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6001
WKB ameliorates DSS-induced colitis through inhibiting enteric glial cells activation and altering the intestinal microbiota
Published 2025-01-01“…The rising prevalence of IBD, linked to Western diets in developing countries, highlights the need for dietary interventions. …”
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6002
GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia
Published 2025-02-01“…The changes in angiogenesis markers, autophagy markers, and eNOS levels were detected using qPCR and Western blotting. 3-MA was used to assess the role of autophagy in the activation of eNOS mediated by AST and its subsequent angiogenic effects.Results: GelMA@LNP/AST significantly promoted blood flow recovery in mice with hind limb ischemia. …”
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6003
Woody Species Structure and Regeneration Status in Kafta Sheraro National Park Dry Forest, Tigray Region, Ethiopia
Published 2020-01-01“…The study was conducted in Kafta Sheraro National Park (KSNP) dry woodland natural forest located in Kafta Humera and Tahitay Adiyabo weredas (districts), Western and Northwestern Zones of Tigray regional governmental state, North Ethiopia. …”
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6004
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice
Published 2025-01-01“…Methods Male wild-type (WT) and mdx mice were divided into three groups: WT, mdx, and AGH-treated mdx mice (40 mg/kg intraperitoneally for two weeks) at 6 weeks of age. Gene expression, western blotting, H&E staining, immunofluorescence, ROS assays, TUNEL apoptosis, glutathione activity, and muscle force measurements were performed. …”
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6005
FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss
Published 2025-02-01“…Immunohistochemical and western blot techniques were used to identify and measure protein expression. …”
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6006
Wind–Wave Misalignment in Irish Waters and Its Impact on Floating Offshore Wind Turbines
Published 2025-01-01“…The investigation highlighted that in western coastal areas, average misalignment could reach <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msup><mn>57.95</mn><mo>∘</mo></msup></mrow></semantics></math></inline-formula>, while sheltered Irish Sea regions experienced lower values, such as <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msup><mn>23.06</mn><mo>∘</mo></msup></mrow></semantics></math></inline-formula>. …”
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6008
A national study of choanal atresia in tertiary care centers in Canada – part I: clinical presentation
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6010
Impact of Amarogentin on Gastric Carcinoma Cell Multiplication, Apoptosis and Migration via circKIF4A/miR-152-3p
Published 2022-01-01“…Cell multiplication, clone formation, as well as apoptosis and migration measurements were made by MTT, plate clone formation, flow cytometry and Transwell assays, respectively; Double luciferase reporter assay was performed for targeting relationship identification between circKIF4A and miR-152-3p; Western blots were carried out to measure Bax and Bcl-2 protein levels. …”
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6011
Dose-Weighted Network Pharmacology: Evaluating Traditional Chinese Medicine Formulations for Lumbar Disc Herniation
Published 2025-01-01“…TSD, YJD, and PQT were evaluated in animal experiments, and the algorithm’s feasibility was validated through GO and KEGG pathway analysis, Thermal Hyperalgesia Test, H&E staining, Western blotting (WB), RT-PCR, and ELISA assays.Results: The computational model indicated that YJD and PQT had higher predicted efficacy compared to TSD. …”
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6012
MicroRNA-21-5p Reduces Hypoxia/Reoxygenation-Induced Neuronal Cell Damage through Negative Regulation of CPEB3
Published 2021-01-01“…Besides, the apoptosis-related proteins including BAX, BCL2, cleaved caspase-3, and caspase-3 as well as proteins of EGFR/PI3K/AKT signaling pathways were measured by Western blot. To verify the target relation between cytoplasmic polyadenylation element binding protein 3 (CPEB3) and miR-21-5p, luciferase reporter gene experiment was performed. …”
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6013
Mobilization of plant genetic resources from the territory of India
Published 2019-02-01“…He explored the Northern, North-Western (Punjab and Kashmir) and Southern India, where he collected 2557 germplasm samples. …”
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6014
Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain
Published 2025-02-01“…Pain threshold of rats was measured by thermal withdrawal latency (TWL) and mechanical withdrawal threshold (MWT), Elisa was used to detect the expression level of inflammatory factors, qRT PCR and Western blotting were used to detect astrocyte polarization markers, C/EBP-β, TGF-β 1, p-smad2 and p-smad3.Results: Following Vincristine administration, the TWL and MWT of rats exhibited a decrease. …”
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6015
Nouveaux éléments concernant l’amphithéâtre antique de Saintes (Charente-Maritime) : l’arène aux iiie et ive s. apr. J.-C.
Published 2024-12-01“…The seemingly quite rapid filling of the arena space, observed in the western third of the building, suggests an abandonment no earlier than the very end of the 4th century, more probably during the following century. …”
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6017
Unveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis
Published 2025-01-01“…Bowen Wei,1,2,* Siwei Wang,1,2,* Suiran Li,1,2,* Qingxiang Gu,3 Qingyun Yue,4 Zhuo Tang,1,2 Jiamin Zhang,1,2 Wei Liu1,2 1Department of Rheumatism and Immunity, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, People’s Republic of China; 3Center of Preventive Treatment of Disease, Cangzhou Hospital of Integrated Traditional Chinese and Western of Hebei Province, Cangzhou, Hebei, People’s Republic of China; 4School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Liu, Email fengshiliuwei@163.comBackground: Ankylosing spondylitis (AS) is a chronic autoimmune disease characterized by inflammation of the sacroiliac joints and spine. …”
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6019
Mechanism of Action of Decitabine in the Treatment of Acute Myeloid Leukemia by Regulating LINC00599
Published 2023-01-01“…The expression of apoptosis-related proteins was analyzed using western blotting. The regulatory relationship between miR-135a-5p and LINC00599 was verified by constructing miR-135a-5p mimics, miR-135a-5p inhibit, wild type LINC00599 3′-untranslated region (UTR), and mutant LINC00599 3′-UTR. …”
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6020