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China, Email sddzfanjing@163.comBackground: This study investigates the correlation between the weight-adjusted waist index (WWI) and cognitive performance in the senior American population, focusing on those without diabetes from 2011 to 2014.Methods: We analyzed data from the 2011– 2012 and 2013– 2014 National Health and Nutrition Examination Surveys (NHANES), focusing on non-diabetic participants aged 60 and older who completed cognitive tests: Establish a Registry for Alzheimer’s disease (CERAD), the Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST). …”
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