Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection by Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács, Eva Hammerlid

“…Methods A search for HNCUP was performed in the Swedish Cancer Registry, Western health district, between the years 1992–2009. …”
Get full text

Translation of a Diabetes Remission Service into Australian Primary Care: Findings from the Evaluation of DiRECT-Australia by Ritesh Chimoriya, Kimberly Mitlehner, Chee L. Khoo, Uchechukwu Levi Osuagwu, Russell Thomson, Lei Si, Michael Lean, David Simmons, Milan K. Piya

“…All patients enrolled in the DiRECT-Australia Type 2 Diabetes Remission Service in a region of Sydney (Macarthur region, South Western Sydney, Australia) were included. Eligible participants were aged 20–70 years, noninsulin treated, with T2DM of ≤6 years’ duration, and body mass index BMI≥27 kg/m2. …”
Get full text

Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis by Mengyuan Li, Hang Yuan, Xiaofei Yang, Yingfeng Lei, Jianqi Lian

“…Metabolic flux analysis, quantitative real-time PCR, western blotting and fluorescence immunohistochemistry were utilized to describe detailed glutamine-glutamate metabolic profiles during JEV infection. …”
Get full text

Paeoniflorin alleviates sepsis-associated acute kidney injury in mice by inhibiting aerobic glycolysis through the β-catenin/c-Myc pathway by GONG Yu, LEI Jiao, ZHANG Ming

“…ELISA was used to determine the contents of serum creatinine （Scr）， neutrophil gelatinase-associated lipocalin （NGAL） and lactate， and renal contents of hexokinase 2 （HK2）， lactate dehydrogenase A （LDHA）， IL-1β and IL-18. Western blotting was performed to detect the expression of total β-catenin， p-β-cateninY654， nucleus β-catenin and c-Myc. …”
Get full text

miR-576-5p Promotes the Proliferation of Papillary Thyroid Carcinoma through the MAPK4-AKT Pathway by Rui Hai, Yang Zhou, Fan Li, Qingxi Guo, Yang Long, Fang Wang, Lian Cheng, Fei Wu, Shi Chen, Xiangyu Zhou

“…Expression levels of mitogen-activated protein kinase 4 (MAPK4) and phosphorylation levels of protein kinase B (AKT), extracellular regulated protein kinase (ERK), and P38 mitogen-activated protein kinase (P38) were detected by western blotting or immunohistochemistry (IHC). Results. …”
Get full text

Disrupted HIV care during COVID-19 pandemic associated with increased disabilities among people living with HIV in Belize by Tracy M. Quetzal, Wei-Cheng Lo, Ya-Wen Chiu, Hung-Yi Chiou

“…A cross-sectional study was conducted at the Western Regional Hospital and Southern Regional Hospital between August and October 2021 among people living with HIV in Belize aged ≥ 21 years and on antiretroviral therapy. …”
Get full text

Genetic Evidence of Killer Whale Predation on White Sharks in Australia by Isabella M. M. Reeves, Andrew R. Weeks, Alison V. Towner, Rachael Impey, Jessica J. Fish, Zach S. R. Clark, Paul A. Butcher, Lauren Meyer, David M. Donnelly, Charlie Huveneers, Nicky Hudson, Adam D. Miller

Get full text

Bridging the gap: attitudes and practices toward complementary and alternative medicine among oncology patients and healthcare professionals in Croatia by Ljerka Armano, Vanja Vasiljev, Tomislav Rukavina, Denis Juraga, Aleksandar Racz, Aleksandar Racz, Vanja Tešić, Vanja Tešić, Vanja Tešić

“…However, limited research exists on the attitudes of healthcare professionals and oncology patients toward CAM, especially within Western evidence-based medical settings. This study aims to address this gap by assessing CAM use prevalence among healthcare professionals and oncology patients and analyzing their cognitive, affective, and behavioral attitudes. …”
Get full text

Linking a distal ejecta with its source crater: a probabilistic approach applied to tektites by Rochette, Pierre, Baratoux, David, Braucher, Regis, Cornec, Jean, Debaille, Vinciane, Devouard, Bertrand, Gattacceca, Jerome, Gounelle, Matthieu, Jourdan, Fred, Moustard, Fabien, Nomade, Sébastien

Get full text

Possibilities to adapt oral history to the research of Soviet and post-Soviet epoch (the problems of the culture of memory and the politics of history) by Aurimas Švedas

“…Good conditions for the development of oral history in Lithuanian historiography are created by a favourable conjuncture in Western historiography—Lithuanian historians have many opportunities to participate in the global academic discourse and contribute to the global research by trying to grasp the issues of the Soviet and post-Soviet epoch. …”
Get full text

Measurement properties of the Minimal Insomnia Symptom Scale (MISS) among cardiac arrest survivors – A Rasch evaluation study by Patrik Hellström, Johan Israelsson, Erik Blennow Nordström, Carina Hjelm, Anders Broström, Peter Hagell, Kristofer Årestedt

Get full text

The effect of a community-based health behaviour intervention on healthcare services use among people with type 2 diabetes in Nepal by Grish Paudel, Corneel Vandelanotte, M Mamun Huda, Padam Kanta Dahal, Lal Rawal

Get full text

A Research Synthesis of Therapeutic Interventions for Whiplash-Associated Disorder (WAD): Part 5 – Surgical and Injection-Based Interventions for Chronic WAD by Robert W Teasell, J Andrew McClure, David Walton, Jason Pretty, Katherine Salter, Matthew Meyer, Keith Sequeira, Barry Death

Get full text

Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving towards a National Action Plan by Selena M. Sagan, Benoit Dupont, Jason Grebely, Mel Krajden, Sonya A. MacParland, Jennifer F. Raven, Sahar Saeed, Jordan J. Feld, D. Lorne Tyrrell, Joyce A. Wilson

Get full text

lncRNA SNHG15 as a ceRNA modulates Osteoclast Differentiation, Proliferation, and Metastasis by Sponging miR-381-3p/NEK2 Axis by YiFan Wang, GuanYin Zhu, Fang Pei, ZhiHe Zhao

“…The expressions of SNHG15, miR-381-3p, and never in mitosis-related kinase 2 (NEK2) mRNA were detected by real-time quantitative polymerase chain reaction (RT-qPCR); Western blot detected NEK2 and osteoclast markers (Cathepsin K, CTSK), matrix metalloproteinase 9 (MMP9), nuclear factor of activated T cell 2 (NFAT2), and tartrate-resistant acid phosphatase (TRAP) protein levels; cell proliferation was detected by Cell Counting Kit-8 (CCK-8), and the formation of osteoclasts was observed by TRAP staining; the F-actin skeleton was stained with tetramethylrhodamine isothiocyanate (TRITC) phalloidin; cell migration rate was detected by Transwell; dual-luciferase reporter gene assay and RNA-binding protein immunoprecipitation (RIP) assay verified the targeting relationship between miR-381-3p, SNHG15, and NEK2. …”
Get full text

Don’t move a mussel: The role of key environmental drivers and management scale in assessing spatial variation in dreissenid spread risk in the Missouri River basin by Joseph Raymond, Lucas S. Bair, Timothy D. Counihan, Wesley M. Daniel, Sofie Duntugan, Matthew E. Neilson, Michael Springborn

Get full text

Tear Film Proteome of Healthy Domestic Cats by Jéssica Fontes Veloso, Paula Elisa Brandão Guedes, Luciana Carvalho Lacerda, Juliano Oliveira Santana, Irma Yuliana Mora-Ocampo, Carlos Priminho Pirovani, Arianne Pontes Oriá, Alexandre Dias Munhoz, Renata Santiago Alberto Carlos

Get full text

A computational role of blood nanofluid induced by a stenosed artery with porous medium and thermophoretic particle deposition effects by Shivalila Hangaragi, N. Neelima, N. Beemkumar, Ankur Kulshreshta, Umair Khan, Noreen Sher Akbar, Mohammad Kanan, Mona Mahmoud

Get full text

Liraglutide Regulates the Kidney and Liver in Diabetic Nephropathy Rats through the miR-34a/SIRT1 Pathway by Shan Xiao, Ye Yang, Yue-Tong Liu, Jun Zhu

“…The levels of SIRT1, HIF-1a, Egr-1, and TGF-β1 in kidney and liver tissues were determined using qRT-PCR, western blot, and immunohistochemistry. Electron microscopy and HE staining were used to observe the ultrastructure and pathological changes. …”
Get full text

EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury by Shuangfei Ni, Bo Yang, Lei Xia, Huafeng Zhang

“…We used lipopolysaccharide (LPS) to induce inflammation of microglia, and we constructed the ASCI animal model. qRT-PCR detected the relative expression levels of EZH2, HIF-1α, miR-146a-5p, IL-6, TNF-α, IL-17, PKM2, GLUT1, and HK2 in cells and tissues. Western blot was performed to detect the expression levels of EZH2, HIF-1α, H3K27me3, IL-6, TNF-α, IL-17, PKM2, GLUT1, and HK2. …”
Get full text