A novel platform for engineered AAV-based vaccines by Sabrina Babutzka, Miranda Gehrke, Anastasia Papadopoulou, Maria Diedrichs-Möhring, Maria Giannaki, Lena Hennis, Bastian Föhr, Cale Kooyman, Andreas Osterman, Evangelia Yannaki, Gerhild Wildner, Hermann Ammer, Stylianos Michalakis

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Clinical manifestations, para-clinical features and outcome of Iranian adults with respiratory syncytial virus (RSV) infection: a report from hospitalized patients by Maryam Shafaati, Abbas Shakoori Farahani, Mohammadreza Salehi, Mohammad Arabzadeh, Helya Bolouki Azari, Arman Soleimany, Maryam Edalatifard, Vahid Salimi, Alireza Abdollahi

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Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction by Jingrun Lin, Xiaoqiu Zhu, Xuan Li, Yu Hong, Yaohui Liang, Siqi Chen, Chenzhuo Feng, Lin Cao

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Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

“…Chao Cheng,1,* Minjia Sun,1– 3,* Jingjing Li,1,* Yitong Xue,1 Xia Cai,4 Jing Liu,1 Xiaolian Wang,5 Shouhong Xu,2 Youhua Xie,1 Junqi Zhang1 1MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, People’s Republic of China; 2Key Laboratory for Advanced Materials and Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China; 3Zhejiang CONBA Pharmaceutical Co., Ltd, Hangzhou, 310052, People’s Republic of China; 4Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, 200032, People’s Republic of China; 5Department of Pathogeny Microbiology and Preventive Medicine, School of Medicine, Hexi University, Zhangye, 734000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junqi Zhang, Email junqizhang@fudan.edu.cn; Youhua Xie, Email yhxie@fudan.edu.cnPurpose: Human noroviruses (HuNoVs) are the main cause of non-bacterial acute gastroenteritis. …”
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Pathogen community composition and co-infection patterns in a wild community of rodents by Abbate, Jessica L., Galan, Maxime, Razzauti, Maria, Sironen, Tarja, Voutilainen, Liina, Henttonen, Heikki, Gasqui, Patrick, Cosson, Jean-François, Charbonnel, Nathalie

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Prospective evaluation of the impact of repeated whole prison testing for hepatitis C by Stuart McPherson, Naw April Phaw, Manoj Valappil, Carolyn Miller, Craig Thompson, Francesca McCullough, Caroline Allsop, Kate McQue, Ryan Jelley, Jenna Kerry, Jodi Aldridge, Tony Jefferson, Colin Lawton, Lee Christensen, Aung Min Thant

“…Overall, 81% (144/178) of active HCV infections received antiviral treatment, and 89% achieved sustained virological response. The proportion of active HCV infections between the HITTs was 7.2% through reception testing.Conclusion A follow-up HITT after 4 years yielded only 0.3% active HCV infection in a high HCV prevalence prison and a reasonably good reception testing and treatment programme. …”
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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications by Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe

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Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease S... by V. T. Ivashkin, V. P. Chulanov, N. A. Mamonova, M. V. Maevskaya, M. S. Zharkova, I. N. Tikhonov, P. O. Bogomolov, E. V. Volchkova, A. S. Dmitriev, O. O. Znojko, E. A. Klimova, K. V. Kozlov, I. E. Kravchenko, E. Yu. Malinnikova, R. V. Maslennikov, M. I. Mikhailov, K. E. Novak, I. G. Nikitin, V. E. Syutkin, E. V. Esaulenko, A. A. Sheptulin, E. N. Shirokova, N. D. Yushchuk

“…The spectrum of their effectiveness allows to achieve a sustained virological response in more than 90 % of cases, even in groups that were not previously considered even as candidates for therapy or were difficult to treat — patients receiving renal replacement therapy, after liver transplantation (or other organs), at the stage of decompensated liver cirrhosis, HIV co-infected, etc. …”
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Clinical guidelines of the Russian gastroenterological association and the Russian society on studying of liver diseases on diagnostics and treatment of adult patients with hepatit... by V. T. Ivashkin, N. D. Yushchuk, M. V. Mayevskaya, O. O. Znoyko, K. R. Dudina, G. N. Karetkina, E. A. Klimova, S. L. Maximov, Yu. V. Martynov, I. V. Mayev, Ch. S. Pavlov, Ye. A. Fedosyina, A. O. Bueverov, D. T. Abdurakhmanov, N. A. Malyshev, I. G. Nikitin, Ya. G. Moysyuk, T. L. Lapina, A. S. Trukhmanov, G. M. Kozhevnikova, K. V. Zhdanov, A. G. Rakhmanova, V. P. Chulanov, I. V. Shahgildyan, V. E. Syutkin, P. O. Bogomolov

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Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

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Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS by Bianca Klee, Sophie Diexer, Susan Langer, Cornelia Gottschick, Carla Hartmann, Nadine Glaser, Johannes Horn, Evelyn Dorendorf, Heike Raupach-Rosin, Lamiaa Hassan, Nicole Rübsamen, Kristin Maria Meyer-Schlinkmann, Carlos A. Guzman, Valerie Heselich, Eva Battin, Thomas Pietschmann, Dietmar H. Pieper, Mathias Pletz, Peggy Riese, Stephanie Trittel, Saskia Thies, Constantin von Kaisenberg, Frank Dressler, Florian Guthmann, Carsten Oberhoff, Ralf L. Schild, Andre Karch, Rafael Mikolajczyk

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Whole genomic analysis uncovers high genetic diversity of rifampicin-resistant Mycobacterium tuberculosis strains in Botswana by Tuelo Mogashoa, Tuelo Mogashoa, Johannes Loubser, Ontlametse T. Choga, Ontlametse T. Choga, Justice Tresor Ngom, Wonderful T. Choga, Wonderful T. Choga, Mpaphi B. Mbulawa, Tuduetso Molefi, One Stephen, Topo Makhondo, Kedumetse Seru, Patience Motshosi, Boitumelo Zuze, Joseph Makhema, Rosemary M. Musonda, Dimpho Otukile, Chawangwa Modongo, Botshelo T. Kgwaadira, Keabetswe Fane, Simani Gaseitsiwe, Rob M. Warren, Sikhulile Moyo, Sikhulile Moyo, Sikhulile Moyo, Sikhulile Moyo, Anzaan Dippenaar, Elizabeth M. Streicher

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Ocular manifestations and treatment safety in hepatitis C patients undergoing direct-acting antiviral therapy: a prospective cohort study by Guilherme Thomé de Carvalho, Carlos Eduardo Brandão Mello, Kelma Macedo Pohlmann Simões, Mário Martins dos Santos Motta, Max Kopti Fakoury, Bruno Vasconcelos Coimbra, Laura Gomes Nunes Melo, Flávio Mac Cord Medina

“…All patients achieved sustained virological response, and a notable improvement in fibrosis degree post-treatment was observed. …”
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Safety and efficacy of telaprevir in treatment of a chronic hepatitis C in patients of the Russian population included in early access program study by D. T. Abrurakhmanov, V. G. Morozov, I. G. Nikitin, P. O. Bogomolov, N. I. Geyvandova, Ye. N. Bessonova, I. G. Bakulin, V. A. Isakov, K. V. Zhdanov, M. V. Mayevskaya, Ye. A. Nurmukhametova, E. Z. Burnevich, Ye. V. Chesnokov, V. D. Pasechnikov, A. Hill, I. Lonjon-Domanec, S. N. Kizhlo

“…Sustained virologic response was achieved in 73 (80%) of patients available for analysis (n=91). …”
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Hyperferritinemia at the patient with chronic hepatitis C by Ye. N. German, A. O. Buyeverov, M. V. Mayevskaya, Ch. S. Pavlov, V. T. Ivashkin, A. A. Levina

“…After cessation of the treatment course clinical and laboratory abnormalities reduced. Sustained virologic response was ascertained.…”
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Russian interferon <i>α</i>-2b drug in the treatment of chronic hepatitis C by N. B. Kovaleva

“…At AVT, including Altevir® and ribavirin to CHC patients with 1b genotype of HCV and favorable prognosis of virologic response, 66% SVR rate can be achieved.…”
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Efficacy and safety of 3D-therapy at HCV-related subcompensated liver cirrhosis (genotype 1b) by P. O. Bogomolov, M. V. Matsiyevich, A. O. Buyeverov, V. D. Beznosenko, Ye. V. Fedosova, M. Yu. Petrachenkova, S. V. Koblov, K. Yu. Kokina, O. S. Kuzmina, N. V. Voronkova

“…The causes of inefficacy of previous modes of combined antiviral therapy (CAT) included absence of virologic response in 43.9% of the cases, recurrence of HCV replication - in 30.3%, virological breakthrough - in 16.7%, development of serious adverse effects - in 9.1%. …”
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Efficacy of daclatasvir and asunaprevir for viral hepatitis С in two donor lung recipients by D. T. Abdurakhmanov, Ye. . Sidorova, I. N. Tikhonov, N. A. Mukhin, V. T. Ivashkin

“…Combined therapy by asunaprevir and daclatasvir for 24 weeks resulted in sustained virologic response. No significant adverse effects on drug to drug interactions, except for mild and controllable alteration of tacrolimus blood level, were noted. …”
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Nucleoside analogues in treatment of liver cirrhosis as an outcome of chronic hepatitis B by I. G. Bakulin

“…Terms of lamivudine treatment for patients with liver cirrhosis should be no less than 22 months, and clearance HBV DNA is achieved in 93,9 % of patients. Sustained virologic response (it was assessed in 4 years after termination of treatment course) is estimated as 39%. …”
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Preliminary results of open comparative randomized study PHG-M3/P01-09 «ORION» on application of «Phosphogliv» in combined therapy of chronic hepatitis C by M. V. Mayevskaya

“…Analysis of cases with rapid virologic response (absence of HCV RNA or its level less than 750 copies/ml) within 4 wks of treatment has shown, that only the group phosphogliv/standard interferon α-2b/ribavirin included 3 such cases and that was especially important – all had the 1-st virus genotype. …”
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