Integrated bioinformatics analysis to explore potential therapeutic targets and drugs for small cell carcinoma of the esophagus by Maofei Zhu, Maofei Zhu, Yueming Chu, Yueming Chu, Qiang Yuan, Qiang Yuan, Junfeng Li, Silin Chen, Lin Li, Lin Li, Lin Li

“…Then, up- and down-regulated genes were intersected with the oncogenes and the tumor suppressor genes respectively, to obtain the differentially expressed onco/tumor suppressor genes in SCCE. …”
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Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer by Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Sung-Sik Han, Sang-Jae Park, Woo Jin Lee

“…We discovered inactivating mutations of tumor suppressor genes, including APC, TP53, and ARID1A, in three patients. …”
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Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus by Marjon Kerkhof, Johannes G. Kusters, Herman van Dekken, Ernst J. Kuipers, Peter D. Siersema

“…In this review, we will summarize the most promising tissue biomarkers, i.e. proliferation/cell cycle proteins, tumor suppressor genes, adhesion molecules, DNA ploidy status and inflammation associated markers, that can be used for risk stratification in BE, and discuss their respective clinical application.…”
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Insights Into the Role of Bmi‐1 Deregulation in Promoting Stemness and Therapy Resistance in Glioblastoma: A Narrative Review by Fatima Shaalan, Nissrine Ballout, Wafaa Takash Chamoun

“…We find that Bmi‐1 participates in regulating the gene expression and chromatin structure of several tumor suppressor genes or cell cycle inhibitors. Bmi‐1 has a critical role in modulating the tumor microenvironment to support the plasticity of GBM stem cells.We explore Bmi‐1's involvement in maintaining glioma stem cell (GSC) proliferation and senescence evasion upon regulating the chromatin structure of several tumor suppressor genes, cell cycle inhibitors, or stem cell genes in tumor cells. …”
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PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate by Robert I. Glazer, Hongyan Yuan, Zhihui Xie, Yuzhi Yin

“…There is now emerging evidence that PPARs regulate tumor suppressor genes and developmental pathways associated with transformation and cell fate determination. …”
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Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature review by I. Kasiulevičiūtė

“…The pathogenic mutation is found in either the TSC1 or TSC2 tumor suppressor genes. The presence of cortical or subcortical tubers is associated with focal epileptiform discharges on the electroencephalogram and subclinical seizures prior to the onset of clinical seizures. …”
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ROLE OF HETEROZYGOUS TUMOR SUPPRESSORS IN THE LIFE LONGEVITY OF DROSOPHILA MELANOGASTER by S. A. Kopyl, L. V. Omelyanchuk, M. V. Shaposhnikov, A. A. Moskalev

“…Role of tumor-suppressor genes in the life longevity has not been studied in detail. …”
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Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science by Yuening Xiang, Zimu Guo, Pengfei Zhu, Jia Chen, Yongye Huang

“…Numerous genes have been reported to be involved when using TCM treatments and so we have selectively highlighted the role of a number of oncogene and tumor suppressor genes in TCM therapy. In addition, the impact of TCM treatment on DNA methylation, histone modification, and the regulation of noncoding RNAs is discussed. …”
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Preclinical Studies of Chemotherapy Using Histone Deacetylase Inhibitors in Endometrial Cancer by Noriyuki Takai, Hisashi Narahara

“…Because epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in endometrial cancers, novel compounds endowed with a histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach. …”
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Molecular landscape of lung cancer: insights into therapeutic targets and clinical outcomes by Saloni Mangal, Abhijit Debnath, Rupa Mazumder, Avijit Mazumder, Rajesh Kumar Singh, Jahanvi Sanchitra, S.K. Asif Jan, Pratibha Pandey, Bimlesh Kumar, Anil Kumar Singh

“…Genetic mutations, chromosomal abnormalities, transcription factors, mutations in tumor suppressor genes, and mutations in oncogenes have all been associated with an increased risk of LC development. …”
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The Notable Role of Telomere Length Maintenance in Complex Diseases by Jiahui Lv, Xinmiao Zhao, Linjie Zhao, Chengjun Gong, Wanjie Zheng, Li Guo, Jun Wang, Tingming Liang

“…Regulatory mechanisms of tumor suppressor genes on telomerase activity are analyzed, with a comprehensive overview of the current state and future potential of telomerase inhibitors. …”
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Therapeutic Implications of PPARγ in Human Osteosarcoma by Eric R. Wagner, Bai-Cheng He, Liang Chen, Guo-Wei Zuo, Wenli Zhang, Qiong Shi, Qing Luo, Xiaoji Luo, Bo Liu, Jinyong Luo, Farbod Rastegar, Connie J. He, Yawen Hu, Barrett Boody, Hue H. Luu, Tong-Chuan He, Zhong-Liang Deng, Rex C. Haydon

“…Although dysregulation of tumor suppressor genes and oncogenes, such as Rb, p53, and the genes critical to cell cycle control, genetic stability, and apoptosis have been identified in OS, consensus genetic changes that lead to OS development are poorly understood. …”
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Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection by Rajnish Kumar Singh, Ramakrishna Vangala, Atharva S. Torne, Dipayan Bose, Erle S. Robertson

“…The resultant reprogramming can lead to activation of oncogenes, silencing of tumor suppressor genes, and evasion of the immune response, which ultimately contributes to the oncogenic potential of these viruses. …”
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SnoRNAs: The promising targets for anti-tumor therapy by Xiaoyun Hu, Wanlin Cui, Min Liu, Fangxiao Zhang, Yingqi Zhao, Mingrong Zhang, Yuhang Yin, Yalun Li, Ying Che, Xianglong Zhu, Yuxuan Fan, Xiaolan Deng, Minjie Wei, Huizhe Wu

“…More importantly, snoRNAs extensively contribute to the development of tumor cell resistance as oncogenes or tumor suppressor genes. Accordingly, we provide a comprehensive review of the clinical diagnosis and treatment associated with snoRNAs and explore their significant potential as novel drug targets.…”
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Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game by Paqui G. Través, Alfonso Luque, Sonsoles Hortelano

“…In most tumors, TAMs show properties of an alternative polarization phenotype (M2) characterized by the expression of a series of chemokines, cytokines, and proteases that promote immunosuppression, tumor proliferation, and spreading of the cancer cells. Tumor suppressor genes have been traditionally linked to the regulation of cancer progression; however, a growing body of evidence indicates that these genes also play essential roles in the regulation of innate immunity pathways through molecular mechanisms that are still poorly understood. …”
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Targeting EZH2 in Cancer: Mechanisms, Pathways, and Therapeutic Potential by Maria Saveria Gilardini Montani, Rossella Benedetti, Mara Cirone

“…This review summarizes some of the mechanisms through which EZH2 regulates the expression and function of tumor suppressor genes and oncogenic molecules such as STAT3, mutant p53, and c-Myc and how it modulates the anti-cancer immune response. …”
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Molecular profiling and detection methods of microRNA in cancer research by Nurul-Syakima Ab Mutalib, Imilia Ismail, Hooi-Leng Ser

“…Acting like a “double-edge” sword, miRNAs can control and/or act as tumor suppressor genes and oncogenes, thus any unwanted alterations in their expression would bring upon disastrous effects on the host. …”
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A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System by Amy Adamson, Dennis LaJeunesse

“…Via our GMR-R model system, we have found that BRLF1 expression results in overproliferation of fly tissue, unlike BZLF1, and does so through the interaction with known tumor suppressor genes. Through an additional genetic screen, we have identified several Drosophila genes, with human homologs, that may offer further insights into the pathways that BRLF1 interacts with in order to promote EBV replication.…”
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Epigenetic Regulation of Stromal and Immune Cells and Therapeutic Targets in the Tumor Microenvironment by Kang Liu, Yue Li, Minmin Shen, Wei Xu, Shanshan Wu, Xinxin Yang, Bo Zhang, Nengming Lin

“…Epigenetic machinery, governing the expression of core oncogenes and tumor suppressor genes in transformed cells, significantly contributes to tumor development at both primary and distant sites. …”
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Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications by Zhenglin He, Yishuo Ji, Yutong Yuan, Tianfang Liang, Chenglin Liu, Yiping Jiao, Yimeng Chen, Yiming Yang, Liang Han, Liang Han, Yue Hu, Yue Hu, Xianling Cong, Xianling Cong, Xianling Cong

“…We elucidate how miRNAs modulate oncogenic pathways and tumor suppressor genes, influencing EC cell behavior and treatment outcomes. …”
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