Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair by Min-ah Kim, Banseok Kim, Jihyeon Jeon, Jonghyun Lee, Hyeji Jang, Minjae Baek, Sang-Uk Seo, Dongkwan Shin, Anindya Dutta, Kyung Yong Lee

Get full text

A Network Pharmacology Study and Experimental Validation to Identify the Potential Mechanism of Heparan Sulfate on Alzheimer’s Disease-Related Neuroinflammation by Dong-Uk Kim, Bitna Kweon, Jinyoung Oh, Yebin Lim, Gyeongran Noh, Jihyun Yu, Hyang-Rin Kang, Tackmin Kwon, Kwang youll Lee, Gi-Sang Bae

Get full text

Proton response and neutron spectrum unfolding by solution-grown trans-stilbene scintillator by Nguyen Duy Quang, H. J. Kim, Sunghwan Kim, Sinchul Kang, Phan Quoc Vuong, Phan Bao Quoc Hieu, Nguyen Kien Cuong, Y. S. Yoon, Uk-Won Nam

Get full text

Black Carbon Exposure Characteristics in Diesel Engine Vehicle-related Jobs by Sangjun Choi, Ju-Hyun Park, Won Kim, Seung Won Kim, Kyong-Hui Lee, Taejin Chung, Jihoon Park, Seung-Hun Ryu, Jungah Shin, Dong-Hee Koh, Dong-Uk Park

Get full text

Comparative analysis of alectinib and brigatinib in real-world treatment of advanced NSCLC with ALK rearrangements by Kyuhwan Kim, Kyu Yean Kim, Hye Seon Kang, Ah Young Shin, Sung Kyoung Kim, Chan Kwon Park, Sang Haak Lee, Seung Joon Kim, Jeong Uk Lim, Chang Dong Yeo

Get full text

Neoadjuvant chemoradiotherapy up-regulates PD-L1 in radioresistant colorectal cancer by Sung Uk Bae, Hye Won Lee, Jee Young Park, Incheol Seo, Jae-Min Cho, Jin Young Kim, Ju Yup Lee, Yoo Jin Lee, Seong Kyu Baek, Nam Kyu Kim, Sang Jun Byun, Shin Kim

Get full text

Lesser Toxicities of Belotecan in Patients with Small Cell Lung Cancer: A Retrospective Single-Center Study of Camptothecin Analogs by Yeon Hee Park, Chae Uk Chung, Bo Mi Park, Myoung Rin Park, Dong Il Park, Jae Young Moon, Hee Sun Park, Jin Hwan Kim, Sung Soo Jung, Ju Ock Kim, Sun Young Kim, Jeong Eun Lee

Get full text

American Society for Gastrointestinal Endoscopy guideline on gastrostomy feeding tubes: methodology and review of evidence by Divyanshoo Rai Kohli, MD, Natalie Cosgrove, MD, Wasif M. Abidi, MD, PhD, Jorge D. Machicado, MD, MPH, Madhav Desai, MD, MPH, Nauzer Forbes, MD, MSc, Neil B. Marya, MD, Nikhil R. Thiruvengadam, MD, Nirav C. Thosani, MD, MHA, Omeed Alipour, MD, Saowanee Ngamruengphong, MD, Sherif E. Elhanafi, MD, Sunil G. Sheth, MD, Wenly Ruan, MD, John C. Fang, MD, Stephen A. McClave, MD, Rodrick C. Zvavanjanja, MD, MSc, FRCR(UK), FSIR, DABR(DR/VIR), Dhruvil K. Radadiya, MBBS, Amir Y. Kamel, PharmD, BCNSP, Bashar J. Qumseya, MD, MPH

Get full text

Observations of Microlensed Images with Dual-field Interferometry: On-sky Demonstration and Prospects by Przemek Mróz, Subo Dong, Antoine Mérand, Jinyi Shangguan, Julien Woillez, Andrew Gould, Andrzej Udalski, Frank Eisenhauer, Yoon-Hyun Ryu, Zexuan Wu, Zhuokai Liu, Hongjing Yang, —, Guillaume Bourdarot, Denis Defrère, Antonia Drescher, Maximilian Fabricius, Paulo Garcia, Reinhard Genzel, Stefan Gillessen, Sebastian F. Hönig, Laura Kreidberg, Jean-Baptiste Le Bouquin, Dieter Lutz, Florentin Millour, Thomas Ott, Thibaut Paumard, Jonas Sauter, T. Taro Shimizu, Christian Straubmeier, Matthias Subroweit, Felix Widmann, (The GRAVITY+ Collaboration), Michał K. Szymański, Igor Soszyński, Paweł Pietrukowicz, Szymon Kozłowski, Radosław Poleski, Jan Skowron, Krzysztof Ulaczyk, Mariusz Gromadzki, Krzysztof Rybicki, Patryk Iwanek, Marcin Wrona, Mateusz J. Mróz, (The OGLE Collaboration), Michael D. Albrow, Sun-Ju Chung, Cheongho Han, Kyu-Ha Hwang, Youn Kil Jung, In-Gu Shin, Yossi Shvartzvald, Jennifer C. Yee, Weicheng Zang, Sang-Mok Cha, Dong-Jin Kim, Seung-Lee Kim, Chung-Uk Lee, Dong-Joo Lee, Yongseok Lee, Byeong-Gon Park, Richard W. Pogge, (KMTNet Collaboration)

Get full text

An interpretable machine learning tool for in-home monitoring of agitation episodes in people living with dementia: a proof-of-concept studyResearch in context by Marirena Bafaloukou, Ann-Kathrin Schalkamp, Nan Fletcher-Lloyd, Alex Capstick, Chloe Walsh, Cynthia Sandor, Samaneh Kouchaki, Ramin Nilforooshan, Payam Barnaghi

“…N.F.L., A.C., C.W. and S.K. are funded by the UK Dementia Research Institute [award number UK DRI-7002].…”
Get full text

Seroprevalence of Borrelia burgdorferi sensu lato antibodies in English adult blood donors: A nationwide cross-sectional study, 2021–2022 by Eilish Hart, John Tulloch, Daniel Bailey, Tim Brooks, Heli Harvala, Peter Simmonds, Roberto Vivancos, Neil French, Amanda Semper

“…This is lower than neighbouring UK nation Scotland and other northern European countries.…”
Get full text

Precision oncology through next generation sequencing in hepatocellular carcinoma by Sayali Shinde, Carola Maria Bigogno, Ana Simmons, Nikita Kathuria, Aruni Ghose, Vedika Apte, Patricia Lapitan, Shania Makker, Aydin Caglayan, Stergios Boussios

Get full text

Nurture-U student mental health longitudinal survey: a study protocol by Kate E Saunders, Samuel R Chamberlain, Jemima Dooley, Edward R Watkins, Liz Forty, Sarah Rees, Anne C Duffy, Anthony Quinn, Ellen Marshall, Lucy Dorey, Kevin A Matlock, Alexandra Newbold, Lucy J Robinson

“…This study aims to address gaps in longitudinal data on student mental health in the UK and to identify risk and protective factors across diverse student populations.Methods and analysis The current Nurture-U survey is developed from the U-Flourish biannual survey study piloted at Queen’s and Oxford universities in Canada and the UK, respectively. …”
Get full text

BSG 2024 IBD guidelines protocol (standard operating procedures) by Philip Smith, Rachel Cooney, Jimmy Limdi, Sreedhar Subramanian, Polychronis Pavlidis, Ajay Verma, Said Din, Gordon W Moran, Naila Arebi, Shahida Din, Morris Gordon, Kamal V Patel, Klaartje Bel Kok, Dennis McGonagle, Matthew Shale, Ana-Maria Darie, Vasiliki Sinopoulou, Newton A C S Wong

“…Based on the available evidence, some of the recommendations will be based on GRADE while others will be best practice statements.A full Delphi process will be used to make recommendations using online response systems.This set of procedures has been approved by the Clinical Services and Standards Committee, the British Society of Gastroenterology executive board and aligned with IBD UK standards.…”
Get full text

Reply to: “Understanding virologic heterogeneity in chronic hepatitis B treatment” by Philippa C. Matthews, Tingyan Wang, Eleanor Barnes

Get full text

Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlle... by Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson

Get full text

Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimu... by Simon Gates, Matthew Collin, Victoria Potter, Rebecca Bishop, Ronjon Chakraverty, Kavita Raj, Adrian Bloor, Andrea Hodgkinson, Jeff Davies, Emma Kempshall, Fiona Dignan, Ram Malladi, Siobhan Smith, Charlotte Gaskell, Gabrielle Smith

“…Introduction Graft-versus-host disease (GvHD) remains a major complication of allogeneic stem cell transplantation (allo-SCT), affecting 30–70% of patients (representing 800 new patients per year in the UK). The risk is higher in patients undergoing unrelated allo-SCT. …”
Get full text

Recommendations for improving accessibility of digital health interventions for cardiometabolic disease for ethnically diverse populations by Mel Ramasawmy, Nushrat Khan, David Sunkersing, Madiha Sajid, Shivali H Modha, Manoj Mistry, Wasim Hanif, Fiona Stevenson, Kiran Patel, Kamlesh Khunti, Paramjit Gill, Lydia Poole, Amitava Banerjee

Get full text

Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study by Samuel Smith, Peter Sasieni, William Cross, Richard Bryant, Steven Kennish, James Catto, Rachel Hubbard, Simon Faulkner, Rohit Chahal, Mohantha Dooldeniya, Marcus Cumberbatch, Bernard North, Alastair D Lamb, Roseann Kealy, Selina Bhattrai

Get full text