The choice of adjuvant radiotherapy in pancreatic cancer patients after up-front radical surgery. by Xia Xiao, Pei Huang, Xiao-Ting Xu

“…<h4>Conclusions</h4>Our analysis demonstrates that adjuvant radiotherapy may be beneficial for N1 stage (N+) pancreatic cancer patients who have undergone up-front radical surgery with T2-4 stage, primary focus on the head of the pancreas, young age of onset, and receiving combination chemotherapy. …”
Get full text

The Potential Impact of Up-Front Drug Sensitivity Testing on India's Epidemic of Multi-Drug Resistant Tuberculosis. by Kuldeep Singh Sachdeva, Neeraj Raizada, Radhey Shyam Gupta, Sreenivas Achuthan Nair, Claudia Denkinger, Chinnambedu Nainarappan Paramasivan, Shubhangi Kulsange, Rahul Thakur, Puneet Dewan, Catharina Boehme, Nimalan Arinaminpathy

Get full text

UP-FRONT TRIPLE COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH SYSTEMIC SCLEROSIS: A CASE REPORT by A. V. Volkov, N. N. Yudkina, E. V. Nikolaeva, I. A. Kurmukov

“…This clinical case demonstrates the predictive capabilities of up-front triple combination therapy for severe PAH associated with SSc.…”
Get full text

The impact of axillary lymph node dissection on the prognosis of breast cancer patients undergoing up-front mastectomy with Sentinel lymph node micrometastases by Wu Ding, YongTian Chen, Yingli Lin, Xiaoliang Chen

“…Patients with T1-2 breast cancer and SLN micrometastases who underwent up-front mastectomy were included. Patients were categorized into two groups: Non-ALND and ALND. …”
Get full text

Real-World Outcomes of Induction Chemotherapy With or Without Low-Dose Nivolumab for Stage III Non–Small Cell Lung Cancer Ineligible for Up-Front Local Therapy: A Propensity Score–Matched Analysis by Praveen Kumar Marimuthu, Josh Thomas Georgy, Deepa Susan Joy Philip, Ajoy Oommen John, Anjana Joel, Divya Bala Thumaty, Raju Titus Chacko, Prashant Jambunathan, Zachariah Thomas, Kovilapu Harikrishna, Rajesh Isiah, Simon Pradeep Pavamani, Balukrishna Sasidharan, Manu Mathew, Thomas Alex Kodiatte, Aparna Irodi, Balamugesh Thangakunam, Barney T.J. Isaac, Richa Gupta, Jansi Rani, Ashish Singh

“…PURPOSEThere is a lack of literature on treating stage III non–oncogene-driven non–small cell lung cancer (NSCLC) with low-dose immunotherapy in combination with chemotherapy for patients who are not candidates for local therapy up front.MATERIALS AND METHODSWe performed an institutional retrospective analysis of patients with stage III non–oncogene-driven NSCLC deemed ineligible for up-front local therapy. …”
Get full text

Up-front dissection of the uterovesical space or “bladder-first approach” reduces hemorrhage and bladder injury during hysterectomy for placenta accreta spectrum: reconfirmed in 78 more cases in a prospective single-center studyAJOG Global Reports at a Glance by Pradip Kumar Saha, MD, MAMS, Rashmi Bagga, MD, DNB, Rimpi Singla, MD, Aashima Arora, MD, Vanita Jain, MD, Vanita Suri, MD, Kajal Jain, MD, Parveen Kumar, MD, DM, Nalini Gupta, MD, Ashish Jain, MD, Tulika Singh, MD, Ravimohan S. Mavuduru, MS, MCh

“…CONCLUSION: Our data support that up-front dissection of the uterovesical space or “bladder-first approach” reduces hemorrhage and bladder injury during cesarean hysterectomy in placenta accreta spectrum disorder, with no adverse effect on neonatal outcome. …”
Get full text

The prognostic significance of MMP-8 tissue Immunoexpression in pancreatic ductal adenocarcinoma after neoadjuvant therapy by Ella Kesti, Annika Eurola, Mirjami Kaasinen, Harri Mustonen, Jaana Hagström, Timo Sorsa, Ari Ristimäki, Hanna Seppänen, Caj Haglund, Malin Sund

“…We studied MMP-8 expression using immunohistochemistry in a tissue microarray with samples from 115 NAT and 144 up-front surgery patients. We examined NAT response from resection specimens by estimating the amount of residual tumour cells. …”
Get full text

Treatment Pattern and Outcome of Locally Advanced Rectal Cancer in Resource-Constrained Countries: Experience at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia by Elias Amare Hailu, Edom Seife Woldetsadik, Biruk Legesse Tadesse, Abdi Dandena Dibaba, Girum Tessema Zingeta, Hidagewoin Frew Kelemu, Yonas Alemayehu Zewde, Ruth Shimeles Aytehgeza, Kebede H. Begna

“…Because of better treatment completion, up-front surgery looks a more viable option than NACT in these situations. …”
Get full text

New trends in international investment law treaty practice: where does Latin America stand? by Mara Valenti

“…During the 90s, those countries stipulated many BilateralInvestment Treaties (BITs), subscribed to the Washington Convention, and, recently,they have been up front in the process of reconsideration regarging the legalsystem revolving around the BITs. …”
Get full text

Book review: Palmer, Sue (2016) Upstart: The case for raising the school starting age and providing what the under-sevens really need. Edinburgh: Floris Books by Kate Wall

“…As such, I find that I need to be up front from the start and say that I am wholly for the perspective argued for in Upstart. …”

« Le nez dans le micro ». Répercussions du travail sous commande vocale dans les entrepôts de la grande distribution alimentaire by David Gaborieau

“…Where the work used to be characterized by a lack of fixed sequencing and the impossibility for operatives of getting ahead of schedule, preparation activities have evolved towards more restrictive temporalities comparable to production line workers’ experience. With “up front and close” vocal guidance, order pickers’ skill is limited to their physical engagement, now considered a resource (i.e. a mode for appropriating the meaning of work) but also a bulwark against the pathologies that arise as the general intensification drive reaches its limits.…”
Get full text

Using Social Media to Engage Communities with Research: Accessibility by Kathryn A. Stofer, Kirsten Hecht, Lisa Lundgren

“…This new 6-page document, part of a series on using social media to engage communities with research, focuses on making your social media inclusive by integrating accessibility up front for individuals with disabilities of various types. …”
Get full text

Competencias de los municipios vascos: tipología y régimen jurídico by Francisco Velasco Caballero

“…And, more importantly, it establishes an innovative system of guarantee for the financial sufficiency of the municipal competences so that any new allocation of powers shall carry an up-front «specific provision of financing». Some of these novelties (specially the provision for a financial sufficiency attached to every new competence) have to be carefully implemented in order to avoid that the municipal aim they serve does not restrict real local autonomy.…”

Transit Fleet Electrification Barriers, Resolutions and Costs by Nawaf Nazir, Vincent Bruscas, Yury Dvorkin, Jeffrey Lidicker, Steven Polunsky, Philip Pugliese, William Tonis, Bolun Xu, Michael Kintner-Meyer

“…Participants identified barriers to fleet electrification including lack of knowledge on fleet electrification, high utility demand charges, lack of charging infrastructure, delays in grid infrastructure upgrades and high up-front costs. To overcome these challenges, panelists emphasized partnering with OEMs and utilities, and having flexible charging infrastructure with software support tools. …”
Get full text

Thoracentesis to alleviate pleural effusion in acute heart failure: study protocol for the multicentre, open-label, randomised controlled TAP-IT trial by Lars Køber, Morten Schou, Kasper Karmark Iversen, Dan Eik Høfsten, Finn Gustafsson, Brian Bridal Løgstrup, Olav W Nielsen, Kasper Rossing, Signe Glargaard, Jakob Hartvig Thomsen, Christian Tuxen, Christian Axel Bang, Matias Greve Lindholm, Ekim Seven, Anders Barasa, Nis Stride, Søren Vraa, Marlene Tofterup, Rasmus Vedby Rasmussen, Jens Jakob Thune

“…Participants will be randomised 1:1, stratified according to site and anticoagulant treatment, and assigned to referral to up-front ultrasound-guided pleural pigtail catheter thoracentesis in addition to standard pharmacological therapy or to standard pharmacological therapy only. …”
Get full text

A case for promoting negative emission technologies: learning from renewable energy support by Leonie P. Meissner

“…With renewable energy technologies (RETs), there has already been the introduction and expansion of a clean technology that faced similar obstacles as NETs—high up-front costs, limited competitiveness, and low public perception. …”
Get full text

The Semantic Analysis of the Security in the Holy Quran Based on the Theory of the Orientational Metaphors by Muhammad Hossein Shirzad, Muhammad Hasan Shirzad, Muhammad Sharifi

“…This research shows that security is expressed the linguistic representation in the form of the orientations “up, front and right” in the Quran language while insecurity is conceptualized in the form of the orientations “down, back and left”.…”
Get full text

The Second Canadian Gastroesophageal Reflux Disease Consensus: Moving Forward to New Concepts by ABR Thomson, N Chiba, D Armstrong, G Tougas, RH Hunt

“…The potential cost effectiveness of using medications with higher acquisition costs that may lower health care costs overall is often disregarded when conducting cost comparisons with medications having lower 'up-front' costs. Limiting therapy to less effective agents condemns many patients to protracted suffering, repeated physician visits and needless reinvestigation of symptoms that could have been resolved by appropriate initial therapy. …”
Get full text

What’s Special about Requirements Engineering for Quantum-Classical by Horacio Pendenti, Libardo Pantoja Yepez, Ricardo Perez Castillo, Julio Ariel Hurtado Alegrı́a, Leandro Antonelli, Alejandro Fernandez

“…The potential speedup of a quantum solution should be estimated and considered up-front. …”
Get full text

Construction and Application of Data Model in the Maritime Stereotactic Space Use by LI Shanchi, PENG Yihuan

“…The data model and application system have supported the up-front exploration of the management and decision on the right to use maritime stereotactic space. …”
Get full text