Pharmacological Mechanism of Zuojin Pill for Gastroesophageal Reflux Disease: A Network Pharmacology Study by Mi Lv, Jinke Huang, Jiayan Hu, Wenxi Yu, Ping Liu, Kunli Zhang, Fengyun Wang

“…The findings suggest that ZJP alleviates the symptoms of GERD and improves the prognosis by regulating ROS metabolism, thereby reducing the secretion of proinflammatory cytokines like IL-1β, COX-2, CXCL8, and MMPs, regulating the expression of oncogenes such as JUN and FOS, and maintaining the normal expression of tumor suppressor genes such as TP53 and MYC. However, whether the effect of this modulation of ROS metabolism is positive or negative needs to be further verified by pharmacological experiments.…”
Get full text

The miRNA‐mRNA Regulatory Network in Human Hepatocellular Carcinoma by Transcriptomic Analysis From GEO by Razieh Heidari, Vahideh Assadollahi, Seyedeh Negar Marashi, Fatemeh Elahian, Seyed Abbas Mirzaei

“…The reduced levels of tumor suppressor miRNAs or down regulated DEmiRs may be increased levels of oncogenes, the oncomirs or up regulated DEmiRs may be decreased levels of tumor suppressor genes in cancerous cells. According to this strategy, increased and decreased DEGs, also increased and decreased DEmiRs were selected. …”
Get full text

The Effect of Atorvastatin on Oncogenic miRNAs in Hematological Malignancies: A Central Study by Jood Hashem, Farah Alsukhni, Hassan Abushukair, Mahmoud Ayesh

“…Atorvastatin upregulated several tumor suppressor genes involved in mediating better prognosis. …”
Get full text

miR-200 family as new potential prognostic factor of overall survival of patients with WHO G2 and WHO G3 brain gliomas by Mateusz Bilski, Marzanna Ciesielka, Magdalena Orzechowska, Bożena Jarosz, Paulina Całka, Sylwia Bilska, Agata Banach, Gabriela Czaja, Jacek Fijuth, Łukasz Kuncman

“…Even after incorporation of IDH1/2 mutations and 1p19q codeletion there are doubts regarding adjuvant treatment in WHO G2/G3 gliomas. miRNA molecules control about 30% of all genes, also many oncogenes, tumor suppressor genes and genes responsible for the response to ionizing radiation and systemic treatment. …”
Get full text

RETRACTED: Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1‐24.2 region in breast carcinoma: Clinical and prognostic implications by Satyabrata Sinha, Ratnesh K. Singh, Nilanjana Bhattacharya, Nupur Mukherjee, Susmita Ghosh, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda

“…Thus, our study suggests that LOH11CR2A, PIG8 and CHEK1 are candidate tumor suppressor genes associated with breast carcinoma and have significant clinical as well as prognostic importance.…”
Get full text