Digital health data security practices among health professionals in low-resource settings: cross-sectional study in Amhara Region, Ethiopia by Ayenew Sisay Gebeyew, Wondwossen Zemene, Binyam Chaklu Tilahun, Nebyu Demeke Mengestie, Berhanu Fikade Endehabtu, Zegeye Regasa Wordofa, Mitiku Kassaw Takillo, Gedefaw Belete Ashagrie, Melaku Molla Sisay

“…Health professionals 41–45-year age group (AOR = 0.107), master’s degree (AOR = 2.45), postmaster’s degree (AOR = 3.87), time to visit the internet for more than two hours (AOR = 2.46), basic computer training (AOR = 2.77), training in digital data security (AOR = 2.14), and knowledge (AOR = 1.76) were associated with the practice of digital health data security. …”
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TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Bintrafusp alfa (BA) is a bifunctional fusion protein that simultaneously blocks nonredundant immunosuppressive TGF-β and PD-(L)1 pathways.Methods This first-in-human, dose-escalation study in patients with advanced solid tumors (N=58; aged ≥18 years, ECOG PS≤1) evaluated M6223 alone (Part 1A, n=40; M6223 10–2400 mg every 2 weeks, n=32; M6223 2400 mg every 3 weeks, n=8) or with BA (Part 1B, n=18; M6223 300–1600 mg with BA 1200 mg; both every 2 weeks, intravenous). …”
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Seroprevalence of brucellosis in camels and humans in the Al-Qassim region of Saudi Arabia and its implications for public health by Abdulaziz M. Almuzaini, Abdullah S. M. Aljohani, Ahmed I. Alajaji, Ayman Elbehiry, Adil Abalkhail, Abdulrahman Almujaidel, Sahar N. Aljarallah, Hazem R. Sherif, Eman Marzouk, Abdelmaged A. Draz

“…The present study aimed to investigate the epidemiology of camel brucellosis as a zoonotic disease by determining the seroprevalence of brucellosis in both camels and humans, assessing potential risk factors (e.g., age, size, and location), and conducting molecular characterization of Brucella spp. associated with abortion in camels. …”
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Cord Direct Antiglobulin Test for Predicting the Need for Phototherapy in Neonates with ABO Incompatibility: A Prospective Cohort Study by Ranjith Balan, Sakthipriya Balaji, Arun Kumar, Subash Sundar, Shrinidhi Krishnan, Ashok Chandrasekaran

“…Babies were monitored for jaundice until 14 days of age. Results: Out of 3,092 eligible deliveries, 523 babies with ABO incompatibility were enrolled. …”
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Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…Materials and methods. 95 children aged 3 to 73 months with liver cirrhosis of various etiologies were surveyed. …”
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Factors influencing in-hospital mortality for salvage percutaneous transjugular intrahepatic portosystemic shunting in cirrhotic patients with recalcitrant variceal bleeding after... by J E J Krige, E G Jonas, M Setshedi, S J Beningfield, U K Lotze, M M Bernon, S Burmeister, J C Kloppers

“…Thirty-four patients (29 men, 5 women), mean age 52 years (range 31 - 80), received sTIPS for uncontrolled (n=11) or refractory (n=23) AVB. …”
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Multiparameter body composition analysis on chest CT predicts clinical outcomes in resectable non-small cell lung cancer by Yilong Huang, Hanxue Cun, Zhanglin Mou, Zhonghang Yu, Chunmei Du, Lan Luo, Yuanming Jiang, Yancui Zhu, Zhenguang Zhang, Xin Chen, Bo He, Zaiyi Liu

“…Results A total of 2712 patients (mean age, 61.53 years; 1146 females) were evaluated. …”
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Effects of a nutrition education intervention on nutrition knowledge and attitude among overweight and obese primary schoolchildren: a cluster randomized controlled trial by Rusidah Selamat, Nur Azlina Abdul Aziz, Junidah Raib, Norlida Zulkafly, WNurul Ashikin W. Mohamad, Ainan Nasrina Ismail, Muhammad Yazid Jalaludin, Fuziah Md. Zain, Zahari Ishak, Abqariyah Yahya, Abdul Halim Mokhtar

“…Methods A school-based cluster randomized controlled trial of the MyBFF@school obesity intervention program was conducted among overweight and obese schoolchildren aged 9–11. Out of 1,196 eligible government primary schools in central Peninsular Malaysia, 23 were randomly assigned into seven intervention schools (647 children) and 16 control schools (750 children). …”
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Potentially inappropriate prescribing in hospitalised children: a retrospective, cross-sectional study at a tertiary children’s hospital in China by Linan Zeng, Lingli Zhang, Dan Yu, Huiqing Wang, Liang Huang, Siyu Li, Guo Cheng, Zhi-Jun Jia

“…Introduction For improving and optimising drug use in children, we previously developed a tool (including a series of criteria for identifying potentially inappropriate prescribing in children) by literature review and the two-round Delphi technique to prevent inappropriate medication prescriptions at the prescribing stage.Objective To assess the prevalence of potentially inappropriate prescription (PIP) among hospitalised children and explore risk factors associated with PIP.Design A retrospective cross-sectional study.Setting A tertiary children’s hospital in China.Participants Hospitalised children with complete medical records who received drug treatment and discharged from 1 January to 31 December 2021.Outcome measures We evaluated the medication prescriptions by using a series of previously developed criteria for detecting the prevalence of PIP in hospitalised children and used logistic regression to explore the risk factors (including sex, age, number of drugs, number of comorbidities, days of hospitalisation and admission departments) for PIP in children.Results A total of 87 555 medication prescriptions for 16 995 hospitalised children were analysed, and 19 722 PIPs were detected. …”
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Spatial analysis of measles cases and vaccination coverage in the Somali region, eastern Ethiopia by Abdilahi Ibrahim Muse, Abdilahi Ibrahim Muse, Mahdi Yonis Kayat, Mohamed Harir Aden, Jemal Beksisa Shuramu, Shikur Mohammed, Musse Ahmed Ibrahim, Musse Ahmed Ibrahim, Binyam Mohammedbirhan Berhe, Ahmed Abdi Kalinle, Sahardiid Ali Abdilahi

“…The majority of the participants, 5,260 (88.7%), were under the age of 59 months, with 3,184 (53.7%) being male. …”
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Long-term outcomes of robot-assisted versus minimally invasive esophagectomy in patients with thoracic esophageal cancer: a propensity score-matched study by Toru Sakurai, Akihiro Hoshino, Kenta Miyoshi, Erika Yamada, Masaya Enomoto, Junichi Mazaki, Hiroshi Kuwabara, Kenichi Iwasaki, Yoshihiro Ota, Shingo Tachibana, Yutaka Hayashi, Tetsuo Ishizaki, Yuichi Nagakawa

“…These variables included age, sex, body mass index, alcohol consumption, smoking history, American Society of Anesthesiologists stage, comorbidities, tumor location, histology, clinical TNM stage, and preoperative therapy. …”
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Comparative analysis of ocular biometrics using spectral domain optical coherence tomography with Purkinje image and optic nerve head alignments in mice by Ying Hon Sze, Bing Zuo, Da Qian Lu, King Kit Li, Dennis Yan Yin Tse, Qian Zhao, Thomas Chuen Lam

“…There was a significant difference in the relative growth trend in VCD (linear regression, p = 0.02), which was relatively stable and showed shortening when measured with ONH alignment from postnatal age 21 to 35 days. Conclusions SD-OCT allowed precise in-vivo measurement and segmentation of ocular dimensions, regardless of the methods adopted. …”
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Shortening duration of untreated illness in young people with first episode eating disorders: protocol of a randomised controlled feasibility trial of a smartphone friendly multi-m... by Luiza Grycuk, Dina Monssen, Molly R. Davies, Helen Sharpe, Karina L. Allen, Vibhore Prasad, Rachel Potterton, Priya Popat, Victoria A. Mountford, Sheryllin McNeil, Vanessa Lawrence, Nina Grant, Kimberley A. Goldsmith, Danielle Glennon, Sarah Byford, Amy Brown, Ulrike Schmidt

“…We aim to recruit 116 participants (young people, aged 16–25, with first episode ED) from primary care, schools and universities, ED services and social media. …”
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Association between Loa loa microfilaremia and anatomical hyposplenia in a rural area of the Republic of Congo: a population-based cross-sectional study by Charlotte Boullé, Elodie Lebredonchel, Jérémy T. Campillo, Valentin Dupasquier, Marlhand C. Hemilembolo, Sébastien D. S. Pion, Jean Claude Djontu, Ludovic Rancé, Philippe Souteyrand, François Missamou, Michel Boussinesq, Francine Ntoumi, Cédric B. Chesnais

“…Methods We included 981 participants aged 18–88 years in a cross-sectional study conducted in May–June 2022 in the Republic of the Congo. …”
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The state of paediatric deceased-organ donation at a South African tertiary public- sector hospital: A 14-year analysis by T Siyotula, J Barrell, K Manning, D Thomson, M McCulloch, T du Toit

“…Ninety-three of the 1 581 patients (5.9%) were referred to the on-call transplant co-ordinator as potential organ donors, of whom 69% had been involved in a traumatic accident, including 52% in road traffic collisions. The mean age of the potential donors was 7 years with 60.2% being boys. …”
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Effectiveness of ertugliflozin during Ramadan fasting in patients with type 2 diabetes mellitus: a real-world study (ErtuRamadan study) by Md Faruque Pathan, Nazma Akter, Marufa Mustari, M. Saifuddin, Mirza Sharifuzzaman, Mohammad Motiur Rahman, Mohammed Ripon, S. M. Mohiuddin, A. B. M. Kamrul-Hasan, Mohammad Abdul Hannan, Muhammad Shah Alam, Samira Mahjabeen, Faria Afsana, Muhammed Abu Bakar, Tahniyah Haq, Afsar Ahammed, Samir Kumar Talukder, Sourav Sarkar, Shahjada Selim

“…The primary endpoints were changes in HbA1c levels, body weight, body mass index (BMI), and the incidence of hypoglycemia during Ramadan fasting.ResultsThe mean age of the study participants was 50.37 ± 11.14 (SD) years, with 40.6% male and 58.7% female. …”
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The effect of the fenugreek hydrolyzed protein on lipid profile in patients with mild-to-moderate hypercholesterolemia: A confirmatory triple-blind randomized-controlled clinical t... by Mahdi Badiee Gavarti, Ali Askari, Hamidreza Roohafza, Mozhde Askari, Zahra Teimouri Jervekani, Shima Kaveh, Mohammad Kermanialghoraishi, Alireza Sadeghimahoonak, Masoumeh Sadeghi

“…Methods: This study is a confirmatory, triple-blind, two-group parallel, randomized controlled trial, phase 3 conducted on patients aged 18–65 years with mild-to-moderate hypercholesterolemia and low risk for cardiovascular disease. …”
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Long-term outcome of a treat-to-target strategy in late-onset rheumatoid arthritis with chronic lung disease: 5-year results of a prospective observational study by Manami Nomura, Takahiko Sugihara, Hiroyuki Baba, Tadashi Hosoya, Mari Kamiya, Tatsuro Ishizaki, Takumi Matsumoto, Kanae Kubo, Fumio Hirano, Masayo Kojima, Nobuyuki Miyasaka, Shinsuke Yasuda, Masayoshi Harigai

“…Methods Data from 197 methotrexate (MTX)-naïve LORA patients (mean age 74.4 years) from a prospective, monocentric registry were analyzed. …”
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Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults by Wenxin Bian, Raaj K. Biswas, Matthew N. Ahmadi, Yu Sun Bin, Svetlana Postnova, Andrew J. K. Phillips, Nicholas A. Koemel, Jean-Philippe Chaput, Shantha M. W. Rajaratnam, Peter A. Cistulli, Emmanuel Stamatakis

“…Methods Population-based prospective cohort study of 82,391 adults aged 43 to 79 years from the UK Biobank accelerometry subsample, collected between 2013 and 2015, followed up to 2022. …”
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Prediction of major adverse cardiovascular events following ST-segment elevation myocardial infarction using cardiac obesity marker—epicardial adipose tissue mass index: a prospect... by Zeyan Liu, Jinbo Wang, Yanfang Yang, Jinglin Cheng, Min Yang, Ye Zhang

“…Subgroup analyses were conducted based on age, gender, body mass index (BMI), left ventricular ejection fraction (LVEF), and culprit artery.ResultsA total of 308 patients were included in the analysis, with 212 in the training set and 96 in the validation set. …”
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