Innovative organ-on-a-chip platforms for exploring tumorigenesis and therapy in head and neck cancer by Chen Lin, Zilin Zhang, Feili Yang, Shanshan Gu, Jiyang Zuo, Yi Wu, Jing Zhang, Tiantian Zhou, Yuna Zhang, Zaozao Chen, Zhongze Gu, Zhisen Shen

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Identification of copper metabolism-related subtypes, the development of a prognosis model, and characterization of the immune landscape in colorectal cancer by Geng Peng, Lin Zhong, Nan Lai, Lina Luo, Fu Cheng, Manzhao Ouyang

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Characteristics of immune-active and immune-silent phenotypes of early-stage cervical carcinoma as revealed by transcriptome sequencing by O. V. Kurmyshkina, P. I. Kovchur, T. O. Volkova

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Antitumor and immunomodulatory effects of oxygen therapy by V. I. Seledtsov, A. B. Dorzhieva, G. V. Seledtsova

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Exploring the effect of canine cancer-associated fibroblasts on T cell dynamics through the CXCL12/CXCR4 axis modulated by TGF-β1 by Ayano Kudo, Shintaro Kamo, Akinori Yamauchi, Sho Yoshimoto, Yuma Harada, Eiichi Kanai, Satoshi Takagi

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Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression by Lixia Cao, Wei Sun, Xiao Chen, Lei Liu, Shaorong Zhao, Jingjing Liu, Yang Ou, Min Guo, Chunchun Qi, Zhaoxian Li, Jie Shi, Yuxin Liu, Qiuying Shuai, Siyu Zuo, Huayu Hu, Tianwen Yu, Yanjing Wang, Mengdan Feng, Jianying Lv, Hang Wang, Peiqing Sun, Jin Zhang, Longlong Wang, Yi Shi, Shuang Yang

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Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression by Devadarssen Murdamoothoo, Zhen Sun, Alev Yilmaz, Gilles Riegel, Chérine Abou‐Faycal, Claire Deligne, Ines Velazquez‐Quesada, William Erne, Marine Nascimento, Matthias Mörgelin, Gérard Cremel, Nicodème Paul, Raphael Carapito, Romain Veber, Hélène Dumortier, Jingping Yuan, Kim S Midwood, Thomas Loustau, Gertraud Orend

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SENP1-Sirt3 axis regulates type II alveolar epithelial cell activity to confer resistance against oxidative damage in lung tissue by Mingming Zhang, Xin Lin, Jianli He, Yong Zuo, Qiuju Fan, Innocent Agida, Hongsheng Tan, Caiying Zhu, Jinke Cheng, Tianshi Wang

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The tricky effects of TROP2 in lung cancer: from clinical practice back to fundamental investigations by Renwang Liu, Renwang Liu, Mingbiao Li, Penghu Gao, Penghu Gao, Xuanguang Li, Xuanguang Li, Zihe Zhang, Zihe Zhang, Jun Chen, Jun Chen

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Integrated oral-gut microbiota therapy: a novel perspective on preventing bacterial translocation for systemic disease management by Jie Zhu, Ziyi Jiang, Fangli Yu, Linglin Gao, Xiaomei Wang, Qiang Wang

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Ultrasound-activated miR-195-5p/shikonin nanobubbles remodel immunosuppressive microenvironment via immunogenic cell death to potentiate PD-1/PD-L1 blockade in hepatocellular carci... by Yandi Tan, Qiao Xu, Yezi Chen, Yun Liu, Chaoqi Liu, Xinwu Cui, Yun Zhao

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The role of formin-like protein 1 in pancreatic cancer and its specific effects on immunity by Jian Liu, Junli Ding, Liang Chen, Shoupeng Shao, Jie Mei, Xuejing Yang

“…Moreover, formin-like protein 1 was linked to an inflamed tumor microenvironment and mediated epithelial–mesenchymal transition and programmed cell death 1 ligand 1 expression in pancreatic cancer. …”
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P16 | A 3D IN VITRO MODEL TO STUDY CAF PLASTICITY AND TUMOR-STROMA INTERACTIONS IN OVARIAN CANCER

“… The tumor microenvironment (TME) plays a pivotal role in cancer progression and therapy resistance. …”
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Precision delivery of estrogen receptor antagonists using bioorthogonal chemistry-based intelligent nanocarriers to overcome cervical cancer drug resistance by Xue Yang, Yang Gu

“…Nanocarriers designed for specific recognition of ERα and ERβ also enable modulation of the tumor microenvironment (TME) and exhibit synergistic potential when combined with immunotherapy to overcome drug resistance. …”
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Unleashing NK cells for cancer immunotherapy in lung cancer: biologic challenges and clinical advances by Quinlan McLaughlin, Dorothy K. Sojka, Kathleen Kennedy, Sytse J. Piersma, Nan Sethakorn

“…Despite their promising potential for anti-tumor killing, NK cell function is often diminished within the tumor microenvironment. There are many factors that lead to decreased tumor-infiltrating NK cell killing, including immunoinhibitory factors from tumor cells and resident tissues, acquired immune tolerance, NK cell exhaustion, and the hypoxic state of the tumor microenvironment. …”
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Roles of the phagocytosis checkpoint in radiotherapy by Yulan Kui, Fan Tong, Ruiguang Zhang, Jian Wang, Xiaorong Dong

“…Phagocytosis checkpoints are regulated by a series of receptor-ligand binding molecules, respectively on the tumor cells and phagocytes, which mediate pro-phagocytosis or anti-phagocytosis signals, modulate tumor antigen presentation, and further determine the infiltration of tumor-specific cytotoxic T cells in the tumor microenvironment. Radiotherapy regulates the different phagocytosis checkpoints on the tumor cells and phagocytes to modulate phagocytic clearance and reshape the irradiated tumor microenvironment. …”
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Oxidative stress in cancer: from tumor and microenvironment remodeling to therapeutic frontiers by Xisong Liang, Jiadi Weng, Zhongyi You, Yang Wang, Jie Wen, Zhiwei Xia, Shaorong Huang, Peng Luo, Quan Cheng

“…Oxidative stress interacts with tumor cell growth regulation and tumor microenvironment remodeling, and has been a critical hallmark of cancer. …”
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Antibody-functionalized iron-based nanoplatform for ferroptosis-augmented targeted therapy of HER2-positive breast cancer by Jingchao Gao, Tong Ye, Hongkun Miao, Mingjiang Liu, Li Wen, Yi Tian, Zhiguang Fu, Li Sun, Lihong Wang, Yu Wang

“…In this study, we proposed an antibody-targeted nanoplatform responsive to the tumor microenvironment, aiming to induce ferroptosis in HER2+ breast cancer cells and thereby enhance the sensitivity to HER2-targeted drugs. …”
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Lymph node transcriptomic profiles suggest susceptibility to bleomycin-induced pulmonary toxicity in classic hodgkin lymphoma by Maja Dam Andersen, Marie Hairing Enemark, Kristina Lystlund Lauridsen, Stephen Jacques Hamilton-Dutoit, Jørn Starklint, Francesco d’Amore, Maja Ludvigsen, Peter Kamper

“…This study aimed to characterize the pre-therapeutic nodal tumor microenvironment in CHL patients with and without BPT development. …”
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PML localization in tumor associated macrophages as a prognostic marker in triple negative breast cancer by Bianca Vezzani, Sonia Missiroli, Massimo Pedriali, Patrizia Querzoli, Iva Maestri, Paolo Carcoforo, Giovanni Lanza, Roberta Gafà, Paolo Pinton, Carlotta Giorgi

“…This promotes a pro-inflammatory tumor microenvironment as seen in patients with adverse outcomes. …”
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