General practice database on mortality in adults on methylphenidate: cohort study by Bruno Stricker, Katia Verhamme, Kiki Cheung

“…Additional adjustment was performed for the intervention (‘intention-to-treat’).Results Although during follow-up, the unadjusted risks of depression and suicide attempt were strongly increased in users, depression and psychosis became non-significant after adjustment for alcohol-abuse and substance-abuse and psychiatric disease in the medical history and after adjustment for ‘intention-to-treat’. …”
Get full text

Geographic Variation and Trends in Laryngeal Cancer Incidence in Iran: A Comprehensive Analysis by Farimah Asghari, Hamideh Rashidian, Fereshteh Lotfi, Fatemeh Mahdavi Sabet, Zahra Faraji, Kazem Zendehdel

“…Our findings suggest that opium use, in addition to established risk factors like tobacco and alcohol, might contribute to the high incidence rates observed in Iran. …”
Get full text

Decline of adolescent smoking in Ireland 1995–2015: trend analysis and associated factors by Shasha Li, Sheila Keogan, Luke Clancy, Keishia Taylor

“…Objectives The study examines trends in smoking among Irish adolescents aged 15–16 years between 1995 and 2015 and the factors associated with their smoking behaviours between 2007 and 2015.Methods Data were obtained from the European School Survey Project on Alcohol and Other Drugs Ireland between 1995 and 2015. …”
Get full text

Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway by Yongnan Piao, Nuoya Wang, Mingji Jin, Jianyu Piao, Mingfeng Han, Zifei Wang, Chunhua Quan, Jishan Yin, Zhonggao Gao, Wenxiang Cui, Shuangqing Wang, Xiuquan Quan

“…Heavy alcohol consumption can lead to various gastrointestinal disorders, with gastric ulcers being the most prevalent. …”
Get full text

Analysis on Flavor Quality of Brassica rapa L. from Different Varieties by MAERHABA·Paerhati, Zhanteng SONG, Ruina YANG, Jing LI, Jing AN, Min LIU, Zhenzhen XU, Jingrong ZHU

“…GC-IMS results showed that 68 volatile flavor components, including testers, alcohols, aldehydes and sulfur, were identified in SFB, RQH, KPZ, and KPB. …”
Get full text

The mental health impact of COVID-19: the need for community interventions and collaboration for recovery by Nadarajah Rajeshkannan, Daya Somasundaram, Balachandran Kumarendran, Thirunavukarasu Kumanan, Ivan Dinesh Aloysius, Nalayini Sugirthan, Sivanantham Sasikumar, Nalayini Jegathesan

“…In the general population, common consequences included common mental health disorders, changing patterns of substance abuse particularly alcohol, and increased domestic violence. Family relationships and interactions generally improved but in a minority had strained dynamics. …”
Get full text

Ginsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases by Mingyu Wu, Ke Li, Jiabin Wu, Xianyi Ding, Xiaotong Ma, Wenhong Wang, Weihua Xiao

“…As a kind of monomer in Chinese medicine with multitarget pharmacological effects, G-Rg1 can provide significant therapeutic benefits in the alleviation of alcoholic liver disease, nonalcoholic fatty liver disease, liver fibrosis, viral hepatitis, etc., which mainly rely on the inhibition of apoptosis, strengthening endogenous anti-inflammatory and antioxidant mechanisms, activation of immune responses and regulation of efflux transport signals, to improve pathological changes in the liver caused by lipid deposition, inflammation, oxidative stress, accumulation of hepatotoxic product, etc. …”
Get full text

Promoting physical activity in vulnerable adults ‘at risk’ of homelessness: a randomised controlled trial protocol by Sarah E Jackson, Lee Smith, Charlotte Stringer, Mike Loosemore, Eloise Moller, Guillermo Felipe López-Sánchez, Joseph Firth, James Johnstone, Brendon Stubbs, Davy Vancampfort

“…Changes in drug use and alcohol dependency will also be explored.Ethics and dissemination Ethical approval to process and analyse data and disseminate findings was obtained through the Anglia Ruskin University Department of Sport and Exercise Sciences Research Ethics Committee. …”
Get full text

A prospective study on association between comprehensive lifestyle scores and cognitive function changes in community-dwelling older adults in Tianjin city by Muya ZHANG, Xian CAI, Liping ZU, Huichao ZHAO, Tianyu WANG, Chenyu LI, Jing YUAN, Fei MA

“…A comprehensive lifestyle score was constructed based on overweight or obesity, physical activity, smoking, alcohol consumption, diet, and sleep. Scores of 0 – 1 were defined as unhealthy lifestyle, 2 – 4 as average lifestyle, and 5 – 6 as healthy lifestyle. …”
Get full text

Metabolic syndrome and pancreatic lesions by O. S. Shifrin, I. A. Sokolina, A. E. Leonovich, M. A. Ashitko, T. L. Lemina, A. V. Korolyov

“…Steatosis of the pancreas can be considered as diffuse development of fatty tissue in all parts of the organ, developing mainly on the background of metabolic syndrome and combined to smoldering pancreatic inflammation under influence of pancreatoxic factors – alcohol, gallstone disease. Efficacy of new phospholipid drug Resalut in patients with steatosis of the pancreas associated to hepatic steatosis and lipidemia is demonstrated.…”
Get full text

Long-term results of antiviral therapy in patients with chronic hepatitis C with sustained virologic response by T. M. Ignatova, T. N. Lopatkina, V. P. Chulanov, Ye. V. Gaydasheva, S. N. Batskikh, G. V. Mikhaylovskaya, D. T. Abdurakhmanov, S. Yu. Karpov, Ye. N. Nikulkina, O. A. Chernova

“…A principal cause of elevation of alanine transaminase activity was non-alcoholic steatohepatitis. In one LC patient development of esophageal varicose veins was detected. …”
Get full text

A comprehensive review on the plant sources, pharmacological activities and pharmacokinetic characteristics of Syringaresinol by Lei Zhang, Yuqing Tian, Lingling Zhang, Huanyu Zhang, Jinghua Yang, Yi Wang, Na Lu, Wei Guo, Liang Wang

“…Syringaresinol, a phytochemical constituent belonging to lignan, is formed from two sinapyl alcohol units linked via a β-β linkage, which can be found in a wide variety of cereals and medicinal plants. …”
Get full text

Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention by Jianmei Zheng, Cen Chen, Zhongcai Fan, Qiang Ye, Yi Zhong, Jinsong Li, Hao Huang, Jianping Deng, Jinghong Zhao, Tinglin Xiong, Wenjie Tian, Xuemei Zhang

“…Compared to patients with TTR-HR 0–50% and >50%–75%, patients with TTR-HR > 75%–100% were older and less alcohol user, less likely to use diuretics and anti-diabetic drugs, these patients had less comorbidities of hyperlipidemia, diabetes, heart failure, and cardiac shock. …”
Get full text

Clustering of non-communicable disease risk factors among school teachers: A cross-sectional study in Kerala, India by Mini GK, Sangeeth KS, Anand Marthanda Pillai, Sarma PS, Thankappan KR

“…Current tobacco use was reported by 5 % of men, while 13.4 % of men and 2.6 % of women reported alcohol use. A quarter of teachers consumed than five servings of fruits and vegetables daily. …”
Get full text

Bioactive phytochemical compounds characterization, anti-oxidant and anti-microbial activity of the methanol and acetonitrile leaf extracts of Pithecellobium dulce by M. Kiranmayee, K. Riazunnisa

“…FTIR analysis identified various functional groups in the leaf extracts, indicating the presence of alcohols, phenols, unsaturated and saturated hydrocarbons, amines, flavonoids, and halogenated compounds. …”
Get full text

A Study Exploring Relationship between Risk Factors and Resilience among Youth by Fenny Leferty Kharpuri, Ramya Bhaskar

“…Results: The results highlighted that smoking, tobacco, alcohol, and self-medication risks were higher and all the aspects of resilience except for adaptability were found to be lower among youth. …”
Get full text

Risk Factors Associated with Falls and Fractures Following Prescription of Opioids Among Privately Insured Patients with Osteoarthritis by Stuart Silverman, Patricia Schepman, J. Bradford Rice, Craig G. Beck, William Pajerowski, Alan G. White, Sheena Thakkar, Rebecca L. Robinson, Birol Emir

“…Significant (_P_<.05) risk factors associated with at least 1 fall or fracture during the follow-up period included alcohol use (odds ratio [OR], 3.41), history of falling (OR, 2.19), non-tramadol opioid use (OR, 1.31), age (OR, 1.03), benzodiazepine use (OR, 1.21), and at least 1 osteoporosis diagnosis (OR, 2.06). …”
Get full text

Epidemiology of Non-Melanoma Skin Cancer Patients Attending at Hiwa Hospital in Sulaimani City, Iraq by Bushra Mohammed Ali, Hiwa Abas Ahmed

“…Most of the cases 32 (45.7%) with type (O) blood group, not smoking cigarette 51 (72.9%) and not drinking alcohol 69 (98.6%). This study showed a statistical significant association between non-melanoma skin cancer with level of education (P value =0.002), family history (P value = 0.02), time of exposure to sun light (P value of < 0.001) and BMI (p value = 0.001).  …”
Get full text

New Zealand policy experts’ appraisal of interventions to reduce smoking in young adults: a qualitative investigation by Janet Hoek, Heather Gifford, Jude Ball, El Shadan Tautolo

“…Participant selection was based on seniority and expertise and ensuring diverse perspectives were represented.Interventions We examined nine interventions that could either promote greater mindfulness or introduce barriers impeding smoking uptake: smoke-free outdoor dining and bars; no tobacco sales where alcohol is sold; social marketing campaigns; real life stories (testimonials); life skills training; raise purchase age to 21; tobacco-free generation; smokers’ licence; make tobacco retail premises R18.Results The policies perceived as more effective denormalised tobacco; made it less convenient to access and use; highlighted immediate disadvantages (eg, impact on fitness); aligned with young people’s values; and addressed the underlying causes of smoking (eg, stress). …”
Get full text

Hypnotics' association with mortality or cancer: a matched cohort study by Daniel F Kripke, Lawrence E Kline, Robert D Langer

“…This study extends previous reports associating hypnotics with excess mortality.Setting A large integrated health system in the USA.Design Longitudinal electronic medical records were extracted for a one-to-two matched cohort survival analysis.Subjects Subjects (mean age 54 years) were 10 529 patients who received hypnotic prescriptions and 23 676 matched controls with no hypnotic prescriptions, followed for an average of 2.5 years between January 2002 and January 2007.Main outcome measures Data were adjusted for age, gender, smoking, body mass index, ethnicity, marital status, alcohol use and prior cancer. Hazard ratios (HRs) for death were computed from Cox proportional hazards models controlled for risk factors and using up to 116 strata, which exactly matched cases and controls by 12 classes of comorbidity.Results As predicted, patients prescribed any hypnotic had substantially elevated hazards of dying compared to those prescribed no hypnotics. …”
Get full text