Evaluation of social deprivation as a modifier of phenotypic divergence in PTEN Hamartoma Tumor Syndrome by Parker L. Bussies, David Bruckman, Lamis Yehia, Takae Mizukami, Karen Hurley, Jarrod Dalton, Charis Eng

“…Pathogenic mutations in phosphatase and tensin homolog (PTEN), a tumor suppressor gene, leads to the development of PTEN Hamartoma Tumor Syndrome (PHTS). …”
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Genotype‐phenotype correlation in 99 familial adenomatous polyposis patients: A prospective prevention protocol by Junea C. de Oliveira, Danilo V. Viana, Cleyton Zanardo, Erika M. M. Santos, André E. de Paula, Edenir I. Palmero, Benedito M. Rossi

“…Abstract Background Familial adenomatous polyposis (FAP) is a syndrome caused by germline pathogenic variants in the tumor suppressor gene adenomatous polyposis coli (APC). Identification of APC pathogenic variants sites and the genotype‐phenotype correlation are important for characterizing, monitoring, and treating members of affected families. …”
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Constructing adverse outcome pathway for per- and polyfluoroalkyl substances and retinoblastoma based on PI3K-AKT/MAPK signaling pathway by Yuyan GUI, Tingji WANG, Minghao WANG, Yaqi XU, Yunhui ZHANG

“…The activation of receptor tyrosine kinases (RTKs) served as the molecular initiating event, leading to the activation of key oncogenes such as RAS and AKT, as well as nuclear factor kappa-light chainenhancer of activated B cells (NF-κB), along with the inhibition of the tumor suppressor gene P53. In this study, 14 types of PFAS demonstrated good binding affinity with most RTKs, with chlorinated polyfluorinated ether sulfonates (Cl-PFESAs) showing particularly favorable predicted binding. …”
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BRCA1 is involved in sustaining rapid antler growth possibly via balancing of the p53/endoplasmic reticulum stress signaling pathway by Qianqian Guo, Zhen Wang, Jiping Li, Chao Ma, Junjun Zheng, Hengxing Ba, Guokun Zhang, Chunyi Li

“…Among these 39 genes, the tumor suppressor gene, BRCA1, was found to be more sensitive to DNA damage in the AnSCs compared to that in the deer somatic cells, and BRCA1 deletion in the AnSCs via CRISPR/Cas9 resulted in significantly higher levels of DNA damage. …”
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Role of early growth response-1 as a tumor suppressor in oral squamous cell carcinoma by Yudai Shimojukkoku, Phuong Thao Nguyen, Kiyohide Ishihata, Takayuki Ishida, Yuka Kajiya, Yasunobu Oku, Koshiro Kawaguchi, Takahiro Tsuchiyama, Hideto Saijo, Kaori Shima, Tomonori Sasahira

“…Its role in cancer is contentious, acting as either an oncogene or a tumor suppressor gene. Methods This study undertook comprehensive analyses, including big data scrutiny, expression profiling using 50 OSCC samples, and in vitro functional assessments, to elucidate EGR-1’s involvement in OSCC. …”
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PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women by H. Gbelcová, P. Bakeš, P. Priščáková, V. Šišovský, I. Hojsíková, Ľ. Straka, M. Konečný, J. Markus, C. W. D’Acunto, T. Ruml, D. Böhmer, Ľ. Danihel, V. Repiská

“…Formalin-fixed and paraffin-embedded tissue samples with simple hyperplasia (3), complex hyperplasia (5), atypical complex hyperplasia (7), endometrioid carcinomas G1 (20) and G3 (5), and serous carcinoma (5) were evaluated for the presence of mutations in coding regions of PTEN gene, the most frequently mutated tumor suppressor gene in endometrial carcinoma. 75% of the detected mutations were clustered in exons 5 and 8. …”
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Phthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer by Yuh-Shyan Tsai, Yeong-Chin Jou, Ian Seng Cheong, Hsiu-Ting Tung, Lin-Nei Hsu, Hsin-Tzu Tsai, Tzong-Shin Tzai

“…Unlike MIR-205, a known tumor suppressor gene in prostate cancer, gene set enrichment analysis revealed that higher MIR-5010 expression was linked to increased Nrf-2 downstream signaling (enriched score: 0.35; p = 0.17). …”
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Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development by Zhangmin Ke, Zhangmin Ke, Kaikai Shen, Li Wang, Hao Xu, Xia Pan, Zhenjue Qian, Yuting Wen, Tangfeng Lv, Xiuwei Zhang, Yong Song

“…SIRT5 exhibits dual functionalities: it can promote tumor proliferation, metastasis, drug resistance, and metabolic reprogramming, thereby acting as an oncogene; conversely, it can also inhibit tumor cell growth and induce apoptosis, functioning as a tumor suppressor gene. This review aims to provide a comprehensive overview of the current research status of SIRT5. …”
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Analysis of the progression of cervical cancer in a low-and-middle-income country: From pre-malignancy to invasive disease by Emma Robinson, Isabel Rodriguez, Victor Argueta, Yi Xie, Hong Lou, Rose Milano, Hyo Jung Lee, Laurie Burdett, Sambit K. Mishra, Meredith Yeager, Lisa Mirabello, Michael Dean, Roberto Orozco

“…In contrast, the TP53 and RB1 tumor suppressor gene expression is significantly decreased in cancer cells. …”
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Identification of a novel immune checkpoint-related gene signature predicts prognosis and immunotherapy in breast cancer and experiment verification by Ke Yin, Yangyang Guo, Jinqiu Wang, Shenchao Guo, Chunxu Zhang, Yongping Dai, Yu Guo, Chen Dai

“…Finally, results of cell-based assays indicated that MAP2K6 may play a pivotal role in the initiation and progression of breast cancer as a tumor suppressor gene. In conclusion, we created a novel ICG signature that has the potential to predict the survival and drug sensitivity of BRCA patients. …”
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Upregulation of HPV16E1 and E7 expression and FOXO3a mRNA downregulation in high-grade cervical neoplasia by Thanayod Sasivimolrattana, Aileen Gunawan, Warattaya Wattanathavorn, Chavis Pholpong, Arkom Chaiwongkot, Pattarasinee Bhattarakosol, Parvapan Bhattarakosol

“…This study aims to investigate the correlation between the expression of HPV16 early genes and the mRNA expression of human FOXO3a, a tumor suppressor gene, in association with various stages of cervical precancerous lesions. …”
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The mutational landscape of ARMC5 in Primary Bilateral Macronodular Adrenal Hyperplasia: an update by Lucas Bouys, Anna Vaczlavik, Isadora P. Cavalcante, Florian Violon, Anne Jouinot, Annabel Berthon, Patricia Vaduva, Stéphanie Espiard, Karine Perlemoine, Peter Kamenicky, Marie-Christine Vantyghem, Antoine Tabarin, Gérald Raverot, Cristina L. Ronchi, Ulrich Dischinger, Martin Reincke, Maria C. Fragoso, Constantine A. Stratakis, Albain Chansavang, Eric Pasmant, Bruno Ragazzon, Jérôme Bertherat, for the COMETE and ENSAT Networks

“…Germline inactivating variants of the tumor suppressor gene ARMC5 are responsible for 20–25% of apparently sporadic PBMAH cases and 80% of familial presentations. …”
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Identification of novel functional compounds from forest onion and its biological activities against breast cancer by Fahrul Nurkolis, Isma Kurniatanty, Elvan Wiyarta, Happy Kurnia Permatasari, Nelly Mayulu, Nurpudji Astuti Taslim, Raymond Rubianto Tjandrawinata, Hardinsyah Hardinsyah, Trina Ekawati Tallei, Apollinaire Tsopmo, Son Radu, Edwin Hadinata, Bonglee Kim, Rosy Iara Maciel Azambuja Ribeiro, Rony Abdi Syahputra

“…Significant (p < 0.05) upregulation of tumor suppressor gene miR-29a-3p in MCF-7 was observed after treatment with EBE in a dose-dependent manner.…”
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Peel of pumpkin (Cucurbita pepo) diets boost growth, digestive-absorptive functions, immune-antioxidant indices, and regulate immunomodulatory genes and mTOR/MAPK-P38/apoptosis sig... by Rowida E. Ibrahim, Gehad E. Elshopakey, Elsayed M. Younis, Abdelwahab A. Abdelwarith, Asmaa Yaseen, Tarek Khamis, Simon J. Davies, Afaf N. Abdel Rahman

“…CPP diets caused down-regulation (P˂0.05) of the splenic expression of the tumor suppressor gene (P53), mitogen-activated protein kinase (P38), caspase-9, and mechanistic target of rapamycin. …”
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Epidermal Growth Factor Receptor (EGFR) and SMAD4 negatively correlated in the progression of gallbladder cancer in Eastern Indian patients by Sounetra Choudhury, Sandip Ghosh, Prosenjeet Chakraborty, Sayari Pal, Koustuv Ghosh, Subhankar Saha, Jitesh Midha, Vinu Sankar, Abhisek Mohata, Bitan Kumar Chattopadhyay, Shibajyoti Ghosh, Soumen Das, Biswarup Basu, Nilabja Sikdar

“…Results The oncogenes (EGFR and ERBB2/Her2-neu) were statistically significantly overexpressed and the tumor suppressor gene (SMAD4) downregulated in our GBC tumor patient samples. …”
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NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model by Ismail M Meraz, Mourad Majidi, Renduo Song, Feng Meng, Lihui Gao, Qi Wang, Jing Wang, Elizabeth J Shpall, Jack A Roth

“…Expression of NPRL2/TUSC4, a tumor-suppressor gene, is reduced in many cancers including NSCLC. …”
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NALCN expression is down-regulated and associated with immune infiltration in gastric cancer by Xuewei Li, Xuewei Li, Na Wu, Chen Wang, Beibei Pei, Xiaoyan Ma, Jun Xie, Jun Xie, Wenhui Yang

“…BackgroundNALCN has been identified as a tumor suppressor gene, and its role in human cancer progression has garnered significant attention. …”
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Meta-analysis: p16INK4α (Cyclin Dependent Kinase Inhibitor 2A) is one of the major causes of nasopharyngeal cancer by Lao Đức Thuận, Nguyễn Thị Ngọc Thảo, Thiều Hồng Huệ, Nguyễn Trung Hiếu, Phạm Thị Thúy Ngọc, Trần Bích Thư, Lê Huyền Ái Thúy

“…The p16INK4α gene, also known as cyclin-dependent kinase inhibitor, is a tumor suppressor gene that inhibits Cyclin-Dependent Kinase (CDK), leading to the inhibition of CDK interaction with cyclin, thereby inhibiting the phosphorylation process on pRb, halting the cell cycle. …”
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The N-Terminal Region of the Transcription Factor E2F1 Contains a Novel Transactivation Domain and Recruits General Transcription Factor GTF2H2 by Lin Zhao, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Yuki Kamiya, Hiroyuki Toh, Hideyuki Komori, Ritsuko Iwanaga, Andrew P. Bradford, Hideo Nishitani, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani

“…We show here that the N-terminal region of E2F1 is critical for the activation of tumor suppressor genes. Deletion of the N-terminal region dramatically compromised E2F1 activation of tumor suppressor genes. …”
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Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation by Wen Zeng, Hanjun Dai, Ming Yan, Xiaojun Cai, Hong Luo, Min Ke, Zeming Liu

“…The epigenetic silencing of tumor suppressor genes in myelodysplastic syndromes (MDS) can potentially confer a growth advantage to individual cellular clones. …”
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